内因性カンナビノイドによる逆行性シナプス伝達の脳機能・脳病態における役割の解明

• Project/Area Number: 21220006
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: 狩野 方伸 東京大学, 医学(系)研究科(研究院), 教授 (40185963)
• Co-Investigator(Kenkyū-buntansha): 崎村 建司 新潟大学, 脳研究所, 教授 (40162325) ; 少作 隆子 金沢大学, 保健学系, 教授 (60179025) ; 岸本 泰司 徳島文理大学, 薬学部, 助教 (90441592)
• Project Period (FY): 2009-05-11 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥210,340,000 (Direct Cost: ¥161,800,000、Indirect Cost: ¥48,540,000); Fiscal Year 2013: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000); Fiscal Year 2012: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000); Fiscal Year 2011: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000); Fiscal Year 2010: ¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000); Fiscal Year 2009: ¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
• Keywords: 神経科学 / 生理学 / 脳・神経 / シナプス / 生理活性物質 / シグナル伝達 / シナプズ

Research Abstract

これまでの研究を継続・発展させ、平成25年度に以下の研究を行った。脳スライス及びin vivoの個体脳の解析は狩野が、培養海馬ニューロンの解析は少作が、行動学的解析は岸本と狩野が担当した。また、遺伝子改変マウスの維持は崎村が担当した。
１． 内因性カンナビノイド(eCB)系によるNMDA受容体機能調節のメカニズム： 逆行性シナプス伝達を担うeCBである2-アラキドノイルグリセロール(2-AG)の合成酵素DGLαの欠損マウスと、2-AGの受容体であるCB1の欠損マウスの側坐核中型有棘ニューロンの興奮性シナプスにおいて、NMDA受容体機能の低下が認められた。その原因として、NR2Bサブユニットを含むNMDA受容体の寄与が低下していることを示す電気生理学的所見を得た。
２．大脳基底核の運動学習におけるeCB系の役割：　3レバーオペラント課題のマウスへの適用について、平成２４年度に引き続き検討した。
３．分界条床核の抑制性シナプス伝達の2-AGによる逆行性伝達抑圧のメカニズム：分界条床核の抑制性シナプスの逆行性伝達抑圧が、eCB系遺伝子改変マウスにおいてどのように変化しているかについて、継続して電気生理学的解析を行った。
４．eCB系の海馬機能における役割： eCB系遺伝子改変マウスにおいて、瞬目反射条件付けのLI (latent inhibition)課題に関する解析を継続した。
５．eCB系の抗炎症作用：U87-MGヒト悪性グリオーマ細胞における、NF-kBシグナルを介する炎症作用に注目し、グリアのeCB系による抗炎症作用のメカニズムを調べるための条件検討を行った。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIa and Calcineurin. (2013)
  • Author(s): Fujii H, Inoue M, Okuno H, Sano Y; Takemoto-Kimura S, Kitamura K, Kano M, Bito H.
  • Journal Title: Cell Reports Volume: 3(印刷中)(掲載確定) Issue: 4 Pages: 978-987
  • DOI: 10.1016/j.celrep.2013.03.033
  • Peer Reviewed
• [Journal Article] Spatiolemporal dynamics of functional clusters of neurons in mouse motor corlex during a voluntary movement (2013)
  • Author(s): Hira R, Okubo F, Ozawa K, Isomura Y, KHamura K, Kano M, Kasai H, Matsuzaki M
  • Journal Title: Journal of Neuroscience Volume: 33 Issue: 4 Pages: 1377-90
  • DOI: 10.1523/jneurosci.2550-12.2013
  • Peer Reviewed
• [Journal Article] The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. (2013)
  • Author(s): Sugaya Y
  • Journal Title: J Neurosci Volume: 33 Issue: 8 Pages: 3588-3601
  • DOI: 10.1523/jneurosci.3141-12.2013
  • Peer Reviewed
• [Journal Article] Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development. (2013)
  • Author(s): Kano M
  • Journal Title: J Physiol (Lond) Volume: -
  • Peer Reviewed
• [Journal Article] The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits (2012)
  • Author(s): Hashimoto R
  • Journal Title: PLoS ONE Volume: 7 Issue: 4 Pages: e35696-e35696
  • DOI: 10.1371/journal.pone.0035696
  • Peer Reviewed
• [Journal Article] GABAergic inhibition regulates developmental synapse elimination in the cerebellum. (2012)
  • Author(s): Nakayama H
  • Journal Title: Neuron Volume: 74 Issue: 2 Pages: 384-396
  • DOI: 10.1016/j.neuron.2012.02.032
  • Peer Reviewed
• [Journal Article] Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression (2012)
  • Author(s): Tanimura A
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Issue: 30 Pages: 12195-12200
  • DOI: 10.1073/pnas.1204404109
  • Peer Reviewed
• [Journal Article] Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain (2012)
  • Author(s): Uesaka N
  • Journal Title: J Neurosci Volume: 32 Issue: 34 Pages: 11688-11699
  • DOI: 10.1523/jneurosci.1097-12.2012
  • Peer Reviewed
• [Journal Article] Dendritic calcium signaling in cerebellar Purkinje cell. (2012)
  • Author(s): Kitamura K
  • Journal Title: Neural Networks Volume: - Pages: 11-7
  • DOI: 10.1016/j.neunet.2012.08.001
  • Peer Reviewed
• [Journal Article] Locally synchronized synaptic inputs (2012)
  • Author(s): Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y
  • Journal Title: Science Volume: 335 Issue: 6066 Pages: 353-356
  • DOI: 10.1126/science.1210362
  • Peer Reviewed
• [Journal Article] Ca(v) 2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical (2012)
  • Author(s): Miyazaki, Taisuke ; Yamasaki, Miwako ; Hashimoto, Kouichi, et
  • Journal Title: Journal of Neuroscience Volume: 32(4) Issue: 4 Pages: 1311-1328
  • DOI: 10.1523/jneurosci.2755-11.2012
  • Peer Reviewed
