• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of interaction mechanism between feeding and respiration

Research Project

Project/Area Number 20KK0353
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionNiigata University

Principal Investigator

Tsujimura Takanori  新潟大学, 医歯学系, 准教授 (00548935)

Project Period (FY) 2021 – 2023
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords嚥下 / 呼吸 / 孤束核 / 迷走神経 / 喉頭 / 咽頭 / 食道 / 動物 / DiI / モルモット / WGA-HRP / CTB-HRP / 三叉神経 / 侵害刺激 / ラット / 咀嚼 / 咳嗽 / 口腔
Outline of Research at the Start

咀嚼と嚥下が円滑に行われるためには,呼吸との協調が必須であり,食物を誤嚥した際には咳嗽により気道が防御される.本国際共同研究では,自由行動下動物の摂食および呼吸に関連する行動学的計測ならびにin vitro摘出標本を用いた神経節細胞外記録を行い,さらにヒトを対象とした咀嚼・嚥下・呼吸の関連を検証する実験を行うことにより,咀嚼・嚥下・呼吸・咳嗽の機能連関および咀嚼・嚥下のメカニズム解明を目的とする.本国際共同研究と基課題の成果から,摂食嚥下障害患者に対する咀嚼タスクの有効性が明らかとなり,将来的に国民のQOL向上に貢献につながると期待できる.

Outline of Final Research Achievements

This study aimed to clarify the relationship between feeding and respiration and the neural mechanism of initiation of swallowing. Male rodents were used in this study. Using electrophysiological, neuropharmacological and histological approaches, we tried to identify the region within the nucleus of the solitary tract (nTS) involved in the initiation of swallowing and to investigate the projection area within the nTS from the pharynx, larynx and esophagus which are regions to initiate swallowing. The results suggest that medial, commissural and ventrolateral subnuclei within the nTS receive inputs from the pharynx, larynx and esophagus and are involved in the initiation of mechanically evoked swallows. Further research that specifically targets these subnuclei will help to uncover the pathological mechanism of dysphagia and to facilitate the development of novel rehabilitation methods for patients with dysphagia.

Academic Significance and Societal Importance of the Research Achievements

嚥下は延髄にある嚥下中枢パターン発生器により制御される運動である.これまでに延髄の孤束核が嚥下誘発に関与することは報告されていたが,自然刺激で誘発される嚥下に孤束核内のどの領域が関与しているかは不明であった.本研究から,孤束核の内側亜核,交連亜核,腹外側亜核が機械刺激で誘発される嚥下反射に重要な役割を果たすことがわかった.これら領域を標的とした研究を進めることは,嚥下障害の病態解明や新規治療法の開発へとつながると期待できる.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (12 results)

All 2024 2023 2022 2021

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results) Presentation (7 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results) Book (1 results)

  • [Int'l Joint Research] ジョンズホプキンス大学医学部(米国)2022

    • Year and Date
      2022-04-01
    • Related Report
      2023 Annual Research Report
  • [Journal Article] Continuous electrical stimulation of superior laryngeal nerve inhibits initiation of swallowing in anesthetized rats2024

    • Author(s)
      Yuta Nakajima, Takanori Tsujimura, Koijun Tsuji, Jin Magara, Makoto Inoue
    • Journal Title

      Neuroscience Letters

      Volume: 825 Pages: 137672-137672

    • DOI

      10.1016/j.neulet.2024.137672

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atropine facilitates water-evoked swallows via central muscarinic receptors in anesthetized rats2023

    • Author(s)
      Yuta Nakajima, Takanori Tsujimura, Yuhei Tsutsui, Titi Chotirungsan, Satomi Kawada, Nozomi Dewa, Jin Magara, Makoto Inoue
    • Journal Title

      American Journal of Physiology Gastrointestinal and Liver Physiology

      Volume: 325 Issue: 2 Pages: G109-G121

    • DOI

      10.1152/ajpgi.00039.2023

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of Water-Evoked Swallowing During Noxious Mechanical Stimulation of Tongue in Anesthetized Rats2022

    • Author(s)
      Tsujimura Takanori、Nakajima Yuta、Chotirungsan Titi、Kawada Satomi、Tsutsui Yuhei、Yoshihara Midori、Suzuki Taku、Nagoya Kouta、Magara Jin、Inoue Makoto
    • Journal Title

      Dysphagia

      Volume: 38 Issue: 3 Pages: 965-972

    • DOI

      10.1007/s00455-022-10522-5

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Presentation] 小動物を用いた嚥下神経機構の解明2023

    • Author(s)
      辻村恭憲,井上 誠
    • Organizer
      第33回日本老年学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] NMDA and non-NMDA glutamate receptors in the rostral-commissural, medial, and ventrolateral nTS subnuclei are involved in the initiation of swallows in anesthetized guinea pigs2023

    • Author(s)
      Takanori Tsujimura,Brendan Canning, Makoto Inoue
    • Organizer
      31st Dysphagia Research Society Annual Meeting
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of swallowing initiation and its impairment2023

    • Author(s)
      Takanori Tsujimura
    • Organizer
      International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 実験動物を用いた嚥下神経機構の解明2022

    • Author(s)
      辻村恭憲,吉原 翠,井上 誠
    • Organizer
      第64回日本平滑筋学会総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 孤束核のグルタミン酸受容体は嚥下誘発に関与する2021

    • Author(s)
      辻村恭憲,Brendan J Canning,井上 誠
    • Organizer
      第45回嚥下医学会学術講演会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Peripheral mechanisms of mechanically evoked swallows2021

    • Author(s)
      Takanori Tsujimura, Makoto Inoue
    • Organizer
      2nd World Dysphagia Summit
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 炭酸刺激による嚥下誘発メカニズム2021

    • Author(s)
      辻村恭憲,井上 誠
    • Organizer
      第26・27回合同学術大会日本摂食嚥下リハビリテーション学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Crosslink言語聴覚療法学テキスト2022

    • Author(s)
      辻村恭憲
    • Total Pages
      6
    • Publisher
      メジカルビュー社
    • Related Report
      2022 Research-status Report

URL: 

Published: 2021-03-19   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi