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内因性カンナビノイドによる逆行性シナプス伝達の脳機能・脳病態における役割の解明

Research Project

Project/Area Number 21220006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo

Principal Investigator

狩野 方伸  東京大学, 医学(系)研究科(研究院), 教授 (40185963)

Co-Investigator(Kenkyū-buntansha) 崎村 建司  新潟大学, 脳研究所, 教授 (40162325)
少作 隆子  金沢大学, 保健学系, 教授 (60179025)
岸本 泰司  徳島文理大学, 薬学部, 助教 (90441592)
Project Period (FY) 2009-05-11 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥210,340,000 (Direct Cost: ¥161,800,000、Indirect Cost: ¥48,540,000)
Fiscal Year 2013: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
Fiscal Year 2012: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
Fiscal Year 2011: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
Fiscal Year 2010: ¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
Fiscal Year 2009: ¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Keywords神経科学 / 生理学 / 脳・神経 / シナプス / 生理活性物質 / シグナル伝達 / シナプズ
Research Abstract

これまでの研究を継続・発展させ、平成25年度に以下の研究を行った。脳スライス及びin vivoの個体脳の解析は狩野が、培養海馬ニューロンの解析は少作が、行動学的解析は岸本と狩野が担当した。また、遺伝子改変マウスの維持は崎村が担当した。
1. 内因性カンナビノイド(eCB)系によるNMDA受容体機能調節のメカニズム: 逆行性シナプス伝達を担うeCBである2-アラキドノイルグリセロール(2-AG)の合成酵素DGLαの欠損マウスと、2-AGの受容体であるCB1の欠損マウスの側坐核中型有棘ニューロンの興奮性シナプスにおいて、NMDA受容体機能の低下が認められた。その原因として、NR2Bサブユニットを含むNMDA受容体の寄与が低下していることを示す電気生理学的所見を得た。
2.大脳基底核の運動学習におけるeCB系の役割: 3レバーオペラント課題のマウスへの適用について、平成24年度に引き続き検討した。
3.分界条床核の抑制性シナプス伝達の2-AGによる逆行性伝達抑圧のメカニズム:分界条床核の抑制性シナプスの逆行性伝達抑圧が、eCB系遺伝子改変マウスにおいてどのように変化しているかについて、継続して電気生理学的解析を行った。
4.eCB系の海馬機能における役割: eCB系遺伝子改変マウスにおいて、瞬目反射条件付けのLI (latent inhibition)課題に関する解析を継続した。
5.eCB系の抗炎症作用:U87-MGヒト悪性グリオーマ細胞における、NF-kBシグナルを介する炎症作用に注目し、グリアのeCB系による抗炎症作用のメカニズムを調べるための条件検討を行った。

Current Status of Research Progress
Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Report

(5 results)
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (148 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (47 results) (of which Peer Reviewed: 39 results) Presentation (95 results) (of which Invited: 4 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIα and Calcineurin2013

    • Author(s)
      Fujii H, Inoue M, Okuno H, Sano Y; Takemoto-Kimura S, Kitamura K, Kano M, Bito H.
    • Journal Title

      Cell Reports

      Volume: 3 Issue: 4 Pages: 978

    • DOI

      10.1016/j.celrep.2013.03.033

    • URL

      https://pure.teikyo.jp/en/publications/099c8509-5cbe-4e1e-bd10-f26e5d3d26b1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiolemporal dynamics of functional clusters of neurons in mouse motor corlex during a voluntary movement2013

    • Author(s)
      Hira R, Okubo F, Ozawa K, Isomura Y, KHamura K, Kano M, Kasai H, Matsuzaki M
    • Journal Title

      Journal of Neuroscience

      Volume: 33 Issue: 4 Pages: 1377-90

    • DOI

      10.1523/jneurosci.2550-12.2013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus2013

    • Author(s)
      Sugaya Y
    • Journal Title

      J Neurosci

      Volume: 33 Issue: 8 Pages: 3588

    • DOI

      10.1523/jneurosci.3141-12.2013

    • URL

      https://localhost/en/publications/c20737e5-7dd2-439e-ae51-213f8c7be1b3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development.2013

    • Author(s)
      Kano M
    • Journal Title

      J Physiol (Lond)

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits2012

    • Author(s)
      Hashimoto R
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 4 Pages: e35696-e35696

    • DOI

      10.1371/journal.pone.0035696

    • URL

      https://pure.teikyo.jp/en/publications/4db5e609-1ad4-45ab-8119-8a26d97d88c8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABAergic inhibition regulates developmental synapse elimination in the cerebellum.2012

    • Author(s)
      Nakayama H
    • Journal Title

      Neuron

      Volume: 74 Issue: 2 Pages: 384-396

    • DOI

      10.1016/j.neuron.2012.02.032

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression2012

    • Author(s)
      Tanimura A
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 30 Pages: 12195

    • DOI

      10.1073/pnas.1204404109

    • URL

      https://pure.teikyo.jp/en/publications/aec65471-3118-4f24-b5a1-bf4b9801e729

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain2012

    • Author(s)
      Uesaka N
    • Journal Title

      J Neurosci

      Volume: 32 Issue: 34 Pages: 11688-11699

    • DOI

      10.1523/jneurosci.1097-12.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic calcium signaling in cerebellar Purkinje cell.2012

