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Roles of Cell Adhesion and Signaling in Cell Morphogenesis

Research Project

Project/Area Number 21227005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionKobe University

Principal Investigator

TAKAI YOSHIMI  神戸大学, 医学(系)研究科(研究院), 教授 (60093514)

Co-Investigator(Kenkyū-buntansha) SHIMONO Yohei  神戸大学, 大学院医学研究科, 准教授 (90594630)
MIZUTANI Kiyohito  神戸大学, 大学院医学研究科, 特命講師 (50559177)
TOGASHI Hideru  神戸大学, 大学院医学研究科, 助教 (90415240)
OGITA Hisakazu  滋賀医科大学, 医学部, 教授 (50379236)
KURITA Souichi  滋賀医科大学, 医学部, 助教 (30595484)
MIZOGUCHI Akira  三重大学, 大学院医学系研究科, 教授 (90181916)
OKAMOTO Miki  大阪府立成人病センター研究所, 分子生物学部門, 研究員 (20332455)
Co-Investigator(Renkei-kenkyūsha) RIKITAKE Yoshiyuki  神戸大学, 大学院医学研究科, 准教授 (50419488)
IKEDA Wataru  カン研究所, 主幹研究員 (90362699)
OKAMOTO Miki  大阪府立成人病センター研究所, 分子生物学部門, 研究員 (20332455)
Project Period (FY) 2009-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥208,000,000 (Direct Cost: ¥160,000,000、Indirect Cost: ¥48,000,000)
Fiscal Year 2013: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Keywordsアドへレンスジャンクション / タイトジャンクション / 異種細胞間接着 / ネクチン / ネクチン様分子 / アファディン / アドヘレンスジャンクション / デスモソーム / ネクチン様分子-5 / 肺腺がん / 神経突起 / 上皮細胞 / 神経シナプス
Outline of Final Research Achievements

Each cell in the body has a variety of morphologies and exerts its own function. The change of cell morphology is important for a body to survive by adapting to its environment. In this research, based on the achievements we have made in the research of the nectin-afadin system, nectin-like molecules, and their downstream signaling molecules, we revealed the molecular mechanisms that regulate the localization of the adhesion apparatuses and the heights of the cells; those of the cell morphogenesis during epithelial-mesenchymal and mesenchymal-epithelial transitions; those involved in the synaptic formation and remodeling of the neural cells; and the cell adhesion molecules involved in the formation of axon and dendrites. Furthermore, by analyzing these results more deeply, we revealed the roles of the cell adhesion molecules in the tissue formation and cell arrangements in the sensory epithelium, central nervous tissues, and the intestinal epithelium.

Assessment Rating
Verification Result (Rating)

A

Report

(7 results)
  • 2015 Research Progress Assessment (Verification Result) ( PDF )
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (102 results)

All 2015 2014 2013 2012 2011 2010 2009

All Journal Article (69 results) (of which Peer Reviewed: 67 results,  Open Access: 23 results,  Acknowledgement Compliant: 7 results) Presentation (32 results) (of which Invited: 8 results) Book (1 results)

  • [Journal Article] Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb.2015

    • Author(s)
      Inoue T, Fujiwara T, Rikitake Y, Maruo T, Mandai K, Kimura K, Kayahara T, Wang S, Ioth Y, Sai K, Mori M, Mori K, Mizoguchi A, Takai Y.
    • Journal Title

      J Comp Neurol.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The cell adhesion molecule necl-4/cadm4 serves as a nobel regulator for contact inhibition of cell movement and proliferation.2015

    • Author(s)
      Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y.
    • Journal Title

      PloS One.

      Volume: 10 Issue: 4 Pages: e0124259-e0124259

    • DOI

      10.1371/journal.pone.0124259

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.2015

    • Author(s)
      Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N.
    • Journal Title

      PLoS Pathog.

      Volume: 16 Issue: 3 Pages: e1004721-e1004721

    • DOI

      10.1371/journal.ppat.1004721

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nectins and nectin-like molecules in development and disease.2015

    • Author(s)
      Mandai K, Rikitake Y, Mori M, Takai Y.
    • Journal Title

      Curr Top Dev Biol.

