Novel radiosensitizer with inorganic nanoparticles and antibodies assembly

• Project/Area Number: 20KK0192
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 52:General internal medicine and related fields
• Research Institution: Kobe University
• Principal Investigator: 佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267)
• Co-Investigator(Kenkyū-buntansha): 荻野 千秋 神戸大学, 工学研究科, 教授 (00313693) ; 赤坂 浩亮 神戸大学, 医学研究科, 非常勤講師 (20707161) ; 西村 勇哉 神戸大学, 科学技術イノベーション研究科, 客員准教授 (40728218) ; 中山 雅央 神戸大学, 医学研究科, 医学研究員 (60582004)
• Project Period (FY): 2020-10-27 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2022: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2021: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ナノ粒子 / 放射線増感 / がん幹細胞 / 過酸化チタンナノ粒子 / 放射線治療 / 表面修飾 / DDS / 金属ナノ粒子 / 無機ナノ粒子 / 表面修飾技術

Outline of Research at the Start

我々は大量の活性酸素を産生し放射線増感効果を有する過酸化チタンナノ粒子の開発に成功し放射線増感剤として開発している。臨床応用には、ナノ粒子の①腫瘍への特異的集積、②生体安全性が必要なため表面修飾技術が必要である。メルボルン大学のFrank Caruso教授はと呼ばれる独自のナノ粒子コーティング技術を開発しており、その技術を過酸化チタンナノ粒子に応用することで、Drug Delivery Systemと体内毒性低減が期待できる。我々は日本・オーストラリアを基軸としたナノ粒子放射線増感研究ネットワークを形成し、画期的な放射線増感剤の開発から臨床応用まで取り組む。

Outline of Annual Research Achievements

我々のグループは放射線と併用することで大量の活性酸素を産生し、放射線増感効果を著明に増加させる過酸化チタンナノ粒子の開発に成功し、世界的にも先駆的な立場で過酸化チタンナノ粒子を利用した放射線増感剤の開発に取り組んでいる。この素材を臨床応用するには、過酸化チタンナノ粒子が腫瘍に特異的に集積する必要がある。これを達成するためには、過酸化チタンナノ粒子の表面修飾技術が必要不可欠である。メルボルン大学のFrank Caruso教授のグループはPMAP（Polyphenol-Mediated Assembly of Proteins)と呼ばれる独自のナノ粒子コーティング技術を開発しており、PMAPを応用することで、過酸化チタンナノ粒子にDrug Delivery System（DDS）をもたらすことが可能であると期待できる。本研究での成果は難治がんの治療成績向上に向けて重要な役割を果たす。
腫瘍細胞への特異的集積性の検討に関して、がん幹細胞に高発現しているCD44を認識する抗体と過酸化チタンナノ粒子を結合させることに成功し、CD44陽性細胞とCD44陰性細胞を用いたin vitroの実験系において腫瘍集積性の評価を行った。蛍光顕微鏡によるCD44陽性細胞またはCD44陰性細胞へのナノ粒子の取り込みを評価し、CD44陽性細胞内への有意なPMAP-過酸化チタンナノ粒子の取り込み量の増加を認めた。
腫瘍増殖抑制効果の検討に関して、PMAP-過酸化チタンナノ粒子と放射線の併用効果をコロニーアッセイにより評価した。CD44陽性細胞においては、PMAP-過酸化チタンナノ粒子と放射線を併用することにより放射線単独または過酸化チタンナノ粒子単独よりも有意な腫瘍増殖抑制効果を認めた。これらの検討により、CD44を高頻度に発現するがん細胞へのPMAPを介して高効率な過酸化チタンナノ粒子の輸送に成功した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

助成期間を通して、過酸化チタンナノ粒子とPMAPの融合に成功した。新型コロナウイルスの感染流行による行動制限のため、動物を用いた検討は実施できなかった。しかし、上記のin vitroの結果により、本申請期間中の目標はほぼ達成できたと言える。

Strategy for Future Research Activity

昨年度には、コロナウイルス感染症の影響もあり、十分な動物実験が実施できなかった。
そのため、今後には、本治療法のインビボでの有用性を明らかにしていきたい。

Research Products

• [Int'l Joint Research] メルボルン大学(オーストラリア)