• [Journal Article] 小脳プルキンエ細胞樹状突起活動のin vivoイメージング (2012)
  • Author(s): 喜多村和郎、橋本浩一、狩野方伸
  • Journal Title: 生体の科学 Volume: 63 Pages: 26-33
• [Journal Article] Synaptogenesis and synaptic elimination (2012)
  • Author(s): Kano M, Watanabe M
  • Journal Title: Handbook of Cerebellum and Cerebellar Disorders Volume: (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] GABAergic inhibition regulates developmental synapse elimination in the cerebellum (2012)
  • Author(s): Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M, Kano M
  • Journal Title: Neuron Volume: (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Endocannabinoids and retrograde modulation of synaptic transmission (2011)
  • Author(s): Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  • Journal Title: Neuroscientist Volume: (Published online on April 29) Issue: 2 Pages: 119-132
  • DOI: 10.1177/1073858410397377
  • Peer Reviewed
• [Journal Article] A role for myosin Va in cerebellar plasticity and motor learning : a possible mechanism underlying neurological disorder in myosin Va disease (2011)
  • Author(s): Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y
  • Journal Title: J.Neurosci. Volume: 31 Issue: 16 Pages: 6067-6078
  • DOI: 10.1523/jneurosci.5651-10.2011
  • Peer Reviewed
• [Journal Article] In vivo two-photon uncaging of glutamate revealing the structure-function relationships o f dendritic spines in the neocortex of adult mice. (2011)
  • Author(s): Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. & Kasai H.
  • Journal Title: J.Physiol. Volume: 589 Issue: 10 Pages: 2320-2329
  • DOI: 10.1113/jphysiol.2011.207100
  • Peer Reviewed
• [Journal Article] Molecular and Morphological Configuration for 2-Arachidonoylglycerol-Mediated Retrograde Signaling at Mossy Cell-Granule Cell Synapses in the Dentate Gyrus (2011)
  • Author(s): Uchigashima, M.; Yamazaki, M.; Yamasaki, M., et al
  • Journal Title: Journal of Neuroscience Volume: 31(21) Issue: 21 Pages: 7700-7714
  • DOI: 10.1523/jneurosci.5665-10.2011
  • NAID: 120003521155
  • Peer Reviewed
• [Journal Article] Postsynaptic P/Q-type Ca(2+) channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum (2011)
  • Author(s): Hashimoto, K.; Tsujita, M.; Miyazaki, T., et al
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108(24) Issue: 24 Pages: 9987-9992
  • DOI: 10.1073/pnas.1101488108
  • Peer Reviewed
• [Journal Article] Developmental Switching of Perisomatic Innervation from Climbing Fibers to Basket Cell Fibers in Cerebellar Purkinje Cells (2011)
  • Author(s): Ichikawa, R.; Yamasaki, M.; Miyazaki, T., et al
  • Journal Title: Journal of Neuroscience Volume: 31(47) Issue: 47 Pages: 16916-16927
  • DOI: 10.1523/jneurosci.2396-11.2011
  • NAID: 120005183171
  • Peer Reviewed
• [Journal Article] Climbing fiber synapse elimination in cerebellar Purkinje cells (2011)
  • Author(s): Watanabe, M.; Kano, M.
  • Journal Title: European Journal of Neuroscience Volume: 34(10) Issue: 10 Pages: 1697-1710
  • DOI: 10.1111/j.1460-9568.2011.07894.x
  • NAID: 120004856989
  • Peer Reviewed
• [Journal Article] シナプス伝達を修飾する脂質メディエーター、内因性カンナビノイド (2011)
  • Author(s): 橋本谷祐輝、谷村あさみ、狩野方伸
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 31 Pages: 105-109
  • NAID: 10029094203
• [Journal Article] 内因性カンナビノイドによるシナプス伝達調節のメカニズム (2011)
  • Author(s): 谷村あさみ、橋本谷祐輝、狩野方伸
  • Journal Title: 生化学 Volume: 83 Pages: 704-714
• [Journal Article] Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus (2011)
  • Author(s): Ludanyi A, Sherry Shu-Jung Hu, S, Yamazaki M, Tanimura A, Piomelli D, Masahiko WatanabeM, Kano M, Sakimura K, Maglbczky Z, Mackie K, Freund TF, Katona I
  • Journal Title: Neuroscience Volume: 174 Pages: 50-63
  • Peer Reviewed
• [Journal Article] Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol (2011)
  • Author(s): Hashimotodani Y, Ohno-Shosaku T, Yamazaki M, Sakimura K, Kano M
  • Journal Title: J Neurosci Volume: 31 Pages: 3104-3109
  • NAID: 120002950596
  • Peer Reviewed
• [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neumns in basal amygdaloid nucleus. (2011)
  • Author(s): Yoshida T Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 3059-3064
  • Peer Reviewed
• [Journal Article] A role for myosin Va in cerebellar plasticity and motor leaming : apossible mechanism underlying neurological disorder hl myosin Va .disease. (2011)
  • Author(s): Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y
