| Project/Area Number |
21200077
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
Applied pharmacology
|
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| Research Institution | Akita Prefectural University (2011)
Gunma University (2009-2010) |
|---|
Principal Investigator |
HOSAKA Masahiro 秋田県立大学, 生物資源科学部, 教授 (80311603)
|
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIHARA Toshitada 群馬大学, 大学院・工学研究科, 助教 (10375561)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IIDA Yasuhiko 鈴鹿医療科学大学, 薬学部, 教授 (60252425)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|
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| Keywords | イメージング / イリジウム錯体 / 低酸素病態 / 腫瘍 / 可視化 |
|---|
| Research Abstract |
Iridium complex is a promising organic light-emitting diode material for next generation video displays that emits phosphorescence quenched by oxygen. We focused this oxygen-quenching feature for imaging tumor hypoxia. We used Red light-emitting Ir(btp)_2(acac) (BTP)to image nude mouse-transplanted tumors, and succeed to image tumors. Since BTP is easily modifiable, we synthesized BTP analogues with a longer excitation/emission wavelength. One of them, BTPHSA, depicted clear imaging from tumors transplanted 6-7 mm deep from the skin surface. Another analogue, BTPDM, shines brighter than BTP in tumors, since BTPDM has character to access easily and reach in cells. We suggest that iridium complex materials have a vast potential for imaging hypoxic lesions such as tumor tissues.
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