• [Int'l Joint Research] The University of Melbourne(オーストラリア)
• [Int'l Joint Research] メルボルン大学(オーストラリア)
• [Journal Article] 2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma (2023)
  • Author(s): Iwahashi Hirofumi、Nagashima Hiroaki、Tanaka Kazuhiro、Uno Takiko、Hashiguchi Mitsuru、Maeyama Masahiro、Somiya Yuichiro、Komatsu Masato、Hirose Takanori、Itoh Tomoo、Sasaki Ryohei、Sasayama Takashi
  • Journal Title: Journal of Neurosurgery Volume: - Issue: 2 Pages: 1-8
  • DOI: 10.3171/2022.12.jns221954
  • Peer Reviewed
• [Journal Article] Ligation of the ethmoid arteries in superselective intra‐arterial infusion of cisplatin for advanced maxillary sinus cancer fed by the ophthalmic artery (2023)
  • Author(s): Tamagawa Kotaro、Shinomiya Hirotaka、Okada Takuya、Tatehara Shun、Teshima Masanori、Sasaki Ryohei、Nibu Ken‐ichi
  • Journal Title: Head & Neck Volume: 45 Issue: 5
  • DOI: 10.1002/hed.27341
  • Peer Reviewed
• [Journal Article] Prognostic Value of Radiomics Analysis of Skeletal Muscle After Radical Irradiation of Esophageal Cancer (2023)
  • Author(s): IWASHITA KAZUMA、KUBOTA HIKARU、NISHIOKA RIKU、EMOTO YUKI、KAWAHARA DAISUKE、ISHIHARA TAKEAKI、MIYAWAKI DAISUKE、NISHIBUCHI IKUNO、NAGATA YASUSHI、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 43 Issue: 4 Pages: 1749-1760
  • DOI: 10.21873/anticanres.16328
  • Peer Reviewed
• [Journal Article] Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells (2022)
  • Author(s): Salah Mohammed、Akasaka Hiroaki、Shimizu Yasuyuki、Morita Kenta、Nishimura Yuya、Kubota Hikaru、Kawaguchi Hiroki、Sogawa Tomomi、Mukumoto Naritoshi、Ogino Chiaki、Sasaki Ryohei
  • Journal Title: Journal of Experimental & Clinical Cancer Research Volume: 41 Issue: 1 Pages: 146-146
  • DOI: 10.1186/s13046-022-02358-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] <i>In vivo</i> stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy (2022)
  • Author(s): Kitayama Yukiya、Yamada Takuya、Kiguchi Kentaro、Yoshida Aoi、Hayashi Shuhei、Akasaka Hiroaki、Igarashi Kazunori、Nishimura Yuya、Matsumoto Yu、Sasaki Ryohei、Takano Eri、Sunayama Hirobumi、Takeuchi Toshifumi
  • Journal Title: Journal of Materials Chemistry B Volume: 10 Issue: 35 Pages: 6784-6791
  • DOI: 10.1039/d2tb00481j
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan (2022)
  • Author(s): Takemori Toshiyuki、Kawamoto Teruya、Hara Hitomi、et al.
