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Visualization of radiation induced mutagenesis in vivo

Research Project

Project/Area Number 21221003
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionThe University of Tokyo

Principal Investigator

MITANI Hiroshi  東京大学, 新領域創成科学研究科, 教授 (70181922)

Co-Investigator(Kenkyū-buntansha) NODA Asao  (財)放射線影響研究所, 遺伝学部, 副部長 (40294227)
FUJIWARA Tomoko  大阪大学, 医学系研究科, 助教 (70402922)
TAKANO Yoshiro  東京医科歯科大学, 大学院医科歯学総合研究科, 教授 (90126425)
Co-Investigator(Renkei-kenkyūsha) ODA Shoji  東京大学, 大学院新領域創成科学研究科, 准教授 (50266714)
ASAKA Tomomi  東京大学, 大学院新領域創成科学研究科, 特任研究員 (90555707)
YASUDA Takako  東京大学, 大学院新領域創成科学研究科, 特任研究員 (40450431)
Research Collaborator 漆原 祐介  
村田 泰彦  
五十嵐 健人  
張 添翼  
大西 壽子  
塩谷 典子  
伊藤 加津沙  
西谷 彩香  
平川 慶  
永田 健斗  
橋本 知佳  
Project Period (FY) 2009-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥99,190,000 (Direct Cost: ¥76,300,000、Indirect Cost: ¥22,890,000)
Fiscal Year 2013: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2010: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2009: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Keywords放射線 / 突然変異 / メダカ / マウス / 細胞死 / 生殖細胞 / 咽頭歯 / DNA修復
Outline of Final Research Achievements

A complex network of signaling proteins sense radiation-induced DNA damage and activates the cellular response, which activates cell-cycle checkpoint, DNA repair and apoptosis. The defects in this process lead to mutation, cancer, and cellular death. However, the comparison of mutation frequency among cells in various kind of tissue is very hard to study. In this project, we used mouse and medaka as model animal to analyze the radiation responses in tissue. We reported that the cell lines from radiation-sensitive mutant medaka strain has a defect in the Histone H2AX phosphorylation after irradiation and its low level of DNA-PK activity causes aberrant DNA-PKcs autophosphorylation. We also found novel roles of radiation induced apoptosis in tissue response including testis-ova in p53 deficient mutant medaka. The visualization of mutagenesis and apoptosis in mouse and medaka tissue was developed to detect radiation response in tissue.

Assessment Rating
Verification Result (Rating)

A-

Report

(7 results)
  • 2015 Research Progress Assessment (Verification Result) ( PDF )
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (58 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 26 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (27 results) Book (2 results) Remarks (2 results)

  • [Journal Article] p53-Dependent suppression of genome instability in germ cells.2014

    • Author(s)
      Otozai S, Ishikawa-Fujiwara T, Oda S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, Todo T.
    • Journal Title

      Mutat Res,

      Volume: 760 Pages: 24-32

    • DOI

      10.1016/j.mrfmmm.2013.12.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fetal irradiation induces persistent translocations in rat mammary epithelial cells.2014

    • Author(s)
      Nakano, M,, Nishimura, M., Hamasaki, K., Mishima, S., Yoshida. M., Nakata. A., Shimada, Y., Noda, A.
    • Journal Title

      Radiation Res.

      Volume: 181(2) Issue: 2 Pages: 172-176

    • DOI

      10.1667/rr13446.1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tooth replacement and putative odontogenic stem cell niches in pharyngeal dentition of medaka (Oryzias latipes)2014

    • Author(s)
      Abduweli, D., O. Baba, M. J. Tabata, K. Higuchi, H. Mitani and Y. Takano
    • Journal Title

      Microscopy (Oxf)

      Volume: 62(2) Issue: 2 Pages: 141-153

    • DOI

      10.1093/jmicro/dft085

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nuclear and cytoplasmic changes in erythrocytes of p53-deficient medaka fish (Oryzias latipes) after exposure to gamma-radiation.2014

    • Author(s)
      Sayed, A. E., S. Oda and H. Mitani
    • Journal Title

      Mutat Res Genet Toxicol Environ Mutagen

      Volume: 771 Pages: 64-70

    • DOI

      10.1016/j.mrgentox.2014.01.013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regular heartbeat rhythm at the heartbeat initiation stage is essential for normal cardiogenesis at low temperature.2014

