Chemical Genetics on Novel Functions of Splicing Factors

• Project/Area Number: 21228003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Applied biochemistry
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YOSHIDA Minoru 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 主任研究員 (80191617)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Shinichi 独立行政法人理化学研究所, 中川RNA生物学研究室, 准主任研究員 (50324679)
• Co-Investigator(Renkei-kenkyūsha): FURUMAI Ryohei 独立行政法人理化学研究所, 基幹研究所, 基礎科学特別研究員 (30450414)
• Project Period (FY): 2009-05-11 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥199,810,000 (Direct Cost: ¥153,700,000、Indirect Cost: ¥46,110,000); Fiscal Year 2013: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000); Fiscal Year 2012: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000); Fiscal Year 2011: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000); Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2009: ¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000)
• Keywords: スプライシング / イントロン / 転写 / 核-細胞質間輸送 / 非コードRNA / エピジェネティクス / 転写終結 / マイクロRNA

Research Abstract

Spliceostatin A (SSA) is a chemically stable derivative of anticancer natural product FR901464, which we identified as the first splicing inhibitor that binds the splicing factor SF3b. SSA provides a unique opportunity to analyze novel function of splicing factors and introns. This project aims to elucidate unknown roles of splicing factors by analyzing the mechanisms by which SSA induces a variety of phenotypes. In consequence, we demonstrated that splicing factors targeted by SSA are involved in the regulation of pre-mRNA nuclear retention, transcriptional elongation, polyadenylation, and subcellular localization of nuclear non-coding RNAs.

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Research Products

• [Journal Article] Splicing inhibition induces gene expression through canonical NF-κB pathway and extracellular signal-related kinase activation (2014)
  • Author(s): Khan, K., Schneider-Poetsch, T., Ishfaq, M., Ito, A., Yoshimoto, R., Mukaida, N., and Yoshida, M
  • Journal Title: FEBS Lett Volume: 588 Issue: 6 Pages: 1053-1057
  • DOI: 10.1016/j.febslet.2014.02.018
  • Peer Reviewed
• [Journal Article] U2 snRNP is required for expression of the 3' end of genes (2014)
  • Author(s): Koga, M., Satoh, T., Takasaki, I., Kawamura, Y., Yoshida, M., and Kaida, D
  • Journal Title: PloS One Volume: 9 Issue: 5 Pages: e98015-e98015
  • DOI: 10.1371/journal.pone.0098015
  • Peer Reviewed
• [Journal Article] Identification of a novel component C2ORF3 in the lariat-intron complex : lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway (2014)
  • Author(s): Yoshimoto, R., Okawa, K., Yoshida, M., Ohno, M., and Kataoka, N
  • Journal Title: Genes Cells Volume: 19 Issue: 1 Pages: 78-87
  • DOI: 10.1111/gtc.12114
  • Peer Reviewed
• [Journal Article] The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing (2014)
  • Author(s): Barry, G., Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Ratnu, V. S., Nayler, S. P., Nones, K., Hu, J., Bredy, T. W., Nakagawa, S., Rigo, F., Taft, R. J., Cairns, M. J., Blackshaw, S., Wolvetang, E. J., and Mattick, J. S.
  • Journal Title: Mol. Psychiatry Volume: 19 Issue: 4 Pages: 486-494
  • DOI: 10.1038/mp.2013.45
  • Peer Reviewed
• [Journal Article] Nuclear lncRNAs as epigenetic regulators-beyond skepticism. (2014)
  • Author(s): Nakagawa, S., Kageyama, Y.
