Molecular mechanisms that determine kinetochore orientation acting at the heart of genome transition

• Project/Area Number: 21000010
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: WATANABE Yoshinori 東京大学, 分子細胞生物学研究所, 教授 (20212326)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥345,800,000 (Direct Cost: ¥266,000,000、Indirect Cost: ¥79,800,000); Fiscal Year 2013: ¥86,450,000 (Direct Cost: ¥66,500,000、Indirect Cost: ¥19,950,000); Fiscal Year 2012: ¥86,450,000 (Direct Cost: ¥66,500,000、Indirect Cost: ¥19,950,000); Fiscal Year 2011: ¥86,450,000 (Direct Cost: ¥66,500,000、Indirect Cost: ¥19,950,000); Fiscal Year 2010: ¥86,450,000 (Direct Cost: ¥66,500,000、Indirect Cost: ¥19,950,000)
• Keywords: 染色体 / セントロメア / 接着因子コヒーシン / シュゴシン / コンデンシン / 遺伝学 / ゲノム

Research Abstract

We have proven that cohesion at the core centromere defines mono-orientation of kinetochores. We show that chiasmata between homologous chromosomes ensure mono-orientation. We identified the kinase antagonizing shugoshin-PP2A. We further identified the inner centromere-shugoshin (ICS) network that is critical for chromosome segregation and the conserved regulatory mechanism of shaping chromosomes.

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes (2014)
  • Author(s): Ishiguro KI., Kim J., Shibuya H., Hernandez-Hernandez A., Suzuki A., Fukagawa T., Shioi G., Kiyonari H., Li XC., Schimenti J., Hoog C., Watanabe Y.
  • Journal Title: Genes Dev. Volume: 28 Issue: 6 Pages: 594-607
  • DOI: 10.1101/gad.237313.113
  • Peer Reviewed
• [Journal Article] The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis. (2014)
  • Author(s): Shibuya, H., Ishiguro, K., and Watanabe, Y.
  • Journal Title: Nat. Cell Biol. Volume: 16 Issue: 2 Pages: 145-156
  • DOI: 10.1038/ncb2896
  • Peer Reviewed
• [Journal Article] Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A)-containing nucleosome positioning in the fission yeast. (2013)
  • Author(s): Yao J, Liu X, Sakuno T, Li W, Xi Y, Aravamudhan P, Joglekar A, Li W, Watanabe Y, He X.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 26 Pages: 19184-19196
  • DOI: 10.1074/jbc.m113.471276
  • Peer Reviewed
• [Journal Article] Mps1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components (2012)
  • Author(s): Yamagishi, Y., Yang, CH., Tanno, Y., & Watanabe, Y
  • Journal Title: Nature Cell Biol Volume: 14 Issue: 7 Pages: 746-752
  • DOI: 10.1038/ncb2515
  • Peer Reviewed
• [Journal Article] Geometry and force behind kinetochore orientation : lessons from meiosis (review article) (2012)
  • Author(s): Watanabe, Y
  • Journal Title: Nature Rev. Mol. Cell Biol Volume: 13 Pages: 370-382
  • Peer Reviewed
• [Journal Article] A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. (2012)
  • Author(s): Morimoto A., et al.
  • Journal Title: Journal of Cell Biology Volume: 198(2) Issue: 2 Pages: 165-172
  • DOI: 10.1083/jcb.201204085
  • Peer Reviewed
• [Journal Article] Geometry and force behind kinetochore orientation: lesson dfrom meiosis (2012)
  • Author(s): Watanabe, Y.
  • Journal Title: Nature Rev. Mol. Cell Biol. Volume: 13 Issue: 6 Pages: 370-382
  • DOI: 10.1038/nrm3349
  • Peer Reviewed
• [Journal Article] Meiotic pairing by non-coding RNA? (2012)
  • Author(s): Yamashita A, Kariyazono, R and Watanabe, Y.
