In vivo molecular analysis of tolerant ability in tardigrades
Project/Area Number |
21200043
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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Allocation Type | Single-year Grants |
Research Field |
Living organism molecular science
Chemistry related to living body
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Research Institution | The University of Tokyo |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|
Keywords | 極限環境耐性 / クマムシ / 次世代シークエンサー / 変異体 / 色素 / トランスクリプトーム / アルビノ |
Research Abstract |
Tardigrades enter an ametabolic dehydrated state called anhydrobiosis upon desiccation and tolerate various extreme environmental stresses in such a state. The molecular mechanisms of the tolerant ability remain unknown and no in vivo analyses have been conducted. Here, we isolated pigment-deficient mutant of anhydrobiotic tardigrade for the first time and revealed that the mutant is more sensitive to radiation stress than wildtype animal. Massive sequencing and comparison with the wildtype genome revealed multiple mutated genes. Furthermore, we characterized the property of the pigments of wildtype tardigrades and these pigments could be good clues to support radiation tolerance in animals.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Two Novel Heat-Soluble Protein Families Abundantly Expressed in an Anhydrobiotic Tardigrade2012
Author(s)
Yamaguchi A, Tanaka S, Yamaguchi S, Kuwahara H, Takamura C, Imajoh-Ohmi S, Horikawa DD, Toyoda A, Katayama T, Arakawa K, Fujiyama A, Kubo T and Kunieda T
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Journal Title
PLoS ONE
Volume: 7
Issue: 8
Pages: e44209-e44209
DOI
Related Report
Peer Reviewed
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