  • Journal Title: J Neumsci Volume: 31(印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] In vivo two-photon uncaging of glutamate reveaEng the structure-fhnction relationships of dendritic spines in the neocortex of adult mice. (2011)
  • Author(s): Noguchi J, Nagaoka A, Watanabe S, Ellis-Davies GCR, Kitamura K Kano M, Matsuzaki M, Kasai H
  • Journal Title: J Physiol(Lond) Volume: 589(印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Endocannabinoids and retrograde modulation of synaptic transmission (2011)
  • Author(s): Ohno-Shosaku T Tanimura A, Hashimotodani Y;Kano M
  • Journal Title: Neuroscientist Volume: 17(印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Role of pre- and postsynaptic activity in thalamocortical axonbranching (2010)
  • Author(s): Yamada A, Uesaka N, Hayano Y, Tabata T, Kano M, Yamamoto N
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 7562-7567
  • Peer Reviewed
• [Journal Article] A new multiple-drug applicator with minimal drug cross-talk, leakage, and consumption (2010)
  • Author(s): Fujita Y, Shimomura T, Hosoguchi M, Kano M, Fukurotani K, Tabata T
  • Journal Title: Neurosci Res Volume: 66 Pages: 412-414
  • Peer Reviewed
• [Journal Article] TARPs γ-2 and γ-7 are essential for AMPA receptor expressionin the cerebellum (2010)
  • Author(s): Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M
  • Journal Title: Eur J Neurosci Volume: 31 Pages: 2204-2220
  • Peer Reviewed
• [Journal Article] カンナビノイド受容体-逆行性シナプス伝達を担う分子- (2010)
  • Author(s): 橋本谷祐輝、狩野方伸
  • Journal Title: 医学のあゆみ Volume: 233 Pages: 912-917
• [Journal Article] 長期抑圧(LTD) (2010)
  • Author(s): 谷村あさみ、橋本谷祐輝、狩野方伸
  • Journal Title: Chnical Neuroscience Volume: 28 Pages: 873-875
• [Journal Article] 古典的条件づけの学習理論と可逆的遺伝子発現制御システムを用いた実験的検証 (2010)
  • Author(s): 岸本泰司
  • Journal Title: 生物物理 Volume: 50 Pages: 195-198
  • NAID: 10026569492
  • Peer Reviewed
• [Journal Article] Cerebellar mechanisms underlying encoding and consoHdation of classical eyeblink conditionillg in mice (2010)
  • Author(s): Kishimoto Y
  • Journal Title: NeuroscL Res.(SupPlement) Volume: 68
• [Journal Article] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission. (2010)
  • Author(s): Tanimura A
  • Journal Title: Neuron 65 Pages: 320-327
  • Peer Reviewed
• [Journal Article] Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents. (2009)
  • Author(s): Tanimura A
  • Journal Title: Neuropharmacology 57 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease. (2009)
  • Author(s): Takeda S
  • Journal Title: Brain Res 1280 Pages: 137-147
  • Peer Reviewed
• [Journal Article] Translocation of a"winner"climbing fiber to the Purkinje cell dendrite and subsequent elimination of"losers"from the soma indeveloping cerebellum. (2009)
  • Author(s): Hashimoto K
  • Journal Title: Neuron 63 Pages: 106-118
  • Peer Reviewed
• [Journal Article] Functional coupling between mGIuRI and Ca_v3. 1 T―type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. (2009)
  • Author(s): Hildebrand M
  • Journal Title: J Neurosci 29 Pages: 9668-9682
  • Peer Reviewed
• [Journal Article] Angiotensin receptor blocker, olmesartan, improved cerebrovascular dysfunction and prevented cognitive decline in early-stage Alzheimer disease model mouse. (2009)
  • Author(s): Takeda S
  • Journal Title: Hypertension 54 Pages: 1345-1352
  • Peer Reviewed
• [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. (2009)
  • Author(s): Taniguchi S
  • Journal Title: EMBO J 28 Pages: 3717-3129
  • Peer Reviewed
• [Journal Article] Synapse elimination in the central nervous system. (2009)
  • Author(s): Kano M
  • Journal Title: Curr Opin Neurobiol 19 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses. (2009)
  • Author(s): Hashimoto k
  • Journal Title: Neuroscience 162 Pages: 601-611
  • Peer Reviewed
• [Journal Article] カンナビノイドとシナプス機能(特集:シナプス機能とその障害の分子機構) (2009)
  • Author(s): 橋本谷祐輝
  • Journal Title: Cognition and Dementia 8 Pages: 25-31
• [Journal Article] 新しい神経伝達物質内因性カンナビノイド-逆行性シナプス伝達を担う分子- (2009)
  • Author(s): 谷村, あさみ
  • Journal Title: 化学 64 Pages: 22-26
• [Presentation] Adaptation of reward-based free-choices is impaired by cannabinoid receptor (CB_1) antagonist (2012)
  • Author(s): N., Kano, M., Kimura, M.
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本文化会館(長野県)
  • Year and Date: 2012-03-31
• [Presentation] Retardation of habituation leaning and suppression or synaptic plasticity in the dentate gyrus by the endocannnabinoid 2-arachidonoylglycerol signaling (2012)
  • Author(s): Sugaya, Y., Yamazaki M., Sakimura, K., Kano, M.