  • Journal Title: EMBO Rep. Volume: 13 Issue: 9 Pages: 766-766
  • DOI: 10.1038/embor.2012.124
  • Peer Reviewed
• [Journal Article] Cell Biology: Cohesin Ring Exit Gate Revealed. (2012)
  • Author(s): Yamagishi, Y and Watanabe, Y.
  • Journal Title: Curr Biol. Volume: 22
  • Peer Reviewed
• [Journal Article] Repositioning of Aurora B promoted by chiasmata ensures sister chromatid mono-orientation at meiosis I (2011)
  • Author(s): Sakuno, T., Tanaka, K., Hauf, S., & Watanabe, Y
  • Journal Title: Dev. Cell Volume: 21 Issue: 3 Pages: 534-545
  • DOI: 10.1016/j.devcel.2011.08.012
  • Peer Reviewed
• [Journal Article] Condensin association with histone H2A shapes mitotic chromosomes (2011)
  • Author(s): Tada, K., Susumu, H., Sakuno, T., & Watanabe, Y
  • Journal Title: Nature (article) Volume: 474 Issue: 7352 Pages: 477-483
  • DOI: 10.1038/nature10179
  • Peer Reviewed
• [Journal Article] Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast (2011)
  • Author(s): Kagami A, Sakuno T, Yamagishi Y, Ishiguro T, Tsukahara T, Shirahige K, Watanabe Y
  • Journal Title: EMBO Reports Volume: 12 Issue: 11 Pages: 1189-1195
  • DOI: 10.1038/embor.2011.188
  • Peer Reviewed
• [Journal Article] A new meiosis-specific cohesin complex implicated in the cohesincode for homologous pairing (2011)
  • Author(s): Kei-ichiro Ishiguro, Jihye Kim, Sally Fujiyama-Nakamura, Shigeaki Kato, Yoshinori Watanabe
  • Journal Title: EMBO reports Volume: 12 Issue: 3 Pages: 267-275
  • DOI: 10.1038/embor.2011.2
  • Peer Reviewed
• [Journal Article] Two histone marks establish the inner centromere and chromosome bi-orientation (2010)
  • Author(s): Yamagishi, Y., Honda, T., Tanno, Y., & Watanabe, Y
  • Journal Title: Science Volume: 330 Issue: 6001 Pages: 239-243
  • DOI: 10.1126/science.1194498
  • Peer Reviewed
• [Journal Article] Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation (2010)
  • Author(s): Tsukahara, T., Tanno, Y., & Watanabe, Y
  • Journal Title: Nature Volume: 467 Issue: 7316 Pages: 719-723
  • DOI: 10.1038/nature09390
  • Peer Reviewed
• [Journal Article] Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres (2010)
  • Author(s): Tanno Y., Kitajima T.S., Honda, T., Ando Y., Ishiguro K., & Watanabe, Y
  • Journal Title: Genes Dev Volume: 24 Issue: 19 Pages: 2169-2179
  • DOI: 10.1101/gad.1945310
  • Peer Reviewed
• [Journal Article] Shugoshin-PP2A counteracts Casein Kinase 1-dependent cleavage of Rec8 by separase (2010)
  • Author(s): Ishiguro, T., Tanaka, K., Sakuno, T., & Watanabe, Y
  • Journal Title: Nature Cell Biol Volume: 12 Issue: 5 Pages: 500-506
  • DOI: 10.1038/ncb2052
  • Peer Reviewed
• [Journal Article] Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin (2010)
  • Author(s): Kawashima, S.A., Yamagishi, Y., Honda, T., Ishiguro, K., & Watanabe, Y
  • Journal Title: Science(article) Volume: 327 Issue: 5962 Pages: 172-177
  • DOI: 10.1126/science.1180189
  • Peer Reviewed
• [Journal Article] Age-related meiotic segregation errors in Mammalian oocytes are preceded by depletion of cohesin and Sgo2 (2010)
  • Author(s): Lister L.M., Kouznetsova A., Hyslop L.A., Kalleas D., Pace S.L., Barel J.C., Nathan A., Floros V., Adelfalk C., Watanabe Y., Jessberger R., Kirkwood T.B., Hoog C., Herbert M.