      Volume: 112 Pages: 197-231

    • DOI

      10.1016/bs.ctdb.2014.11.019

    • ISBN
      9780124077584
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.2015

    • Author(s)
      Fujiwara Y, Goda N, Tamashiro T, Narita H, Satomura K, Tenno T, Nakagawa A, Oda M, Suzuki M, Sakisaka T, Takai Y, Hiroaki H.
    • Journal Title

      Protein Sci.

      Volume: 24 Issue: 3 Pages: 376-385

    • DOI

      10.1002/pro.2628

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative analysis of the cellular composition in seminiferous tubules in normal and genetically modified infertile mice.2015

    • Author(s)
      Nakata H, Wakayama T, Takai Y, Iseki S.
    • Journal Title

      J Histochem Cytochem.

      Volume: 63 Issue: 2 Pages: 99-113

    • DOI

      10.1369/0022155414562045

    • NAID

      120005593935

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium.2014

    • Author(s)
      Tanaka-Okamoto M, Itoh Y, Miyoshi J, Mizoguchi A, Mizutani K, Takai Y, Inoue M.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 10 Pages: e110549-e110549

    • DOI

      10.1371/journal.pone.0110549

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.2014

    • Author(s)
      Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T.
    • Journal Title

      Genes Cells.

      Volume: 19 Issue: 11 Pages: 842-852

    • DOI

      10.1111/gtc.12184

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.2014

    • Author(s)
      Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, Takai Y.
    • Journal Title

      Genes Cells.

      Volume: 19 Issue: 12 Pages: 853-863

    • DOI

      10.1111/gtc.12185

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.2014

    • Author(s)
      Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ.
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 10 Pages: 4503-4516

    • DOI

      10.1172/jci71245

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.2014

    • Author(s)
      Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW.
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 10 Pages: 4517-4528

    • DOI

      10.1172/jci75572

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a.2014

    • Author(s)
      Suzuki T, Mizutani K, Minami A, Nobutani K, Kurita S, Nagino M, Shimono Y, Takai Y.
    • Journal Title

      Genes Cells.

      Volume: 19 Issue: 9 Pages: 667-675

    • DOI

      10.1111/gtc.12166

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.2014

    • Author(s)
      Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: e89763-e89763

    • DOI

      10.1371/journal.pone.0089763

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.2014

    • Author(s)
      Fukuda T, Kominami K, Wang S, Togashi H, Hirata K, Mizoguchi A, Rikitake Y, Takai Y.
    • Journal Title

      Development.

      Volume: 141 Issue: 2 Pages: 399-409

    • DOI

      10.1242/dev.094995

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Absence of primary cilia in cell cycle-arrested human breast cancer cells.2014

    • Author(s)
      Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y.
    • Journal Title

      Genes Cells.

      Volume: 19 Issue: 2 Pages: 141-152

    • DOI

      10.1111/gtc.12122

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.2013

    • Author(s)
      Yamamoto H, Maruo T, Majima T, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Mandai K, Takai Y.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 11 Pages: e80356-e80356

    • DOI

      10.1371/journal.pone.0080356

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.2013

    • Author(s)
      Yamada T, Kuramitsu K, Rikitsu E, Kurita S, Ikeda W, Takai Y.
    • Journal Title

      Genes Cells.

      Volume: 18 Issue: 11 Pages: 985-998

    • DOI

      10.1111/gtc.12091

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis.2013

    • Author(s)
      Komaki R, Togashi H, Takai Y.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 10 Pages: e76201-e76201

    • DOI

      10.1371/journal.pone.0076201

    • Related Report
      2013 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.2013

    • Author(s)
      Ratta-Apha W, Hishimoto A, Mouri K, Shiroiwa K, Sasada T, Yoshida M, Supriyanto I, Ueno Y, Asano M, Shirakawa O, Togashi H, Takai Y, Sora I.
    • Journal Title

      Neurosci Res.

      Volume: 77 Issue: 4 Pages: 222-227

    • DOI

      10.1016/j.neures.2013.08.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.2013

    • Author(s)
      Kurita S, Yamada T, Rikitsu E, Ikeda W, Takai Y.
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 41 Pages: 29356-29368

    • DOI

      10.1074/jbc.m113.453464

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons.2013

    • Author(s)
      Yamada A, Inoue E, Deguchi-Tawarada M, Matsui C, Togawa A, Nakatani T, Ono Y, Takai Y.
    • Journal Title

      Mol Cell Neurosci.