  • Journal Title: Biochim. Biophys. Acta. Volume: 1839 Issue: 3 Pages: 215-222
  • DOI: 10.1016/j.bbagrm.2013.10.009
  • Peer Reviewed
• [Journal Article] Gathering around Firre (2014)
  • Author(s): Nakagawa, S. and Hirano, T
  • Journal Title: Nat. Struc.t Mol. Biol Volume: 21 Issue: 3 Pages: 207-208
  • DOI: 10.1038/nsmb.2782
  • Peer Reviewed
• [Journal Article] Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression (2013)
  • Author(s): Matsushita, K., Tamura, M., Tanaka, N., Tomonaga, T., Matsubara, H., Shimada, H., Levens, D., He, L., Liu, J., Yoshida, M., and Nomura, F
  • Journal Title: Mol. Cancer Res Volume: 11 Pages: 689-698
  • Peer Reviewed
• [Journal Article] RNA-methylation-dependent RNA processing controls the speed of the circadian clock (2013)
  • Author(s): Fustin JM, Doi M, Yamaguchi Y, Hayashi H, Nishimura S, Yoshida M, Isagawa T, Suimye-Morioka M, Kakeya H, Manabe I, Okamura H
  • Journal Title: Cell Volume: 155 Issue: 4 Pages: 793-806
  • DOI: 10.1016/j.cell.2013.10.026
  • Peer Reviewed
• [Journal Article] The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis (2013)
  • Author(s): Nishimoto, Y., Nakagawa, S., Hirose, T., Okano, H. J., Takao, M., Shibata, S., Suyama, S., Kuwako, K., Imai, T., Murayama, S., Suzuki, N., and Okano, H
  • Journal Title: Mol. Brain Volume: 6 Issue: 1 Pages: 31-31
  • DOI: 10.1186/1756-6606-6-31
  • Peer Reviewed
• [Journal Article] Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression. (2013)
  • Author(s): Matsushita, K. et al.
  • Journal Title: Mol. Cancer Res. Volume: 11 Pages: 689-698
  • Peer Reviewed
• [Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression (2012)
  • Author(s): Matsushita, K., Kajiwara, T., Tamura, M., Satoh, M., Tanaka, N., Tomonaga, T., Matsubara, H., Shimada, H., Yoshimoto, R., Ito, A., Kubo, S., Natsume, T., Levens, D., Yoshida, M., and Nomura, F
  • Journal Title: Mol. Cancer Res Volume: 10 Issue: 6 Pages: 787-799
  • DOI: 10.1158/1541-7786.mcr-11-0462
  • Peer Reviewed
• [Journal Article] Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles (2012)
  • Author(s): Naganuma, T., Nakagawa, S., Tanigawa, A., Sasaki, Y. F., Goshima, N., and Hirose, T
  • Journal Title: EMBO J Volume: 31 Issue: 20 Pages: 4020-4034
  • DOI: 10.1038/emboj.2012.251
  • Peer Reviewed
• [Journal Article] Malat1 is not an essential component of nuclear speckles in mice (2012)
  • Author(s): Nakagawa, S., Ip, J. Y., Shioi, G., Tripathi, V., Zong, X., Hirose, T., and Prasanth, K. V
  • Journal Title: RNA Volume: 18 Issue: 8 Pages: 1487-1499
  • DOI: 10.1261/rna.033217.112
  • Peer Reviewed
• [Journal Article] Drug screening for ALS using patient-specific induced pluripotent stem cells (2012)
  • Author(s): Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H
  • Journal Title: Sci. Transl. Med. Volume: 4 Issue: 145 Pages: 1-8
  • DOI: 10.1126/scitranslmed.3004052
  • Peer Reviewed
• [Journal Article] Splicing in oncogenesis and tumor suppression (2012)
  • Author(s): Kaida, D., Schneider-Poetsch, T., and Yoshida, M
  • Journal Title: Cancer Sci Volume: 103 Issue: 9 Pages: 1611-1616
  • DOI: 10.1111/j.1349-7006.2012.02356.x
  • Peer Reviewed
• [Journal Article] Paraspeckle nuclear bodies--useful uselessness? (2012)
  • Author(s): Nakagawa, S. and Hirose, T
  • Journal Title: Cell Mol. Life Sci Volume: 69 Issue: 18 Pages: 3027-3036
  • DOI: 10.1007/s00018-012-0973-x
  • Peer Reviewed
• [Journal Article] Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction (2012)
  • Author(s): Tamura Y., Furukawa K., Yoshimoto R., Kawai Y., Yoshida M., Tsuneda S., Ito Y., and Abe H.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 22 Issue: 23 Pages: 7248-7251