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本文化会館(長野県)
  • Year and Date: 2012-03-29
• [Presentation] Refinement of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development (2012)
  • Author(s): Kano, M.
  • Organizer: 1^<st> International Syposium/59^<th> NIBB Conference
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)(招待講演)
  • Year and Date: 2012-03-11
• [Presentation] Retrograde modulation of synaptic transmission by the endocannabinoid 2-arachidonoylglycerol (2011)
  • Author(s): M.KANO, A.TANIMURA, M.YAMAZAKI, M.UCHIGASHIMA, M.WATANABE, K.SAKIMURA
  • Organizer: 17th International Biophysics Congress (IUPAB)
  • Place of Presentation: the China National Convention Centre(中国)(招待講演)
  • Year and Date: 2011-11-02
• [Presentation] Activity-dependent refinement of climbing fiber to Purkinje cell synapses during postnatal cerebellar development (2011)
  • Author(s): M.KANO, K.HASHIMOTO, Y.KAWAMURA, H.NAKAYAMA, K.KITAMURA, K.SAKIMURA
  • Organizer: COLD SPRING HARBOR ASIA CONFERENCE : "Assembly, Plasticity, Dysfunction and Repair of Neural Circuits"
  • Place of Presentation: 蘇州Dushu Lake Conference Center(中国)(招待講演)
  • Year and Date: 2011-10-19
• [Presentation] Endocannabinoid release and retrograde synaptic suppression mediated by group I mGluR and other G_q/11-coupled receptors (2011)
  • Author(s): M.KANO
  • Organizer: 7th International Meeting on Metabotropic Glutamate Receptors
  • Place of Presentation: Grande Albergo Capotaormina(イタリア)(招待講演)
  • Year and Date: 2011-10-04
• [Presentation] Activity-dependent maturtion of climbing fiber to Purkinje cell synapses during postnatal cerebellar development (2011)
  • Author(s): M.KANO
  • Organizer: 4^<th> International Symposium of the Society for Research on the Cerebellum
  • Place of Presentation: 東京大学(東京都)(招待講演)
  • Year and Date: 2011-09-18
• [Presentation] The endocannabinoid, 2-arachidonoylglycerol, has different effects on long-term potentiation in vivo between the dentate gyrus and the hippocampal CA1 (2011)
  • Author(s): Sugaya, Y., Tanimura, A., Yamazaki, M., Sakimura, K., Kano, M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] Roles of Purkinje cell activity in climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata (2011)
  • Author(s): Mikuni, T., Uesaka, M., Kano, M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] Postsynaptic P/Q type voltage-dependent Ca^<2+> channel is involved in refinement of cerebellar climbing fiber to Purkinje cell synapses in early postnatal development (2011)
  • Author(s): Hashimoto, K., Tsujita, M., Miyazaki, T., Kitamura, K., Yamazaki M., Shin Hee-sup, Watanabe M., Sakimura K., Kano, M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] Impaired reward-related behaviors in mice lacking the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha (2011)
  • Author(s): Cagniard, B., Tanimura, A., Yamazaki, M., Sakimura, K., Kano.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Enhanced synchrony of climbing fiber-induced Ca^<2+> signaling in cerebellar Purkinje cells in GluD2 (GluRδ2) knockout mouse (2011)
  • Author(s): Hashizume, M., Kitamura, K., Sakimura, K., Kano, M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediates depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells (2011)
  • Author(s): Tanimura, A., Yamazaki, M., Uchigashima, M., Uesaka, N., Mikuni, T., Hashimoto, K., Watanabe, M., Sakimura, K., Kano, M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Desynchronization of cerebellar Purkinje cell population activity during postnatal development (2011)
  • Author(s): Good, JK., Kitamura, K., Kano, M.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Adenosine A1 receptor interacts with mGluR1 and regulates cerebellar LTD (2011)
  • Author(s): Kamikubo, U., Fujita, Y., Shimomura, T., Miyajima, T., Fujino, M., Tabata, T., Fukurotani, K., Kano, M., Sakurai, T.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Activity-dependent synapse elimination during postnatal development (2011)
  • Author(s): M.KANO
  • Organizer: Gordon Research Conference on Cerebellum
  • Place of Presentation: Colby-Sawyer Colloge(アメリカ)(招待講演)
  • Year and Date: 2011-08-24
• [Presentation] Requirement of type 1 metabotropic glutamate receptor for experience-dependent pruning of retinogeniculate synapses (2011)
  • Author(s): Narushima, M., Uchigashima, M., Hashimoto, K., Aiba, A., Watanabe, M., Miyata, M., Kano, M.
  • Organizer: 8th IBRO World Congress of Neuroscience, 2011
  • Place of Presentation: Fortezza da Basso(イタリア)
  • Year and Date: 2011-07-18
• [Presentation] Mode of endocannabinoid degradation after depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells (2011)
  • Author(s): Tanimura, A., Yamazaki, M., Uchigashima, M., Uesaka, N., Mikuni, T., Hashimoto, K., Watanabe, M., Sakimura, K., Kano, M.
