The mechanisms of language acquisition and evolution of mouse brain in Foxp2-KI mice
| Project/Area Number |
21200011
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
Physical anthropology
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
MOMOI Takashi 国際医療福祉大学, 保健医療学部, 教授 (40143507)
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| Co-Investigator(Kenkyū-buntansha) |
MOMOI Mariko 自治医科大学, 医学部, 教授 (90166348)
JINBO Eriko 自治医科大学, 医学部, 講師 (20291651)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 進化 / 言語 / 言語障害 / Broca / FOXP2 |
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| Research Abstract |
The phenotype of speech-language disorder segregates as an autosomal dominant trait. One-half the members of the KE family with speech-language disorder have severe articulation difficulties accompanied by verbal and orofacial impairment. A missense mutation (R553H) in the forkhead domain of FOXP2 co-segregates with the affected members of the KE family. We have bridged the gap between the fMRI data and speech-language ability using knock-in mice with the Foxp2(R552H) mutation, Foxp2(R552H)-KI mice (Foxp2-KI mice), which is related to the FOXP2(R553H) mutation (PNAS 2008). Foxp2-KI mice exhibit impaired USV communication.Foxp2(R552H) increase cerebellar CNTNAP2 gene expression (Neurosci. Lett. 2012). FOXP2 promotes the nuclear translocation of POT1, but FOXP2(R553H), mutation related to speech-language disorder, partially prevents it.
Cadm1-expressing synapses on Purkinje cell dendrites are involved in mouse ultrasonic vocalization activity (PLoS One. 2012). We generated transgenic mouse lines (Pcp2-FOXP2-myc-Tg;FOXP2-Tg) that specifically express human FOXP2 in Purkinje cells, by using BAC transgenesis of Pcp2 gene and Foxp2(R552H)-KI/ Pcp2-FOXP2-myc-Tg mice (Foxp2-KI/FOXP2-Tg) by mating with Foxp2-KI mice and examined the effects of FOXP2 on the USV function and Purkinje cells.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Endoplasmic reticulum stress induced by synaptic adhesion molecules, CADM1, with mutation related to the Autism Spectrum Discorders.2010
Author(s)
Fujita E., Dai, H., Tanabe, Y., Zhiling Y., Yamagata, T., Miyakawa, T., Tanokura, M., Momoi, MY., Momoi, T.
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Journal Title
Cell Death and Disease
Volume: 1(6)
Related Report
Peer Reviewed
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