| Budget Amount *help |
¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Research Abstract |
We have developed axial chirality induction utilizing chromium tricarbonyl migration of N-arylacridane chromium complex, which has a pro-chiral N-C bond. We also succeeded to control the slippage reaction of chromium tricarbonyl group in conjugated aromatic compound. It was found that the introduction of TES group at the edge of carbazole and naphthalene compound could induce the reversible chromium tricarbonyl migration by external stimuli i.e. light or heat. In addition, it was confirmed that the electron density of the aromatic ring was largely changed due to the migration of electron withdrawing chromium tricarbonyl group. On the other hand, the chromium tricarbonyl group in a non-conjugated axially chiral biaryl chromium complex with a hydroxymethyl directing group could migrate to the another arene face of biaryl stereoselectively. In addition, axially chiral teraryl chromium complex also was synthesized and second migration reaction to the newly introduced arene could be achieved to give a migrated complex.
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