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A Combinatorial Approach Towards Multimetallic Artificial Receptors for Cancer-Related Biomarkers

Research Project

Project/Area Number 20K22552
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0502:Inorganic/coordination chemistry, analytical chemistry, inorganic materials chemistry, energy-related chemistry, and related fields
Research InstitutionTokyo Institute of Technology (2021)
Kanazawa University (2020)

Principal Investigator

Catti Lorenzo  東京工業大学, 科学技術創成研究院, 助教 (50873478)

Project Period (FY) 2020-09-11 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsArtificial Bioreceptor / Molecular building block / Metal Complex / Bromo-bissalicylaldehyde / Aqueous bioreceptor / Metal complex / Carbohydrate Receptor / DCC / Cancer Biomarker / Combinatorial Chemistry / Multimetallic Complex / Tetradentate Ligand / Oligopeptides
Outline of Research at the Start

A highly modular, multimetallic carbohydrate receptor is proposed, whose peptide-based binding pocket can be readily optimized via dynamic combinatorial chemistry (DCC) using the targeted carbohydrate as the template. This new class of artificial metalloreceptor will be specifically employed for the binding of cancer-related carbohydrate motifs. The coordinative bonding between the metal ions and the target in combination with the non-covalent interactions with the peptide residues is expected to result in an unprecedented degree of selectivity and binding affinity.

Outline of Final Research Achievements

The research led to the preparation of a new bromo-bissalicylaldehyde building block, which can be coupled to boronic acids/esters via standard Suzuki coupling conditions. Its attachment to metal complexes has not been performed yet, but could in principle lead to new metal receptors for biomolecules in water using biomolecule-metal interactions. Using the salicylaldehyde units, I plan to vary the second coordination sphere of the receptor in the future via dynamic covalent chemistry to tune its selectivity. The advantage of the salicylaldehyde units over conventional aldehyde units is their increased stability in aqueous media against oxidation.

Academic Significance and Societal Importance of the Research Achievements

Artificial bioreceptors are important for the detection of diseases via recognition of disease-related biomarkers. Previous receptors required long and difficult synthetic protocols. The herein attempted strategy aims to give simple access to a receptor framework whose target can be tuned on demand.

Report

(3 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • Research Products

    (7 results)

All 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Aqueous polyaromatic receptors for biomolecules with high selectivity2022

    • Author(s)
      Catti Lorenzo、Sumida Ryuki、Yoshizawa Michito
    • Journal Title

      Coordination Chemistry Reviews

      Volume: 460 Pages: 214460-214470

    • DOI

      10.1016/j.ccr.2022.214460

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Supramolecular Singlet Fission of Pentacene Dimers within Polyaromatic Capsules2021

    • Author(s)
      Catti Lorenzo、Narita Haruna、Tanaka Yuya、Sakai Hayato、Hasobe Taku、Tkachenko Nikolai V.、Yoshizawa Michito
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 25 Pages: 9361-9367

    • DOI

      10.1021/jacs.0c13172

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Aromatic Micelle‐Based Saccharide Cluster with Changeable Fluorescent Color and its Protein Interactions2021

    • Author(s)
      Narita Haruna、Catti Lorenzo、Yoshizawa Michito
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 23 Pages: 12791-12795

    • DOI

      10.1002/anie.202102547

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expanding the Protecting Group Scope for the Carbonyl Olefin Metathesis Approach to 2,5-Dihydropyrroles2021

    • Author(s)
      Huck Fabian、Catti Lorenzo、Reber Gian Lino、Tiefenbacher Konrad
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 87 Issue: 1 Pages: 419-428

    • DOI

      10.1021/acs.joc.1c02447

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Pyridinium Core Units for V-shaped Anthracene Dimers: Rapid Access to New Polyaromatic Amphiphiles2022

    • Author(s)
      Lorenzo Catti, Michito Yoshizawa
    • Organizer
      The 102nd CSJ Annual Meeting (2022)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Saccharide modification of an aromatic micelle and its guest-dependent fluorescence in water2021

    • Author(s)
      Lorenzo Catti, Haruna Narita, Michito Yoshizawa
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reversible photoswitch-controlled structure transitions of biomolecules and their real-time visualization by high-speed atomic force microscopy2021

    • Author(s)
      Lorenzo Catti, Holger Flechsig, Noriyuki Kodera, Mark J. MacLachlan, Shigehisa Akine
    • Organizer
      The 101st CSJ Annual Meeting (2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research

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Published: 2020-09-29   Modified: 2023-01-30  

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