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Comprehensive analysis of the mechanism of novel bioactive lipids transport system.

Research Project

Project/Area Number 21200071
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Functional biochemistry
Research InstitutionOsaka University

Principal Investigator

NISHI Tsuyoshi  大阪大学, 産業科学研究所, 准教授 (60403002)

Co-Investigator(Renkei-kenkyūsha) NAKASHIMA Ryosuke  大阪大学, 産業科学研究所, 助教 (20379100)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords輸送体 / 脂質メディエーター / スフィンゴシン1リン酸 / ABC トランスポーター / 免疫抑制剤 / リンパ球 / 細胞遊走 / 動脈硬化 / オーファン輸送体 / 血管内皮細胞 / MFS型 / 赤血球 / FTY720 / ABCトランスポーター / スフィンゴ脂質 / コレステロール / トランスポーター / 構造機能相関 / ABC輸送体
Research Abstract

Sphingosine 1-phosphate (S1P) is one of the most important lipid mediators and essential for cell migration. To elucidate a physiological role of SPNS2 in mammals, we analyzed Spns2-defecient mice. Spns2 transcripts were detected in vascular endothelial cells and S1P secretion were abolished in the vascular endothelial cells prepared from SPNS2-defecient mice. Consequently, blood plasma S1P concentration of SPNS2-defecient mice was reduced to approximately 60% of wild-type. Although about a half of S1P remaining in blood plasma, the blood of SPNS2-deficient mice contained significantly fewer lymphocytes. However, lymphocytes in SPNS2-defecient mice thymus express more S1p1 and show a high migration activity at a lower S1P concentration. These results suggested that S1P at microenvironments around the thymus endothelial cells is rather important for the lymphocytes egress from the thymus than overall S1P concentration in plasma.
Among the constructed various ABC transporters knockout mice, ABCA5 deficinet macrophage decrease cholesterol efflux and enhance the atheroscrelosis. These results suggested various orphan transporters play physiological important lipids odulators.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (69 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (55 results) Remarks (1 results)

  • [Journal Article] Functional roles of sphingosine-1- phosphate (S1P) in immunity2012

    • Author(s)
      Hisano Y., Nishi T. and Kawahara A
    • Journal Title

      J. Biochem

      Volume: 152 Pages: 305-311

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mouse SPNS2 functions as a sphingoshine 1phosphate transporter in vascular endothelial cells2012

    • Author(s)
      Hisano, Y., Kobayashi, N., Yamaguchi, A. and Nishi T
    • Journal Title

      PloS ONE

      Volume: 7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphopeptide-dependent fluorescence labeling of 14-3-3ζ by fusicoccins2012

    • Author(s)
      Takahashi, M., Kawamura, A., Kato, N., Nishi T., Hamachi, I. and Ohkanda, J
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 51 Pages: 509-512

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mouse SPNS2 functions as a sphingoshine 1-phosphate transporter in vascular endothelial cells2012

    • Author(s)
      Hisano, Y., Kobayashi, N., Yamaguchi, A., Nishi T.
    • Journal Title

      PloS ONE

      Volume: 7 Issue: 6 Pages: 38941-38941

    • DOI

      10.1371/journal.pone.0038941

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphopeptide-Dependent Labeling of 14-3-3ζ Proteins by Fusicoccin-Based Fluorescent Probes2012

    • Author(s)
      M.Takahashi, A.Kawamura, N.Kato, T.Nishi, I.Hamachi, J.Ohkanda
    • Journal Title

      Angew.Chem.Int.Ed.

