| Outline of Final Research Achievements |
In collaboration with Professor Sergio Grinstein and Assistant Professor Spencer A. Freeman of the Department of Biochemistry, University of Toronto (The Hospital for Sick Children, Canada, we identified IL-1 receptor as a direct target of trans-fatty acids (TFAs), such as elaidic acid, that functions as the most upstream molecule in a pro-inflammatory signaling. We also identified NADPH oxidase, which produces reactive oxygen species (ROS) mainly on the plasma membrane, as the target of trans-arachidonic acids that play an anti-ferroptotic role. Furthermore, we revealed that mechanosensitive channels, including Piezo1 and TRP channels, are targets of membrane phospholipid peroxidation during ferroptosis, which play a critical role in ferroptosis execution.
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