      Volume: 56 Pages: 234-243

    • DOI

      10.1016/j.mcn.2013.06.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statins exert pleiotropic effects through SmgGD S up-regulation with a resultant Rac l degradation2013

    • Author(s)
      Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H
    • Journal Title

      Arterioscter Thromz Vasc Biol

      Volume: (in press) Issue: 7 Pages: 1591-1600

    • DOI

      10.1161/atvbaha.112.300922

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.2013

    • Author(s)
      Sugiyama H, Mizutani K, Kurita S, Okimoto N, Shimono Y, Takai Y.
    • Journal Title

      Genes Cells.

      Volume: 18 Issue: 6 Pages: 519-528

    • DOI

      10.1111/gtc.12056

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nectin-like molecule-5 regulates intimal thickening after carotid artery ligation in mice.2013

    • Author(s)
      Kureha F, Satomi-Kobayashi S, Kubo Y, Kinugasa M, Ishida T, Takai Y, Hirata K, Rikitake Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Issue: 6 Pages: 1206-1211

    • DOI

      10.1161/atvbaha.113.301425

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a.2013

    • Author(s)
      Minami A, Shimono Y, Mizutani K, Nobutani K, Momose K, Azuma T, Takai Y.
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 17 Pages: 11845-11853

    • DOI

      10.1074/jbc.m112.405993

    • NAID

      40019873148

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium.2013

    • Author(s)
      Du, M.
    • Journal Title

      Biol Reprod.

      Volume: 88 Issue: 3 Pages: 1-17

    • DOI

      10.1095/biolreprod.112.104851

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.2013

    • Author(s)
      Momose, K.
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 3 Pages: 195-202

    • DOI

      10.1111/gtc.12027

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.2013

    • Author(s)
      Kamran, N.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: e54406-e54406

    • DOI

      10.1371/journal.pone.0054406

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory Upregulation of Myelin Protein Zero-Like 2 Expression in Spermatogenic Cells in Cell Adhesion Molecule-1-Deficient Mice2012

    • Author(s)
      Nakata, H.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 45 Issue: 1 Pages: 47-56

    • DOI

      10.1267/ahc.11057

    • NAID

      130001854317

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis.2012

    • Author(s)
      Yoshida, M.
    • Journal Title

      Genes Cells

      Volume: 17 Issue: 6 Pages: 455-472

    • DOI

      10.1111/j.1365-2443.2012.01601.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER).2012

    • Author(s)
      Satomi-Kobayashi, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 36 Pages: 30336-30345

    • DOI

      10.1074/jbc.m111.329110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer’s disease.2012

    • Author(s)
      Matsui, C.
    • Journal Title

      Brain Pathol.

      Volume: 22 Issue: 6 Pages: 776-787

    • DOI

      10.1111/j.1750-3639.2012.00587.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of nectins in different types of cell-cell adhesion.2012

    • Author(s)
      Rikitake, Y.
    • Journal Title

      J Cell Sci.

      Volume: 125 Issue: 16 Pages: 3713-3722

    • DOI

      10.1242/jcs.099572

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoglobulin superfamily receptors and adherens junctions.2012

    • Author(s)
      Shimono, Y.
    • Journal Title

      Subcell Biochem.

      Volume: 60 Pages: 137-170

    • DOI

      10.1007/978-94-007-4186-7_7

    • ISBN
      9789400741850, 9789400741867
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cell adhesion gene PVRL3 is associated with congenital ocular defects.2012

    • Author(s)
      Lachke, S.A. et al.
    • Journal Title

      Hum Genet.

      Volume: 131 Issue: 2 Pages: 235-250

    • DOI

      10.1007/s00439-011-1064-z

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity.2012

    • Author(s)
      Giangreco, A. et al.
    • Journal Title

      J. Immunol.

      Volume: 188 Issue: 3 Pages: 1514-1522

    • DOI

      10.4049/jimmunol.1003342

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necl-5/Poliovirus Receptor Interacts with VEGFR2 and Regulates VEGF-induced Angiogenesis.2012

    • Author(s)
      Kinugasa, M. et al.
    • Journal Title

      Circ. Res.

