| Budget Amount *help |
¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Research Abstract |
Reactive oxygen species (ROS) is generated outside and inside the cells. An excess level of ROS results in damages on cells and cell death, which may cause various pathologic processes. By contrast, a lower level of ROS rather activates cell viability and growth. Cellular signaling involved in how the distinct effects of ROS is unsolved. Here, we identify peroxiredoxin proteins, which are known to be antioxidant protein, can act as sensor for ROS and have ability to regulate the glucose metabolism and the translational reprograming.
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