    • Author(s)
      Kitamura K
    • Journal Title

      Neural Networks

      Volume: - Pages: 11-7

    • DOI

      10.1016/j.neunet.2012.08.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locally synchronized synaptic inputs2012

    • Author(s)
      Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y
    • Journal Title

      Science

      Volume: 335 Issue: 6066 Pages: 353-356

    • DOI

      10.1126/science.1210362

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca <sub>v</sub>2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization2012

    • Author(s)
      Miyazaki, Taisuke ; Yamasaki, Miwako ; Hashimoto, Kouichi, et
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 4 Pages: 1311

    • DOI

      10.1523/jneurosci.2755-11.2012

    • NAID

      120005208889

    • URL

      https://pure.teikyo.jp/en/publications/f48c739e-0c26-431e-95dd-f1e84b54f236

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小脳プルキンエ細胞樹状突起活動のin vivoイメージング2012

    • Author(s)
      喜多村和郎、橋本浩一、狩野方伸
    • Journal Title

      生体の科学

      Volume: 63 Pages: 26-33

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Synaptogenesis and synaptic elimination2012

    • Author(s)
      Kano M, Watanabe M
    • Journal Title

      Handbook of Cerebellum and Cerebellar Disorders

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABAergic inhibition regulates developmental synapse elimination in the cerebellum2012

    • Author(s)
      Nakayama H, Miyazaki T, Kitamura K, Hashimoto K, Yanagawa Y, Obata K, Sakimura K, Watanabe M, Kano M
    • Journal Title

      Neuron

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocannabinoids and retrograde modulation of synaptic transmission2011

    • Author(s)
      Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
    • Journal Title

      Neuroscientist

      Volume: (Published online on April 29) Issue: 2 Pages: 119-132

    • DOI

      10.1177/1073858410397377

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for myosin Va in cerebellar plasticity and motor learning : a possible mechanism underlying neurological disorder in myosin Va disease2011

    • Author(s)
      Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y
    • Journal Title

      J.Neurosci.

      Volume: 31 Issue: 16 Pages: 6067-6078

    • DOI

      10.1523/jneurosci.5651-10.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo two-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice2011

    • Author(s)
      Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. & Kasai H.
    • Journal Title

      J.Physiol.

      Volume: 589 Issue: 10 Pages: 2447

    • DOI

      10.1113/jphysiol.2011.207100

    • URL

      https://pure.teikyo.jp/en/publications/6bd20e90-3fe3-4d5d-8c39-c671ea0eeda1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and morphological configuration for 2-Arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus2011

    • Author(s)
      Uchigashima, M.; Yamazaki, M.; Yamasaki, M., et al
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Issue: 21 Pages: 7700

    • DOI

      10.1523/jneurosci.5665-10.2011

    • NAID

      120003521155

    • URL

      https://localhost/en/publications/a845dd63-8f1e-46ba-957d-e33605d5b9c3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postsynaptic P/Q-type Ca<sup>2+</sup> channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum2011

    • Author(s)
      Hashimoto, K.; Tsujita, M.; Miyazaki, T., et al
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 108 Issue: 24 Pages: 9987

    • DOI

      10.1073/pnas.1101488108

    • URL

      https://pure.teikyo.jp/en/publications/7e964aef-9002-441a-94a1-96c5c4c49bbf

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells2011

    • Author(s)
      Ichikawa, R.; Yamasaki, M.; Miyazaki, T., et al
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Issue: 47 Pages: 16916

    • DOI

      10.1523/jneurosci.2396-11.2011

    • NAID

      120005183171

    • URL

      https://pure.teikyo.jp/en/publications/15e91974-f404-4407-8493-ce34617ee015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Climbing fiber synapse elimination in cerebellar Purkinje cells2011

    • Author(s)
      Watanabe, M.; Kano, M.
    • Journal Title

      European Journal of Neuroscience

      Volume: 34 Issue: 10 Pages: 1697

    • DOI

      10.1111/j.1460-9568.2011.07894.x

    • NAID

      120004856989

    • URL

      https://localhost/en/publications/0b7e1cbb-a988-4161-83a7-4a69edf3d1fa

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シナプス伝達を修飾する脂質メディエーター、内因性カンナビノイド2011

    • Author(s)
      橋本谷祐輝、谷村あさみ、狩野方伸
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 31 Pages: 105-109

    • NAID

      10029094203

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 内因性カンナビノイドによるシナプス伝達調節のメカニズム2011

    • Author(s)
      谷村あさみ、橋本谷祐輝、狩野方伸
    • Journal Title

      生化学

      Volume: 83 Pages: 704-714

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus2011

    • Author(s)
      Ludanyi A, Sherry Shu-Jung Hu, S, Yamazaki M, Tanimura A, Piomelli D, Masahiko WatanabeM, Kano M, Sakimura K, Maglbczky Z, Mackie K, Freund TF, Katona I
    • Journal Title

      Neuroscience

      Volume: 174 Pages: 50-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol2011

