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The mechanism for activation of aldosterone/mineralocorticoid receptor in life style-related diseases

Research Project

Project/Area Number 21229012
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionThe University of Tokyo

Principal Investigator

FUJITA Toshiro  東京大学, 先端科学技術研究センター, 特任研究員、名誉教授 (10114125)

Co-Investigator(Kenkyū-buntansha) NAGASE Miki  順天堂大学, 医学部解剖学, 准教授 (60302733)
ANDO Katsuyuki  東京大学, 医学部附属病院, 特任准教授 (60184313)
安東 克之  東京大学, 医学部附属病院, 特任准教授 (30436456)
Co-Investigator(Renkei-kenkyūsha) TANAKA Hirotoshi  東京大学, 医科学研究所, 教授 (00171794)
Project Period (FY) 2009-05-11 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥211,770,000 (Direct Cost: ¥162,900,000、Indirect Cost: ¥48,870,000)
Fiscal Year 2013: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2012: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2010: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2009: ¥66,170,000 (Direct Cost: ¥50,900,000、Indirect Cost: ¥15,270,000)
Keywordsアルドステロン / 食塩感受性高血圧 / エピジェネティクス / 交感神経 / 核内受容体 / Rac1 / 酸化的ストレス / 鉱質コルチコイド受容体 / ポドサイト / 食塩 / 生活習慣病 / Racl / 心腎連関 / 酸化ストレス / 腎障害 / メタボリックシンドローム / アルドステロン分泌刺激因子 / 肥満糖尿病マウス / 臓器障害
Research Abstract

We previously reported the novel mechanism of mineralocorticoid receptor (MR) activation by Rac1 (Nat Med 2008). In this project, we found that activation of Rac1-MR pathway, induced by reactive oxygen species, causes injury of the heart, kidney and brain. Rac1-MR activation in glomerular podocytes and renal tubular cells causes glomerular damage and salt-sensitive hypertension (JCI 2011), respectively.
We also found that activation of glucocorticoid receptor (GR), another nuclear receptor, stimulates renal sympathetic activity resulting in activation of GR-WNK4-NCC pathway by changing histone modulation (Nat Med 2011). It suggests that epigenetic modulation is intimately involved in the MR and GR activation with sodium reabsorption in the different tubular sites.
Taken together, we identified the two novel pathways of MR- and GR-activation for the development of salt-sensitive hypertension, leading to the clue of epigenetic regulation of organ damage in metabolic syndrome.

Assessment Rating
Verification Result (Rating)

A-

Report

(7 results)
  • 2014 Research Progress Assessment (Verification Result) ( PDF )
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (137 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (105 results) (of which Peer Reviewed: 103 results) Presentation (31 results) (of which Invited: 14 results) Remarks (1 results)

  • [Journal Article] Mechanism of Salt-Sensitive Hypertension : Focus on Adrenal and Sympathetic Nervous Systems2014

    • Author(s)
      Fujita T
    • Journal Title

      J Am Soc Nephrol

      Volume: 25(6) Pages: 1148-55

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency2014

    • Author(s)
      Jimbo, R., Kawakami-Mori, F., Mu, S., Hirohama, D., Majtan, B., Shimizu, Y., Yatomi, Y., Fukumoto, S., Fujita, T., and Shimosawa, T.
    • Journal Title

      Kidney Int

      Volume: 85 Issue: 5 Pages: 1103

    • DOI

      10.1038/ki.2013.332

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local Mineralocorticoid Receptor Activation and the Role of Rac1 in Obesity-Related Diabetic Kidney Disease.2014

    • Author(s)
      Yoshida S, Ishizawa K, Ayuzawa N, Ueda K, Takeuchi M, Kawarazaki W, Fujita T, Nagase M.
    • Journal Title

      Nephron Exp Nephrol

      Volume: in press Issue: 1 Pages: 16-24

    • DOI

      10.1159/000358758

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of murine renal distal convoluted tubular cells for the target genes of mineralocorticoid receptor2014

