The role of lipid-mediated intercellular communications in neuronal circuit development and regeneration

• Project/Area Number: 21200009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology; Cell biology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: KAMIGUCHI Hiroyuki 独立行政法人理化学研究所, 神経成長機構研究チーム, チームリーダー (10233933)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000); Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 脊髄 / 後根神経節 / 感覚神経 / 軸索ガイダンス / 成長円錐 / リゾリン脂質 / Gタンパク質共役型受容体 / カルシウムイオン / アンタゴニスト / リゾ脂質 / Gタンパク質 / 受容体

Research Abstract

Axon growth along the correct path is necessary for neuronal circuit formation. We have discovered the axon-guiding lipid molecule Lysophosphatidylglucoside (LysoPtdGlc), identified its receptor and downstream signaling pathway, and elucidateid its functional significance in the spinal sensory axon tract formation. In contrast to previous studies on the role of proteins as axon guidance cues, thei project has demonstrated the importance of lipid-mediateid axon guidance in neuronal circuit formation

Research Products

• [Journal Article] Scond messengers and membrane trafficking direct and organize growth cone steering (2011)
  • Author(s): Tojima T, Hines JH, Henley JR, Kamiguchi H
  • Journal Title: Nat Rev Neurosci Volume: 12 Pages: 191-203
• [Journal Article] Polarizing membrane dynamics and adhesion for growth cone navigation (2011)
  • Author(s): Itofusa R, Kamiguchi H
  • Journal Title: Mol Cell Neurosci Volume: 48 Pages: 332-338
• [Journal Article] Second messengers and membrane trafficking direct and organize growth cone steering (2011)
  • Author(s): 戸島拓郎
  • Journal Title: Nature Reviews Neuroscience Volume: 12 Issue: 4 Pages: 191-203
  • DOI: 10.1038/nrn2996
  • Peer Reviewed
• [Journal Article] Polarizing membrane dynamics and adhesion for growth cone navigation (2011)
  • Author(s): 糸総るり香
  • Journal Title: Molecular and Cellular Neuroscience Volume: 48 Issue: 4 Pages: 332-338
  • DOI: 10.1016/j.mcn.2011.03.007
  • Peer Reviewed
• [Journal Article] Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance (2010)
  • Author(s): Tojima T, Itofusa R, Kamiguchi H
  • Journal Title: Neuron Volume: 66 Pages: 370-377
• [Journal Article] Asymmetric clathrin-mediated endocytosis drives repulsive growth coneguidance. (2010)
  • Author(s): Tojima T, Itofusa R, Kamiguchi H.
  • Journal Title: Neuron Volume: 66 Pages: 370-377
  • Peer Reviewed
• [Presentation] Growth cone membrane trafficking for axon gauidance (2012)
  • Author(s): Kamiguchi H
  • Organizer: Keystone Symposia on Molecular and Cellular Biology "Membranes in Motion"
  • Place of Presentation: Tahoe City, USA
  • Year and Date: 2012-01-27
• [Presentation] Membrane dynamics in growth cone guidance (2011)
  • Author(s): Kamiguchi H
  • Organizer: The 8th IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-16
• [Presentation] Lipid-mediated axon guidance in the developing spinal cord (2011)
  • Author(s): Guy A, Nagatsuka Y, Greimel P, Nabetani T, Inoue M, Nakata A, Ooashi N, Ito Y, Ohta K, Hirabayashi Y, Kamiguchi H
  • Organizer: The 7th IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-16
• [Presentation] Lipid-mediated axon guidance in the developing spinal cord (2011)
  • Author(s): Adam T.Guy
  • Organizer: The 8th IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-16
• [Presentation] Lysophosphatidylglucoside controls neuronal circuit formation in the spinal cord (2011)
  • Author(s): Kamiguchi H
  • Organizer: The 30th Naito Conference on Membrane Dynamics and Lipid Biology II: Domains, Droplets and Diseases
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2011-07-01
• [Presentation] Lipid- mediated axon guidance in the developing spinal cord (2010)
  • Author(s): Kamiguchi H
  • Organizer: The 6th International Academy of Perinatal Medicine
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2010-10-23
• [Presentation] Lipid-mediated axon guidance in the developing spinal cord. (2010)
  • Author(s): Kamiguchi H.
  • Organizer: The 6th International Academy of Perinatal Medicine
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-23
• [Presentation] Lipid-mediated axon guidance in the developing spinal cord (2010)
  • Author(s): Guy A, Nagatsuka Y, Greimel P, Nabetani T, Ito Y, Ohta K, Hirabayashi Y, Kamiguchi H
  • Organizer: Cold Spring Harbor Laboratory Meeting on Axon Guidance, Synaptic Plasticity and Regeneration
  • Place of Presentation: Ner York, USA
  • Year and Date: 2010-09-21
• [Presentation] Lipid-mediated axon guidance in the developing spinal cord. (2010)
  • Author(s): Guy A, Kamiguchi H.
  • Organizer: Cold Spring Harbor Laboratory Meeting on Axon Guidance, Synaptic Plasticity and Regeneration
  • Place of Presentation: New York, USA.
  • Year and Date: 2010-09-21
• [Presentation] リゾホスファチジルグルコシドによる軸索ガイダンス (2009)
  • Author(s): 上口裕之
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] リゾボスファチジルグルコシドによる軸索ガイダンス (2009)
  • Author(s): 上口裕之
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2009-09-17
• [Book] The driving machinery for growth cone navigation In: Advances in Neurobiology "Cytoskeleton of the Nervous System" (Eds) Nixon RA, Yuan A (2011)
  • Author(s): Tojima T, Kamiguchi H
  • Publisher: Springer
• [Patent(Industrial Property Rights)] リゾホスファチジルグルコシドに結合する抗体および該抗体を含む組成物 (2010)
  • Industrial Property Number: 2010-155278
  • Filing Date: 2010-07-07
  • Overseas