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Dissection of mRNA degradation pathways and anomalies associated with targeted disruption of CCR4-NOT deadenylase complex

Research Project

Project/Area Number 21229006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionOkinawa Institute of Science and Technology Graduate University (2011-2013)
The University of Tokyo (2009-2010)

Principal Investigator

YAMAMOTO TADASHI  沖縄科学技術大学院大学, 細胞シグナルユニット, 教授 (40134621)

Project Period (FY) 2009-05-11 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥206,960,000 (Direct Cost: ¥159,200,000、Indirect Cost: ¥47,760,000)
Fiscal Year 2013: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2012: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2009: ¥56,160,000 (Direct Cost: ¥43,200,000、Indirect Cost: ¥12,960,000)
KeywordsmRNA代謝 / mRNA分解 / 遺伝子欠損マウス / 疾患モデル / CCR4-NOT複合体 / 脱アデニル化反応 / 3’UTR / poly(A)配列 / デアデニレース / mRNA / 翻訳 / AU-rich / AU-rich配列
Research Abstract

We have studied the physiological roles of the CCR4-NOT deadenylase complex by generating mouse lines in which each gene encoding individual subunit of the CCR4-NOT complex is disrupted. Mice thus produced were analyzed pathologically and anatomically, and we so far found that those mice were either embryonic lethal or abnormal in tissue development or showed loss of regulation in immune system and/or energy metabolism. We, therefore, assumed that CCR4-NOT deficient mouse lines could be models of human diseases. We also analyzed the molecular mechanisms by which the CCR4-NOT complex recognizes and degrades poly(A) tail of its target mRNAs. We solved the crystal structures of oligo(dA)-interacting enzymatic subunits CNOT6L and CNOT7. We also found the enzymatic subunits can target poly(A) tail of specific mRNA species through their interaction with regulatory subunits such as CNOT1 and CNOT3 that can recognize specific sequences present at 3'UTR regions of particular mRNAs.

Assessment Rating
Verification Result (Rating)

A

Report

(6 results)
  • 2014 Research Progress Assessment (Verification Result) ( PDF )
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (102 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (34 results) (of which Peer Reviewed: 34 results,  Open Access: 1 results) Presentation (62 results) (of which Invited: 1 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Stability of mRNA influences steoporotic bone mass via CNOT32014

    • Author(s)
      Watanabe, C. Morita, M. Yamamoto T. (13名)
    • Journal Title

      Natl Acad Sci U S A

      Volume: Vol.111 Issue: 7 Pages: 2692-2697

    • DOI

      10.1073/pnas.1316932111

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits2013

    • Author(s)
      Hoshina, N. Tanimura, Yamamoto T. (17名)
    • Journal Title

      Neuron

      Volume: Vol.78 Pages: 839-854

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma2013

    • Author(s)
      Yanagida S, Taniue K, Yamamoto T. (9名)
    • Journal Title

      Sci Rep

      Volume: Vol.3 Issue: 1 Pages: 1305-1305

    • DOI

      10.1038/srep01305

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The δ2 glutamate receptors gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites2013

    • Author(s)
      Kohda K, Kakegawa W, Yamamoto T. (6名)
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: Vol.110 Issue: 10

    • DOI

      10.1073/pnas.1218380110

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones2013

    • Author(s)
      Sekino-Suzuki N, Yuyama K, Yamamoto T. (10名)
    • Journal Title

      J Neurochem

      Volume: Vol.124 Issue: 4 Pages: 514-522

    • DOI

      10.1111/jnc.12040

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor2013

    • Author(s)
      Yoshikawa S, Kukimoto-Niino M, Yamamoto T. (20名)
    • Journal Title

      Oncogene

      Volume: Vol.32 Issue: 1 Pages: 27-38

    • DOI

      10.1038/onc.2012.21

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits2013

    • Author(s)
      Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
    • Journal Title