    • Author(s)
      Hashimotodani Y, Ohno-Shosaku T, Yamazaki M, Sakimura K, Kano M
    • Journal Title

      J Neurosci

      Volume: 31 Pages: 3104-3109

    • NAID

      120002950596

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neumns in basal amygdaloid nucleus.2011

    • Author(s)
      Yoshida T Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Pages: 3059-3064

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for myosin Va in cerebellar plasticity and motor leaming : apossible mechanism underlying neurological disorder hl myosin Va .disease.2011

    • Author(s)
      Miyata M, Kishimoto Y, Tanaka M, Hashimoto K, Hirashima N, Murata Y, Kano M, Takagishi Y
    • Journal Title

      J Neumsci

      Volume: 31(印刷中)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo two-photon uncaging of glutamate reveaEng the structure-fhnction relationships of dendritic spines in the neocortex of adult mice.2011

    • Author(s)
      Noguchi J, Nagaoka A, Watanabe S, Ellis-Davies GCR, Kitamura K Kano M, Matsuzaki M, Kasai H
    • Journal Title

      J Physiol(Lond)

      Volume: 589(印刷中)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocannabinoids and retrograde modulation of synaptic transmission2011

    • Author(s)
      Ohno-Shosaku T Tanimura A, Hashimotodani Y;Kano M
    • Journal Title

      Neuroscientist

      Volume: 17(印刷中)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of pre- and postsynaptic activity in thalamocortical axonbranching2010

    • Author(s)
      Yamada A, Uesaka N, Hayano Y, Tabata T, Kano M, Yamamoto N
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 7562-7567

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new multiple-drug applicator with minimal drug cross-talk, leakage, and consumption2010

    • Author(s)
      Fujita Y, Shimomura T, Hosoguchi M, Kano M, Fukurotani K, Tabata T
    • Journal Title

      Neurosci Res

      Volume: 66 Pages: 412-414

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TARPs γ-2 and γ-7 are essential for AMPA receptor expressionin the cerebellum2010

    • Author(s)
      Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M
    • Journal Title

      Eur J Neurosci

      Volume: 31 Pages: 2204-2220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カンナビノイド受容体-逆行性シナプス伝達を担う分子-2010

    • Author(s)
      橋本谷祐輝、狩野方伸
    • Journal Title

      医学のあゆみ

      Volume: 233 Pages: 912-917

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 長期抑圧(LTD)2010

    • Author(s)
      谷村あさみ、橋本谷祐輝、狩野方伸
    • Journal Title

      Chnical Neuroscience

      Volume: 28 Pages: 873-875

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 古典的条件づけの学習理論と可逆的遺伝子発現制御システムを用いた実験的検証2010

    • Author(s)
      岸本泰司
    • Journal Title

      生物物理

      Volume: 50 Pages: 195-198

    • NAID

      10026569492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellar mechanisms underlying encoding and consoHdation of classical eyeblink conditionillg in mice2010

    • Author(s)
      Kishimoto Y
    • Journal Title

      NeuroscL Res.(SupPlement)

      Volume: 68

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission.2010

    • Author(s)
      Tanimura A
    • Journal Title

      Neuron 65

      Pages: 320-327

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents.2009

    • Author(s)
      Tanimura A
    • Journal Title

      Neuropharmacology 57

      Pages: 157-163

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease.2009

    • Author(s)
      Takeda S
    • Journal Title

      Brain Res 1280

      Pages: 137-147

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Translocation of a"winner"climbing fiber to the Purkinje cell dendrite and subsequent elimination of"losers"from the soma indeveloping cerebellum.2009

    • Author(s)
      Hashimoto K
    • Journal Title

      Neuron 63

      Pages: 106-118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional coupling between mGIuRI and Ca_v3. 1 T―type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.2009

    • Author(s)
      Hildebrand M
    • Journal Title

      J Neurosci 29

      Pages: 9668-9682

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor blocker, olmesartan, improved cerebrovascular dysfunction and prevented cognitive decline in early-stage Alzheimer disease model mouse.2009

    • Author(s)
      Takeda S
    • Journal Title

      Hypertension 54

      Pages: 1345-1352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior.2009

    • Author(s)
      Taniguchi S
    • Journal Title

      EMBO J 28

      Pages: 3717-3129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synapse elimination in the central nervous system.2009

    • Author(s)
      Kano M
    • Journal Title

      Curr Opin Neurobiol 19

      Pages: 154-161

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses.2009

    • Author(s)
      Hashimoto k
    • Journal Title

      Neuroscience 162

      Pages: 601-611

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カンナビノイドとシナプス機能(特集:シナプス機能とその障害の分子機構)2009

    • Author(s)
      橋本谷祐輝
    • Journal Title

      Cognition and Dementia 8

      Pages: 25-31

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 新しい神経伝達物質内因性カンナビノイド-逆行性シナプス伝達を担う分子-2009

    • Author(s)
      谷村, あさみ
    • Journal Title

      化学 64

      Pages: 22-26

    • Related Report
      2009 Annual Research Report
  • [Presentation] Adaptation of reward-based free-choices is impaired by cannabinoid receptor (CB_1) antagonist2012

