|Budget Amount *help
¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
There are two isozymes (L-PIPase and P-PIPase) which dephosphorylate PI(3,4)P2. However the functions of L-PIPase and P-PIPase are unclear. In this study we showed that L-PIPase suppresses neuronal cell death after brain ischemia while P-PIPase contributes to malignant progression. We also found that each enzyme has different activities against several PI(3,4)P2 species. It is suggested that the different functions between L-PIPase and P-PIPase might be caused by the substrate specificity.