  • Organizer: 8th IBRO World Congress of Neuroscience, 2011
  • Place of Presentation: Fortezza da Basso(イタリア)
  • Year and Date: 2011-07-18
• [Presentation] Neuroscience research and education in Tokyo after the 0311 disaster (2011)
  • Author(s): Kano, M
  • Organizer: 8th IBRO World Congress of Neuroscience, 2011
  • Place of Presentation: Fortezza da Basso(イタリア)
  • Year and Date: 2011-07-17
• [Presentation] Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus (2011)
  • Author(s): Uchigashima, M., Yamazaki, M., Yamasaki, M., Tanimura, A., Sakimura K., Kano, M., Watanabe M
  • Organizer: 8th IBRO World Congress of Neuroscience, 2011
  • Place of Presentation: Fortezza da Basso(イタリア)
  • Year and Date: 2011-07-16
• [Presentation] Activity-dependent refinement of climbing fiber to Purkinje cell synapses during postnatal development (2011)
  • Author(s): M.KANO
  • Organizer: Symposium on Organization and Function of Neuronal Circuits in Movement Control
  • Place of Presentation: Trolleholm Castle(スウェーデン)(招待講演)
  • Year and Date: 2011-05-28
• [Presentation] Synapse type-independent degradation of 2-arachidonoylglycerol in the cerebellum (2011)
  • Author(s): M.KANO
  • Organizer: Gordon Research Conference on Cannabinoid Function in the CNS
  • Place of Presentation: レ・ディアブレレ・コンファレンスセンター(スイス)(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] 歯状回における2-アラキドノイルグリセロールを介した逆行性シグナル伝達機構の分子解剖学的基盤は苔状細胞-顆粒細胞シナプス間のクロストークを示唆する (2011)
  • Author(s): 内ヶ島基政、山崎真弥、山崎美和子、谷村あさみ、崎村建司、狩野方伸、渡辺雅彦
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: 誌上発表
  • Year and Date: 2011-03-30
• [Presentation] APPxPS2 Tgマウスにおける加齢依存性学習障害の検出 (2011)
  • Author(s): 岸本泰司
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県静岡市静岡県立大学
  • Year and Date: 2011-03-30
• [Presentation] 内因性カンナビノイドの2-アラキドニルグリセロールは、麻酔下および自由行動下のマウスの海馬歯状回における長期増強を抑制する (2011)
  • Author(s): 菅谷佑樹、谷村あさみ、山崎真弥、崎村建司、狩野方伸
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: 誌上発表
  • Year and Date: 2011-03-28
• [Presentation] Emotional behaviors in mice lacking the endocannabinoid synthesizing enzyme diacylglycerol lipase α (2011)
  • Author(s): Cagniard, B., Tanimura, A., Yamazaki, M, Sakimura, K, Kano, M.
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: 誌上発表
  • Year and Date: 2011-03-28
• [Presentation] アルツハイマー病の分子機構と検出法の探索～行動学からのアプローチ (2011)
  • Author(s): 岸本泰司
  • Organizer: 第3回AD研究会(私立大学戦略的基盤形成支援事業)
  • Place of Presentation: 香川県さぬき市グリーンヒル大串
  • Year and Date: 2011-03-06
• [Presentation] Activity-dependent strengthening of single climbing fiber synaptic inputs in Purkinje cells of developing cerebellum (2010)
  • Author(s): Kallo, M., Kawamura, Y, Nakayama, H., Kitamura, K
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫県神戸市神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Loss of cerebellar granule cell AMPA receptors contributes to ataxia in stargazer mice. (2010)
  • Author(s): M.Yamazaki
  • Organizer: NEUROSCIENCE2010
  • Place of Presentation: San Diego Convention Center, San Diego, the U.S.A.
  • Year and Date: 2010-11-14
• [Presentation] Activity-dependent maturation of climbing fiber to Purkinje cell synapses during postnatal cerebellar development. (2010)
  • Author(s): Kaao, M.
  • Organizer: International Workshop : High Resolution Optical Imaging of the Living Brain
  • Place of Presentation: Neue Aula, Tubingen, Gemany
  • Year and Date: 2010-10-08
• [Presentation] Activity-dependent ehmination of redundallt climbing fiber synapsesduring postnatal cerebellar development. (2010)
  • Author(s): Kano, M.