  • DOI: 10.1016/j.bmcl.2012.09.033
  • Peer Reviewed
• [Journal Article] Histone deacetylase inhibitors block NF-κB-dependent transcription by interfering with RNA polymerase II recruitment (2011)
  • Author(s): Furumai, R., Ito, A., Ogawa, K., Maeda, S., Saito, A., Nishino, N., Horinouchi, S., and Yoshida, M
  • Journal Title: Cancer Sci Volume: 102 Issue: 5 Pages: 1081-1087
  • DOI: 10.1111/j.1349-7006.2011.01904.x
  • Peer Reviewed
• [Journal Article] Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product (2011)
  • Author(s): Hasegawa, M., Miura, T., Kuzuya, K., Inoue, A., Ki, S. W., Horinouchi, S., Yoshida, T., Kunoh, T., Koseki, K., Mino, K., Sasaki, R., Yoshida, M., and Mizukami, T
  • Journal Title: ACS Chem. Biol Volume: 6 Issue: 3 Pages: 229-233
  • DOI: 10.1021/cb100248e
  • Peer Reviewed
• [Journal Article] Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise : implications for alternative splicing regulation (2011)
  • Author(s): Schmidt, U., Basyuk, E., Robert, M.-C., Yoshida, M., Villemin, J.-P., Auboeuf, D., Aitken, S., and Bertrand, E
  • Journal Title: J. Cell Biol Volume: 193 Issue: 5 Pages: 819-829
  • DOI: 10.1083/jcb.201009012
  • Peer Reviewed
• [Journal Article] Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3′ end of human genes (2011)
  • Author(s): Martins, S. B., Rino, J., Carvalho, T., Carvalho, C., Yoshida, M., Klose, J. M., Almeida, S. F. d., and Carmo-Fonseca, M
  • Journal Title: Nat. Str. Mol Biol Volume: 18 Issue: 10 Pages: 1115-1123
  • DOI: 10.1038/nsmb.2124
  • Peer Reviewed
• [Journal Article] Competition between a noncoding exon and introns : Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1 (2011)
  • Author(s): Tsuiji, H., Yoshimoto, R., Hasegawa, Y., Furuno, M., Yoshida, M., and Nakagawa, S
  • Journal Title: Genes Cells Volume: 16 Issue: 5 Pages: 479-490
  • DOI: 10.1111/j.1365-2443.2011.01502.x
  • Peer Reviewed
• [Journal Article] Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice (2011)
  • Author(s): Nakagawa, S., Naganuma, T., Shioi, G., and Hirose, T
  • Journal Title: J. Cell Biol Volume: 193 Issue: 1 Pages: 31-39
  • DOI: 10.1083/jcb.201011110
  • Peer Reviewed
• [Journal Article] Fluorescence detection of intron lariat RNA with reduction-triggered fluorescent probes (2011)
  • Author(s): Furukawa, K., Abe, H., Tamura, Y., Yoshimoto, R., Yoshida, M., Tsuneda, S., and Ito, Y
  • Journal Title: Angew. Chem. Int. Ed. Volume: 50 Issue: 50 Pages: 12020-12023
  • DOI: 10.1002/anie.201104425
  • Peer Reviewed
• [Journal Article] Long non-coding RNAs in nuclear bodies (2011)
  • Author(s): Ip JY, Nakagawa S
  • Journal Title: Dev Growth Differ Volume: 54 Issue: 1 Pages: 44-54
  • DOI: 10.1111/j.1440-169x.2011.01303.x
  • Peer Reviewed
• [Journal Article] V. eXIST with matrix-associated proteins (2011)
  • Author(s): Nakagawa, S. and Prasanth, K
  • Journal Title: Trends Cell Biol Volume: 21 Issue: 6 Pages: 321-327
  • DOI: 10.1016/j.tcb.2011.02.001
  • Peer Reviewed
• [Journal Article] Revisiting the function of nuclear scaffold/matrix binding proteins in X chromosome inactivation (2011)
  • Author(s): Hasegawa, Y. and Nakagawa, S
  • Journal Title: RNA Biol Volume: 8 Issue: 5 Pages: 735-739
  • DOI: 10.4161/rna.8.5.16367
  • Peer Reviewed
• [Journal Article] Identification of SAP155 as the target of GEX1A(Herboxidiene), an antitumor Natural product (2011)
  • Author(s): Hasegawa, M., et al.
  • Journal Title: ACS Chemical Biology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Real-time imaging of co-transcriptional splicing reveals a kinetic model that reduces noise : implications for alternative splicing regulation (2011)
  • Author(s): Schmidt, U., et al.
