Development of a Biomolecule Simulation System Using the Single Amino Acid Potential Force Field
| Project/Area Number |
21200005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
Bioinformatics/Life informatics
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MINEZAKI Toshiya 東海大学, 理学部, 准教授 (30190713)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | タンパク質 / アミノ酸 / 力場 / 分子シミュレーション / タンパク質構造データベース / ポテンシャル / 分子軌道計算 / フォールディング / 生物物理 / 蛋白質 / 構造・機能予測 / コンピュータシミュレーション / フオールデイング |
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| Research Abstract |
To elucidate the process of structural folding of proteins, four subjects were focused in this study. First, the Single Amino Acid Potential force field was improved, and the accuracy was evaluated. Second, the roles of the single amino acid potentials in protein structures were quantitatively analyzed. Third, the strain energy of protein structures was analyzed based on the single amino acid potentials. Fourth, the developed molecular simulation program was released on the web.
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Report
(4 results)
Research Products
(60 results)