  • Journal Title: Cancers Volume: 14 Issue: 12 Pages: 3023-3023
  • DOI: 10.3390/cancers14123023
  • Peer Reviewed / Open Access
• [Journal Article] The <i>TIGD5</i> gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor (2022)
  • Author(s): Dai Yuntao、Kawaguchi Tetsuya、Nishio Miki、Otani Junji、Tashiro Hironori、Terai Yoshito、Sasaki Ryohei、Maehama Tomohiko、Suzuki Akira
  • Journal Title: Genes to Cells Volume: 27 Issue: 11 Pages: 633-642
  • DOI: 10.1111/gtc.12980
  • Peer Reviewed / Open Access
• [Journal Article] Fiducial marker position affects target volume in stereotactic lung irradiation (2022)
  • Author(s): Akasaka Hiroaki、Mizonobe Kazufusa、Oki Yuya、Uehara Kazuyuki、Nakayama Masao、Tamura Shuhei、Munetomo Yoshiki、Kawaguchi Haruna、Ishida Jun、Harada Aya、Ishihara Takeaki、Kubota Hikaru、Kawaguchi Hiroki、Sasaki Ryohei、Mayahara Hiroshi
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: ‐ Issue: 6 Pages: 1-10
  • DOI: 10.1002/acm2.13596
  • Peer Reviewed / Open Access
• [Journal Article] Gafchromic EBT3 Film Measurements of Dose Enhancement Effects by Metallic Nanoparticles for 192Ir Brachytherapy, Proton, Photon and Electron Radiotherapy (2022)
  • Author(s): Sisin Noor Nabilah Talik、Rashid Raizulnasuha Ab、Abdullah Reduan、Razak Khairunisak Abdul、Geso Moshi、Akasaka Hiroaki、Sasaki Ryohei、Tominaga Takahiro、Miura Hayato、Nishi Masashi、Rahman Wan Nordiana
  • Journal Title: Radiation Volume: 2 Issue: 1 Pages: 130-148
  • DOI: 10.3390/radiation2010010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer (2022)
  • Author(s): Komatsu Hirokazu、Furukawa Tatsuya、Iritani Keisuke、Tatehara Shun、Takahashi Miki、Iwaki Shinobu、Kakei Yasumasa、Hasegawa Takumi、Teshima Masanori、Shinomiya Hirotaka、Otsuki Naoki、Hashikawa Kazunobu、Kiyota Naomi、Sasaki Ryohei、Akashi Masaya、Nibu Ken-ichi
  • Journal Title: Auris Nasus Larynx Volume: 49 Issue: 3 Pages: 477-483
  • DOI: 10.1016/j.anl.2021.10.013
  • Peer Reviewed / Open Access
• [Journal Article] Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy (2021)
  • Author(s): Nakayama Masao、Akasaka Hiroaki、Miyazaki Eiichi、Goto Yoshihiro、Oki Yuya、Kawate Yosuke、Morita Kenta、Sasaki Ryohei
  • Journal Title: Physics and Imaging in Radiation Oncology Volume: 20 Pages: 94-97
  • DOI: 10.1016/j.phro.2021.11.003
  • NAID: 120007179179
  • Peer Reviewed / Open Access
• [Journal Article] Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species (2021)
  • Author(s): Nakaoka Ai、Nakahana Makiko、Inubushi Sachiko、Akasaka Hiroaki、Salah Mohammed、Fujita Yoshiko、Kubota Hikaru、Hassan Mennaallah、Nishikawa Ryo、Mukumoto Naritoshi、Ishihara Takeaki、Miyawaki Daisuke、Sasayama Takashi、Sasaki Ryohei
  • Journal Title: Oncology Reports Volume: 45 Issue: 4 Pages: 1-1
  • DOI: 10.3892/or.2021.7964
  • NAID: 120006975755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study (2021)
  • Author(s): KAWAGUCHI HIROKI、DEMIZU YUSUKE、MUKUMOTO NARITOSHI、ISHIHARA TAKEAKI、MIYAWAKI DAISUKE、KOMATSU SHOHEI、AKASAKA HIROAKI、SHINOTO MAKOTO、SHIOYAMA YOSHIYUKI、NAKAMURA KATSUMASA、FUKUMOTO TAKUMI、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 41 Issue: 1 Pages: 503-508
  • DOI: 10.21873/anticanres.14801
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells (2021)
