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Early neural processes underlying fluent reading: the functional role of rapid activation in the inferior frontal cortex.

Research Project

Project/Area Number 20K22263
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section :Education and related fields
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

Uno Tomoki  国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 流動研究員 (40881785)

Project Period (FY) 2020-09-11 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords視覚単語認知 / 経頭蓋磁気刺激 / 読みの流暢性 / 言語 / 音読 / 認知神経科学
Outline of Research at the Start

流暢な「読み」のためには,文字の形態を同定し音韻情報へと変換する過程(書記素-音素変換)を素早く行う必要がある。この背景にある脳のメカニズムとして,文字形態に関わる腹側後頭皮質と,左半球の前頭皮質の間の素早い相互作用があるとされている。本研究では,後頭側頭-前頭皮質間の早い時間帯における機能連関がどのように達成されているのか,そしてそれが流暢な読みにどのように貢献するかについて,経頭蓋磁気刺激と脳磁図を用いて検討を行う。こうした早い処理過程は読みの流暢性の獲得に重要であり,その神経生物学的基盤を明らかにすることは,発達性ディスレクシアの障害メカニズムの理解に貢献すると考えられる。

Outline of Final Research Achievements

Although reading written words quickly is an essential ability for daily life, people with developmental dyslexia are likely to have residual difficulties in fluent reading. It is necessary to clarify the neuropsychological mechanism underlying fast reading for educational support for them, however, this is still elusive to date. This study aimed to elucidate the functional and causal role of rapid activity in the left inferior frontal cortex in fluent reading. The present outcomes provide the first evidence showing that early activation in the left inferior frontal cortex specifically mediates the rapid motor production of speech sounds in reading and that it is not necessarily the functioning “downstream” of other reading-related brain regions.

Academic Significance and Societal Importance of the Research Achievements

本研究の知見は、左下前頭皮質で生じる高速な発話処理が、従来のモデルで提案されてきたような読み処理過程の「機能的下流」では必ずしもないことを初めて示したことに学術的意義がある。さらにこうした高速な神経処理過程の機能不全は,文字を読むことの遅さ(流暢性の障害)の直接的な要因となり得ることから,本研究から得られた知見は,将来的には読字障害の原因機序解明の一助となることが期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (5 results)

All 2023 2022 2021 2020

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] The Developmental Change of Print‐Tuned N170 in Highly Transparent Writing Systems2021

    • Author(s)
      Uno Tomoki、Kasai Tetsuko、Seki Ayumi
    • Journal Title

      Japanese Psychological Research

      Volume: - Issue: 1 Pages: 82-89

    • DOI

      10.1111/jpr.12397

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Object-based Attention inLeft-lateralization of Print-specific ERP2020

    • Author(s)
      宇野 智己, 片倉 崇吏, 河西 哲子
    • Journal Title

      Japanese Journal of Physiological Psychology and Psychophysiology

      Volume: 38 Issue: 3 Pages: 139-148

    • DOI

      10.5674/jjppp.2009oa

    • NAID

      130008000372

    • ISSN
      0289-2405, 2185-551X
    • Year and Date
      2020-12-31
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] The anterior temporal semantic hub in the left and right hemispheres: A unified system or two separate systems for meaning?2023

    • Author(s)
      Tomoki Uno, Marc Teichmann, Kouji Takano, Mio Yokoi, Kimihiro Nakamura
    • Organizer
      Cognitive Neuroscience Society 2023 Annual Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early activation of Broca's area causally contributes to speeded reading2022

    • Author(s)
      Tomoki Uno, Kouji Takano, Kimihiro Nakamura
    • Organizer
      Cognitive Neuroscience Society 2022 Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Early activation of Broca's area plays a causal role in visual word recognition2021

    • Author(s)
      Tomoki Uno, Kouji Takano, Kimihiro Nakamura
    • Organizer
      Cognitive Neuroscience Society 2021 virtual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2020-09-29   Modified: 2024-01-30  

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