  • Organizer: 3rd International Workshop : Molecular and Cellular Mechanisms of Axon Degeneration
  • Place of Presentation: Eibsee Rotel, Eibsee, Gemally
  • Year and Date: 2010-10-05
• [Presentation] PS2遺伝子変異導入アルツハイマーモデルマウスにおける瞬目反射条件付けの解析 (2010)
  • Author(s): 岸本泰司
  • Organizer: 日本生物物理学会第48回年会
  • Place of Presentation: 宮城県仙台市東北大学
  • Year and Date: 2010-09-22
• [Presentation] 内因性カンナビノイドによる逆行性シナプス伝達修飾 (2010)
  • Author(s): 狩野方伸、橋本谷祐輝、谷村あさみ
  • Organizer: 第20回日本臨床精神神経薬理学会・ 第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 宮城県仙台市仙台国際センター
  • Year and Date: 2010-09-16
• [Presentation] 代謝型グルタミン酸受容体(mGluR1)とアデノシンA1受容体(A1R)相互作用による小脳LTDの制御 (2010)
  • Author(s): 上窪裕二、藤田洋介、下村岳司、田端俊英、袋谷賢吉、櫻井隆、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] 登上線維の発達過程におけるP/Q型電位依存性カルシウムチャネルの役割 (2010)
  • Author(s): 橋本浩一、辻田実加、喜多村和郎、宮崎太輔、山崎真弥、Hee-Sup Shin、渡辺雅彦、崎村建司、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] マウス瞬目反射条件付けにおける記憶の符号化と固定化の小脳機構(シンポジウム小脳の回路:発達と可塑性の最前線) (2010)
  • Author(s): 岸本泰司
  • Organizer: 第33回日本神経科学学会大会
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] プルキンエ細胞選択的ノツクアウトを用いた小脳AMPA受容体サブユニットの生理機能解析 (2010)
  • Author(s): 阿部学、橋本浩一、宮崎太輔、畦地裕統、夏目里恵、渡辺雅彦、狩野方伸、崎村建司
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] 扁桃体基底外側核におけるカンナビノイドおよびセロトニンを介するシナプス伝達調整機構 (2010)
  • Author(s): 吉田隆行、内ヶ島基政、泉剛、山口拓、狩野方伸、渡辺雅彦、吉岡光弘
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] TARPγ2、γ7は小脳AMPA型グルタミン酸受容体の機能的構成成分である (2010)
  • Author(s): 山崎真弥、深谷昌弘、橋本浩一、山崎美和子、板倉誠、高橋正身、狩野方伸、渡辺雅彦、崎村建司
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] ジアシルグリセロールリパーゼαによって産生される2-アラキドノイルグリセロールが、逆行性のシナプス伝達抑圧を引き起こす (2010)
  • Author(s): 谷村あさみ、山崎真弥、橋本谷祐輝、内ヶ島基政、川田慎也、阿部学、北芳博、橋本浩一、清水孝雄、渡辺雅彦、崎村建司、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] Analysis of physiological functions of cerebellar AMPA receptor subunitsusing a Purkinje cell-celective gene targeting system. (2010)
  • Author(s): 阿部学
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] 中枢神経系の組織培養細胞における効果的な神経活動の操作 (2010)
  • Author(s): 三國貴康、上阪直史、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] GluD2(GluRσ2)ノツクアウトマウスの小脳プルキンエ細胞集団の2光子カルシウムイメージング解析 (2010)
  • Author(s): 橋爪幹、喜多村和郎、崎村建司、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] 小脳を延髄との共培養標本を用いたシナプス発達のメカニズムを解明するためのアプローチ方法 (2010)
  • Author(s): 上阪直史、三國貴康、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Transmembrane AMPA receptor regulatory protein gamma-2 and gamma-7 are essential for cerebellar AMPA receptor complex (2010)
  • Author(s): Yamazaki, M., Fukaya, M, Hashimoto, K, Kano, M., Watanabe, M., Sakimura, K.
  • Organizer: 7th FENS Forum of European Neuroscienoe
  • Place of Presentation: RAI Convendon Centre, Amsterdam, The Netherlands
  • Year and Date: 2010-07-06
• [Presentation] Retrograde synaptic suppression in the cerebellum, hippocampus and striatum is mediated by 2-arachidonoylglycerol produced by diacylglycerol lipase alpha (2010)
  • Author(s): Tanimura, A., Yamazaki, M., Hashimotodalli, Y, Uchigashima, M., Kawata, S., Abe, M, Kita, Y, Hashimoto, K, Shimizu, T., Watanabe, M., Sakimura, K., Kano, M.
  • Organizer: 7th FENS Forum of European Neuroscienoe
  • Place of Presentation: RAI Convention Centre, Amsterdam, The Netherlands
  • Year and Date: 2010-07-06
• [Presentation] Transmembrane AMPA receptor regulatory protein gamma-2 and gamma-7 are essential for AMPA receptor complex. (2010)
  • Author(s): M.Yamazaki
  • Organizer: FENS Forum 2010
  • Place of Presentation: RAI Convention Centre Amsterdam, the Netherlands
  • Year and Date: 2010-07-06
• [Presentation] Involvement of GluN2A Tyrosine phosphorylation in depression-relatedbahavior (2010)
  • Author(s): Nakazawa, T., Talliguchi, S., Tanimura, A., Kiyama, Y, Tezuka, T., Kallo, M., Manabe, T., Yamamoto, T.
  • Organizer: 7th FENS Forum of European Neuroscienoe
  • Place of Presentation: RAI Convention Centre, Amsterdam, The Netherlands
  • Year and Date: 2010-07-05
• [Presentation] Production and degradation of endocannabinoids mediating retrograde suppression of synaptic transmission (2010)
  • Author(s): Kano, M.
  • Organizer: 7th FENS Fomm of Eumpean Neuroscience
  • Place of Presentation: RAI Convention Centre, Amsterdam, The Netherlallds
  • Year and Date: 2010-07-04
• [Presentation] Spike timing-dependent strengthening of climbing fiber inputs in developing cerebellum. (2010)
  • Author(s): Kano, M.
  • Organizer: Jacques Monod Conference
  • Place of Presentation: Biological Station, CNRS, Roscoff, France
  • Year and Date: 2010-07-01
• [Presentation] Simultaneous two-photoll calcium imaging and patch-clamp recordings in vivo. (2010)
  • Author(s): Kitamura, K, Hausser, M., Kano, M.