  • Author(s): Morita Kenta、Nishimura Yuya、Nakamura Satoko、Arai Yuki、Numako Chiya、Sato Kazuyoshi、Nakayama Masao、Akasaka Hiroaki、Sasaki Ryohei、Ogino Chiaki、Kondo Akihiko
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 198 Pages: 111451-111451
  • DOI: 10.1016/j.colsurfb.2020.111451
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base (2021)
  • Author(s): Teshima Masanori、Shinomiya Hirotaka、Kimura Hidehito、Hashikawa Kazunobu、Kiyota Naomi、Miyawaki Daisuke、Sasaki Ryohei、Kohmura Eiji、Nibu Ken‐ichi
  • Journal Title: Laryngoscope Investigative Otolaryngology Volume: 6 Issue: 6 Pages: 1347-1352
  • DOI: 10.1002/lio2.687
  • NAID: 120007179199
  • Peer Reviewed / Open Access
• [Journal Article] PET/MRI is useful for early detection of pelvic insufficiency fractures after radiotherapy for cervical cancer (2021)
  • Author(s): Azumi Maho、Matsumoto Masuyo、Suzuki Kaho、Sasaki Ryohei、Ueno Yoshiko、Nogami Munenobu、Terai Yoshito
  • Journal Title: Oncology Letters Volume: 22 Issue: 5 Pages: 776-776
  • DOI: 10.3892/ol.2021.13037
  • NAID: 120007153052
  • Peer Reviewed / Open Access
• [Journal Article] The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma (2021)
  • Author(s): Hamada Mostafa、Ueshima Eisuke、Ishihara Takeaki、Koide Yutaka、Okada Takuya、Horinouchi Hiroki、Ishida Jun、Mayahara Hiroshi、Sasaki Koji、Gentsu Tomoyuki、Sofue Keitaro、Yamaguchi Masato、Sasaki Ryohei、Sugimoto Koji、Murakami Takamichi
  • Journal Title: Acta Radiologica Open Volume: 10 Issue: 7 Pages: 20584-20584
  • DOI: 10.1177/20584601211034965
  • NAID: 120007153054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal (2021)
  • Author(s): Shinomiya Hirotaka、Uehara Natsumi、Fujita Takeshi、Miyawaki Daisuke、Imamura Yoshinori、Teshima Masanori、Kakigi Akinobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken-ichi
  • Journal Title: European Archives of Oto-Rhino-Laryngology Volume: - Issue: 6 Pages: 2805-2810
  • DOI: 10.1007/s00405-021-06974-4
  • Peer Reviewed / Open Access
• [Journal Article] New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear (2021)
  • Author(s): Shinomiya H、Uehara N、Fujita T、Yoshida K、Imamura Y、Teshima M、Kimura H、Miyawaki D、Kakigi A、Kiyota N、Otsuki N、Sasaki R、Kohmura E、Nibu K
  • Journal Title: The Journal of Laryngology &amp; Otology Volume: 135 Issue: 4 Pages: 297-303
  • DOI: 10.1017/s002221512100089x
  • NAID: 120007041636
  • Peer Reviewed / Open Access
• [Journal Article] Surgical spacer placement for proton radiotherapy in locally advanced pancreatic body and tail cancers: initial clinical results (2021)
  • Author(s): Dongha Lee et al.
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s13014-020-01731-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma (2021)
  • Author(s): Kubota Hikaru、Miyawaki Daisuke、Mukumoto Naritoshi、Ishihara Takeaki、Matsumura Megumi、Hasegawa Takumi、Akashi Masaya、Kiyota Naomi、Shinomiya Hirotaka、Teshima Masanori、Nibu Ken-ichi、Sasaki Ryohei
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s13014-020-01701-5
  • NAID: 120006954052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases) (2021)
  • Author(s): Hara H、Sakai Y、Kawamoto T、Fukase N、Kawakami Y、Takemori T、Fujiwara S、Kitayama K、Yahiro S、Miyamoto T、Kakutani K、Niikura T、Miyawaki D、Okada T、Sakashita A、Imamura Y、Sasaki R、Kizawa Y、Minami H、Matsumoto T、Matsushita T、Kuroda R、Akisue T