      Neuron

      Volume: 78 Issue: 5 Pages: 839

    • DOI

      10.1016/j.neuron.2013.03.031

    • URL

      https://localhost/en/publications/9a3f8593-f1a7-4ad9-9e1b-b33363b03e50

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.2012

    • Author(s)
      Takesita K
    • Journal Title

      J. Biochem.

      Volume: 152 Issue: 5 Pages: 487-495

    • DOI

      10.1093/jb/mvs085

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.2012

    • Author(s)
      Suzuki T
    • Journal Title

      J Biol Chem

      Volume: Nov 23;287(48) Issue: 48 Pages: 40256-40265

    • DOI

      10.1074/jbc.m112.353805

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tob2 Inhibits Peroxisome Proliferator-Activated Receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation2012

    • Author(s)
      Takahashi A, Morita M, Yamamoto T. (5名)
    • Journal Title

      Mol and Cell Biol

      Volume: Vol.32 Issue: 24 Pages: 5067-5077

    • DOI

      10.1128/mcb.00610-12

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice2012

    • Author(s)
      Unezaki S, Sasaki A, Yamamoto T. (12名)
    • Journal Title

      Mol Pain

      Volume: Vol.8 Pages: 8-8

    • DOI

      10.1186/1744-8069-8-59

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation2012

    • Author(s)
      Ozaki Y, Matsui H, Yamamoto T. (12名)
    • Journal Title

      Mol Cell

      Volume: Vol.47 Pages: 694-706

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits2012

    • Author(s)
      Hashimoto R
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 4 Pages: e35696-e35696

    • DOI

      10.1371/journal.pone.0035696

    • URL

      https://pure.teikyo.jp/en/publications/4db5e609-1ad4-45ab-8119-8a26d97d88c8

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMDAR2B tyrosine phosphorylation is involved in thermal nociception2012

    • Author(s)
      Delawary M, Tezuka T, Yamamoto T. (9名)
    • Journal Title

      Neurosci Lett

      Volume: Vol.516 Issue: 2 Pages: 270-273

    • DOI

      10.1016/j.neulet.2012.04.007

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] oly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation2012

    • Author(s)
      Ozaki, Yuko
    • Journal Title

      Molecular Cell

      Volume: 47 Issue: 5 Pages: 694-706

    • DOI

      10.1016/j.molcel.2012.06.033

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression2012

    • Author(s)
      Takahashi A, et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 419 Issue: 2 Pages: 268-273

    • DOI

      10.1016/j.bbrc.2012.02.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obesity resistance and increased hepatic expression of catabolism- related mRNAs in Cnot3+/- mice2011

    • Author(s)
      Morita M, Oike Y, Yamamoto T (10名)
    • Journal Title

      EMBO J

      Volume: Vol.30 Issue: 22 Pages: 4678-4691

    • DOI

      10.1038/emboj.2011.320

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT2011

    • Author(s)
      Fabian MR, Cieplak MK, Yamamoto T (11名)
    • Journal Title

      Nat Struct and Mol Biol

      Volume: Vol.18 Issue: 11 Pages: 1211-1217

    • DOI

      10.1038/nsmb.2149

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability.2011

    • Author(s)
      Ito K
    • Journal Title

      Protein & Cell

      Volume: 2 Issue: 9 Pages: 755-763

    • DOI

      10.1007/s13238-011-1092-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NYAP : a phosphoprotein family that links PI3K to WAVE1 signalling in neurons2011

    • Author(s)
      K.Yokoyama
    • Journal Title

      EMBO J

      Volume: 30 Issue: 23 Pages: 4739-4754

    • DOI

      10.1038/emboj.2011.348

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development2011

    • Author(s)
      Chen C, et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 411 Issue: 2 Pages: 360-364

    • DOI

      10.1016/j.bbrc.2011.06.148

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitination.2011

    • Author(s)
      Suzuki T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 409 Issue: 1 Pages: 70-4

