| Budget Amount *help |
¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Research Abstract |
We performed cis-regulatory analyses of genes involved in development and disease in a genome-wide manner, using comparative genomics approach and an efficient transgenesis technique in Xenopus. Conserved enhancers were identified in a variety of genes including Pax family and Polycomb-related genes. Furthermore, comparative functional analysis between the vertebrate and amphioxus cis-regulatory elements revealed that silencer innovation, rather than enhancer degeneration, was crucial for the diversification of paralog expression during vertebrate evolution.
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