  • Journal Title: Curr Biol. Volume: 20 Issue: 17 Pages: 1511-1521
  • DOI: 10.1016/j.cub.2010.08.023
  • Peer Reviewed
• [Journal Article] Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin. (2010)
  • Author(s): Kawashima, S.A.
  • Journal Title: Science Volume: 327 Pages: 172-177
  • Peer Reviewed
• [Journal Article] CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis (2009)
  • Author(s): Tanaka, K., Chang, H.L., Kagami, A., & Watanabe, Y
  • Journal Title: Dev. Cell Volume: 17 Issue: 3 Pages: 334-343
  • DOI: 10.1016/j.devcel.2009.08.004
  • Peer Reviewed
• [Journal Article] Kinetochore geometry defined by cohesion within the centromere (2009)
  • Author(s): Sakuno, T., Tada, K., & Watanabe, Y
  • Journal Title: Nature(article) Volume: 458 Issue: 7240 Pages: 852-858
  • DOI: 10.1038/nature07876
  • Peer Reviewed
• [Journal Article] Kinetochore geometry defined by cohesion within the centromere. (2009)
  • Author(s): Sakuno, T.
  • Journal Title: Nature Volume: 458 Pages: 852-858
  • Peer Reviewed
• [Journal Article] CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis. (2009)
  • Author(s): Tanaka, K.
  • Journal Title: Dev.Cell Volume: 17 Pages: 334-343
  • Peer Reviewed
• [Journal Article] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. (2009)
  • Author(s): Takemoto, A.
  • Journal Title: Nat.Struct.Mol.Biol. Volume: 16 Pages: 1302-1308
  • Peer Reviewed
• [Presentation] The spindle assembly checkpoint (SAC) network links directly to chromosome alignment (2013)
  • Author(s): Watanabe, Y
  • Organizer: Cell Biology of Yeasts
  • Place of Presentation: New York, USA
  • Year and Date: 2013-11-08
• [Presentation] The spindle assembly checkpoint (SAC) network links directly to chromosome alignment (2013)
  • Author(s): Watanabe, Y.
  • Organizer: Cell Biology of Yeasts
  • Place of Presentation: New York, U.S.
  • Year and Date: 2013-11-08
  • Invited
• [Presentation] Cohesin Rad21L mediates DSB-independent homolog pairing in mouse spermatocytes (2013)
  • Author(s): Watanabe, Y
  • Organizer: EMBO Workshop on : Meiosis
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2013-10-18
• [Presentation] Cohesin Rad21L mediates DSB-independent homolog pairing in mouse spermatocytes (2013)
  • Author(s): Watanabe, Y.
  • Organizer: EMBO Conference on Meiosis
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2013-09-18
  • Invited
• [Presentation] The major mechanism of chromosomal instability in cancer cells (2013)
  • Author(s): Watanabe, Y
  • Organizer: Wenner-Gren Foundations International Symposium, Meiosis and chromosome segregation - a mammalian perspective
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2013-08-30
• [Presentation] Mechanisms of CIN in cancer cells (2013)
  • Author(s): Watanabe, Y.
  • Organizer: Meiosis and chromosome segregation - a mammalian perspective
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2013-08-30
  • Invited
• [Presentation] Tension across centromeres refines centromeric protection by shugoshin (2012)
  • Author(s): Watanabe, Y
  • Organizer: EMBO Workshop on : Structure, Function & Regulation of Centromeres and Kinetochores
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2012-10-03
• [Presentation] Tension across centromeres refines centromeric protection by shugoshin, (2012)
  • Author(s): Watanabe, Y.
  • Organizer: EMBO Workshop on: Structure, Function & Regulation of Centromeres and Kinetochores
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2012-10-03
  • Invited
• [Presentation] Tension across centromeres changes centromeric protection by shugoshin (2012)
  • Author(s): Watanabe, Y
  • Organizer: FASEB Mitosis : Spindle Assembly and Function
  • Place of Presentation: Colorado, USA
  • Year and Date: 2012-08-08
• [Presentation] Tension across centromeres changes centromeric protection by shugoshin (2012)
  • Author(s): Watanabe, Y.
