A Combinatorial Approach Towards Multimetallic Artificial Receptors for Cancer-Related Biomarkers
| Project/Area Number |
20K22552
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0502:Inorganic/coordination chemistry, analytical chemistry, inorganic materials chemistry, energy-related chemistry, and related fields
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| Research Institution | Tokyo Institute of Technology (2021)
Kanazawa University (2020) |
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Principal Investigator |
Catti Lorenzo 東京工業大学, 科学技術創成研究院, 助教 (50873478)
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Artificial Bioreceptor / Molecular building block / Metal Complex / Bromo-bissalicylaldehyde / Aqueous bioreceptor / Metal complex / Carbohydrate Receptor / DCC / Cancer Biomarker / Combinatorial Chemistry / Multimetallic Complex / Tetradentate Ligand / Oligopeptides |
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| Outline of Research at the Start |
A highly modular, multimetallic carbohydrate receptor is proposed, whose peptide-based binding pocket can be readily optimized via dynamic combinatorial chemistry (DCC) using the targeted carbohydrate as the template. This new class of artificial metalloreceptor will be specifically employed for the binding of cancer-related carbohydrate motifs. The coordinative bonding between the metal ions and the target in combination with the non-covalent interactions with the peptide residues is expected to result in an unprecedented degree of selectivity and binding affinity.
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| Outline of Final Research Achievements |
The research led to the preparation of a new bromo-bissalicylaldehyde building block, which can be coupled to boronic acids/esters via standard Suzuki coupling conditions. Its attachment to metal complexes has not been performed yet, but could in principle lead to new metal receptors for biomolecules in water using biomolecule-metal interactions. Using the salicylaldehyde units, I plan to vary the second coordination sphere of the receptor in the future via dynamic covalent chemistry to tune its selectivity. The advantage of the salicylaldehyde units over conventional aldehyde units is their increased stability in aqueous media against oxidation.
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| Academic Significance and Societal Importance of the Research Achievements |
Artificial bioreceptors are important for the detection of diseases via recognition of disease-related biomarkers. Previous receptors required long and difficult synthetic protocols. The herein attempted strategy aims to give simple access to a receptor framework whose target can be tuned on demand.
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Report
(3 results)
Research Products
(7 results)