    • Author(s)
      Watanabe-Asaka, T., Y. Sekiya, H. Wada, T. Yasuda, I. Okubo, S. Oda and H. Mitani
    • Journal Title

      BMC Dev Biol

      Volume: 14 Issue: 1 Pages: 12-12

    • DOI

      10.1186/1471-213x-14-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.2013

    • Author(s)
      Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K.
    • Journal Title

      Mol Biol Cell

      Volume: 24(9) Issue: 9 Pages: 1387-1395

    • DOI

      10.1091/mbc.e12-11-0830

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA-PKによるDSB修復経路の多面的制御2013

    • Author(s)
      漆原 祐介
    • Journal Title

      放射線生物研究

      Volume: 48 Pages: 39-51

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allelic expression changes in Medaka (Oryzias latipes) hybrids between inbred strains derived from genetically distant populations.2012

    • Author(s)
      Murata, Y.
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis–ova in the testis of p53-deficient medaka (Oryzias latipes)2012

    • Author(s)
      Yasuda, T
    • Journal Title

      Cell Death and Disease

      Volume: 3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka (Oryzias latipes) cells.2012

    • Author(s)
      Urushihara, U.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 429 Pages: 131-136

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International workshop: Radiation effects on mutation in somatic and germline stem cells2012

    • Author(s)
      Kodama, Y.
    • Journal Title

      Int J Radiat Biol

      Volume: 88 Pages: 501-506

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells.2012

    • Author(s)
      Noda, A.
    • Journal Title

      J. Cell Sci.

      Volume: 125 Pages: 5280-5287

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 突然変異率の再考:revisiting mutation rate calculations.2012

    • Author(s)
      野田 朝男
    • Journal Title

      放射線生物研究

      Volume: 47 Pages: 1-7

    • NAID

      40019324998

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎児は小児よりもリスクが大きいか?2012

    • Author(s)
      中村 典
    • Journal Title

      放射線生物研究

      Volume: 47 Pages: 272-286

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurocytotoxic effects of iron-ions on the developing brain measured in vivo using medaka (Oryzias latipes), a vertebrate model2011

    • Author(s)
      Yasuda, T.
    • Journal Title

      Int.J.Radiat.Biol.

      Volume: 87 Issue: 9 Pages: 915-922

    • DOI

      10.3109/09553002.2011.584944

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel Rieske-type protein derived from an apoptosis-inducing factor-like (AIFL) transcript with a retained intron 4 induces change in mitochondrial morphology and growth arrest2011

    • Author(s)
      Murata, Y.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 407 Issue: 1 Pages: 92-97

    • DOI

      10.1016/j.bbrc.2011.02.115

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Easy detection of GFP-positive mutants following forward mutations at specific gene locus in cultured human cells2011

    • Author(s)
      Noda, A.
    • Journal Title

      Mutat Res

      Volume: 721 Issue: 1 Pages: 101-107

    • DOI

      10.1016/j.mrgentox.2010.12.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] scale- and tooth phenotypes in medaka with mutated ectodysplasin-A receptor2011

    • Author(s)
      Atukorala, A.D.S.
    • Journal Title

      Arch Histol Cytol

      Volume: 73 Pages: 139-148

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メダカ胚発生中の脳で起こる放射線誘発アポトーシスのin vivoイメージング2011

    • Author(s)
      保田隆子
    • Journal Title

      放射線生物研究

      Volume: 46 Pages: 15-29

    • NAID

      40018784404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Easy detection of GFP-positive mutants following forward mutations at specific gene locus in cultured human cells2011

    • Author(s)
      Noda, et.al.
    • Journal Title

      Mutation Res

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurocytotoxic effects of iron-ions on the developing brain measured in vivo using Medaka (Oryzias latipes), a vertebrate model2011

    • Author(s)
      Yasuda, et al.
    • Journal Title

      Int.J.Radiat.Biol

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel Rieske-type protein derived from an apoptosis-inducing factor-like (AIFL) transcript with a retained intron 4 induces changein mitochondrial morphology and growth arrest2011

    • Author(s)
      Murata, et al.
    • Journal Title

      BBRC

      Volume: 407 Pages: 92-97

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メダカ胚八世中の脳で起こる放射線誘発アポトーシスのinvivoイメージング2011