  • Organizer: FASEB Mitosis: Spindle Assembly and Function
  • Place of Presentation: Colorado, U.S.
  • Year and Date: 2012-08-08
  • Invited
• [Presentation] Chromosome segregation in meiosis (2012)
  • Author(s): Watanabe, Y
  • Organizer: FASEB Yeast Chromosome Structure, Replication & Segregation
  • Place of Presentation: Colorado, USA
  • Year and Date: 2012-07-18
• [Presentation] Chromosome segregation in meiosis (2012)
  • Author(s): Watanabe, Y.
  • Organizer: FASEB Yeast Chromosome Structure, Replication & Segregation
  • Place of Presentation: Colorado, U.S.
  • Year and Date: 2012-07-18
  • Invited
• [Presentation] Pairing might be promoted by identical cohesin distribution patterns between homologs (2012)
  • Author(s): Watanabe, Y
  • Organizer: Gordon Research Seminar : The 2012 Meiosis Gordon Research Conference
  • Place of Presentation: New London, USA
  • Year and Date: 2012-06-06
• [Presentation] Pairing might be promoted by identical cohesin distribution patterns between homologs (2012)
  • Author(s): Watanabe, Y.
  • Organizer: Gordon Research Seminar, The 2012 Meiosis Gordon Research Conference
  • Place of Presentation: New London, U.S.
  • Year and Date: 2012-06-06
  • Invited
• [Presentation] Histone marks for shugoshin-CPC localization prevent chromosomal instability (2012)
  • Author(s): Watanabe, Y
  • Organizer: Epigenetics meeting
  • Place of Presentation: Adelaide, AUS
  • Year and Date: 2012-05-08
• [Presentation] Histone marks for shugoshin-CPC localization prevent chromosomal instability (2012)
  • Author(s): Watanabe, Y.
  • Organizer: Epigenetics meeting
  • Place of Presentation: Adelaide, Australia
  • Year and Date: 2012-05-08
  • Invited
• [Presentation] Histone marks for shugoshin-CPC localization prevent chromosomal instability. (2012)
  • Author(s): Watanabe, Y.
  • Organizer: Epigenetics meeting
  • Place of Presentation: 4th Australian Scientific Conference （Australia）
  • Invited
• [Presentation] Pairing might be promoted by identical cohesin distribution patterns between homologs. (2012)
  • Author(s): Watanabe, Y.
  • Organizer: Gordon Research Seminar
  • Place of Presentation: Colby-Sawyer College (U.S.A.）
  • Invited
• [Presentation] Chromosome segregation in meiosis. (2012)
  • Author(s): Watanabe, Y.
  • Organizer: FASEB Yeast Chromosome Structure, Replication & Segregation
  • Place of Presentation: Steamboat Grand Resort （U.S.A.）
  • Invited
• [Presentation] Tension across centromeres changes centromeric protection by shugoshin. (2012)
  • Author(s): Watanabe, Y.
  • Organizer: FASEB Mitosis: Spindle Assembly and Function
  • Place of Presentation: Steamboat Grand Resort （U.S.A.）
  • Invited
• [Presentation] Chromosomal instability in cancer cells is caused by shugoshin dysfunction. (2012)
  • Author(s): 渡邊嘉典
  • Organizer: 第71回日本癌学会学術総会コアシンポジウム
  • Place of Presentation: ロイトン札幌 (北海道)
  • Invited
• [Presentation] Tension across centromeres refines centromeric protection by shugoshin (2012)
  • Author(s): Watanabe, Y
  • Organizer: EMBO Workshop on: Structure, Function & Regulation of Centromeres and Kinetochores
  • Place of Presentation: Institut d'Estudis Catalans（Spain）
  • Invited
• [Presentation] 染色体サイクルの制御 (2012)
  • Author(s): 渡邊嘉典
  • Organizer: 東京都医学総合研究所 国際シンポジウム
  • Place of Presentation: 東京都医学総合研修所（東京）
  • Invited
• [Presentation] Aurora B distribution coordinates chromosome segregation with cell cycle progression (2011)
  • Author(s): 渡邊嘉典
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-12-15
• [Presentation] Aurora B-dependent condensin association with histone H2A shapes mitotic chromosomes (2011)
  • Author(s): Watanabe, Y
  • Organizer: Sixth international Fission Yeast Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2011-06-27
• [Presentation] Aurora B-dependent condensin association with histone H2A shapes mitotic chromosomes (2011)
  • Author(s): Watanabe, Y.