    • Author(s)
      N., Kano, M., Kimura, M.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Retardation of habituation leaning and suppression or synaptic plasticity in the dentate gyrus by the endocannnabinoid 2-arachidonoylglycerol signaling2012

    • Author(s)
      Sugaya, Y., Yamazaki M., Sakimura, K., Kano, M.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Refinement of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development2012

    • Author(s)
      Kano, M.
    • Organizer
      1^<st> International Syposium/59^<th> NIBB Conference
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県)(招待講演)
    • Year and Date
      2012-03-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Retrograde modulation of synaptic transmission by the endocannabinoid 2-arachidonoylglycerol2011

    • Author(s)
      M.KANO, A.TANIMURA, M.YAMAZAKI, M.UCHIGASHIMA, M.WATANABE, K.SAKIMURA
    • Organizer
      17th International Biophysics Congress (IUPAB)
    • Place of Presentation
      the China National Convention Centre(中国)(招待講演)
    • Year and Date
      2011-11-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activity-dependent refinement of climbing fiber to Purkinje cell synapses during postnatal cerebellar development2011

    • Author(s)
      M.KANO, K.HASHIMOTO, Y.KAWAMURA, H.NAKAYAMA, K.KITAMURA, K.SAKIMURA
    • Organizer
      COLD SPRING HARBOR ASIA CONFERENCE : "Assembly, Plasticity, Dysfunction and Repair of Neural Circuits"
    • Place of Presentation
      蘇州Dushu Lake Conference Center(中国)(招待講演)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endocannabinoid release and retrograde synaptic suppression mediated by group I mGluR and other G_q/11-coupled receptors2011

    • Author(s)
      M.KANO
    • Organizer
      7th International Meeting on Metabotropic Glutamate Receptors
    • Place of Presentation
      Grande Albergo Capotaormina(イタリア)(招待講演)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activity-dependent maturtion of climbing fiber to Purkinje cell synapses during postnatal cerebellar development2011

    • Author(s)
      M.KANO
    • Organizer
      4^<th> International Symposium of the Society for Research on the Cerebellum
    • Place of Presentation
      東京大学(東京都)(招待講演)
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] The endocannabinoid, 2-arachidonoylglycerol, has different effects on long-term potentiation in vivo between the dentate gyrus and the hippocampal CA12011

    • Author(s)
      Sugaya, Y., Tanimura, A., Yamazaki, M., Sakimura, K., Kano, M.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of Purkinje cell activity in climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata2011

    • Author(s)
      Mikuni, T., Uesaka, M., Kano, M.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Postsynaptic P/Q type voltage-dependent Ca^<2+> channel is involved in refinement of cerebellar climbing fiber to Purkinje cell synapses in early postnatal development2011

    • Author(s)
      Hashimoto, K., Tsujita, M., Miyazaki, T., Kitamura, K., Yamazaki M., Shin Hee-sup, Watanabe M., Sakimura K., Kano, M.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Impaired reward-related behaviors in mice lacking the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha2011

    • Author(s)
      Cagniard, B., Tanimura, A., Yamazaki, M., Sakimura, K., Kano.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhanced synchrony of climbing fiber-induced Ca^<2+> signaling in cerebellar Purkinje cells in GluD2 (GluRδ2) knockout mouse2011

    • Author(s)
      Hashizume, M., Kitamura, K., Sakimura, K., Kano, M.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediates depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells2011

    • Author(s)
      Tanimura, A., Yamazaki, M., Uchigashima, M., Uesaka, N., Mikuni, T., Hashimoto, K., Watanabe, M., Sakimura, K., Kano, M.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Desynchronization of cerebellar Purkinje cell population activity during postnatal development2011

    • Author(s)
      Good, JK., Kitamura, K., Kano, M.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Adenosine A1 receptor interacts with mGluR1 and regulates cerebellar LTD2011

    • Author(s)
      Kamikubo, U., Fujita, Y., Shimomura, T., Miyajima, T., Fujino, M., Tabata, T., Fukurotani, K., Kano, M., Sakurai, T.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activity-dependent synapse elimination during postnatal development2011

    • Author(s)
      M.KANO
    • Organizer
      Gordon Research Conference on Cerebellum
    • Place of Presentation
      Colby-Sawyer Colloge(アメリカ)(招待講演)
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Requirement of type 1 metabotropic glutamate receptor for experience-dependent pruning of retinogeniculate synapses2011

    • Author(s)
      Narushima, M., Uchigashima, M., Hashimoto, K., Aiba, A., Watanabe, M., Miyata, M., Kano, M.
    • Organizer
      8th IBRO World Congress of Neuroscience, 2011
    • Place of Presentation
      Fortezza da Basso(イタリア)
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mode of endocannabinoid degradation after depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells2011

    • Author(s)
      Tanimura, A., Yamazaki, M., Uchigashima, M., Uesaka, N., Mikuni, T., Hashimoto, K., Watanabe, M., Sakimura, K., Kano, M.
    • Organizer
      8th IBRO World Congress of Neuroscience, 2011
    • Place of Presentation
      Fortezza da Basso(イタリア)
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuroscience research and education in Tokyo after the 0311 disaster2011

