| Project/Area Number |
20K22525
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | NIR laser / Liposomes / Cellular application / Spatiotemporal dynamics / Local release / liposomes / Bioactive molecules / bioactive molecules |
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| Outline of Research at the Start |
Herein, we propose to encapsulate bioactive molecules inside the hydrophilic core of thermosensitive liposomes containing NIR light responsive compounds. The encapsulated cargo molecules from liposomes will be released on-demand upon illumination with near infrared (NIR) laser.
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| Outline of Final Research Achievements |
The main advantage of NIR laser modulated liposomes is that encapsulated cargos was released at the subcellular level without any temperature increment to the surrounding areas. Hence, we have revealed the spatiotemporal dynamics of neurotransmitter at the subcellular level in vitro. We have also observed the spatiotemporal dynamics using myotubes as well as Drosophila model (i.e., ex vivo).
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| Academic Significance and Societal Importance of the Research Achievements |
Our findings will pave the way to release any drugs or bioactive molecules locally. Hence, it will be very useful to reduce toxicity as well as the of the drugs for practical applications.
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