  • Organizer: Sixth international Fission Yeast Meeting
  • Place of Presentation: Boston, U.S.A.(招待講演)
  • Year and Date: 2011-06-27
• [Presentation] Spatiotemporal regulation of chromosome architecture by Aurora B (2011)
  • Author(s): Watanabe, Y
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Windermere, U. K.
  • Year and Date: 2011-04-12
• [Presentation] Spatiotemporal regulation of chromosome architecture by Aurora B (2011)
  • Author(s): Watanabe, Y.
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Windermere, U.K.(招待講演)
  • Year and Date: 2011-04-12
• [Presentation] Spatiotemporal regulation of chromosome architecture by Aurora B (2011)
  • Author(s): Watanabe, Y
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: London Research Institute (U. K.)
  • Invited
• [Presentation] Aurora B-dependent condensin association with histone H2A shapes mitotic chromosomes (2011)
  • Author(s): Watanabe, Y.
  • Organizer: Sixth international Fission Yeast Meeting
  • Place of Presentation: Longwood neighborhood of Boston (U. S. A.)
  • Invited
• [Presentation] Aurora B distribution coordinates chromosome segregation with cell cycle progression. (2011)
  • Author(s): 渡邊嘉典
  • Organizer: 第３４回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Invited
• [Presentation] Chromosome orientation determined by Aurora B locating at the inner centromere (2010)
  • Author(s): 渡邊嘉典
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2010-12-09
• [Presentation] Shugoshin impacting on eukaryotic chromosome segregation (2010)
  • Author(s): Watanabe, Y
  • Organizer: Integrated aspects of molecular cell biology
  • Place of Presentation: Lion, France
  • Year and Date: 2010-11-09
• [Presentation] Shugoshin impacting on eukaryotic chromosome segregation (2010)
  • Author(s): Watanabe, Y.
  • Organizer: Integrated aspects of molecular cell biology
  • Place of Presentation: Lion, France(招待講演)
  • Year and Date: 2010-11-09
• [Presentation] Interplay of kinetochore geometry and tension determines chromosome orientation during mitosis and meiosis (2010)
  • Author(s): Watanabe, Y
  • Organizer: FASEB Summer Research Conference
  • Place of Presentation: Arizona, USA
  • Year and Date: 2010-08-10
• [Presentation] Interplay of kinetochore geometry and tension determines chromosome orientation during mitosis and meiosis (2010)
  • Author(s): Watanabe, Y.
  • Organizer: FASEB Summer Research Conference
  • Place of Presentation: Arizona, U.S.A.(招待講演)
  • Year and Date: 2010-08-10
• [Presentation] Interplay of kinetochore geometry and tension determines chromosome orientation during meiosis (2010)
  • Author(s): Watanabe, Y.
  • Organizer: Gordon Research Conference on Meiosis
  • Place of Presentation: New Hampshire, U.S.A.(招待講演)
  • Year and Date: 2010-06-17
• [Presentation] Interplay of kinetochore geometry and tension determines chromosome orientation during meiosis (2010)
  • Author(s): Watanabe, Y., Tanaka, K., Sakuno, T
  • Organizer: Gordon Research Conference on Meiosis
  • Place of Presentation: New Hampshire, USA
  • Year and Date: 2010-06-10
• [Presentation] Phosphorylation of H3 and H2A establishes the inner centromere and chromosome bi-orientation (2010)
  • Author(s): Watanabe, Y
  • Organizer: The LXXV Cold Spring Harbor Symposium on Quantitative Biology Nuclear Organization & Function
  • Place of Presentation: New York, USA
  • Year and Date: 2010-06-07
• [Presentation] Phosphorylation of H3 and H2A establishes the inner centromere and chromosome bi-orientation (2010)
  • Author(s): Watanabe, Y.