    • Author(s)
      Kano, M
    • Organizer
      8th IBRO World Congress of Neuroscience, 2011
    • Place of Presentation
      Fortezza da Basso(イタリア)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus2011

    • Author(s)
      Uchigashima, M., Yamazaki, M., Yamasaki, M., Tanimura, A., Sakimura K., Kano, M., Watanabe M
    • Organizer
      8th IBRO World Congress of Neuroscience, 2011
    • Place of Presentation
      Fortezza da Basso(イタリア)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activity-dependent refinement of climbing fiber to Purkinje cell synapses during postnatal development2011

    • Author(s)
      M.KANO
    • Organizer
      Symposium on Organization and Function of Neuronal Circuits in Movement Control
    • Place of Presentation
      Trolleholm Castle(スウェーデン)(招待講演)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synapse type-independent degradation of 2-arachidonoylglycerol in the cerebellum2011

    • Author(s)
      M.KANO
    • Organizer
      Gordon Research Conference on Cannabinoid Function in the CNS
    • Place of Presentation
      レ・ディアブレレ・コンファレンスセンター(スイス)(招待講演)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯状回における2-アラキドノイルグリセロールを介した逆行性シグナル伝達機構の分子解剖学的基盤は苔状細胞-顆粒細胞シナプス間のクロストークを示唆する2011

    • Author(s)
      内ヶ島基政、山崎真弥、山崎美和子、谷村あさみ、崎村建司、狩野方伸、渡辺雅彦
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      誌上発表
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] APPxPS2 Tgマウスにおける加齢依存性学習障害の検出2011

    • Author(s)
      岸本泰司
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県静岡市静岡県立大学
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内因性カンナビノイドの2-アラキドニルグリセロールは、麻酔下および自由行動下のマウスの海馬歯状回における長期増強を抑制する2011

    • Author(s)
      菅谷佑樹、谷村あさみ、山崎真弥、崎村建司、狩野方伸
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      誌上発表
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Emotional behaviors in mice lacking the endocannabinoid synthesizing enzyme diacylglycerol lipase α2011

    • Author(s)
      Cagniard, B., Tanimura, A., Yamazaki, M, Sakimura, K, Kano, M.
    • Organizer
      第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      誌上発表
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病の分子機構と検出法の探索~行動学からのアプローチ2011

    • Author(s)
      岸本泰司
    • Organizer
      第3回AD研究会(私立大学戦略的基盤形成支援事業)
    • Place of Presentation
      香川県さぬき市グリーンヒル大串
    • Year and Date
      2011-03-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activity-dependent strengthening of single climbing fiber synaptic inputs in Purkinje cells of developing cerebellum2010

    • Author(s)
      Kallo, M., Kawamura, Y, Nakayama, H., Kitamura, K
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫県神戸市神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Loss of cerebellar granule cell AMPA receptors contributes to ataxia in stargazer mice.2010

    • Author(s)
      M.Yamazaki
    • Organizer
      NEUROSCIENCE2010
    • Place of Presentation
      San Diego Convention Center, San Diego, the U.S.A.
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activity-dependent maturation of climbing fiber to Purkinje cell synapses during postnatal cerebellar development.2010

    • Author(s)
      Kaao, M.
    • Organizer
      International Workshop : High Resolution Optical Imaging of the Living Brain
    • Place of Presentation
      Neue Aula, Tubingen, Gemany
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activity-dependent ehmination of redundallt climbing fiber synapsesduring postnatal cerebellar development.2010

    • Author(s)
      Kano, M.
    • Organizer
      3rd International Workshop : Molecular and Cellular Mechanisms of Axon Degeneration
    • Place of Presentation
      Eibsee Rotel, Eibsee, Gemally
    • Year and Date
      2010-10-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] PS2遺伝子変異導入アルツハイマーモデルマウスにおける瞬目反射条件付けの解析2010

    • Author(s)
      岸本泰司
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      宮城県仙台市東北大学
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内因性カンナビノイドによる逆行性シナプス伝達修飾2010

    • Author(s)
      狩野方伸、橋本谷祐輝、谷村あさみ
    • Organizer
      第20回日本臨床精神神経薬理学会・ 第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      宮城県仙台市仙台国際センター
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 代謝型グルタミン酸受容体(mGluR1)とアデノシンA1受容体(A1R)相互作用による小脳LTDの制御2010

    • Author(s)
      上窪裕二、藤田洋介、下村岳司、田端俊英、袋谷賢吉、櫻井隆、狩野方伸
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 登上線維の発達過程におけるP/Q型電位依存性カルシウムチャネルの役割2010

    • Author(s)
      橋本浩一、辻田実加、喜多村和郎、宮崎太輔、山崎真弥、Hee-Sup Shin、渡辺雅彦、崎村建司、狩野方伸
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス瞬目反射条件付けにおける記憶の符号化と固定化の小脳機構(シンポジウム小脳の回路:発達と可塑性の最前線)2010

