| Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Research Abstract |
DNA-based molecular device that is capable of responding to biological molecular recognition events was tackled for futuristic nano-, bio-device developments based on in-situ electoconductive modification of DNA self-assembly. Some direct or indirect assistance necessary to the goal were successfully developed; novel psoralen compounds that enable versatile functionalization of DNA duplexes by covalent conjugation, single-molecule assay for various DNA affinity reactions including single-nucleotide polymorphism using atomic force microscope, new types of bottom-up, supramolecular DNA nanomaterials based on dendrimer formation of three-way junction DNA, and etc. We are committed to taking on the challenges by installing the DNA dendrimer materials into interdigitated array electrode to provide state-of-the-art, molecularly responsive devices adaptable to various bioanalytical purposes.
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