    • DOI

      10.1016/j.bbrc.2011.04.107

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability2011

    • Author(s)
      Ito K, et al
    • Journal Title

      Protein Cell

      Volume: 2 Issue: 4 Pages: 755-763

    • DOI

      10.1111/j.1365-2443.2011.01492.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic incorporation of a photo-crosslinkable amino acid reveals novel protein complexes with GRB2 in mammalian cells.2011

    • Author(s)
      Hino N., et al
    • Journal Title

      J Mol Biol

      Volume: 406 Pages: 343-353

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CNOT2-depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.2011

    • Author(s)
      Ito K., et al
    • Journal Title

      Genes to Cells

      Volume: 4 Pages: 368-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity2010

    • Author(s)
      Wang H, Morita M, Yang X, Yamamoto T (12名)
    • Journal Title

      EMBO J

      Volume: Vol.29 Issue: 15 Pages: 2566-2576

    • DOI

      10.1038/emboj.2010.152

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The structural basis for deadenylation by the CCR4-NOT complex2010

    • Author(s)
      Bartlam M, Yamamoto T
    • Journal Title

      Protein & Cell

      Volume: Vol.1 Issue: 5 Pages: 443-452

    • DOI

      10.1007/s13238-010-0060-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism under lyingaberrant EGFR signaling.2010

    • Author(s)
      Tasaki S., et al
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.2010

    • Author(s)
      Watanabe M., et al
    • Journal Title

      FEBS Lett.

      Volume: 585 Pages: 65-70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Sucl-as sociated neurotrophic factor-induced tyrosine-phosphorylated target-2.2010

    • Author(s)
      Koshiba S., et al
    • Journal Title

      J Struct Funct Genomics.

      Volume: 11 Pages: 125-141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal .structure of the human CNOT6L nuclease domain reveals strictpoly(A) substrate specificity.2010

    • Author(s)
      Wang H., et al
    • Journal Title

      EMBO J.

      Volume: 129 Pages: 2566-2576

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The structural basis for deadenylation by the CCR4-NOT complex.2010

    • Author(s)
      Bartlam M, Yamamoto T.
    • Journal Title

      Protein & Cell

      Volume: 1 Pages: 443-452

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for the antiproliferative activity of the Tob-hCaf1 complex2009

    • Author(s)
      Horiuchi M, Takeuchi K, Yamamoto T (10名)
    • Journal Title

      J Biol Chem

      Volume: Vol.284 Issue: 19 Pages: 13244-13255

    • DOI

      10.1074/jbc.m809250200

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteasome-mediated degradation of Tob is pivotal for triggering UV-induced apoptosis2009

    • Author(s)
      Suzuki T, Tsuzuku J, Yamamoto T (5名)
    • Journal Title

      Oncogene

      Volume: Vol.28 Issue: 3 Pages: 401-411

    • DOI

      10.1038/onc.2008.387

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ErbBファミリー研究の黎明期2013

    • Author(s)
      山本雅
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肥満症発症におけるCCR4-NOT脱アデニル化酵素活性サブユニットの重要性2013

    • Author(s)
      高橋明格, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ストレス応答におけるCCR4-NOT複合体のリン酸化の解析2013

    • Author(s)
      星名実幸, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Importance of CCR4-NOT complex-mediated mRNA degradation in liver development2013

    • Author(s)
      鈴木亨, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Alteration of T cell development and functions in mice with T cell-specific CNOT3 deletion2013

    • Author(s)
      呉羽拓, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肺癌におけるCNOT3の機能解析2013

    • Author(s)
      白井陽太郎, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪組織の発達と機能におけるCNOT3 の役割2013

    • Author(s)
      李雪, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] CCR4-NOT複合体とRNA結合因子による, 肝臓における代謝機構の解析2013

    • Author(s)
      森田斉弘, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] B細胞分化におけるCCR4-NOT脱アデニル化酵素複合体サブユニットCNOT3の機能解析2013

    • Author(s)
      井上毅, 山本雅ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] CCR4-NOT複合体による肥満症制御機構の解明2013

    • Author(s)
      高橋明格, 山本雅ら
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of cell growth and death by Tob protein2013

    • Author(s)
      山本雅
    • Organizer
      DSKミニシンポジウム : Perspectives in Cancer Biology
    • Place of Presentation
      京都大学大学院メディカルイノベーションセンター
    • Year and Date
      2013-10-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Physiology of deadenylation : Analysis of phenotypes and gene expression profiles in mice with altered deadenylation2013

    • Author(s)
      山本雅
    • Organizer
      国際システムズバイオロジー学会
    • Place of Presentation
      コペンハーゲン
    • Year and Date
      2013-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] CCR4-NOT 複合体の肥満における機能解析2013

    • Author(s)
      高橋明格, 山本雅ら
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      愛媛ひめぎんホール
    • Year and Date
      2013-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] CCR4-NOT複合体の肥満における機能解析2013

    • Author(s)
      高橋明格、森田斉弘、鈴木亨、山本雅
    • Organizer
      第 15 回 日本RNA学会年会
    • Place of Presentation
      愛媛ひめぎんホール
    • Related Report
      2013 Annual Research Report
  • [Presentation] Physiology of deadenylation: Analysis of phenotypes and gene expression profiles in mice with altered deadenylation2013

    • Author(s)
      山本雅、高橋明格、李雪、菊口千智、森田斉弘、鈴木亨
    • Organizer
      第14回国際システムズバイオロジー学会
    • Place of Presentation
      コペンハーゲン、デンマーク
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of cell growth and death by Tob protein2013

    • Author(s)
      山本雅
    • Organizer
      DSKミニシンポジウム: Perspectives in Cancer Biology
    • Place of Presentation
      京都大学大学院メディカルイノベーションセンター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functonal analysis of γ-tubulin1 and γ-tubulin2 in cancer cell line Poster presentation2013

    • Author(s)
      大橋翼、山本雅、大杉美穂
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] CCR4-NOT複合体による肥満症制御機構の解明2013

    • Author(s)
      高橋明格、山本雅
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional analysis of CNOT3 in lung cancer2013

    • Author(s)
      白井陽太郎、山本雅
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肥満症発症におけるCCR4-NOT脱アデニル化酵素活性サブユニットの重要性2013

    • Author(s)
      高橋明格、森田斉弘、鈴木亨、山本雅
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストレス応答におけるCCR4-NOT複合体のリン酸化の解析2013

    • Author(s)
      星名実幸、星名直祐、鈴木亨、高橋明格、山本雅
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脂肪組織の発達と機能におけるCNOT3の役割2013

    • Author(s)
      李雪、高橋明格、森田斉弘、鈴木亨、山本雅
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] CCR4-NOT複合体と RNA結合因子による、肝臓における代謝制御機構の解析2013

    • Author(s)
      森田斉弘、Nadeem Siddiqui、Christopher Rouya、長嶋剛史、Ola Larsson、高橋明格、Marc Fabian、岡田眞理子、山本雅、Nahum Sonenberg
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] B細胞分化における CCR4-NOT脱アデニル化酵素複合体サブユニットCNOT3の機能解析2013

    • Author(s)
      井上毅、森田斉弘、足達俊吾、夏目徹、深尾太郎、小原收、山本雅、黒崎知博
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of CCR4-NOT deadenylase complex in the regulation of energy metabolism2012

    • Author(s)
      高橋明格, 山本雅ら
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] The Role of the CCR4-NOT Deadenylase Complex in Obesity2012

    • Author(s)
      高橋明格, 山本雅ら
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] A Critical Role for Deadenylase-mediated mRNA Degradation in Metabolism and Obesity2012

    • Author(s)
      Morita M, Yamamoto T, et al.
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 脱アデニル酵素CCR4-NOT複合体による肥満症制御2012

    • Author(s)
      高橋明格, 山本雅ら
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都
    • Year and Date
      2012-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell signaling in the brain2012

    • Author(s)
      山本雅
    • Organizer
      19th East Asia Joint Symposium on Biomedical Research
    • Place of Presentation
      ソウル, 韓国
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 脱アデニル化酵素 CCR4-NOT 複合体による肥満症制御2012

    • Author(s)
      高橋明格
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Role of the CCR4-NOT Deadenylase Complex in Obesity.2012

    • Author(s)
      高橋明格
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Male pronuclear formation in a cell-free system from mouse oocytes.2012

    • Author(s)
      Inoue, F.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Critical Role for Deadenylase-mediated mRNA Degradation in Metabolism and Obesity.2012

    • Author(s)
      Morita M
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression Analysis of γ-tubulin2 in Cancer Cells.2012

    • Author(s)
      Ohashi, T
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of Multifunctional Mitotic Motor Kid/kinesin-10.2012

    • Author(s)
      Soeda, S
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of CCR4-NOT deadenylase complex in the regulation of energy metabolism.2012

    • Author(s)
      Takahashi, A
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cell signaling in the brain2012

    • Author(s)
      Yamamoto, T
    • Organizer
      19th East Asia Joint Symposium on Biomedical Research
    • Place of Presentation
      Seoul National University, Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tob2 inhibits adipogenesis2012

    • Author(s)
      Akinori Takahashi
    • Organizer
      第5回東京大学GCOE リトリート生体シグナルを基盤とする統合生命科学
    • Place of Presentation
      八ヶ岳ロイヤルホテル
    • Related Report
      2011 Annual Research Report
  • [Presentation] Competition of Cdc7/Tob with Cul4-DDB1-Cdt2 E3 complex in DNA damage-induced apoptosis2011

    • Author(s)
      鈴木亨, 山本雅ら
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Tob2 inhibits adipocyte differentiation2011

    • Author(s)
      Takahashi A, Yamamoto T, et al
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Tropomyosin 4, actin binding protein, contributes to the proper spindle orientation during mitosis and meiosis2011

    • Author(s)
      Tokai-Nishiizumi N, Yamamoto T, et al
    • Organizer
      The 2011 Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      Denver, Co, USA
    • Year and Date
      2011-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] The CCR4-NOT complex, a deadenylase that controls decay for specific sets of mRNAs in a context- dependent manner2011

    • Author(s)
      山本雅
    • Organizer
      東大フォーラム2011
    • Place of Presentation
      リヨン, フランス
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] CDC7-dependent inhibition of Tob degradation maintains cell survival after DNA damage2011

    • Author(s)
      鈴木亨, 山本雅ら
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Localization of Kif8A/kinesin-8 depends on its tail domain and microtubule stability2011

    • Author(s)
      大杉美穂, 山本雅ら
    • Organizer
      International symposium "Cel Division"
    • Place of Presentation
      箱根
    • Year and Date
      2011-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Female pronuclear formation in mouse oocytes requires Kid-mediated telophase chromosome clustering2011

    • Author(s)
      Miho Ohsugi
    • Organizer
      6th UK-Japan Cell Cycle Workshop
    • Place of Presentation
      Lake Windermere, England
    • Related Report
      2011 Annual Research Report
  • [Presentation] Localization of Kif18A/kinesin-8 depends on its tail domain and microtubule stability2011

    • Author(s)
      Miho Ohsugi
    • Organizer
      International symposium “Cell Division”
    • Place of Presentation
      箱根
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tob2 inhibits adipocyte differentiation2011

    • Author(s)
      Akinori Takahashi
    • Organizer
      東大フォーラム2011
    • Place of Presentation
      Lyon, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] The CCR4-NOT complex, a deadenylase that controla decay for specific sets of mRNAs in a context-dependent manner2011