  • Organizer: Jacques Monod Conibrence
  • Place of Presentation: Biological Station, CNRS, Roscoff, France
  • Year and Date: 2010-07-01
• [Presentation] 中枢神経系の組織培養細胞への遺伝子導入方法の応用 (2010)
  • Author(s): 三国貴康、上阪直史、狩野方伸
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市盛岡市民文化ホール(マリオス)
  • Year and Date: 2010-05-21
• [Presentation] 逆行性シナプス伝達を仲介する内因性カンナビノイド産生の分子機構 (2010)
  • Author(s): 橋本谷祐輝、少作隆子、谷村あさみ、狩野方伸
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市いわて県民情報交流センター(アイーナ)
  • Year and Date: 2010-05-20
• [Presentation] 小脳登上線維・プルキンエ細胞シナプスの生後発達におけるP/Q型電位依存性カルシウムチャネルの役割 (2010)
  • Author(s): 橋本浩一、辻田実加、宮崎太輔、山崎真弥、喜多村和郎、Hee-sup Shin、渡辺雅彦、崎村建司、狩野方伸
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市盛岡市民文化ホール(マリオス)
  • Year and Date: 2010-05-19
• [Presentation] ES細胞における相同組換え効率上昇法の開発 (2010)
  • Author(s): 阿部学
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都府京都市京都テルサ
  • Year and Date: 2010-05-12
• [Presentation] Protease-activated receptor 1 induces suppression of inhibitory synaptic transmission in the hippocampus. (2009)
  • Author(s): Hashimotodani Y
  • Organizer: 39^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ、シカゴMcCormick Place
  • Year and Date: 2009-10-20
• [Presentation] Adenosine Al receptor regulates mGluRl signaling and LTD in cerebellar Purkinje cells. (2009)
  • Author(s): Kamikubo Y
  • Organizer: 39^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ、シカゴMcCormick Place
  • Year and Date: 2009-10-19
• [Presentation] Analysis of the physiological function of cerebellar AMPA receptor subunits using Purkinje cell-specific gene targeting system. (2009)
  • Author(s): Abe M
  • Organizer: 39^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ、シカゴMcCormick Place
  • Year and Date: 2009-10-18
• [Presentation] 発達期小脳における登上線維-プルキンエ細胞間シナプス除去への抑制性GABA作動性伝達の関与 (2009)
  • Author(s): 中山寿子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] 成熟マウス小脳における2-アラキドノイルグリセロールによる逆行性シナワ゜ス伝達 (2009)
  • Author(s): 谷村, あさみ
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] mGluRlは瞬目反射条件づけ記憶の獲得に必要であり、その発現や保持には必要ではない (2009)
  • Author(s): 中尾晴美
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] 小脳プルキンエ細胞のグルタミン酸感受性長期抑圧の制御機構としてのAIアデノシン受容体 (2009)
  • Author(s): 藤田洋介
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] 中枢神経系組織培養細胞への遺伝子導入方法 (2009)
  • Author(s): 上阪直史
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] Two-Photon Imaging of Population Activity in Cerebellar Purkinje Cells in GluR δ2 Knockout Mouse. (2009)
  • Author(s): Hashizume M
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-31
• [Presentation] Bi-directional regulation of cerebellar synaptic plasticity throughinter-GPCR interplay. (2009)
  • Author(s): Kamikubo Y
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Analysis of climbing fiber inputs to Purkinje cells in the developing rat cerebellum in vivo. (2009)
  • Author(s): Kawamura Y
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Translocation of the Strongest climbing fiber to Purkinje cell dendrites after synaptic competition on the soma in developing cerebellum. (2009)
  • Author(s): Hashimoto K
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Modulation of hippocampal inhibitory synaptic transmission through protease-activated receptor 1. (2009)
  • Author(s): Hashimotodani Y
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Activity-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development. (2009)
  • Author(s): Kano M
  • Organizer: Gordon Research Conference on Neural Circuits & Plasticity
  • Place of Presentation: アメリカSalve Regina大学
  • Year and Date: 2009-06-07
• [Presentation] "2-Arachidonoylglycerol mediates short-term retrograde suppression of synaptic transmission in the cerebellum. (2009)
  • Author(s): Kano M
  • Organizer: 4^<th> International Conference on Phospholipase A_2 and Lipid Mediators(PLM2009)
  • Place of Presentation: 東京都千代田区一ツ橋学術総合センター
  • Year and Date: 2009-05-25
• [Presentation] Control of synaptic function by endogenous cannabinoid
  • Author(s): Kano M
  • Organizer: 8th FENS Forum of European Neuroscience
  • Place of Presentation: International Convention Center（バルセロナ、スペイン）
  • Invited
• [Presentation] Postnatal climbing fiber synapse remodeling desynchronizes population activity of Purkinje cells in developing cerebellum
  • Author(s): Good JM
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] Cav2.1カルボキシル末端部位を欠損したマウスの作製
  • Author(s): 相川知徳
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] 試行錯誤学習課題遂行中の、サルの線条体CB1受容体が果たす役割について
  • Author(s): 上田康雅
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] ｐ２５０GAP/TCGAPファミリーRhoGAP遺伝子と統合失調症との関連性の解析
  • Author(s): 中澤敬信
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] 発達期小脳におけるシナプス除去カルシウム依存性調節
  • Author(s): 狩野方伸
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] グルタミン酸トランスポーターGLT1コンディショナル欠損マウスにおけるグルタミン酸神経伝達の障害と異常繰り返し行動
  • Author(s): 相田知海
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] 新規活動依存的プロモーターE-SAREを用いた、大脳皮質における機能的回路の同定