  • Journal Title: Journal of Cell Biology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] The matrix protein hnRNP U is required for chromosomal localization of Xist RNA (2010)
  • Author(s): Hasegawa, Y., Brockdorff, N., Kawano, S., Tsutui, K., and Nakagawa, S
  • Journal Title: Dev. Cell Volume: 19 Issue: 3 Pages: 469-476
  • DOI: 10.1016/j.devcel.2010.08.006
  • Peer Reviewed
• [Journal Article] Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF (2010)
  • Author(s): Furumai, R., Uchida, K., Komi, Y., Yoneyama, M., Ishigami, K., Watanabe, H., Kojima, S., and Yoshida, M
  • Journal Title: Cancer Sci Volume: 101 Issue: 11 Pages: 2483-2489
  • DOI: 10.1111/j.1349-7006.2010.01686.x
  • NAID: 10027834015
  • Peer Reviewed
• [Journal Article] Emerging world of nuclear long noncoding RNAs (2010)
  • Author(s): Nakagawa, S
  • Journal Title: Seikagaku Volume: 82 Pages: 42-46
  • NAID: 10026300263
  • Peer Reviewed
• [Journal Article] Garbled messages and corrupted translations (2010)
  • Author(s): Schneider-Poetsch, T., Usui, T., Kaida, D., and Yoshida, M
  • Journal Title: Nature Chem. Biol Volume: 6 Issue: 3 Pages: 189-198
  • DOI: 10.1038/nchembio.326
  • Peer Reviewed
• [Journal Article] 微生物由来抗がん活性物質の作用機序研究から明らかになった新しい創薬標的 (2010)
  • Author(s): 吉田 稔
  • Journal Title: バイオサイエンスとインダストリー Volume: 68 Pages: 8-14
  • NAID: 10026194945
• [Journal Article] The matrix protein hnRNP U is required for chromosomal localization of Xist RNA (2010)
  • Author(s): Hasegawa, Y., et al.
  • Journal Title: Developmental Cell Volume: 19 Pages: 469-476
  • Peer Reviewed
• [Journal Article] Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF (2010)
  • Author(s): Furumai, R., et al.
  • Journal Title: Cancer Science Volume: 101 Pages: 2483-2489
  • NAID: 10027834015
  • Peer Reviewed
• [Journal Article] Garbled messages and corrupted translations (2010)
  • Author(s): Schneider-Poetsch, T., et al.
  • Journal Title: Nature Chem.Biol 6 Pages: 189-198
  • Peer Reviewed
• [Journal Article] Real-time imaging of histone H4 hyperacetylation in living cells (2009)
  • Author(s): Sasaki, K., et al.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 106 Pages: 16257-16262
  • Peer Reviewed
• [Presentation] Genome-wide analysis of pre-mRNA splicing-inhibition (2014)
  • Author(s): Yoshimoto R. Furuno M. Burroughs M. Suzuki H. Hayashizaki Y. Nakagawa S. and Yoshida M.
  • Organizer: The 7th Japan-Korea Chemical Biology Symposium
  • Place of Presentation: Jeju Island, Korea
• [Presentation] 天然由来抗がん物質の作用機構 から明らかになったスプライシングとエ ピジェネティクスとの機能相関 (2013)
  • Author(s): 吉田 稔
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-04
• [Presentation] Functional analysis of nuclear long noncoding RNAs (2013)
  • Author(s): Shinichi Nakagawa
  • Organizer: Riboclub 2013
  • Place of Presentation: Cheribourg, Canada
  • Year and Date: 2013-09-25
• [Presentation] 化学遺伝学による新規がん分子標的の発見とエピジェネティクス創薬への展開 (2013)
  • Author(s): 吉田 稔
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館 京都府京都市左京区
  • Invited
• [Presentation] エピジェネティクス創薬研究の流れと課題 (2013)
  • Author(s): 吉田 稔
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館 京都府京都市左京区
  • Invited
• [Presentation] 化学遺伝学によるエピジェネティクス研究 (2013)
  • Author(s): 吉田 稔
  • Organizer: 千里ライフサイエンスセミナー「エピジェネティクス制御からの生命活動の理解とその展望」
  • Place of Presentation: 千里ライフサイエンスセンタービル 大阪府豊中市
  • Invited
• [Presentation] Mode of action study of splicing inhibitor, SSA - Prediction of SSA-induced miRNAs by small RNA-seq - (2013)
  • Author(s): 河村優美、Tilman Schneider-Poetsch、鈴木治和、吉田稔
  • Organizer: 第三回NGS現場の会
  • Place of Presentation: 神戸国際会議場 兵庫県神戸市
• [Presentation] 天然由来抗がん物質の作用機構から明らかになったスプライシングとエピジェネティクスとの機能相関 (2013)
  • Author(s): 吉田 稔
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 神奈川県横浜市
  • Invited
• [Presentation] レトロトランスポゾンSINE B1と相同配列を持つ核内ノンコーディングRNAによるグローバルな遺伝子発現制御 (2013)
  • Author(s): 中川真一、石田賢太郎
  • Organizer: 日本遺伝学会
  • Place of Presentation: 慶応大学日吉キャンパス 神奈川県横浜市
  • Invited
• [Presentation] Molecular mode of action of natural products that inhibit pre-mRNA splicing (2013)
  • Author(s): Yoshida M.