    • Author(s)
      保田隆子, ら
    • Journal Title

      放射線生物研究

      Volume: 46 Pages: 15-29

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Intraspecific variation in the mitochondrial genome among local populations of Medaka Oryzias latipes2010

    • Author(s)
      Hirayama, et al.
    • Journal Title

      Gene

      Volume: 457 Pages: 13-24

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell Lines Derived from a Medaka Radiation-Sensitive Mutant have Defects in DNA Double-Strand Break Responses.2010

    • Author(s)
      Hidaka, M., et al.
    • Journal Title

      J Radiat Res(Tokyo) 51

      Pages: 165-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infrared laser-mediated local gene induction in medaka, zebrafish and Arabidopsis thaliana.2009

    • Author(s)
      Deguchi, T., et al.
    • Journal Title

      Dev Growth Differ 51

      Pages: 769-775

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Live imaging of radiation-induced apoptosis by yolk injection of Acridine Orange in the developing optic tectum of medaka.2009

    • Author(s)
      Yasuda, T., et al.
    • Journal Title

      J Radiat Res(Tokyo) 50

      Pages: 487-494

    • NAID

      10025912894

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射線により誘発されるp53遺伝子欠損メダカ精巣内の卵原幹細胞の分化と成長2013

    • Author(s)
      西谷彩香、保田隆子、尾田正二、三谷啓志
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2013-12-03 – 2013-12-06
    • Related Report
      2013 Annual Research Report
  • [Presentation] メダカにおける人工ヌクレアーゼ(TALEN)を用いた損傷乗り越えポリメラーゼ変異体の作製.2013

    • Author(s)
      藤川芳宏、藤原(石川)智子、佐久間哲史、山本卓、藤堂剛
    • Organizer
      日本環境変異原学会第42回大会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2013-11-20 – 2013-11-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeted Inactivation of Rev1 gene.2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo:
    • Organizer
      The 6th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2013-11-10 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] The molecular structure and damaged-DNA repair activity affected by the chromophore binding states in Cryptochrome-DASH from Platynereis dumerili.2013

    • Author(s)
      Kazunori Zikihara, Kohei Kasakawa, Tomoko Ishikawa, Kristin Tessmar-Raible, Satoru Tokutomi、Takeshi Todo:
    • Organizer
      The 6th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2013-11-10 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeted Inactivation of DNA photolyase family genes using CRISPR system.2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      The 6th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2013-11-10 – 2013-11-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線で生じる修復不能なDSBの特徴付けの試み2013

    • Author(s)
      野田朝男、平井裕子
    • Organizer
      第56回日本放射線影響学会
    • Place of Presentation
      ホテルクラウンパレス青森(青森青森県青森市)
    • Year and Date
      2013-10-18 – 2013-10-20
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA-PK 自己リン酸化異常時におけるp53のDSB 修復経路選択への関わり2013

    • Author(s)
      大西 壽子、漆原 佑介、藤原 智子、尾田 正二、藤堂  剛、三谷 啓志
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森(青森青森県青森市)
    • Year and Date
      2013-10-18 – 2013-10-20
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線による胚の神経細胞傷害を除去するミクログリアの活性化には二つの経路がある2013

    • Author(s)
      保田隆子、尾田正二、佐藤聡海、三谷啓志
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      ホテルクラウンパレス青森(青森青森県青森市)
    • Year and Date
      2013-10-18 – 2013-10-20
    • Related Report
      2013 Annual Research Report
  • [Presentation] Progerin, the causal protein for the accelerated premature aging in humans, enhances levels of unrepaired DNA damages following genotoxic stress insult.2013

    • Author(s)
      Noda, A., Mishima, S., Hirai, Y., Hamasaki, K., Haga, K., Kiyono, T., Nakamura, N., Kodama, Y.
    • Organizer
      The 44th Annual meeting of US Environmental Mutagenesis and Genomics Society.
    • Place of Presentation
      Monterey, California USA
    • Year and Date
      2013-09-21 – 2013-09-25
    • Related Report
      2013 Annual Research Report
  • [Presentation] The pivotal role of the p53 gene in the elimination of spontaneous testis-ova in medaka testes.2013