    • Author(s)
      岸本泰司
    • Organizer
      第33回日本神経科学学会大会
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] プルキンエ細胞選択的ノツクアウトを用いた小脳AMPA受容体サブユニットの生理機能解析2010

    • Author(s)
      阿部学、橋本浩一、宮崎太輔、畦地裕統、夏目里恵、渡辺雅彦、狩野方伸、崎村建司
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 扁桃体基底外側核におけるカンナビノイドおよびセロトニンを介するシナプス伝達調整機構2010

    • Author(s)
      吉田隆行、内ヶ島基政、泉剛、山口拓、狩野方伸、渡辺雅彦、吉岡光弘
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] TARPγ2、γ7は小脳AMPA型グルタミン酸受容体の機能的構成成分である2010

    • Author(s)
      山崎真弥、深谷昌弘、橋本浩一、山崎美和子、板倉誠、高橋正身、狩野方伸、渡辺雅彦、崎村建司
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ジアシルグリセロールリパーゼαによって産生される2-アラキドノイルグリセロールが、逆行性のシナプス伝達抑圧を引き起こす2010

    • Author(s)
      谷村あさみ、山崎真弥、橋本谷祐輝、内ヶ島基政、川田慎也、阿部学、北芳博、橋本浩一、清水孝雄、渡辺雅彦、崎村建司、狩野方伸
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of physiological functions of cerebellar AMPA receptor subunitsusing a Purkinje cell-celective gene targeting system.2010

    • Author(s)
      阿部学
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢神経系の組織培養細胞における効果的な神経活動の操作2010

    • Author(s)
      三國貴康、上阪直史、狩野方伸
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] GluD2(GluRσ2)ノツクアウトマウスの小脳プルキンエ細胞集団の2光子カルシウムイメージング解析2010

    • Author(s)
      橋爪幹、喜多村和郎、崎村建司、狩野方伸
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小脳を延髄との共培養標本を用いたシナプス発達のメカニズムを解明するためのアプローチ方法2010

    • Author(s)
      上阪直史、三國貴康、狩野方伸
    • Organizer
      第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO 2010
    • Place of Presentation
      兵庫県神戸市神戸コンベンションセンター
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transmembrane AMPA receptor regulatory protein gamma-2 and gamma-7 are essential for cerebellar AMPA receptor complex2010

    • Author(s)
      Yamazaki, M., Fukaya, M, Hashimoto, K, Kano, M., Watanabe, M., Sakimura, K.
    • Organizer
      7th FENS Forum of European Neuroscienoe
    • Place of Presentation
      RAI Convendon Centre, Amsterdam, The Netherlands
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Retrograde synaptic suppression in the cerebellum, hippocampus and striatum is mediated by 2-arachidonoylglycerol produced by diacylglycerol lipase alpha2010

    • Author(s)
      Tanimura, A., Yamazaki, M., Hashimotodalli, Y, Uchigashima, M., Kawata, S., Abe, M, Kita, Y, Hashimoto, K, Shimizu, T., Watanabe, M., Sakimura, K., Kano, M.
    • Organizer
      7th FENS Forum of European Neuroscienoe
    • Place of Presentation
      RAI Convention Centre, Amsterdam, The Netherlands
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transmembrane AMPA receptor regulatory protein gamma-2 and gamma-7 are essential for AMPA receptor complex.2010

    • Author(s)
      M.Yamazaki
    • Organizer
      FENS Forum 2010
    • Place of Presentation
      RAI Convention Centre Amsterdam, the Netherlands
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of GluN2A Tyrosine phosphorylation in depression-relatedbahavior2010

    • Author(s)
      Nakazawa, T., Talliguchi, S., Tanimura, A., Kiyama, Y, Tezuka, T., Kallo, M., Manabe, T., Yamamoto, T.
    • Organizer
      7th FENS Forum of European Neuroscienoe
    • Place of Presentation
      RAI Convention Centre, Amsterdam, The Netherlands
    • Year and Date
      2010-07-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Production and degradation of endocannabinoids mediating retrograde suppression of synaptic transmission2010

    • Author(s)
      Kano, M.
    • Organizer
      7th FENS Fomm of Eumpean Neuroscience
    • Place of Presentation
      RAI Convention Centre, Amsterdam, The Netherlallds
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spike timing-dependent strengthening of climbing fiber inputs in developing cerebellum.2010

    • Author(s)
      Kano, M.
    • Organizer
      Jacques Monod Conference
    • Place of Presentation
      Biological Station, CNRS, Roscoff, France
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Simultaneous two-photoll calcium imaging and patch-clamp recordings in vivo.2010

    • Author(s)
      Kitamura, K, Hausser, M., Kano, M.
    • Organizer
      Jacques Monod Conibrence
    • Place of Presentation
      Biological Station, CNRS, Roscoff, France
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢神経系の組織培養細胞への遺伝子導入方法の応用2010

    • Author(s)
      三国貴康、上阪直史、狩野方伸
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手県盛岡市盛岡市民文化ホール(マリオス)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 逆行性シナプス伝達を仲介する内因性カンナビノイド産生の分子機構2010

