| Budget Amount *help |
¥207,350,000 (Direct Cost: ¥159,500,000、Indirect Cost: ¥47,850,000)
Fiscal Year 2013: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2012: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2011: ¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2010: ¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2009: ¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
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| Research Abstract |
T lymphocytes are known to play important roles in the control of the immune system that is essential to maintain homeostasis in our body, thereby keeping our health. It is therefore important to understand molecular mechanisms that govern differentiation of several T lymphocyte subsets. This study mainly focused on a transcription factors network that regulates CD4-helper versus CD8-cytotoxic lineage determination and revealed that antagonistic interplay between ThPOK and Runx transcription factors is central to control this lineage dichotomy. In addition, this study not only provided novel insights into an epigenetic regulation of Thpok gene but also identified Bcl11b and SATB1 as novel upstream factors regulating Thpok gene expression. Furthermore, we found an unappreciated developmental plasticity retained in CD4+ T cells that allow them to be reprogrammed to acquire cytotoxic-related features upon exposure to the gut specific environment.
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