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Development of a real-time feedback method to regulate spontaneous brain oscillations during sleep to facilitate learning in older adults

Research Project

Project/Area Number 20K22297
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0110:Psychology and related fields
Research InstitutionInstitute of Physical and Chemical Research (2021-2022)
National Institute of Occupational Safety and Health,Japan (2020)

Principal Investigator

Tamaki Masako  国立研究開発法人理化学研究所, 脳神経科学研究センター, 理研白眉研究チームリーダー (20586276)

Project Period (FY) 2020-09-11 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords睡眠 / 学習 / 加齢 / 技能学習 / フィードバック / 自発脳活動
Outline of Research at the Start

睡眠が学習などの脳機能に重要な役割を果たすことが示唆されている。しかし加齢に伴い、睡眠の質が悪化し学習に関連する睡眠中の自発脳活動が変容する可能性がある。今後、日本社会では一層労働力が高齢化することが予見され、加齢により慢性的な睡眠変容と学習低下が生じると、高年齢の労働者が新しい職場に適応できず精神衛生が悪化したり事故や怪我が引き起こされたりなど、社会に深刻な影響がある可能性がある。そこで加齢に伴う睡眠と学習の低下を防ぐ方法を開発することは急務の課題である。本研究では、睡眠中の自発脳活動の非侵襲的な操作方法を開発し、高齢者の睡眠の質、睡眠中の自発脳活動や学習への効果を調べることを目的とする。

Outline of Final Research Achievements

Accumulating body of evidence shows that sleep contributes to learning and memory. Previous research in young healthy subjects indicate that spontaneous brain oscillations during sleep play essential roles in learning, i.e. offline performance gains and stabilization of learning. It has been shown that aging impairs sleep quality and may alter brain oscillatory activities during sleep. The results of the present research suggest that aging indeed impairs offline performance gains over sleep, but not the training itself. We have also constructed an online feedback system where sounds were presented in realtime during sleep to modulate brain activities during sleep.

Academic Significance and Societal Importance of the Research Achievements

加齢に伴う睡眠の質の低下や睡眠障害が認知機能に及ぼす影響が示唆されており、加齢による睡眠の変化と認知機能の問題を解決することは、労働力の高齢化する日本社会における急務の課題である。本研究結果から加齢に伴う睡眠依存の学習プロセスへの影響が示唆されたこと、そして自発脳活動をリアルタイムで検出し音刺激を提示するシステムは、今後の高齢者における学習機能の回復を目指す上で意義があると考えられる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (25 results)

All 2022 2021 2020

All Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 4 results,  Invited: 10 results) Book (2 results)

  • [Journal Article] Shift-Work Schedule Intervention for Extending Restart Breaks after Consecutive Night Shifts: A Non-randomized Controlled Cross-Over Study2022

    • Author(s)
      Kubo Tomohide、Matsumoto Shun、Izawa Shuhei、Ikeda Hiroki、Nishimura Yuki、Kawakami Sayaka、Tamaki Masako、Masuda Sanae
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 22 Pages: 15042-15042

    • DOI

      10.3390/ijerph192215042

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep-Dependent Facilitation of Visual Perceptual Learning Is Consistent with a Learning-Dependent Model2022

    • Author(s)
      Tamaki Masako、Sasaki Yuka
    • Journal Title

      Journal of Neuroscience

      Volume: 42 Issue: 9 Pages: 1777-1790

    • DOI

      10.1523/jneurosci.0982-21.2021

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of NREM and REM Sleep in Visual Perceptual Learning2021

    • Author(s)
      玉置應子
    • Journal Title

      Japanese Journal of Physiological Psychology and Psychophysiology

      Volume: 39 Issue: 1 Pages: 36-51

    • DOI

      10.5674/jjppp.2108si

    • NAID

      130008130236

    • ISSN
      0289-2405, 2185-551X
    • Year and Date
      2021-04-30
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coregistration of magnetic resonance spectroscopy and polysomnography for sleep analysis in human subjects2021

    • Author(s)
      Tamaki Masako、Watanabe Takeo、Sasaki Yuka
    • Journal Title

      STAR Protocols

      Volume: 2 Issue: 4 Pages: 100974-100974

    • DOI

      10.1016/j.xpro.2021.100974

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Visual perceptual learning of a primitive feature in human V1/V2 as a result of unconscious processing, revealed by decoded functional MRI neurofeedback (DecNef)2021

    • Author(s)
      Wang Zhiyan、Tamaki Masako、Frank Sebastian M.、Shibata Kazuhisa、Worden Michael S.、Yamada Takashi、Kawato Mitsuo、Sasaki Yuka、Watanabe Takeo
    • Journal Title

      Journal of Vision

      Volume: 21 Issue: 8 Pages: 24-24

    • DOI

      10.1167/jov.21.8.24

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 睡眠と記憶や学習の定着:ノンレム睡眠とレム睡眠中の記憶処理2021