      Volume: 17 Issue: 5 Pages: 716-726

    • DOI

      10.1161/circresaha.111.256834

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.2011

    • Author(s)
      Kurooka, T. et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 8 Pages: 6832-6843

    • DOI

      10.1074/jbc.m110.183772

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the cis-Dimer of nectin-1: implications for architecture of cell-cell Junctions.2011

    • Author(s)
      Narita, H. et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 14 Pages: 12659-12669

    • DOI

      10.1074/jbc.m110.197368

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative role of the nectin-nectin and nectin-afadin interactions in the formation of the nectin-based cell-cell adhesion.2011

    • Author(s)
      Kurita, S. et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 42 Pages: 36297-36303

    • DOI

      10.1074/jbc.m111.261768

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of nectin-like molecule 2 with integrin α6β4 and inhibition of the disassembly of integrin α6β4 from hemidesmosomes.2011

    • Author(s)
      Mizutani, K. et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 42 Pages: 36667-36676

    • DOI

      10.1074/jbc.m110.200535

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.2011

    • Author(s)
      Fukumoto, Y. et al.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 50 Pages: 43537-43548

    • DOI

      10.1074/jbc.m111.308858

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.2011

    • Author(s)
      Togashi, H. et al.
    • Journal Title

      Science

      Volume: 333 Issue: 6046 Pages: 1144-1147

    • DOI

      10.1126/science.1208467

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia.2011

    • Author(s)
      Tanaka-Okamoto, M. et al.
    • Journal Title

      J. Cell Sci.

      Volume: 124 Issue: 13 Pages: 2331-2240

    • DOI

      10.1242/jcs.081000

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Refolding, crystallization and preliminary X-ray crystallographic study of the whole extracellular regions of nectins.2011

    • Author(s)
      Narita, H. et al.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun.

      Volume: 67 Issue: 3 Pages: 344-348

    • DOI

      10.1107/s174430911100337x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae2011

    • Author(s)
      Noma A, Yi S, Katoh T, Takai Y, Suzuki T and Suzuki T
    • Journal Title

      RNA

      Volume: 17 Issue: 6 Pages: 1111-1119

    • DOI

      10.1261/rna.2653411

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway2011

    • Author(s)
      Shibata, S. et al.
    • Journal Title

      J Clin Invest.

      Volume: 121 Issue: 8 Pages: 3233

    • DOI

      10.1172/jci43124

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth2011

    • Author(s)
      Kurooka, T.
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 6832-6843

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Refolding, crystallization and preliminary X-ray crystallographic study of the whole extracellular regions of nectins2011

    • Author(s)
      Narita, H.
    • Journal Title

      Acta.Crystallogr.Sect.F Struct.Biol.Cryst.Commun.

      Volume: 67 Pages: 344-348

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5-α/β2010

    • Author(s)
      Hotta, A.
    • Journal Title

      J.Cell Biol.

      Volume: 189 Pages: 901-917

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis2010

    • Author(s)
      Tawa, H.
    • Journal Title

      Circ.Res.

      Volume: 106 Pages: 1731-1742

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma2010

    • Author(s)
      Nakai, R.
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1326-1330

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of integrin α_6β_4 with ErbB3 and implication in heregulin-induced ErbB3/ErbB2-mediated DNA synthesis2010

    • Author(s)
      Kawano, S.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 995-1001

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperation of Nectin-1 and Nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth2010

    • Author(s)
      Yoshida, T.
    • Journal Title

      Dev.Dyn.

      Volume: 239 Pages: 2558-2569

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trophoblast glycoprotein : possible candidate mediating podocyte injuries in glomerulonephritis2010

    • Author(s)
      Murakami, T.
    • Journal Title

      Am.J.Nephrol.

      Volume: 32 Pages: 505-521

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necl-5/PVR enhances PDGF-induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells2010

    • Author(s)
      Minami, A.
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 1123-113

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in MDCK cells.2010

    • Author(s)
      Ooshio, T.
    • Journal Title

      J.Biol.Chem. 285巻・7号

      Pages: 5003-5012

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Doc2β is a High Affinity Ca^<2+> Sensor for Spontaneous neurotransmitter Release.2010

    • Author(s)
      Groffen, A.J.
    • Journal Title

      Science (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma.2010

    • Author(s)
      Nakai, R.
    • Journal Title

      Cancer Science (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2.2009

    • Author(s)
      Kawano, S.
    • Journal Title

      J.Biol.Chem. 284巻・35号

      Pages: 23793-23805

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.2009

    • Author(s)
      Miyata, M.
    • Journal Title

      J.Biol.Chem. 284巻・36号

      Pages: 24595-24609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synaptic activity prompts γ-secretase-mediated cleavage of EphA4 and dendritic spine formation.2009

