| Project/Area Number |
21227005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kobe University |
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Principal Investigator |
TAKAI YOSHIMI 神戸大学, 医学(系)研究科(研究院), 教授 (60093514)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMONO Yohei 神戸大学, 大学院医学研究科, 准教授 (90594630)
MIZUTANI Kiyohito 神戸大学, 大学院医学研究科, 特命講師 (50559177)
TOGASHI Hideru 神戸大学, 大学院医学研究科, 助教 (90415240)
OGITA Hisakazu 滋賀医科大学, 医学部, 教授 (50379236)
KURITA Souichi 滋賀医科大学, 医学部, 助教 (30595484)
MIZOGUCHI Akira 三重大学, 大学院医学系研究科, 教授 (90181916)
OKAMOTO Miki 大阪府立成人病センター研究所, 分子生物学部門, 研究員 (20332455)
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| Co-Investigator(Renkei-kenkyūsha) |
RIKITAKE Yoshiyuki 神戸大学, 大学院医学研究科, 准教授 (50419488)
IKEDA Wataru カン研究所, 主幹研究員 (90362699)
OKAMOTO Miki 大阪府立成人病センター研究所, 分子生物学部門, 研究員 (20332455)
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| Project Period (FY) |
2009-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥208,000,000 (Direct Cost: ¥160,000,000、Indirect Cost: ¥48,000,000)
Fiscal Year 2013: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2009: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
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| Keywords | アドへレンスジャンクション / タイトジャンクション / 異種細胞間接着 / ネクチン / ネクチン様分子 / アファディン / アドヘレンスジャンクション / デスモソーム / ネクチン様分子-5 / 肺腺がん / 神経突起 / 上皮細胞 / 神経シナプス |
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| Outline of Final Research Achievements |
Each cell in the body has a variety of morphologies and exerts its own function. The change of cell morphology is important for a body to survive by adapting to its environment. In this research, based on the achievements we have made in the research of the nectin-afadin system, nectin-like molecules, and their downstream signaling molecules, we revealed the molecular mechanisms that regulate the localization of the adhesion apparatuses and the heights of the cells; those of the cell morphogenesis during epithelial-mesenchymal and mesenchymal-epithelial transitions; those involved in the synaptic formation and remodeling of the neural cells; and the cell adhesion molecules involved in the formation of axon and dendrites. Furthermore, by analyzing these results more deeply, we revealed the roles of the cell adhesion molecules in the tissue formation and cell arrangements in the sensory epithelium, central nervous tissues, and the intestinal epithelium.
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| Assessment Rating |
Verification Result (Rating)
A
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