  • Organizer: International Symposium on Natural Products Chemistry and Chemical Biology
  • Place of Presentation: Hotel Rubura Ohzan, Nagoya, Japan
  • Invited
• [Presentation] 長鎖非コードRNA の局在と機能に対する RNA 結合タンパク質 hnRNP U の役割 (2013)
  • Author(s): 長谷川優子、中川真一
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場ポートピアホール 兵庫県神戸市
  • Invited
• [Presentation] スプライシング阻害剤の発見と新しいエピドラッグとしての可能性 (2013)
  • Author(s): 吉田 稔
  • Organizer: さきがけ「エピジェネティクスの制御と生命機能」領域 研究成果報告会 特別講演
  • Place of Presentation: 東京都、東京ガーデンパレス
  • Invited
• [Presentation] 天然由来抗がん活性物質の化学遺伝学から明らかになった新しい創薬標的 (2013)
  • Author(s): 吉田 稔
  • Organizer: 第19回神経芽腫研究会
  • Place of Presentation: 千葉県、がんセンター
  • Invited
• [Presentation] Chemical Biology on Splicing and Epigenetics (2013)
  • Author(s): Minoru Yoshida
  • Organizer: RIKEN-Academia Sinica Joint Conference on Chemical Biology
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] Opening new frontiers through chemical genetics of natural products (2012)
  • Author(s): Minoru Yoshida
  • Organizer: Charles E. Dohme memorial lecture 2012
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2012-11-28
• [Presentation] An Architectural Long Noncoding RNA NEAT1 Controls Corpus Luteum Formation in an Age-Dependent Manner (2012)
  • Author(s): Shinichi Nakagawa
  • Organizer: Keystone Symposia "Non-Coding RNAs"
  • Place of Presentation: Snowbird, Utah USA
  • Year and Date: 2012-04-03
• [Presentation] 天然物化学遺伝学による生命科学の新展開 (2012)
  • Author(s): 吉田 稔
  • Organizer: 新学術領域研究「天然物ケミカルバイオロジー：分子標的と活性制御」第2回公開シンポジウム
  • Place of Presentation: 東京都、東京大学弥生講堂
  • Invited
• [Presentation] Genome-wide analysis of cellular transcripts in the presence of Spliceostatin A (2012)
  • Author(s): 芳本 玲、古野正朗、Burroughs Alexander Maxwell、鈴木治和、林崎良英、中川真一、吉田 稔
  • Organizer: 第14回日本RNA学会年会
  • Place of Presentation: 宮城県、東北大学百周年記念会館川内萩ホール
• [Presentation] 核内構造体パラスペックルの骨格ncRNAであるNEAT1を欠損するマウスは早期に不妊になる (2012)
  • Author(s): 中川真一
  • Organizer: 第14回日本RNA学会年会
  • Place of Presentation: 宮城県、東北大学百周年記念会館川内萩ホール
• [Presentation] 長鎖non-coding RNA と細胞増殖に関する研究 (2012)
  • Author(s): 中川真一
  • Organizer: 第4回日本RNAi研究会
  • Place of Presentation: 広島県、グランドプリンスホテル広島
  • Invited
• [Presentation] がん治療を目指した創薬ケミカルバイオロジー研究 (2012)
  • Author(s): 吉田 稔
  • Organizer: グローバルEOC系統講義トランスレーショナルリサーチコース
  • Place of Presentation: 愛知県、名古屋大学
  • Invited
• [Presentation] Functional analyses of nuclear enriched abundant long noncoding RNAs (2011)
  • Author(s): Shinichi Nakagawa
  • Organizer: 第34回日本分子生物学会年会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Functional analyses of nuclear enriched abundant long noncoding RNAs (2011)
  • Author(s): Nakagawa, S.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Genome-wide analysis of mode of action of spliceostatin A that affects pre-mRNA splicing (2011)
  • Author(s): Yoshimoto, R., Furuno, M., Burroughs, AM., Suzuki, H., Hayashizaki, Y, Nakaeawa, S., Yoshida, M.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Mode of action of an anticancer agent that inhibits pre-mRNA splicing (2011)
  • Author(s): Yoshimoto, R., Yoshida, M.