    • Author(s)
      Kohei Ueda, Katsunori Fujiki, Katsuhiko Shirahige, Celso E. Gomez-Sanchez, Toshiro Fujita, Masaomi Nangaku, Miki Nagase.
    • Journal Title

      Biochemical and Biophysical Research Commnications

      Volume: 445 Issue: 1 Pages: 132-137

    • DOI

      10.1016/j.bbrc.2014.01.125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading2014

    • Author(s)
      Yoshida S, Ishizawa K, Ayuzawa N, Ueda K, Takeuchi M, Kawarazaki W, Fujita T, Nagase M.
    • Journal Title

      Clin Exp Nephrol

      Volume: in press Issue: 4 Pages: 593-599

    • DOI

      10.1007/s10157-013-0893-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Salt-Sensitive Hypertension: Focus on Adrenal and Sympathetic Nervous Systems2014

    • Author(s)
      Fujita, T
    • Journal Title

      J Am Soc Nephrol

      Volume: in press Issue: 6 Pages: 1148-1155

    • DOI

      10.1681/asn.2013121258

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease2013

    • Author(s)
      Nagase M, Fujita T
    • Journal Title

      Nat Rev Nephrol

      Volume: 9(2) Pages: 86-98

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice.2013

    • Author(s)
      Hayashi, M., Tojo, A., Shimosawa, T., and Fujita, T.
    • Journal Title

      J Diabetes Res

      Volume: - Pages: 134395-134395

    • DOI

      10.1155/2013/134395

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRET-based sensor analysis reveals caveolae are spatially distinct Ca2+ stores in endothelial cells.2013

    • Author(s)
      Isshiki, M., Nishimoto, M., Mizuno, R., and Fujita, T.
    • Journal Title

      Cell Calcium

      Volume: 54 Issue: 6 Pages: 395-403

    • DOI

      10.1016/j.ceca.2013.09.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing oxidized LDL receptor.2013

    • Author(s)
      Ogura S, Shimosawa T, Mu SY, Sonobe T, Kawakami-Mori F, Wang H, Uetake y. Yoshida K, Yatomi Y, S hirai M, Fujita T.
    • Journal Title

      Am J Physiol Heart and Circ Physiol

      Volume: 305(2) Issue: 2 Pages: H155-H162

    • DOI

      10.1152/ajpheart.00169.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat.2013

    • Author(s)
      Yamamoto, T., Izumi-Yamamoto, K., Iizuka, Y., Shirota, M., Nagase, M., Fujita, T., and Gotoda, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 440 Issue: 4 Pages: 521-526

    • DOI

      10.1016/j.bbrc.2013.09.096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of CNS in salt-sensitive hypertension2013

    • Author(s)
      Fujita, M., and Fujita, T
    • Journal Title

      Curr Hypertens Rep

      Volume: 15 Issue: 4 Pages: 390-394

    • DOI

      10.1007/s11906-013-0358-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension2013

    • Author(s)
      Kawarazaki, W., and Fujita, T
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 40 Issue: 12 Pages: 929-936

    • DOI

      10.1111/1440-1681.12177

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease2012

    • Author(s)
      Fujita M, Ando K, Kawarazaki H, Kawarasaki C, Muraoka K, Ohtsu H, Shimizu H, Fujita T
    • Journal Title

      Hypertension

      Volume: 59(1) Pages: 105-12

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation2012

    • Author(s)
      Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T
    • Journal Title

      Am Soc Nephrol

      Volume: 23(6) Pages: 997-1007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes : role of small GTPase Rac12012

    • Author(s)
      Nagase M, Ayuzawa N, Kawarazaki W, Ishizawa K, Ueda K, Yoshida S, Fujita T
    • Journal Title

      Hypertension

      Volume: 59(2) Pages: 500-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NADPH oxidase-mediated Rac1 GTP activity is necessary for non-genomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus2012

    • Author(s)
      Kawakami-Mori F, Shimosawa T, Mu S, Wang H, Ogura S, Yatomi Y, Fujita T
    • