| Co-Investigator(Kenkyū-buntansha) |
AOKI Masahiro 京都大学, 大学院・医学研究科, 准教授 (60362464)
KITAMURA Takanori 京都大学, 大学院・医学研究科, 助教 (10378622)
SONOSHITA Masahiro 京都大学, 大学院・医学研究科, 准教授 (80511857)
AOKI Koji 京都大学, 大学院・医学研究科, 助教 (40402862)
FUJISHITA Teruaki 京都大学, 大学院・医学研究科, 助教 (50511870)
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| Budget Amount *help |
¥207,090,000 (Direct Cost: ¥159,300,000、Indirect Cost: ¥47,790,000)
Fiscal Year 2012: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2011: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2010: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2009: ¥51,090,000 (Direct Cost: ¥39,300,000、Indirect Cost: ¥11,790,000)
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| Research Abstract |
Metastasis is responsible for most cancer deaths. Here, we show that immature myeloid cells (iMCs) promote liver metastasis of colon cancer cells. We also found that Notch signaling stimulates colon cancer metastasis, and endogenous metastasis suppressor Aes inhibits the signaling. In addition, we demonstrate that JNK stimulates tumor formation in the intestine by activating mTORC1 signaling. These results should open new horizons in metastasis research and treatment of colon cancer.
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