  • Journal Title: Journal of Bone Oncology Volume: 27 Pages: 100352-100352
  • DOI: 10.1016/j.jbo.2021.100352
  • NAID: 120007038644
  • Peer Reviewed / Open Access
• [Journal Article] The air gap between bolus and skin affects dose distribution in helical and direct tomotherapy (2020)
  • Author(s): Akasaka Hiroaki、Oki Yuya、Mizonobe Kazufusa、Uehara Kazuyuki、Mayahara Hiroshi、Harada Aya、Hashimoto Naoki、Kitatani Keiji、Yabuuchi Tomonori、Ishihara Takeaki、Iwashita Kazuma、Miyawaki Daisuke、Mukumoto Naritoshi、Nakaoka Ai、Sasaki Ryohei
  • Journal Title: Journal of Radiotherapy in Practice Volume: 4 Issue: 3 Pages: 1-6
  • DOI: 10.1017/s1460396920000333
  • Peer Reviewed
• [Journal Article] Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells (2020)
  • Author(s): Kashin Masahiko、Kakei Yasumasa、Teraoka Shun、Hasegawa Takumi、Yamaguchi Akinobu、Fukuoka Takao、Sasaki Ryohei、Akashi Masaya
  • Journal Title: BioMed Research International Volume: 2020 Pages: 1-10
  • DOI: 10.1155/2020/1281645
  • NAID: 120006940231
  • Peer Reviewed / Open Access
• [Journal Article] Elucidation of gastrointestinal dysfunction in response to irradiation using metabolomics (2020)
  • Author(s): Salah Mohammed、Osuga Saki、Nakahana Makiko、Irino Yasuhiro、Shinohara Masakazu、Shimizu Yasuyuki、Mukumoto Naritoshi、Akasaka Hiroaki、Nakaoka Ai、Miyawaki Daisuke、Ishihara Takeaki、Yoshida Kenji、Okamoto Yoshiaki、Sasaki Ryohei
  • Journal Title: Biochemistry and Biophysics Reports Volume: 23 Pages: 100789-100789
  • DOI: 10.1016/j.bbrep.2020.100789
  • NAID: 120007041619
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Comparative Assessment of Mechanisms and Effectiveness of Radiosensitization by Titanium Peroxide and Gold Nanoparticles (2020)
  • Author(s): Hassan Mennaallah、Nakayama Masao、Salah Mohammed、Akasaka Hiroaki、Kubota Hikaru、Nakahana Makiko、Tagawa Tatsuichiro、Morita Kenta、Nakaoka Ai、Ishihara Takeaki、Miyawaki Daisuke、Yoshida Kenji、Nishimura Yuya、Ogino Chiaki、Sasaki Ryohei
  • Journal Title: Nanomaterials Volume: 10 Issue: 6 Pages: 1125-1125
  • DOI: 10.3390/nano10061125
  • NAID: 120006878579
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients (2020)
  • Author(s): INUBUSHI SACHIKO、KAWAGUCHI HIROKI、MIZUMOTO SACHIKO、KUNIHISA TOMONARI、BABA MOTOI、KITAYAMA YUKIYA、TAKEUCHI TOSHIFUMI、HOFFMAN ROBERT M.、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 40 Issue: 6 Pages: 3091-3096
  • DOI: 10.21873/anticanres.14290
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Space-making particle therapy for sarcomas derived from the abdominopelvic region (2020)
  • Author(s): Komatsu Shohei、Demizu Yusuke、Sulaiman Nor Shazrina、Terashima Kazuki、Suga Masaki、Kido Masahiro、Toyama Hirochika、Tokumaru Sunao、Okimoto Tomoaki、Sasaki Ryohei、Fukumoto Takumi
  • Journal Title: Radiotherapy and Oncology Volume: 146 Pages: 194-199
  • DOI: 10.1016/j.radonc.2020.02.021
  • Peer Reviewed / Open Access
• [Journal Article] Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears (2020)
  • Author(s): Takeuchi Toshifumi、Mori Kisho、Sunayama Hirobumi、Takano Eri、Kitayama Yukiya、Shimizu Taku、Hirose Yuzuki、Inubushi Sachiko、Sasaki Ryohei、Tanino Hirokazu
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 14 Pages: 6617-6624
  • DOI: 10.1021/jacs.9b13874