    • Author(s)
      Yasuda T., Li Z., Urushihara Y., Suzuki Y., Oda S. and Mitani H
    • Organizer
      8th European Zebrafish Meeting
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2013-07-09 – 2013-07-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] 近交系間交雑F1個体における対立遺伝子間の発現調節2012

    • Author(s)
      三谷 啓志
    • Organizer
      第14回 日本進化学会年会
    • Place of Presentation
      首都大学東京(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線により誘導されるアレル不均衡発現のトランスクリプトーム解析2012

    • Author(s)
      三谷 啓志
    • Organizer
      第55回 日本放射線影響学会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] メダカ細胞を用いたDSB初期応答におけるDNA‐PK機能の解析2012

    • Author(s)
      漆原 祐介
    • Organizer
      第55回 日本放射線影響学会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] メダカ胚の脳に対する重粒子炭素線マイクロビーム照射応答解析2012

    • Author(s)
      保田 隆子
    • Organizer
      第55回 日本放射線影響学会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The radiation induced transdifferentiation in the testis of medaka (Orvzias atipes) p53 deficient mutant2012

    • Author(s)
      Hiroshi Mitani
    • Organizer
      International Workshop "Radiation Effects on Mutation in Somatic and Germline Stem Cells
    • Place of Presentation
      Hiroshima(放影研)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of recombinant mouse model for the study of genetic effects of radiation2012

    • Author(s)
      Asao Noda
    • Organizer
      International Workshop "Radiation Effects on Mutation in Somatic and Germline Stem Cells
    • Place of Presentation
      Hiroshima(放影研)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome-wide detection of allelic imbalance using intestine of hybrids between two medaka inbred strains2011

    • Author(s)
      Murata Yasuhiko
    • Organizer
      7th European Zebrafish Meeting
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2011 Annual Research Report
  • [Presentation] Isolation and characterization of p53, ATM and ATR mutants in medaka fish2011

    • Author(s)
      Tomoko Fujiwara-Ishikawa
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of germ cells specific DNA damage response in Japanese Medaka (Orvzias latipes)2011

    • Author(s)
      Yusuke Urushihara
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] Heavy ion radiation effects on spermatogenesis in Medaka (Oryzias latipes) p53 nonsense mutant2011

    • Author(s)
      Hiroshi Mitani
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Related Report
      2011 Annual Research Report
  • [Presentation] p53(-/-)メダカ精巣組織で観察される精巣卵の放射線照射による変化2011

    • Author(s)
      三谷啓志
    • Organizer
      第54回放射線影響学会
    • Place of Presentation
      神戸市(神戸商工会議所会館)
    • Related Report
      2011 Annual Research Report
  • [Presentation] メメダカを用いた宇宙環境における雄性生殖細胞突然変異生成の解析2010

    • Author(s)
      三谷啓志, 他
    • Organizer
      宇宙生物学会
    • Place of Presentation
      東北大学
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] メダカ精巣放射線組織応答におけるp53の役割2010

    • Author(s)
      三谷啓志, ら
    • Organizer
      第53回放射線影響学会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] P53(-/-)メダカ胚発生中の脳で起こる放射線誘発アポトーシス2010

    • Author(s)
      保田隆子, ら
    • Organizer
      第53回放射線影響学会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロサテライトを指標としたメダカにおけるゲノム不安定性の解析2010

    • Author(s)
      石川智子, ら
    • Organizer
      第53回放射線影響学会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] メダカ近交系統の交雑個体をモデルとした対立遺伝子間の不均等な転写量解析2010

    • Author(s)
      村田泰彦, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] メダカricl系統におけるDNA二本鎖切断修復異常の解析2009

    • Author(s)
      漆原祐介
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Book] Annual Review of Genetics2014

    • Author(s)
      Nakamura, N., Suyama, A., Noda, A., Kodama, Y.
    • Total Pages
      27
    • Publisher
      Radiation effects on human heredity.
    • Related Report
      2013 Annual Research Report
  • [Book] 次世代シークエンサー目的別アドバンスメソッド2012

    • Author(s)
      村田 泰彦
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2012 Annual Research Report
  • [Remarks] 先端生命科学専攻-東京大学新領域創成科学研究科

    • URL

      http://www.ib.k.u-tokyo.ac.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://park.itc.u-tokyo.ac.jp/K-medaka/Publications.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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