    • Author(s)
      Inoue, E.
    • Journal Title

      J.Cell Biol. 185巻・3号

      Pages: 551-564

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of afadin in the formation and remodeling of synapses In the hippocampus.2009

    • Author(s)
      Majima, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 385巻・4号

      Pages: 539-544

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.2009

    • Author(s)
      Satomi-Kobayashi, S.
    • Journal Title

      Hypertention 54巻・4号

      Pages: 825-831

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRTAM confers late-stage activation of CD8^+ T cells to regulate retention withinlymph node.2009

    • Author(s)
      Takeuchi, A.
    • Journal Title

      J.Immunol. 183巻・7号

      Pages: 4220-4228

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of nectin-free afadin at the leading edge and its Involvement in directional cell movement Induced by platelet-derived growth factor.2009

    • Author(s)
      Miyata, M.
    • Journal Title

      J.Cell Sci. 122巻・23号

      Pages: 4319-4329

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necl2 regulates epidermal adhesion and wound repair.2009

    • Author(s)
      Giangreco, A.
    • Journal Title

      Development 136巻・20号

      Pages: 3505-3514

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.2009

    • Author(s)
      Szodorai, A.
    • Journal Title

      J.Neurosci. 29巻・46号

      Pages: 14534-14544

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Togashi, H.
    • Journal Title

      The Sticky Synapse : Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance(Springer)

      Pages: 185-206

    • Related Report
      2009 Annual Research Report
  • [Presentation] SBF-SEM 3D reconstitution analysis reveals alterations in composition and morphology of mouse hippocampal mossy fiber synapses by afadin knockout.2015

    • Author(s)
      Takeshi Fujiwara, Shujie Wang, Yu Itoh, Kousyoku Sai, Aika Kaito, Naoyuki Miyazaki, Kazuyoshi Murata, Tomohiko Maruo, Hideaki Yamamoto, Kenji Mandai, Yoshimi Takai, Akira Mizoguchi
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2013 Annual Research Report
  • [Presentation] Afadin plays an important role in formation of puncta adherentia junction and differentiation of presynapses in hippocampal neurons.2014

    • Author(s)
      Daisaku Toyoshima, Kenji Mandai, Tomohiko Maruo, Irwan Supriyanto, Hideru Togashi, Takahito Inoue, Masahiro Mori, Yoshimi Takai
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロRNA-199aはTGFβ-1で誘導されるSNAI1とN-cadherinの発現を抑制する2014

    • Author(s)
      鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2013 Annual Research Report
  • [Presentation] Afadin-deficiency leads to the formation of double cortex by abnormal radial glial scaffold and cell-autonomous impairment of neuronal migration during development.2014

    • Author(s)
      Hideaki Yamamoto, Kenji Mandai, Daijiro Konno, Tomohiko Maruo, Fumio Matsuzaki, Yoshimi Takai
    • Organizer
      2014 CSHL Conference on Glia in Health & Disease
    • Place of Presentation
      New York, NY, USA
    • Year and Date
      2014-07-17 – 2014-07-21
    • Related Report
      2013 Annual Research Report
  • [Presentation] シグナル伝達と細胞接着―研究の歴史と展望―2014

    • Author(s)
      高井義美
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Nectin and afadin in cell adhesion and signaling.2014

    • Author(s)
      Yoshimi Takai
    • Organizer
      Symposium on Membrane Biology, Univesity of Washington and Kobe University
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2014-03-27 – 2014-03-28
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Nectins Regulate the Mosaic Cellular Pattern Formation in the Olfactory Epithelium.2013

    • Author(s)
      Sayaka Katsunuma, Hideru Togashi , Ken-ichi Nibu and Yoshimi Takai
    • Organizer
      16th Asian Research Symposium in Rhinology (ARSR)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2013-08-29 – 2013-08-31
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of mode of action of nectins in the mosaic cellular pattering in sensory organs.2012

    • Author(s)
      富樫英
    • Organizer
      第45回日本発生生物学会(JSDB)/第64回日本細胞生物学会(JSCB)合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Primary cillia are depleted in human breast cancer cell line, tissue, and human-mouse xenograft tumor2012