    • Author(s)
      玉置應子
    • Journal Title

      Progress in Medicine

      Volume: 41 Pages: 1171-1175

    • Related Report
      2021 Research-status Report
  • [Journal Article] Visual perceptual learning of a primitive feature in human V1/V2 as a result of unconscious processing, revealed by Decoded fMRI Neurofeedback (DecNef)2020

    • Author(s)
      Wang Zhiyan、Tamaki Masako、Shibata Kazuhisa、Worden Michael S.、Yamada Takashi、Kawato Mitsuo、Sasaki Yuka、Watanabe Takeo
    • Journal Title

      bioRxiv

      Volume: N/A

    • DOI

      10.1101/2020.11.30.405209

    • Related Report
      2020 Research-status Report
    • Open Access / Int'l Joint Research
  • [Presentation] Why we sleep poorly in a new place2022

    • Author(s)
      Masako Tamaki
    • Organizer
      Consciousness Talks
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 視覚学習に睡眠はどのような役割を果たすのか2022

    • Author(s)
      玉置應子
    • Organizer
      東京電機大学
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 視覚学習における睡眠の役割2022

    • Author(s)
      玉置應子
    • Organizer
      脳科学コンソーシアム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Reading out sleep spindles from cortical and subcortical brain circuits during sleep.2022

    • Author(s)
      Uji M, Li X, Saotome A, Katsumata R, Aritake S, Suzuki C, Ueno K, Tamaki M.
    • Organizer
      Neuroscience 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The first-night effect impairs neurochemical processing of visual plasticity during NREM sleep, revealed by simultaneous magnetic resonance spectroscopy and polysomnography.2021

    • Author(s)
      Tamaki M, Barnes-Diana T, Wang Z, Watanabe T, Sasaki Y.
    • Organizer
      Neuroscience 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 夜勤後の勤務感インターバル確保を念頭位においた3交代勤務シフトスケジュールへの介入調査2021

    • Author(s)
      久保智英、松元俊、井澤修平、西村悠貴、川上澄香、池田大樹、玉置應子
    • Organizer
      第69回日本職業・災害医学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Safety assessment study on temperature rise during MR scans with EEG electrode cap.2021

    • Author(s)
      Ueno K, Tamaki M, Suzuki C, Kamiguchi H, Tanaka K and Waggoner RA.
    • Organizer
      The 49th Japan Society for Magnetic Resonance in Medicine (JSMRM)
    • Related Report
      2021 Research-status Report
  • [Presentation] Sleep depth is represented in the early visual area: evidence from multivoxel pattern analysis.2021

    • Author(s)
      Yamada T, Tamaki M, Watanabe T, Sasaki Y.
    • Organizer
      Vision Sciences Society Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of NREM and REM sleep in offline gains and stabilization of visual perceptual learning2021

    • Author(s)
      玉置應子
    • Organizer
      日本睡眠学会第46回定期学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 睡眠における知覚学習のメカニズム2021

    • Author(s)
      玉置應子
    • Organizer
      2021年秋 第37回 日本臨床化学会関東支部例会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 視覚学習におけるノンレム睡眠とレム睡眠の役割2021

    • Author(s)
      玉置應子
    • Organizer
      日本視覚学会 2022年 冬季大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 睡眠中の相反する神経化学的および 機能的プロセスと視覚学習2021

    • Author(s)
      玉置應子
    • Organizer
      戦略的国際脳科学研究推進プログラム(国際脳) 非線形動力学に基づく次世代AIと基盤技術に関する研究開発 東大・理研共催セミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 視覚学習の促進と定着におけるノンレム睡眠とレム睡眠の相補的な役割2021

    • Author(s)
      玉置應子
    • Organizer
      2021年度生理学研究所研究会 記憶研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 睡眠中の相反する神経化学的および機能的プロセスと視覚学習2021

    • Author(s)
      玉置應子
    • Organizer
      精神神経内分泌免疫学研究会 第27回研究集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Complementary roles of NREM and REM sleep in facilitation of visual perceptual learning2021

    • Author(s)
      Masako Tamaki
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Different but complementary roles of NREM and REM sleep in facilitation of visual perceptual learning associated with neurotransmitters changes revealed by magnetic resonance spectroscopy.2020

    • Author(s)
      Masako Tamaki, Zhiyan Wang, Tyler Barnes-Diana, DeeAnn Guo, Aaron V. Berard, Edward Walsh, Takeo Watanabe, Yuka Sasaki.
    • Organizer
      25th Congress of The European Sleep Research Society.
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] 快眠研究と製品開発、社会実装 (学習と記憶における睡眠の役割(2章5節)担当)2022

    • Author(s)
      玉置應子(田中 秀樹、岩城 達也、白川 修一郎編)
    • Total Pages
      812
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860437848
    • Related Report
      2022 Annual Research Report
  • [Book] 睡眠学 (第2版)第8章 8.6 睡眠恒常性と局所睡眠.2020

    • Author(s)
      玉置應子,佐々木由香
    • Total Pages
      11696
    • Publisher
      朝倉書店
    • ISBN
      9784254301205
    • Related Report
      2020 Research-status Report

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Published: 2020-09-29   Modified: 2024-01-30  

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