      Volume: 51 Issue: 2 Pages: 509-512

    • DOI

      10.1002/anie.201106995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The sphingosine 1-phosphate transporter, SPNS2 function as an exporter for thephosphorilatedform of immunomodulating agent FTY720 from the cells2011

    • Author(s)
      Hisano, Y., Kobayashi, N., Kawahara, A., Yamaguchi, A. and Nishi, T
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 11758-1766

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The sphingosine 1-phosphate transporter, Spns2 function as an exporter for the phosphorilated form of immunomodulating agent FTY720 from the cells.2011

    • Author(s)
      Hisano, Y., Kobayashi, N., Kawahara, A., Yamaguchi, A., Nishi, T.
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 1758-1766

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage Abca5influences cellular cholesterol efflux and increases susceptibility to atheroscrosis in female Ldlr knockout mice2010

    • Author(s)
      Ye, D., Meurs, I., Ohigashi, M., Zhao, Y., Kubo, Y., Yamaguchi A, van Beckel, T.J.C., Nishi T. and van Eck, M
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 395 Pages: 387-394

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage Abca5 influences cellular cholesterol efflux and increases susceptibility to atheroscrosis in female Ldlr knockout mice.2010

    • Author(s)
      Ye, D., Meurs, I., Ohigashi, M., Zhao, Y., Habets, K.LL., Calpe-Berdiel, L., Kubo, Y., Yamaguchi, A, van Beckel, T.J.C., Nishi, T., van Eck, M.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 395 Pages: 387-394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the ATPdependent sphingosine-1-phosphate transporter in rat erythrocytes2009

    • Author(s)
      Kobayashi N., Kobayashi N., Yamaguchi A. and Nishi T
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 221192-21200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] スフィンゴシン-1-リン酸の輸送体Spns2は心臓前駆細胞の移動を制御する2009

    • Author(s)
      川原敦雄、西 毅、山口明人、望月直樹
    • Journal Title

      細胞工学

      Volume: 28 Pages: 390-391

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of the ATP-dependent sphingosine-1-phosphate transporter in rat erythrocytes2009

    • Author(s)
      N.Kobayashi, N.Kobayashi, A.Yamaguchi, T.Nishi
    • Journal Title

      J.Biol.Chem 284

      Pages: 21192-21200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スフィンゴシン-1-リン酸の輸送体Spns2は心臓前駆細胞の移動を制御する2009

    • Author(s)
      川原敦雄、西毅、山口明人、望月直樹
    • Journal Title

      細胞工学 28

      Pages: 390-391

    • Related Report
      2009 Annual Research Report
  • [Presentation] 哺乳類におけるスフィンゴシン1リン酸輸送体の同定と生理機能の解析2013

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第33回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2013-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of physiological functions of the sphingosine 1-phosphate transporter in mice2012

    • Author(s)
      Tuyoshi Nishi
    • Organizer
      Gordon Research Conference "Glycolipid & Sphingolipid Biology"
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2012-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の生理的な役割の解明2012

    • Author(s)
      西毅、久野 悠、山口明人
    • Organizer
      日本薬学会 第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の生理的な役割の解明2012

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      日本薬学会 第132年会
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 輸送体による情報伝達物質の局所による量的制御が細胞の動きを調節する2011

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      本生体エネルギー研究会第37回討論会
    • Place of Presentation
      京都産業大学
    • Year and Date
      2011-12-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 輸送体による情報伝達物質の局所による量的制御が細胞の動きを調節する2011

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      日本生体エネルギー研究会 第37回討論会
    • Place of Presentation
      京都産業大学(京都市)
    • Year and Date
      2011-12-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂質メディエーター分泌輸送体 SPNS2ノックアウトマウスの解析と生理的役割の解明2011

    • Author(s)
      久野 悠、山口明人、西 毅
    • Organizer
      本生体エネルギー研究会第37回討論会
    • Place of Presentation
      京都産業大学
    • Year and Date
      2011-12-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 哺乳類におけるスフィンゴシン 1リン酸輸送体の同定と生理機能の解析2011

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第33回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      岡山大学
    • Year and Date
      2011-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of the ATP-dependent sphingosine 1-phosphate (S1P) transporter in rat erythrocyte2011