    • Author(s)
      橋本谷祐輝、少作隆子、谷村あさみ、狩野方伸
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手県盛岡市いわて県民情報交流センター(アイーナ)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小脳登上線維・プルキンエ細胞シナプスの生後発達におけるP/Q型電位依存性カルシウムチャネルの役割2010

    • Author(s)
      橋本浩一、辻田実加、宮崎太輔、山崎真弥、喜多村和郎、Hee-sup Shin、渡辺雅彦、崎村建司、狩野方伸
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手県盛岡市盛岡市民文化ホール(マリオス)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ES細胞における相同組換え効率上昇法の開発2010

    • Author(s)
      阿部学
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都府京都市京都テルサ
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protease-activated receptor 1 induces suppression of inhibitory synaptic transmission in the hippocampus.2009

    • Author(s)
      Hashimotodani Y
    • Organizer
      39^<th> Annual meeting of the Society for Neuroscience
    • Place of Presentation
      アメリカ、シカゴMcCormick Place
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adenosine Al receptor regulates mGluRl signaling and LTD in cerebellar Purkinje cells.2009

    • Author(s)
      Kamikubo Y
    • Organizer
      39^<th> Annual meeting of the Society for Neuroscience
    • Place of Presentation
      アメリカ、シカゴMcCormick Place
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of the physiological function of cerebellar AMPA receptor subunits using Purkinje cell-specific gene targeting system.2009

    • Author(s)
      Abe M
    • Organizer
      39^<th> Annual meeting of the Society for Neuroscience
    • Place of Presentation
      アメリカ、シカゴMcCormick Place
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 発達期小脳における登上線維-プルキンエ細胞間シナプス除去への抑制性GABA作動性伝達の関与2009

    • Author(s)
      中山寿子
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成熟マウス小脳における2-アラキドノイルグリセロールによる逆行性シナワ゜ス伝達2009

    • Author(s)
      谷村, あさみ
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] mGluRlは瞬目反射条件づけ記憶の獲得に必要であり、その発現や保持には必要ではない2009

    • Author(s)
      中尾晴美
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小脳プルキンエ細胞のグルタミン酸感受性長期抑圧の制御機構としてのAIアデノシン受容体2009

    • Author(s)
      藤田洋介
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢神経系組織培養細胞への遺伝子導入方法2009

    • Author(s)
      上阪直史
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市名古屋国際会議場
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Two-Photon Imaging of Population Activity in Cerebellar Purkinje Cells in GluR δ2 Knockout Mouse.2009

    • Author(s)
      Hashizume M
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      京都府国立京都国際会館
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bi-directional regulation of cerebellar synaptic plasticity throughinter-GPCR interplay.2009

    • Author(s)
      Kamikubo Y
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      京都府国立京都国際会館
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of climbing fiber inputs to Purkinje cells in the developing rat cerebellum in vivo.2009

    • Author(s)
      Kawamura Y
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      京都府国立京都国際会館
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Translocation of the Strongest climbing fiber to Purkinje cell dendrites after synaptic competition on the soma in developing cerebellum.2009

    • Author(s)
      Hashimoto K
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      京都府国立京都国際会館
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modulation of hippocampal inhibitory synaptic transmission through protease-activated receptor 1.2009

    • Author(s)
      Hashimotodani Y
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      京都府国立京都国際会館
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activity-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development.2009

    • Author(s)
      Kano M
    • Organizer
      Gordon Research Conference on Neural Circuits & Plasticity
    • Place of Presentation
      アメリカSalve Regina大学
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] "2-Arachidonoylglycerol mediates short-term retrograde suppression of synaptic transmission in the cerebellum.2009

    • Author(s)
      Kano M
    • Organizer
      4^<th> International Conference on Phospholipase A_2 and Lipid Mediators(PLM2009)
    • Place of Presentation
      東京都千代田区一ツ橋学術総合センター
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Control of synaptic function by endogenous cannabinoid

    • Author(s)
      Kano M
    • Organizer
      8th FENS Forum of European Neuroscience
    • Place of Presentation
      International Convention Center(バルセロナ、スペイン)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Postnatal climbing fiber synapse remodeling desynchronizes population activity of Purkinje cells in developing cerebellum

    • Author(s)
      Good JM
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cav2.1カルボキシル末端部位を欠損したマウスの作製

    • Author(s)
      相川知徳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 試行錯誤学習課題遂行中の、サルの線条体CB1受容体が果たす役割について

    • Author(s)
      上田康雅
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] p250GAP/TCGAPファミリーRhoGAP遺伝子と統合失調症との関連性の解析

    • Author(s)
      中澤敬信
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発達期小脳におけるシナプス除去カルシウム依存性調節

    • Author(s)
      狩野方伸
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] グルタミン酸トランスポーターGLT1コンディショナル欠損マウスにおけるグルタミン酸神経伝達の障害と異常繰り返し行動

    • Author(s)
      相田知海
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規活動依存的プロモーターE-SAREを用いた、大脳皮質における機能的回路の同定

    • Author(s)
      川島尚之
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発達期マウス網膜-外側膝状体シナプス除去における代謝型グルタミン酸受容体1型の役割

    • Author(s)
      鳴島円
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Retrograde suppression of synaptic transmission by the endocannabinoid 2-arachidonoylglycerol. Cell Symposia