  • Organizer: 11^<th> iCeMS International Symposium
  • Place of Presentation: 京都
  • Year and Date: 2011-12-06
• [Presentation] Nonessentials for nothing?-Nuclear bodies paraspeckles are not essential for animal's life (2011)
  • Author(s): Shinichi Nakagawa
  • Organizer: 第63回日本細胞生物学会大会シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-29
• [Presentation] Nonessentials for nothing?-Nuclear bodies paraspeckles are not essential for animal's life (2011)
  • Author(s): Nakagawa, S.
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-29
• [Presentation] Mode of action of an anticancer agent that inhibits pre-mRNA splicing (2011)
  • Author(s): Yoshimoto, R., Yoshida, M.
  • Organizer: RNA 2011 Kyoto
  • Place of Presentation: 京都
  • Year and Date: 2011-06-15
• [Presentation] 分子遺伝学を基盤とした天然生理活性物質の化学生物学的研究 (2011)
  • Author(s): 吉田稔
  • Organizer: 社団法人日本農芸化学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-06
• [Presentation] Mode of action of an anticancer agent that inhibits pre-mRNA splicing (2010)
  • Author(s): Minoru Yoshida
  • Organizer: The International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, Hawai, USA
  • Year and Date: 2010-12-17
• [Presentation] Mode of action of an antitumor agent that inhibits pre-mRNA splicing (2010)
  • Author(s): Minoru Yoshida
  • Organizer: 2011 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-17
• [Presentation] 大量に蓄積する核内ノンコーディングRNAの機能解析-Gomafuを例にとって (2010)
  • Author(s): 中川真一, ほか
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
  • Place of Presentation: 国際会議場、ポートピアホテル・神戸
  • Year and Date: 2010-12-08
• [Presentation] A long noncoding RNA Gomafu regulates behavior of animals (2010)
  • Author(s): Shinichi Nakagawa
  • Organizer: RiboClub Annual Meeting 2010
  • Place of Presentation: Cheribourg, Canada
  • Year and Date: 2010-09-22
• [Presentation] 核内長鎖ノンコーディングRNA Gomafuは動物の行動を制御する (2010)
  • Author(s): 中川真一
  • Organizer: 第12回日本RNA学会年会
  • Place of Presentation: 一橋記念講堂・東京
  • Year and Date: 2010-07-29
• [Presentation] スプライシング阻害剤スプライソスタチンAによるVEGF発現抑制を介した腫瘍血管新生阻害剤 (2010)
  • Author(s): 内田和代, ほか
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: タワーホール船堀・東京
• [Presentation] Daisuke Kaida "Chemistry and biology of spliceostatin A : An antitumor agent that inhibits pre-mRNA splicing" (2009)
  • Author(s): Minoru Yoshida, Ryohei Furumai
  • Organizer: Fall 2009 ACS National Meeting (The 238th ACS National Meeting)
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2009-08-18
• [Presentation] Chemistry and biology of spliceostatin A : An antitumor agent that inhibits pre-mRNA splicing (2009)
  • Author(s): Yoshida, M., et al.
  • Organizer: Fall 2009 ACS National Meeting(The 238th ACS National Meeting)
  • Place of Presentation: Washington, DC, USA
• [Remarks]
  • URL: http://www.riken.jp/research/labs/chief/chem_genet/