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International cooperative study for spatial-temporal disease clustering and risk factors on emerging infectious diseases

Research Project

Project/Area Number 20KK0218
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionNagoya City University (2021-2024)
Jichi Medical University (2020)

Principal Investigator

Manabe Toshie  名古屋市立大学, データサイエンス学部, 准教授 (50723110)

Co-Investigator(Kenkyū-buntansha) 藤倉 雄二  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 内科, 准教授 (60598796)
中村 晃久  自治医科大学, 医学部, 講師 (00880072)
小谷 和彦  自治医科大学, 医学部, 教授 (60335510)
間辺 広樹  四天王寺大学, 高等教育推進センター, 教授 (80906529)
畠山 修司  自治医科大学, 医学部, 教授 (40463864)
赤津 裕康  名古屋市立大学, 医薬学総合研究院(医学), 教授 (00399734)
神林 弾  昭和薬科大学, 薬学部, 講師 (50890787)
野原 康弘  宇都宮大学, 地域デザイン科学部, 技術職員 (80833053)
Project Period (FY) 2020-10-27 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2022: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2021: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords新興感染症 / COVID-19 / 重症化要因 / 空間・時間解析 / KAP調査 / 数理モデル / ベトナム / メキシコ / 流行予測 / 空間疫学 / 疾病集積性 / 流行監視 / 知識・態度・行動(KAP)調査 / 知識・態度・行動 (KAP) 調査
Outline of Research at the Start

COVID-19パンデミックは世界中に拡大した一方で、国や地域により感染者・死亡者数は大きく異なる。本研究は、COVID-19の感染者・死亡者数や過去の新興感染症(SARS、鳥インフルエンザH5N1、2009年新型インフルエンザ等)経験の異なる三国(ベトナム、メキシコ、日本)の国際共同研究で、各国のCOVID-19の空間的・時間的疾病集積性や、発生・重症化の学際的・医学的重症化要因の比較・検討を行い、感染や重症者数を左右した要因の解明と継続した疾病モニタリング(流行監視)、迅速な情報発信を可能とするシステムを構築する。これにより、今後の感染拡大や重症化阻止、将来の新興感染症対策に資する。

Outline of Final Research Achievements

Clinical factors that contributed to severity of COVID-19 were vaccination conditions and secondary bacterial infection in Vietnam, and kidney disease as the underlying disease in Mexico. In terms of epidemiology, high periodicity in COVID-19 observed in Mexico and Japan, but no periodicity in Vietnam. Furthermore, it was revealed that infection prevention behavior, understanding of policies, medical system, lifestyle habits, and knowledge and attitudes about emerging infectious diseases themselves vary greatly depending on the country's past impacts of emerging infectious diseases and suggested that these factors influencing the disease severity of emerging infectious diseases. The importance of further developing the analysis of the characteristics of these countries in the future is suggested, which is likely to contribute to reducing the number of severe patients with borderless emerging infectious diseases worldwide.

Academic Significance and Societal Importance of the Research Achievements

COVID-19患者の重症化要因は、臨床的な要因以外にも、その国の過去の新興感染症の経験、社会経済要因、医療制度、日常からの新興感染症についての教育、民族性、医療体制、政策等の要因が影響することが示唆された。新興感染症の重症化の防止には、医学・疫学・人文社会学など、学際的かつ包括的に検討することが必須である。各国のこれら特徴分析を展開することで、国境のない新興感染症による世界的な感染者や重症者の減少に寄与すると思われる。

Report

(6 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (29 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 9 results) Presentation (12 results) (of which Int'l Joint Research: 10 results,  Invited: 6 results) Book (3 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Bach Mai Hospital(ベトナム)

    • Related Report
      2024 Annual Research Report
  • [Int'l Joint Research] National Institute of Respiratory(メキシコ)

    • Related Report
      2024 Annual Research Report
  • [Journal Article] Simple mathematical model for predicting COVID-19 outbreaks in Japan based on epidemic waves with a cyclical trend2024