    • Author(s)
      Tadashi Yamamoto
    • Organizer
      東大フォーラム2011
    • Place of Presentation
      Lyon, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Competition of Cdc7/Tob with Cul4-DDB1-Cdt2 E3 complex in DNA damage-induced apoptosis2011

    • Author(s)
      Toru Suzuki
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tropomyosin 4, actin binding protein, contributes to the proper spindle orientation during mitosis and meiosis2011

    • Author(s)
      Noriko Tokai-Nishizumi
    • Organizer
      The 2011 Annual Meeting of the American Society for Cell Biology
    • Place of Presentation
      Denver, CO, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tob2 inhibits adipocyte differentiation2011

    • Author(s)
      Akinori Takahashi
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] CNOT7 deficiency affects protein association and activities of murine Ccr4-Not deadenylase complex, leading to abnormal spamatogenesis2010

    • Author(s)
      Zang Y, Yamamoto T, et al
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] CNOT7 deficiency affects protein association and activities ofmurine Ccr4-Not deadenylase complex, leading to abnormal , spamatogenesis2010

    • Author(s)
      Yan Zhang
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸、神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of Tob2 in adipocyte differentiation2010

    • Author(s)
      高橋明格
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸、神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] A critical role of deadenylase-mediated mRNA degration in energy metabolism2010

    • Author(s)
      森田斉弘, 山本雅ら
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Acritical role of deadenylase-mediated mRNA degradation in energy me tabolism2010

    • Author(s)
      森田斉弘、山本雅
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜・長奈川國際会議場
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] CNOT1 and CNOT2 are essential for maintaining the structural integrity and deadenylase activity of the CCR4-NOT complex2010

    • Author(s)
      伊藤健太郎, 山本雅ら
    • Organizer
      The 17th East Asia Joint and 9th Cross-Strait Symposium on n Biomedical Research
    • Place of Presentation
      Gis NTU Convention Center Taipei, Taiwan
    • Year and Date
      2010-07-01
    • Related Report
      2013 Final Research Report
  • [Presentation] デアデニレース篠合体の構造と機能2010

    • Author(s)
      伊藤健太郎、山本雅
    • Organizer
      第2回シグナルネットワーク研究会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] CNOT1 and CNOT2 are essential for maintaining the structura lintegrity and deadenylase activity of the CCR4-NOT complex2010

    • Author(s)
      伊藤健太郎
    • Organizer
      The 17th East Asia Joint and 9th Cross-Strait Symposium on Biomedical Research
    • Place of Presentation
      Gis NTU Convention Center Taipei, Taiwan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anti-proliferative protein Tob is relevant to RNA metabolism and facilitates the interaction between P-body and stress granule2009

    • Author(s)
      小川晋一, 山本雅ら
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Critical involvement of deadenylase-mediated mRNA degradation in energy metabolism2009

    • Author(s)
      森田斉弘, 山本雅ら
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of CCR4-NOT deadenylase complex in spermatogenesis and energy metabolism2009

    • Author(s)
      山本雅
    • Organizer
      KSMBMB Annual International conference
    • Place of Presentation
      ソウル, 韓国
    • Year and Date
      2009-10-29
    • Related Report
      2013 Final Research Report
  • [Book] ErbB2/HER2, its contribution to basic cancer biology and development of molecular targeted therapy2011

    • Author(s)
      Yamamoto T, et al.
    • Publisher
      INTECH Croatia
    • Related Report
      2013 Final Research Report
  • [Book] Breast Cancer Cells, Book 12011

    • Author(s)
      Saito M
    • Total Pages
      32
    • Publisher
      INTECH
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://groups.oist.jp/csu/unit-introduction

    • Related Report
      2013 Final Research Report
  • [Remarks] OIST 細胞シグナルユニットホームページ

    • URL

      https://groups.oist.jp/ja/csu

    • Related Report
      2012 Annual Research Report
  • [Remarks] OIST 細胞シグナルユニットホームページ

    • URL

      https://groups.oist.jp/ja/csu

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/gannsig/paper.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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