  • Organizer: The LXXV Cold Spring Harbor Symposium on Quantitative Biology Nuclear Organization & Function
  • Place of Presentation: New York, U.S.A.(招待講演)
  • Year and Date: 2010-06-07
• [Presentation] Regulation of centromeric localization of shugoshin (2009)
  • Author(s): Watanabe, Y
  • Organizer: The EMBO conference on meiosis (1^<st>)
  • Place of Presentation: Sorgue, France
  • Year and Date: 2009-09-22
• [Presentation] Regulation of centromeric localization of shugoshin (2009)
  • Author(s): Watanabe, Y.
  • Organizer: The EMBO conference on meiosis (1^<st>)
  • Place of Presentation: Isle sur la Sorgue, France
  • Year and Date: 2009-09-22
• [Presentation] Identification of the primary Bub1 substrate impacting on chromosome segregation (2009)
  • Author(s): Watanabe, Y
  • Organizer: Late summer meeting (Chromosome Dynamics)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2009-09-10
• [Presentation] Aurora B mediated phosphorylation of hSgo2 is crucial for chromosome congression and centromeric protection (2009)
  • Author(s): Watanabe, Y
  • Organizer: International Workshop on Chromosome Segregation Machinery
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2009-06-05
• [Presentation] Kinetochore orientation is elaborately regulated by cohesion within the centromere (2009)
  • Author(s): Watanabe, Y
  • Organizer: Gordon Research Conference on Chromosome Dynamics
  • Place of Presentation: Il Ciocco Hotel and Resort Barga, Italy
  • Year and Date: 2009-05-27
• [Presentation] Kinetocore orientation is elaborately regulated by cohesion within the centromere (2009)
  • Author(s): Watanabe, Y.
  • Organizer: Gordon Research Conference on Chromosome Dynamics
  • Place of Presentation: Barga, Italy
  • Year and Date: 2009-05-27
• [Book] 染色体と細胞核のダイナミクス-DNAを操る細胞の仕組み：減数分裂期染色体構造とダイナミクス (2013)
  • Author(s): 作野 剛士、渡邊 嘉典
  • Total Pages: 15
  • Publisher: 化学同人
• [Book] 実験医学,31(6)：減数分裂特異的コヒーシンと染色体異数性疾患 (2013)
  • Author(s): 石黒啓一郎、渡邊嘉典
  • Total Pages: 7
  • Publisher: 羊土社
• [Book] シュゴシンのもつ2つの分子機能,細胞周期フロンティア (2010)
  • Author(s): 本田貴史、渡邊嘉典
  • Publisher: 共立出版
• [Remarks] 1. 生殖細胞への関与物質特定(日経産業新聞 2014.3.11)
• [Remarks] 2. 染色体分配の基本原理の解明(読売新聞 2013.3.21)
• [Remarks] 3. 染色体分配の基本原理の解明(朝日新聞 2013.3.21)
• [Remarks] 4. 染色体の分配制御仕組みを発見(毎日新聞 2009.12.1)
• [Remarks]
  • URL: http://www.iam.u-tokyo.ac.jp/watanabe-lab/watanabe_lab/Home.html
• [Remarks] 東京大学分子細胞生物学研究所 染色体動態研究分野 渡邊研究室
  • URL: http://www.iam.u-tokyo.ac.jp/watanabe-lab/watanabe_lab/Home.html
• [Remarks] 研究室ホームページ
  • URL: http://www.iam.u-tokyo.ac.jp/watanabe-lab/watanabe_lab/Home.html