| Project/Area Number |
20K22684
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
CHEN Chih-Yang 京都大学, 高等研究院, 特定助教 (30884689)
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| Project Period (FY) |
2020-09-11 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Innate fear / Marmoset / Electrophysiology / Optogenetics / marmoset / innate fear |
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| Outline of Research at the Start |
Innate fear is a type of negative emotion that even if one did not learn or experience before, one is afraid of it. However, in human, this could cause unnecessary phobia or anxiety that is difficult to treat. Until now, the neuronal mechanisms of innate fear in primate is still largely unknown. Here, I would like to propose a series of experiments trying to understand the origin of visual innate fear in primate and the potential neuronal networks that convey it using a small new world monkey, the common marmoset.
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| Outline of Final Research Achievements |
Innate fear is a type of negative emotion that even if one did not learn or experience before, one is afraid of it. The neural mechanisms of innate fear in primate is still largely unknown. With the help of Kakenhi startup grant, I have performed a series of proposed experiments to uncover the neural mechanism of innate fear. I have designed a full-hemisphere electrocorticography (ECoG) and successfully implanted it in two marmosets. I have also started to record their brain-wide activity and pupil response simultaneously while they are viewing pictures of their predators or other animals. I have completed recording from 1 marmoset. We have also validated the possibility of remotely recording blood pressure and heart rate while the marmosets performing the task. Finally, I have tested several AAV vectors for inhibiting the brain areas with precise time control in rodents. Overall, the experiments are progressing smoothly and I will be able to understand the neural bases of innate fear.
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| Academic Significance and Societal Importance of the Research Achievements |
Innate fear is a new research field. It is largely unknown in primate. The human extreme of it would be anxiety disorders like social phobia or panic attacks. Through studying innate fear, I hope I can advance our knowledge of fear processing and understand the cause of anxiety disorders.
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