    • Author(s)
      Kobayshi N., Kobayashi N., Adachi H. Yamaguchi A. and Nishi T
    • Organizer
      The 30^<th> Naito conference on Membrane Dynamics and Lipid Biology [II]
    • Place of Presentation
      札幌市
    • Year and Date
      2011-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of the ATP- dependent sphingosine 1-phosphate (SIP) transporter in rat erythrocyte2011

    • Author(s)
      Kobayshi N., Kobayashi N., Adachi H. Yamaguchi A., Nishi T.
    • Organizer
      The 30^<th> Naito conference on Membrane Dynamies and Lipid Biology [II]
    • Place of Presentation
      ガトーキングダムサッポロ(札幌市)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Physiological roles of sphingosine 1-phosphate transporters2011

    • Author(s)
      Nishi, T. Hisano, Y. Kobayashi, N. and Yamaguchi, A
    • Organizer
      Symposium on Bioinspired Materials and Functionalities
    • Place of Presentation
      Hampshire Hotel Plaza, Groningen, Netherland
    • Year and Date
      2011-06-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Physiological roles of sphingosine 1-phosphate transporters2011

    • Author(s)
      Nishi, T. Hisano, Y. Kobayashi, N. Yamaguchi, A.
    • Organizer
      Symposium on Bioinspired Materials and Function alities
    • Place of Presentation
      Hampshire Hotel Plaza (Groningen, Netherland)(招待講演)
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 哺乳類における新規スフィンゴシン1-リン酸(S1P)輸送体の同定及び解析2011

    • Author(s)
      久野悠、山口明人、西毅
    • Organizer
      第58回日本生化学会近畿支部例会
    • Place of Presentation
      守口市
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 哺乳類における新規スフィンゴシン1-リン酸(SIP)輸送体の同定及び解析2011

    • Author(s)
      久野悠、山口明人、西毅
    • Organizer
      第58回日本生化学会近畿支部例会
    • Place of Presentation
      関西医科大学(守口市)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] フィンゴシン1 リン酸輸送体の同定と機能解析2010

    • Author(s)
      西毅、小林直木、久野悠、川原敦雄、山口明人
    • Organizer
      日本生体エネルギー研究会 第35回討論会
    • Place of Presentation
      旭川大学
    • Year and Date
      2010-12-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 新規S1P輸送体SPNS2の機能解析2010

    • Author(s)
      久野悠、川原敦雄、山口明人、西毅、
    • Organizer
      日本生体エネルギー研究会 第35回討論会
    • Place of Presentation
      旭川
    • Year and Date
      2010-12-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional analysis of a novel S1P transporter2010

    • Author(s)
      Hisano, Y. Yamaguchi, A. Nishi, T
    • Organizer
      SPNS2、BMB2010
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional analysis of a novel S1P transporter, SPNS22010

    • Author(s)
      Hisano, Y., Yamaguchi, A., Nishi, T.
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫抑制剤FTY720の作用機序におけるS1P輸送体SPNS2の役割2010

    • Author(s)
      久野悠、山口明人、西毅
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山市
    • Year and Date
      2010-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 免疫抑制剤FTY720の作用機序におけるS1P輸送体SPNS2の役割2010

    • Author(s)
      久野悠、山口明人、西毅
    • Organizer
      第32回 生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] スフィンゴシン1-リン酸(S1P)輸送体Spns2による心臓発生の制御機構2010

    • Author(s)
      久野悠、川原敦雄、山口明人、望月直樹、西毅
    • Organizer
      第19回日本循環薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2010-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] S1P輸送体SPNS2の生理機能の解析2010

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第36回日本生体エネルギー研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] S1P輸送体SPNS2の生理機能の解析2010

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第36回 日本生体エネルギー研究会
    • Place of Presentation
      大阪大学銀杏会館
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] スフィンゴシン1リン酸(S1P)の光反応性アナログを用いたS1P輸送体の探索2010

    • Author(s)
      小林直木、西毅、山口明人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] The analysis of sphingosine 1-phosphate secretion from cells expressing Spns22010

