Photoresponsive RNA-binding ligands for regulation of RNA functions
| Project/Area Number |
21200042
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
Chemistry related to living body
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| Research Institution | Osaka University |
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Principal Investigator |
DHONO Chikara 大阪大学, 産業科学研究所, 准教授 (60420395)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKATANI Kazuhiko 大阪大学, 産業科学研究所, 教授 (70237303)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 分子認識 / ケミカルバイオロジー / バイオテクノロジー / RNA / DNA / ミスマッチ / 分子糊 / 光スイッチ / 生体認識・機能化学 / RNA結合リガンド |
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| Research Abstract |
Recent studies have revealed that RNA molecules directly involve in modulation of a wide variety of cellular functions. We have developed a series of small synthetic ligands that can bind to specific RNA structures and regulate the RNA-related functions. Ligand binding induced the structural change of target mRNA and resulted in translational regulation of the gene expression through a riboswitch-type regulatory mechanism.
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Report
(4 results)
Research Products
(28 results)