    • Author(s)
      Manabe Hiroki、Manabe Toshie、Honda Yuki、Kawade Yoshihiro、Kambayashi Dan、Manabe Yoshiki、Kudo Koichiro
    • Journal Title

      BMC Infectious Diseases

      Volume: 24 Issue: 1 Pages: 465-465

    • DOI

      10.1186/s12879-024-09354-5

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aetiological agents of adult community-acquired pneumonia in Japan: systematic review and meta-analysis of published data2023

    • Author(s)
      Fujikura Yuji、Somekawa Kohei、Manabe Toshie、Horita Nobuyuki、Takahashi Hiroshi、Higa Futoshi、Yatera Kazuhiro、Miyashita Naoyuki、Imamura Yoshifumi、Iwanaga Naoki、Mukae Hiroshi、Kawana Akihiko
    • Journal Title

      BMJ Open Respiratory Research

      Volume: 10 Issue: 1 Pages: e001800-e001800

    • DOI

      10.1136/bmjresp-2023-001800

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics and mortality risk among critically ill patients with COVID-19 owing to the B.1.617.2 (Delta) variant in Vietnam: A retrospective observational study2023

    • Author(s)
      Do Thanh Van、Manabe Toshie、Vu Giap Van、Nong Vuong Minh、Fujikura Yuji、Manabe Hiroki、et al.
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 1 Pages: e0279713-e0279713

    • DOI

      10.1371/journal.pone.0279713

    • Related Report
      2023 Research-status Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of human mobility and networking on spread of COVID-19 at the time of the 1st and 2nd epidemic waves in Japan: An effective distance approach2022

    • Author(s)
      Nohara Yasuhiro、Manabe Toshie
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 8 Pages: e0272996-e0272996

    • DOI

      10.1371/journal.pone.0272996

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of asthma, COPD, and ACO on COVID-19: A systematic review and meta-analysis2022

    • Author(s)
      Uruma Yuka、Manabe Toshie、Fujikura Yuji、Iikura Motoyasu、Hojo Masayuki、Kudo Koichiro
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 11 Pages: e0276774-e0276774

    • DOI

      10.1371/journal.pone.0276774

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Favipiravir for the treatment of patients with COVID-19: A systematic review and meta-analysis2021

    • Author(s)
      Manabe T, Kambayashi D, Akatsu H, Kudo K
    • Journal Title

      BMC Infectious Diseases

      Volume: 21 Issue: 1 Pages: 489-489

    • DOI

      10.1186/s12879-021-06164-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Knowledge, attitudes, and practices regarding COVID-19 among pharmacists partnering with community residents: A national survey in Japan.2021

    • Author(s)
      Kambayashi D, Manabe T, Kawade Y, Hirohara M.
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 10 Pages: e0258805-e0258805

    • DOI

      10.1371/journal.pone.0258805

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatiotemporal distribution of COVID-19 during the first 7 months of the epidemic in Vietnam.2021

    • Author(s)
      Manabe T, Phan D, Nohara Y, Kambayashi D, Nguyen TH, Van Do T, Kudo K.
    • Journal Title

      BMC Infectious Diseases

      Volume: 21 Issue: 1 Pages: 1124-1124

    • DOI

      10.1186/s12879-021-06822-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Favipiravir for the treatment of patients with COVID-19: A systematic review and meta-analysis2021

    • Author(s)
      Manabe T, Kambayashi D, Akatsu H, Kudo K.
    • Journal Title

      BMC Infectious Diseases

      Volume: in press

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trends in clinical features of novel coronavirus disease (COVID-19): A systematic review and meta-analysis of studies published from December 2019 to February 2020.2020

    • Author(s)
      Manabe T, Akatsu H, Kotani K, Kudo K.
    • Journal Title

      Respiratory Investigation

      Volume: 58 Issue: 5 Pages: 409-418

    • DOI

      10.1016/j.resinv.2020.05.005

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Periodicity of COVID-19 in Countries of the World2024

    • Author(s)
      Hiroki Manabe, Toshie Manabe, Yoshihiro Kawade, Koichiro Kudo
    • Organizer
      Asia Pacific Society of Respirology (APSR 2024)
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Method for Estimating the Number of COVID-19 cases in Japan using Spatial-Temporal Analysis in post pandemic period2024

