| Project/Area Number |
20K22752
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0802:Biomedical structure and function and related fields
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
LAMRI Lynda 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー (90883984)
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| Project Period (FY) |
2020-09-11 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Troponin / Embryonic development / embryonic development |
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| Outline of Research at the Start |
Components of the Troponin protein complex are involved in the regulation of muscle contraction; however, they are expressed in various cell types, and completely different mechanisms of actions have been proposed. Furthermore, much is left unknown about possible abnormalities due to their deficiency. This study aims to analyze how a Troponin complex gene is regulated during embryonic development and further elucidate its unexplored functions in embryonic development and disease.
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| Outline of Final Research Achievements |
Components of the Troponin protein complex are involved in the regulation of muscle contraction. However, much is left unknown about possible abnormalities due to their deficiency. This study analyses how a Troponin complex gene is regulated during embryonic development and is elucidating its unexplored functions in embryonic development and disease. we have obtained various data including their phenotypes at the level of skeletal muscle structure, as well as defects of the lymphatic system in embryos.
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| Academic Significance and Societal Importance of the Research Achievements |
We will study the mechanisms of abnormalities in troponin mutant embryos based on: (1)The defects of sarcomeric Troponin impair skeletal muscle contractility and result in abnormal phenotypes, and (2) The troponin elicits non-sarcomeric actions mainly in the embryonic skeletal muscle.
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