    • Author(s)
      Hisano, Y., Yamaguchi, A. Nish, T
    • Organizer
      51st International conference on the Bioscience of Lipids
    • Place of Presentation
      Alhondiga Conference Center, Bilbao, Spain
    • Year and Date
      2010-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] The analysis of sphingosine 1-phosphate secretion from cells expressing Spns2.2010

    • Author(s)
      Hisano, Y., Yamaguchi, A., Nish, T.
    • Organizer
      51^<st> International conference on the Bioscience of Lipids
    • Place of Presentation
      Alhondiga Conference Center, Bilbao, Spain
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of the mammalian sphingosine 1-phosphate transporters2010

    • Author(s)
      Nishi T., Hisano Y., Kobayashi N. Yamaguchi A
    • Organizer
      The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of the mammalian sphingosine 1-phosphate transporters2010

    • Author(s)
      Nishi T., Hisano Y., Kobayashi N., Yamaguchi A.
    • Organizer
      The 27^<th> Naito Conference on Membrane Dynamics and Lipid Biology [I]
    • Place of Presentation
      シャトレーゼガトーキングダム サッポロ
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional analysis of novel S1P transporter, Spns22010

    • Author(s)
      Hisano, Y., Yamaguchi, A., Nishi T.
    • Organizer
      The 27^<th> Naito Conference on Membrane Dynamics and Lipid Biology [I]
    • Place of Presentation
      シャトレーゼガトーキングダム サッポロ
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の同定と生理機能の解析2010

    • Author(s)
      西毅、久野悠、小林直木、山口明人
    • Organizer
      第52回日本脂質生化学会
    • Place of Presentation
      伊香保、群馬
    • Year and Date
      2010-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の同定と生理機能の解析2010

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第52回 日本脂質生化学会
    • Place of Presentation
      伊香保・森秋旅館
    • Year and Date
      2010-06-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of the ATP dependent sphingosine-1-phosphate (S1P) transporter in rat erythrocytes2010

    • Author(s)
      Kobayashi N., Kobayashi, N., Nishi T. and Yamaguchi A
    • Organizer
      The 5th Takeda Science Foundation Symposium on PharmaSciences "Bioactive Lipid Molecules and Transporters
    • Place of Presentation
      グランドプリンスホテル高輪(東京)
    • Year and Date
      2010-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Platelet-like particles derived from MEG-01 cells release S1P with thrombin stimulus2010

    • Author(s)
      Hisano Y., Nishi T. and Yamaguchi A
    • Organizer
      The 5th Takeda Science Foundation Symposium on PharmaSciences "Bioactive Lipid Molecules and Transporters
    • Place of Presentation
      グランドプリンスホテル高輪(東京)
    • Year and Date
      2010-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 血小板様分子を賛成するMEG-01細胞を用いたS1P輸送体の探索2010

    • Author(s)
      久野悠、西毅、山口明人
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      東京大学弥生講堂
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット赤血球におけるATP依存的スフィンゴシン1リン酸輸送体の解析2010

    • Author(s)
      小林直木、小林伸好、西毅、山口明人
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      東京大学弥生講堂
    • Year and Date
      2010-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] スフィンゴシン1リン酸の細胞外放出機構の解明に向けた取り組み2010

    • Author(s)
      西毅
    • Organizer
      第3回「情報と細胞機能」研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] スフィンゴシン1リン酸の細胞外放出機構の解明に向けた取り組み2010

    • Author(s)
      西毅
    • Organizer
      第3回「情報と細胞機能」研究会
    • Place of Presentation
      北海道大学 ファカルティハウス エンレイソウ
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の同定と機能解析2009

    • Author(s)
      西毅・小林直木・久野悠・川原敦雄・山口明人
    • Organizer
      日本生体エネルギー研究会 第35回討論会
    • Place of Presentation
      旭川医科大学
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規S1P輸送体Spns2の機能解析2009

