| Project/Area Number |
21220010
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMAMURA Ken-ichi 熊本大学, 生命資源研究・支援センター, 教授 (90115197)
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| Co-Investigator(Kenkyū-buntansha) |
WAKANA Shigeharu 独立行政法人理化学研究所, バイオリソースセンター, チームリーダー (90192434)
YAMAGATA Kazuya 熊本大学, 生命科学研究部, 教授 (70324770)
YOSHINOBU Kumiko 熊本大学, 生命資源研究・支援センター, 助教 (20274730)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKI Kimi 熊本大学, 生命資源研究・支援センター, 准教授 (90211705)
TAKEDA Naoki 熊本大学, 生命資源研究・支援センター, 助教 (90304998)
ARAKI Masatake 熊本大学, 生命資源研究・支援センター, 准教授 (80271609)
LI Zhenghua 熊本大学, 生命資源研究・支援センター, 助教 (80398239)
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| Project Period (FY) |
2009-05-11 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥210,600,000 (Direct Cost: ¥162,000,000、Indirect Cost: ¥48,600,000)
Fiscal Year 2013: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2011: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2010: ¥66,560,000 (Direct Cost: ¥51,200,000、Indirect Cost: ¥15,360,000)
Fiscal Year 2009: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
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| Keywords | 野生マウス / 膵炎 / 糖尿病 / 行動パターン / ヒト化マウス / 可変型相同組換え / 行動 |
|---|
| Research Abstract |
In MSM/Ms mouse, we showed that coordinate function of thalamus, midbrain, pons, and medulla was essential for its agility. In addition, high induction of Spink3 was involved in resistance to cerulein-induced pancreatitis. Furthermore, we succeeded to create knock out and knock-in mice in MODY associated genes including HNF1alpha, HNF1beta, HNF4alpha, Pdx1, NeuroD, Gck, that become valuable resources in research community.
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| Assessment Rating |
Verification Result (Rating)
A-
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