  • Author(s): 川島尚之
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] 発達期マウス網膜－外側膝状体シナプス除去における代謝型グルタミン酸受容体１型の役割
  • Author(s): 鳴島円
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] Retrograde suppression of synaptic transmission by the endocannabinoid 2-arachidonoylglycerol. Cell Symposia
  • Author(s): Kano M
  • Organizer: Cell Symposia
  • Place of Presentation: Hilton New Orleans（ニューオリンズ、アメリカ）
  • Invited
• [Presentation] Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development
  • Author(s): Kano M
  • Organizer: Satellite symposium of SFN 2012 meeting
  • Place of Presentation: LSUHSC, Neuroscience Center of Excellence（ニューオリンズ、アメリカ）
  • Invited
• [Presentation] Possible involvement of the Ca2+-dependent gene Arc in activity-dependent synapse elimination in the cerebellum
  • Author(s): Mikuni T
  • Organizer: Neuroscience 2012 （北米神経科学学会）
  • Place of Presentation: Ernest N. Morial Convention Center（ニューオリンズ、アメリカ）
• [Presentation] Synapse type-independent degradation of 2-arachidonoylglycerol after retrograde synaptic suppression in the cerebellum
  • Author(s): Tanimura A
  • Organizer: Neuroscience 2012 （北米神経科学学会）
  • Place of Presentation: Ernest N. Morial Convention Center（ニューオリンズ、アメリカ）
• [Presentation] Visualization of an active ensemble of cortical neurons in vivo using a novel activity-dependent promoter E-SARE
  • Author(s): Kawashima T
  • Organizer: Neuroscience 2012 （北米神経科学学会）
  • Place of Presentation: Ernest N. Morial Convention Center（ニューオリンズ、アメリカ）
• [Presentation] Electrical contribution of postsynaptic T-type calcium channels to parallel fiber-Purkinje cell synaptic transmission
  • Author(s): Ly R
  • Organizer: Neuroscience 2012 （北米神経科学学会）
  • Place of Presentation: Ernest N. Morial Convention Center（ニューオリンズ、アメリカ）
• [Presentation] Impairment of reward-based adaptive choice of actions by local injection of cannabinoid CB1 receptor antagonist into the striatum of behaving monkeys
  • Author(s): Ueda Y
  • Organizer: Neuroscience 2012 （北米神経科学学会）
  • Place of Presentation: Ernest N. Morial Convention Center（ニューオリンズ、アメリカ）
• [Presentation] Activity-dependent Refinement of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development
  • Author(s): Kano M
  • Organizer: International Symposium on “Sensory Systems and Neural Circuits” Celebrating the 22nd Anniversary of Odorant-Receptor Gene Discoverys
  • Place of Presentation: 東京大学伊藤ホール（東京）
  • Invited
• [Presentation] RhoGAP gene dysregulation in schizophrenia has implications for both spine development and adult brain function
  • Author(s): Nakazawa T
  • Organizer: International Symposium on “Sensory Systems and Neural Circuits” Celebrating the 22nd Anniversary of Odorant-Receptor Gene Discoverys
  • Place of Presentation: 東京大学伊藤ホール（東京）
• [Presentation] The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus
  • Author(s): Sugaya Y
  • Organizer: International Symposium on “Sensory Systems and Neural Circuits” Celebrating the 22nd Anniversary of Odorant-Receptor Gene Discoverys
  • Place of Presentation: 東京大学伊藤ホール（東京）
• [Presentation] 組織培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズム
  • Author(s): 上阪直史
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] マウスバレル皮質における感覚シナプス入力の可視化
  • Author(s): 喜多村和郎
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] マウス小脳における登上繊維応答の同期性とaldolase C発現パターンとの関連
  • Author(s): 堤新一郎
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] 内因性カンナビノイド2-アラキドノイルグリセロールは歯状回の興奮性シナプス伝達を抑制し発作を減弱する
  • Author(s): 菅谷佑樹
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] 小脳登上繊維－プルキンエ細胞シナプスの発達において競合する登上繊維間の相対的な強度の差と登上繊維の絶対的な強度がそれぞれ異なる段階に寄与している
  • Author(s): 川田慎也
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）
• [Presentation] Climbing fiber network refinement and desynchronization of Purkinje cell population activity during postnatal cerebellar development
  • Author(s): Good JM
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）
• [Book] Synaptogenesis and Synaptic elimination.In : Handbook of Cerebellum and Cerebellar Disorders, Mario Mallto, Donna Gruol, Jeremy Schmahmann, Nori Koibuchi, Ferdinando Rossi, (eds) (2011)
  • Author(s): Kano M, Watanabe M.
  • Publisher: Springer(印刷中)(掲載確定)
• [Book] 内因性カンナビノイドによるシナプス伝達修飾実験医学28(増刊号/分子から個体へと深化する脂質生物学.佐々木雄彦、横溝岳彦、竹縄忠臣/編) (2010)
  • Author(s): 橋本谷祐輝、谷村あさみ、狩野方伸
  • Total Pages: 938
  • Publisher: 羊土社
• [Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition Neural Signaling Mechanisms. (2009)
  • Author(s): Tabata T
  • Total Pages: 632
  • Publisher: Springer Science Business Media
• [Remarks] 東京大学大学院医学系研究科神経生理学教室
  • URL: http://plaza.umin.ac.jp/~neufophy/kano%201ab/Top.html
• [Remarks] 東京大学大学院医学系研究科神経生理学教室
  • URL: http://plaza.umin.ac.jp/~neurophy/Kano%201ab/Top.html
• [Patent(Industrial Property Rights)] ES細胞における相同組換え効率を改善する方法 (2010)
  • Inventor(s): 暗村建司・阿部学・八矢幸大
  • Industrial Property Rights Holder: 国立大学法人 新潟大学
  • Filing Date: 2010-10-08