    • Author(s)
      Yoshihiro Kawade, Hiroki Manabe, Sumiko Daicho, Toshie Manabe
    • Organizer
      Asia Pacific Society of Respirology (APSR 2024)
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medical Information Research using Data Science-Research Activities and Outcomes regarding COVID-192024

    • Author(s)
      Toshie Manabe
    • Organizer
      ランス・シャンパーニュ・アルデンヌ大学(フランス)来校講演会
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] COVID-19 Across Borders: Exploring Risk Differences in Infection, Severity, and Future Pandemic Forecasting for emerging infectious diseases.2024

    • Author(s)
      Toshie Manabe
    • Organizer
      2024NCU拠点校シンポジウム
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Similarities and differences between COVID-19-induced and typical ARDS at the time of hospital admission2023

    • Author(s)
      Toshie Manabe, Chinh Quoc Luong, Son Ngoc Do, Thanh Van Do, Giap Van Vu, Yuji Fujikura, Hiroki Manabe, et al.
    • Organizer
      The 27th Congress of the Asia Pacific Society of Respirology
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prediction of COVID-19 outbreak of Japan based on simple mathematical model2023

    • Author(s)
      Hiroki Manabe, Toshie Manabe. Yoshihiro Kawade.
    • Organizer
      The 27th Congress of the Asia Pacific Society of Respirology
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical characteristics and mortality risk among critically ill patients with COVID-19 owing to the B.1.617.2 (Delta) variant in Vietnam: a retrospective observational study2023

    • Author(s)
      間辺利江
    • Organizer
      International Scientific Conference on infectious and tropical diseases
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] How to conduct clinical research using the example of studies on COVID-19 in Vietnam2023

    • Author(s)
      間辺利江、間辺広樹、神林弾
    • Organizer
      The International Scientific Conference on Emerging and Re-emerging infectious diseases
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Factors influencing to infection and severity of COVID-19 from the comprehensive perceptions2022

    • Author(s)
      間辺利江
    • Organizer
      The 6th NTS-Asia Consortium Annual Conference Planetary Health: Managing Converging Risks in Asia
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 地域在住高齢者へのCOVID-19対策の検討:健康サポート薬局の薬剤師の全国調査の結果から2021

    • Author(s)
      神林弾,間辺利江,廣原正宜
    • Organizer
      第95回日本感染症学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] 健康サポート薬局薬剤師のCOVID-19に関する知識・態度・行動の全国調査:地域高齢者へのCOVID-19対策の検討.2021

    • Author(s)
      神林弾,間辺利江,廣原正宜
    • Organizer
      第5回日本老年薬学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] How to control COVID-19 pandemic successfully, lesson learned from Japan2021

    • Author(s)
      間辺利江
    • Organizer
      The 110th Anniversary of Establishment & the 31st Scientific Congress of Bach Mai Hospital
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 名市大ブックス【第18巻】データサイエンスが拓ぐ未来2024

    • Author(s)
      間辺 利江(分担執筆)
    • Total Pages
      150
    • Publisher
      中日新聞
    • Related Report
      2024 Annual Research Report
  • [Book] 新しい国際協力論[第3版]2023

    • Author(s)
      山田 満、堀江 正伸
    • Total Pages
      400
    • Publisher
      明石書店
    • ISBN
      9784750355788
    • Related Report
      2023 Research-status Report
  • [Book] 新しい国際協力論【第3版】2023

    • Author(s)
      山田 満、堀江 正伸
    • Total Pages
      400
    • Publisher
      明石書店
    • ISBN
      9784750355788
    • Related Report
      2022 Research-status Report
  • [Remarks] COVID-19 Research Library

    • URL

      https://research.eid-library.gr.jp/

    • Related Report
      2024 Annual Research Report
  • [Funded Workshop] The International Scientific Conference on Emerging and Re-emerging infectious diseases in Vietnam2024

    • Related Report
      2024 Annual Research Report

URL: 

Published: 2020-10-29   Modified: 2026-01-16  

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