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Studying polydiacetylene mechanochromism by nanofriction force microscopy

Research Project

Project/Area Number 20K22324
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0202:Condensed matter physics, plasma science, nuclear engineering, earth resources engineering, energy engineering, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Sugihara Kaori  東京大学, 生産技術研究所, 講師 (60740800)

Project Period (FY) 2020-09-11 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsメカノクロミックポリマー / 摩擦力顕微鏡 / 原子間力顕微鏡 / 脂質
Outline of Research at the Start

メカノクロミック素材とは押したり引っ張ったり力を加えることで色を変化させたり蛍光を発光したりする特殊なマテリアルである。その物性を活かして、分子レベルでの力を検知するセンサの開発が進められている。本研究では、メカノクロミックポリマー、ポリジアセチレンがどの向きに、どの程度の力を加えることでどれだけ発光するのかという「力と発光の定量的ナノスケールでの相関」を、近年自身で開発した「ナノ摩擦力顕微鏡」を導入することで解明する。メカノクロミック素材を理解する上で核となる問いを明らかにすることで、ナノ力センサ開発への大きな前進を目指す。

Outline of Final Research Achievements

Mechanochromic materials are attracting attention for their visual impact and interesting principle of changing color and emitting light when force is applied externally, and as sensors that can detect nanoscale forces that cannot be measured with existing devices. Among them, polydiacetylene is highly sensitive due to its unique principle of sensing force by "twisting," and is being developed for use as a biosensor to detect biomolecules and other substances. In this study, we have studied the "quantitative nanoscale correlation between force and luminescence" by introducing the "nano friction force microscope" that we have recently developed.

Academic Significance and Societal Importance of the Research Achievements

メカノクロミック素材を理解する上で核となる問いを明らかにすることで、分子レベルでの力を検知するセンサへの応用開発を前進させる意義がある。例えばエネルギー損失となっている機械の摩擦、患者に不快感を与えている義足と肢体間の摩擦、ナノスケールでかかる生体分子間の力など、既存の装置では測定することが難しい力を空間マッピングすることが可能となる。このような力を可視化し問題解決に繋げることでエネルギー効率の高いマシン、つけ心地のよい義足、高感度のバイオセンサ開発などに貢献する。

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (25 results)

All 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results) Presentation (16 results) (of which Int'l Joint Research: 5 results,  Invited: 9 results)

  • [Int'l Joint Research] ジュネーブ大学(スイス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ジュネーブ大学(スイス)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Recent progress in polydiacetylene mechanochromism2022

    • Author(s)
      Das Bratati、Jo Seiko、Zheng Jianlu、Chen Jiali、Sugihara Kaori
    • Journal Title

      Nanoscale

      Volume: 14 Issue: 5 Pages: 1670-1678

    • DOI

      10.1039/d1nr07129g

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a membrane force sensor based on mechanochromic polymers2021

    • Author(s)
      杉原 加織
    • Journal Title

      SEISAN KENKYU

      Volume: 73 Issue: 3 Pages: 147-149

    • DOI

      10.11188/seisankenkyu.73.147

    • NAID

      130008049218

    • ISSN
      0037-105X, 1881-2058
    • Year and Date
      2021-05-01
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Lipid nanotubes as an organic template for the fabrication of carbon nanostructures by pyrolysis2021

    • Author(s)
      Jajcevic Kristina、Sequeira Ashlin Mario、Kalbacova Jana、Zahn Dietrich R. T.、Sugihara Kaori
    • Journal Title

      Nanoscale

      Volume: 13 Issue: 14 Pages: 6927-6933

    • DOI

      10.1039/d1nr00530h

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis of PDA Dose Curves for the Extraction of Antimicrobial Peptide Properties2021

    • Author(s)
      Zhao Jiangtao、Sugihara Kaori
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 125 Issue: 44 Pages: 12206-12213

    • DOI

      10.1021/acs.jpcb.1c07533

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recharging N95 masks using a van de Graaff generator for safe recycling2021

    • Author(s)
      Sugihara K.
    • Journal Title

      Soft Matter

      Volume: 17 Issue: 1 Pages: 10-15

    • DOI

      10.1039/d0sm02004d

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cooperative Function of LL-37 and HNP1 Protects Mammalian Cell Membranes from Lysis2020

    • Author(s)
      Drab Ewa、Sugihara Kaori
    • Journal Title

      Biophysical Journal

      Volume: 119 Issue: 12 Pages: 2440-2450

    • DOI

      10.1016/j.bpj.2020.10.031

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative and Anisotropic Mechanochromism of Polydiacetylene at Nanoscale2020

    • Author(s)
      Juhasz Levente、Ortuso Roberto D.、Sugihara Kaori
    • Journal Title

      Nano Letters

      Volume: 21 Issue: 1 Pages: 543-549

    • DOI

      10.1021/acs.nanolett.0c04027

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 押すと発光するメカノクロミックポリマー2022

    • Author(s)
      杉原 加織
    • Organizer
      Inspire Talk
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a mask charger2022

    • Author(s)
      杉原 加織
    • Organizer
      Science × Design - Israel Month @UTokyo Komaba Research Campus -
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポリジアセチレンの定量的・異方的・ナノスケールでの力と発光の相関2021

    • Author(s)
      杉原 加織
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗菌薬開発に向けたペプチド・ダブルコオペラティブ効果の原理解明2021

    • Author(s)
      杉原 加織
    • Organizer
      化学工学会第52回秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Lipid as a building material for biotechnologies2021

    • Author(s)
      杉原 加織
    • Organizer
      MERIT seminar
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Nanofabrication based on biological materials2021

    • Author(s)
      杉原 加織
    • Organizer
      Third IIS - MESA+ Workshop
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗菌薬開発に向けたペプチド・ダブルコオペラティブ効果の原理解明2021

    • Author(s)
      杉原 加織
    • Organizer
      第73回日本生物工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Antimicrobial peptide double cooperativity2021

    • Author(s)
      杉原 加織
    • Organizer
      第59回日本生物物理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Lipid as a building material for biotechnologies2021

    • Author(s)
      杉原 加織
    • Organizer
      NTU ChE & UTokyo CSE Joint Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anisotropic mechanochromism of polydiacetylene at nanoscale2021

    • Author(s)
      杉原 加織
    • Organizer
      Pacifichem 2021 The Many Flavors of Mechanochemistry
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポリジアセチレン・メカノクロミズムの力方向依存性2021

    • Author(s)
      徐 聖子
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗菌ペプチドのダブル・コオペラティブ効果2021

    • Author(s)
      杉原 加織
    • Organizer
      第10回日本生物物理学会関東支部会
    • Related Report
      2020 Research-status Report
  • [Presentation] 製薬応用に向けたペプチドー生体膜間相互作用解析手法の開発2020

    • Author(s)
      杉原 加織
    • Organizer
      化学システム工学専攻公開セミナー、東京大学
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ナノポアを用いた膜電位感受性色素の特性解析2020

    • Author(s)
      杉原 加織
    • Organizer
      第81回応用物理学会 秋季学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 強力な抗菌薬 開発に向けた抗菌ペプチド・ コオペラティブ効果の原理解明2020

    • Author(s)
      杉原 加織
    • Organizer
      金森財団授賞式
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 人工生体膜の創薬への応用2020

    • Author(s)
      杉原 加織
    • Organizer
      セミナー、エーザイ株式会社筑波研究所
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2020-09-29   Modified: 2023-01-30  

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