Development of the anti-tumor DDS based on novel tumor-homing peptides
| Project/Area Number |
21200078
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
Applied pharmacology
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| Research Institution | 愛知県がんセンター研究所 (2011)
Aichi Cancer Center Research Institute (2009-2010) |
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Principal Investigator |
KONDO Eisaku 愛知県がんセンター研究所, 腫瘍病理学部, 部長 (30252951)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ken 三菱化学生命科学研究所, 特別研究員 (70426584)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUSHITA Masayuki (30273965)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 分子腫瘍学 / ドラッグデリバリー / 細胞選択的透過性ペプチド / がん細胞 / 分子標的 |
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| Research Abstract |
We developed novel tumor linegae-homing CPPs that are highly permeable to cancer cells according to their tumor linages. Random peptide library constructed by mRNA display technology was employed for isolating the CPPs encoded by novel aminoacid sequences which differ from conventional CPPs such as TAT,pAnt. Screening of over 40 CPPs of these,10 of them showed unique response that were efficiently incorporated to tumor cells following their tumor origins. These tumor linage-homing CPPs were efficiently incorporated to target cells in vivo and in vitro and are useful in peptide-based non-invasive medical technologies such as anti-cancer therapeutics and imaging.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Tumour lineage-homing cell-penetrating peptides for peptide-based anti-cancer molecular delivery systems. (※ correspondence ; Kondo E and Matsushita M)2012
Author(s)
Kondo E, Saito K, Tashiro Y, Kamide K, Uno S, Furuya T, Mashita M, Nakajima K, Tsumuraya T, Kobayashi N, Nishibori M, Tanimoto M, Matsushita M
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Journal Title
Nature Communications
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell, poorly-differentiated adenocarcinoma cell lines with low and high malignant potential2012
Author(s)
Murakami, H., Nakanishi, H., Tanaka, H., Ito, S., Misawa, K., Ito, Y., Ikehara, Y., Kondo, E., Kodera, Y
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Journal Title
Gastric Cancer
Volume: (Epubahead of print)
Related Report
Peer Reviewed
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[Journal Article] TGF-b synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth2012
Author(s)
Fujii, M., Toyoda, T., Nakanishi, H., Yatabe, Y., Sato, A., Matsudaira, Y., Ito, H., Murakami, H., Kondo, Y., Kondo, E., Hida, T., Tsujimura, T., Osada, H., Sekido, Y.
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Journal Title
J. Exp. Med.
Volume: 209(3)
Pages: 479-94
Related Report
Peer Reviewed
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[Journal Article] Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signaling pathway2012
Author(s)
Maseki, S., Ijichi, K., Tanaka, H., Fujii, M., Hasegawa, Y., Ogawa T, Murakami, S., Kondo, E., Nakanishi, H.
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Journal Title
Br. J. Cancer
Volume: 106(6)
Pages: 1196-20
Related Report
Peer Reviewed
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[Journal Article] NFATc1 affects mouse splenic B cell function by controlling the calcineurin. NFAT signaling network2011
Author(s)
Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Muller MR, Kondo E, Edgar Serfling
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Journal Title
J. Exp. Med.
Volume: 208(4)
Pages: 823-39
Related Report
Peer Reviewed
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[Journal Article] miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg..2011
Author(s)
Yamamoto M, Kondo E, Takeuchi M, Harashima A, Otani T, Tsuji-Takayama K, Yamasaki F, Kumon H, Kibata M, Nakamura S.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against human tumors with diverse origins2011
Author(s)
Inoue T, Tashiro Y, Takeuchi M, Otani T, Tsuji-Takayama K, Okochi A, Mukae Y, Koreishi M, Yamasaki F, Kumon H, Nakamura S, Kibata M, Kondo E.
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Journal Title
Int. J. Oncol.
Volume: 38(5)
Pages: 1299-1306
Related Report
Peer Reviewed
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[Journal Article] Treatment of acute liver failure in mice by hepatocyte xenotransplantation2010
Author(s)
Yamamoto T, Navarro-Alvarez N, Soto-Gutierrez A, Yuasa T, Iwamuro M, Kubota Y, Seita M, Kawamoto H, Javed SM, Kondo E, Noguchi H, Kobayashi S, Nakaji S, Kobayashi N.
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Journal Title
Cell Transplant
Volume: 19
Pages: 799-806
Related Report
Peer Reviewed
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[Journal Article] Hepatic differentiation of mouse iPS cells in vitro2010
Author(s)
Iwamuro M, Komaki T, Kubota Y, Seita M, Kawamoto H, Yuasa T, Javed SM, Hassan RARA, Nakaji S, Nishikawa Y, Kondo E, Yamamoto K, Fox IJ, Kobayashi N
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Journal Title
CellTransplantation
Volume: 19
Pages: 841-847
Related Report
Peer Reviewed
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[Journal Article] Comparative analysis of endoderm formation efficiency between mouse EScellsand iPS cells.2010
Author(s)
Iwamuro M, Komaki T, Kubota Y, Seita M, Kawamoto H, Yuasa T, Javed SM, Hassan RARA, Nakaji S, Nishikawa Y, Kondo E, Yamamoto K, Kobayashi N
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Journal Title
Cell Transplantation
Volume: 19
Pages: 831-839
Related Report
Peer Reviewed
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[Journal Article] Characteristics of CD133(+) human colon cancer SW620 cells2010
Author(s)
Kawamoto H, Yuasa T, Kubota Y, Seita M, Sasamoto H, Javed SM, Hayashi T, Nakahara H, Hassan R, Iwamuro M, Kondo E, Nakaji S, Tanaka N, Kobayashi N
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Journal Title
CellTransplantation
Volume: 19
Pages: 857-864
Related Report
Peer Reviewed
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[Journal Article] Isolation andpropagation of a human CD133-negative colon tumor-derived cell line withtumorigenic and angiogenic properties2010
Author(s)
Navarro-Alvarez N, Kondo E, Soto-gutierrez A, Kawamoto H, Hassan W, Yuasa T, Kubota Y, Seita M, Nakahara H, Hayashi T, Nishikawa Y, Hassan RARA, JavedSM, Noguchi H, Matsumoto S, Nakaji S, Tanaka N, Kobayashi N
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Journal Title
Cell Transplantation
Volume: 19
Pages: 865-877
Related Report
Peer Reviewed
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[Presentation]2009
Author(s)
近藤英作
Organizer
第68回日本癌学会学術総会
Place of Presentation
パシフィコ横浜
Related Report
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