    • Author(s)
      Kano M
    • Organizer
      Cell Symposia
    • Place of Presentation
      Hilton New Orleans(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Calcium-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development

    • Author(s)
      Kano M
    • Organizer
      Satellite symposium of SFN 2012 meeting
    • Place of Presentation
      LSUHSC, Neuroscience Center of Excellence(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Possible involvement of the Ca2+-dependent gene Arc in activity-dependent synapse elimination in the cerebellum

    • Author(s)
      Mikuni T
    • Organizer
      Neuroscience 2012 (北米神経科学学会)
    • Place of Presentation
      Ernest N. Morial Convention Center(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synapse type-independent degradation of 2-arachidonoylglycerol after retrograde synaptic suppression in the cerebellum

    • Author(s)
      Tanimura A
    • Organizer
      Neuroscience 2012 (北米神経科学学会)
    • Place of Presentation
      Ernest N. Morial Convention Center(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Visualization of an active ensemble of cortical neurons in vivo using a novel activity-dependent promoter E-SARE

    • Author(s)
      Kawashima T
    • Organizer
      Neuroscience 2012 (北米神経科学学会)
    • Place of Presentation
      Ernest N. Morial Convention Center(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Electrical contribution of postsynaptic T-type calcium channels to parallel fiber-Purkinje cell synaptic transmission

    • Author(s)
      Ly R
    • Organizer
      Neuroscience 2012 (北米神経科学学会)
    • Place of Presentation
      Ernest N. Morial Convention Center(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impairment of reward-based adaptive choice of actions by local injection of cannabinoid CB1 receptor antagonist into the striatum of behaving monkeys

    • Author(s)
      Ueda Y
    • Organizer
      Neuroscience 2012 (北米神経科学学会)
    • Place of Presentation
      Ernest N. Morial Convention Center(ニューオリンズ、アメリカ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Activity-dependent Refinement of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development

    • Author(s)
      Kano M
    • Organizer
      International Symposium on “Sensory Systems and Neural Circuits” Celebrating the 22nd Anniversary of Odorant-Receptor Gene Discoverys
    • Place of Presentation
      東京大学伊藤ホール(東京)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] RhoGAP gene dysregulation in schizophrenia has implications for both spine development and adult brain function

    • Author(s)
      Nakazawa T
    • Organizer
      International Symposium on “Sensory Systems and Neural Circuits” Celebrating the 22nd Anniversary of Odorant-Receptor Gene Discoverys
    • Place of Presentation
      東京大学伊藤ホール(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus

    • Author(s)
      Sugaya Y
    • Organizer
      International Symposium on “Sensory Systems and Neural Circuits” Celebrating the 22nd Anniversary of Odorant-Receptor Gene Discoverys
    • Place of Presentation
      東京大学伊藤ホール(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 組織培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズム

    • Author(s)
      上阪直史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウスバレル皮質における感覚シナプス入力の可視化

    • Author(s)
      喜多村和郎
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス小脳における登上繊維応答の同期性とaldolase C発現パターンとの関連

    • Author(s)
      堤新一郎
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 内因性カンナビノイド2-アラキドノイルグリセロールは歯状回の興奮性シナプス伝達を抑制し発作を減弱する

    • Author(s)
      菅谷佑樹
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小脳登上繊維-プルキンエ細胞シナプスの発達において競合する登上繊維間の相対的な強度の差と登上繊維の絶対的な強度がそれぞれ異なる段階に寄与している

    • Author(s)
      川田慎也
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Climbing fiber network refinement and desynchronization of Purkinje cell population activity during postnatal cerebellar development

    • Author(s)
      Good JM
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Book] Synaptogenesis and Synaptic elimination.In : Handbook of Cerebellum and Cerebellar Disorders, Mario Mallto, Donna Gruol, Jeremy Schmahmann, Nori Koibuchi, Ferdinando Rossi, (eds)2011

    • Author(s)
      Kano M, Watanabe M.
    • Publisher
      Springer(印刷中)(掲載確定)
    • Related Report
      2010 Annual Research Report
  • [Book] 内因性カンナビノイドによるシナプス伝達修飾実験医学28(増刊号/分子から個体へと深化する脂質生物学.佐々木雄彦、横溝岳彦、竹縄忠臣/編)2010

    • Author(s)
      橋本谷祐輝、谷村あさみ、狩野方伸
    • Total Pages
      938
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition Neural Signaling Mechanisms.2009

    • Author(s)
      Tabata T
    • Total Pages
      632
    • Publisher
      Springer Science Business Media
    • Related Report
      2009 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科神経生理学教室

    • URL

      http://plaza.umin.ac.jp/~neufophy/kano%201ab/Top.html

    • Related Report
      2010 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科神経生理学教室

    • URL

      http://plaza.umin.ac.jp/~neurophy/Kano%201ab/Top.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ES細胞における相同組換え効率を改善する方法2010

    • Inventor(s)
      暗村建司・阿部学・八矢幸大
    • Industrial Property Rights Holder
      国立大学法人 新潟大学
    • Filing Date
      2010-10-08
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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