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Biological reactions to extremely high dose rate X-ray irradiation to mouse brain and tumor models. (2022)
  • Author(s): Ryohei SASAKI, Naritoshi MUKUMOTO, Masao NAKAYAMA, Hiroaki AKASAKA, Yasuyuki SHIMIZU, Takeaki ISHIHARA, Daisuke MIYAWAKI
  • Organizer: 日本放射線影響学会 第65回大会
  • Invited
• [Presentation] エクソソームによる膵がん細胞の肝転移制御効果に関する基礎的検討 (2022)
  • Author(s): 中岡藍、仲波名真希子、清水康之、金城裕士、椋本成俊、小林加奈、石原武明、宮脇大輔、佐々木良平
  • Organizer: 日本放射線腫瘍学会第35回学術大会
• [Presentation] 同一腫瘍細胞間の放射線応答を制御するエクソソーム内マイクロRNAの網羅的解析 (2021)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、西川 遼、平野 駿太、石原 武明、宮脇 大輔、佐々木 良平
  • Organizer: 第58回日本放射線腫瘍学会生物部会学術大会
• [Presentation] エクソソーム内マイクロRNAを介した放射線応答制御に関する基礎的検討 (2021)
  • Author(s): 中岡藍、仲波名真希子、椋本成俊、赤坂浩亮、清水康之、Mohammed Salah、西川遼、平野駿太、石原武明、宮脇大輔、佐々木良平
  • Organizer: 第34回 日本放射線腫瘍学会学術大会
• [Presentation] Image contrast enhancements caused by nanoparticles as theranostic agents in radiation therapy (2021)
  • Author(s): 中山雅央、赤坂浩亮、宮崎英一、佐々木良平
  • Organizer: 第34回 日本放射線腫瘍学会学術大会
• [Presentation] A study of lung shielding in total body irradiation prior to reduced-intensity stem cell transplantation (2021)
  • Author(s): 川口弘毅、岩下和真、妹尾悟史、窪田光、清水康之、江本裕樹、椋本成俊、赤坂浩亮、小林加奈、石原武明、宮脇大輔、西谷隆治、佐々木良平
  • Organizer: 第34回 日本放射線腫瘍学会学術大会
• [Presentation] A treatment planning study comparison between spine or prone position according to the lung tumor site in CyberKnife (2021)
  • Author(s): Hiroaki Akasaka, Kazufusa Mizonobe, Yuya Oki, Kazuyuki Uehara, Aya Harada, Keiji Kitatani, Shunichirou Miyazaki, Tomonori Yabuuchi, and Hiroshi Mayahara
  • Organizer: 第121回日本医学物理学会学術大会
• [Presentation] Radiosensitive Effect induced by exosomes from irradiated cancer cells (2021)
  • Author(s): Ai Nakaoka, Makiko Nakahana, Naritoshi Mukumoto, Hiroaki Akasaka, Mohammed Salah, Ryo Nishikawa, Takeaki Ishihara, Daisuke Miyawaki, Takashi Sasayama and Ryohei Sasaki
  • Organizer: The 4 th International Cancer Research Symposium a Training for Oncology Professionals
  • Int'l Joint Research
• [Presentation] 過酸化チタンナノ粒子による免疫放射線治療増感効果の検討 (2020)
  • Author(s): 窪田 光、藤田 佳子、清水 康之、Mohammed Salah、岩下 和真、妹尾 悟史、川口 弘毅、小林 加奈、石原 武明、宮脇 大輔、吉田 賢史、西村 勇哉、荻野 千秋、佐々木 良平
  • Organizer: 第33回日本放射線腫瘍学会
• [Presentation] がん細胞から放出されたエクソソームによる放射線増感効果 (2020)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、石原 武明、宮脇 大輔、佐々木 良平
  • Organizer: 第33回日本放射線腫瘍学会
• [Presentation] エクソソームを介した腫瘍細胞への放射線増感効果 (2020)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、石原 武明、宮脇 大輔、佐々木 良平
  • Organizer: 第63回日本放射線影響学会
• [Presentation] Titanium peroxide nanoparticle enhance the efficacy of immuno-radiotherapy via activated CD8+ T cell dependent antitumor effect in vivo (2020)
  • Author(s): Hikaru Kubota, Yoshiko Fujita, Mohammed Salah, Yasuyuki Shimizu, Hiroaki Akasaka, Ryohei Sasaki
  • Organizer: American Society for Radiation Oncology 62nd Annual Meeting
  • Int'l Joint Research
• [Book] Exrtacelluar vesicles (2021)
  • Author(s): Ai Nakaoka, Kana Kobayashi, Mennaallah Hassan and Ryohei Sasaki
  • Total Pages: 300
  • Publisher: INTECH
• [Patent(Industrial Property Rights)] 医薬 (2023)
  • Inventor(s): 佐々木 良平、荻野 千秋、藤田 佳子
  • Industrial Property Rights Holder: 国立大学法人神戸大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2023-055654
  • Filing Date: 2023