    • Author(s)
      久野悠・川原敦雄・山口明人・西毅
    • Organizer
      日本生体エネルギー研究会 第35回討論会
    • Place of Presentation
      旭川医科大学
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sphingosine-1-phosphate transporter Spns2 regulates cardiac morphogenesis2009

    • Author(s)
      川原敦雄、西毅、久野悠、山口明人、望月直樹
    • Organizer
      第32回日本分子生化学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Sphingosine-1-phosphate transporter Spns2 regulates cardiac morphogenesis2009

    • Author(s)
      川原敦雄・西毅・久野悠・山口明人・望月直樹
    • Organizer
      第32回 日本分子生化学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analysis of human spinster-like protein 3 ; a homologue of sphingosine 1-phosphate transporter, spns22009

    • Author(s)
      村田真紀・久野悠・山口明人・西毅
    • Organizer
      第31回 生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-12-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of the sphingosine 1-phosphate transporter2009

    • Author(s)
      西毅、小林直木、久野悠、山口明人
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター、大阪
    • Year and Date
      2009-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of the sphingoshin-1-phosphate transporter2009

    • Author(s)
      西毅・小林直木・久野悠・山口明人
    • Organizer
      第31回 生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] スフィンゴシン1-リン酸(S1P)輸送体Spns2による心臓発生の制御機構2009

    • Author(s)
      久野悠・川原敦雄・山口明人・望月直樹・西毅
    • Organizer
      第19回 日本循環薬理学会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spns2 functions as a sphingosine-1-phosphate(S1P)transporter2009

    • Author(s)
      川原敦雄、西毅、久野悠、山口明人、望月直樹
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Spns2 functions as a sphingosine-1-phosphate (S1P) transporter2009

    • Author(s)
      川原敦雄・西毅・久野悠・山口明人・望月直樹
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] スフィンゴシン1リン酸(S1P)の光反応性アナログを用いたS1P輸送体の探索2009

    • Author(s)
      小林直木・西毅・山口明人
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血小板モデル細胞を用いたS1P輸送体の探索2009

    • Author(s)
      久野悠・山口明人・西毅
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心臓前駆細胞の移動を制御するスフィンゴシン-1-リン酸(S1P)輸送体:Spns22009

    • Author(s)
      川原敦雄、西毅、山口明人、望月直樹
    • Organizer
      51回日本脂質生化学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-07-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 心臓前駆細胞の移動を制御するスフィンゴシン-1-リン酸(S1P)輸送体:Sps22009

    • Author(s)
      川原敦雄・西毅・山口明人・望月直樹
    • Organizer
      第51回 日本脂質生化学会
    • Place of Presentation
      ウィルあいち(名古屋市)
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of the ATP dependent sphingosine-1-phosphate (S1P) transporter in rat erythrocytes2009

    • Author(s)
      N.Kobayashi, N.Kobayashi, T.Nishi, A.Yamaguchi
    • Organizer
      The 5th Takeda Science Foundation Symposium on PharmaSciences "Bioactive Lipid Molecules and Transporters
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Platelet-like particles derived from MEG-01 cells release S1P with thrombin stimulus2009

    • Author(s)
      Y.Hisano, T.Nishi, A.Yamaguchi
    • Organizer
      The 5th Takeda Science Foundation Symposium on PharmaSciences "Bioactive Lipid Molecules and Transporters
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血小板様分子を賛成するMEG-01細胞を用いたS1P輸送体の探索2009

    • Author(s)
      久野悠・西毅・山口明人
    • Organizer
      第4回 トランスポーター研究会
    • Place of Presentation
      東京大学 弥生講堂
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット赤血球におけるATP依存的スフィンゴシン1リン酸輸送体の解析2009

    • Author(s)
      小林直木・小林伸好・西毅・山口明人
    • Organizer
      第4回 トランスポーター研究会
    • Place of Presentation
      東京大学 弥生講堂
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Remarks] ありません

    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2018-03-28  

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