    • Author(s)
      信谷健太郎
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Targeting of Necl-2 and enhancement of heregulin-induced ErbB2/ErbB3 signaling by miR-214 in colon cancer cells.2012

    • Author(s)
      百瀬健次
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ネクチン-3ノックアウトマウス蝸牛の異常接着した有毛細胞における不動毛束の配向と形態の異常2012

    • Author(s)
      福田旭伸
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ZO-1は培養ラット海馬神経細胞において樹状突起の複雑な形態を制御する2012

    • Author(s)
      小牧遼平
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] PLEKHA7 binds to afadin and regulates the formation of adherens junctions in epithelial cells.2012

    • Author(s)
      栗田宗一
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 異種細胞間接着形成におけるネクチンの機能と作用機構2011

    • Author(s)
      高井義美
    • Organizer
      第28回日本医学会総会2011
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Roles and modes of action of nectin in adhesion between heterogeneous cells.2011

    • Author(s)
      Yoshimi Takai
    • Organizer
      Gordon Research Conference on Cell Contact & Adhesion 2011
    • Place of Presentation
      Vermont, USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] マウス海馬神経細胞のシナプス形成におけるアファディンの役割2011

    • Author(s)
      豊嶋大作 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 足場タンパク質ADIPによるVav2とRacを介する細胞運動制御2011

    • Author(s)
      福元友梨 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neclとインテグリンα6β4の相互作用およびNeclによるへミデスモソーム崩壊制御機構2011

    • Author(s)
      水谷清人 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺癌細胞においてNecl-2は腫瘍原性マイクロRNA-214により発現抑制される2011

    • Author(s)
      南 晶洋 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞のがん化と細胞接着装置2011

    • Author(s)
      高井義美
    • Organizer
      第70回日本癌学会学術総会 モーニングレクチャー
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Roles of nectins in heterotypic cell adhesion.2011

    • Author(s)
      Yoshimi Takai
    • Organizer
      5th Mechanobiology Conference 2011
    • Place of Presentation
      Singapore
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Roles and modes of action of nectins and cadherins in the morphogenesis of the olfactory epithelium.2011

    • Author(s)
      Sayaka Katsunuma et al.
    • Organizer
      The 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kobe
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Localization of nectin-1 at dendro-dendritic contacts between mitral/tufted cells in the external plexiform layer of mouse olfactory bulb2011

    • Author(s)
      井上貴仁 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of intimal thickeningfollowing carotid artery ligation in mice by the immunoglobulin-like cell adhesion molecule Necl-52011

    • Author(s)
      久保嘉輝 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] ネクチンのヘテロフィリックな相互作用による内耳感覚上皮の細胞配列パターン形成の制御2010

    • Author(s)
      小南賀乃子
    • Organizer
      BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫グロブリン様分子Necl-5による血管新生の制御2010

    • Author(s)
      宮田宗明
    • Organizer
      BMB2010第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新しいがん浸潤・転移のメカニズム2010

    • Author(s)
      扇田久和
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)(招待講演)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Necl-2とインテグリンα_6β_4の相互作用およびNecl-2によるヘミデスモソーム崩壊抑制機構2010

    • Author(s)
      水谷清人
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 方向性を持って運動するNIH3T3細胞でのNecl-5による微小管配向の制御2010

    • Author(s)
      南晶洋
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 嗅上皮の形態形成と再生における細胞接着分子の機能2010

    • Author(s)
      勝沼紗矢香
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulatory Mechanism of Active Zone Formation by Nectin-Afadin Adhesion System2009

    • Author(s)
      Yoshimi Takai
    • Organizer
      "Current Trends in Biomedicine"workshop"Active Zones as organizers of neuronal communication"
    • Place of Presentation
      UNIA(Spain)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nectins and nectin-like molecules : roles and modes of action in tumorigenesis, invasion, and metastasis2009

    • Author(s)
      Yoshimi Takai
    • Organizer
      Global COE international Symposium"New Aspects in Immunology and Cancer Research"
    • Place of Presentation
      秋田大学(秋田県)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Book] Int. Rev. Cell Mol Biol.2011

    • Author(s)
      Rikitake, Y. et al.
    • Publisher
      Elsevier Inc.
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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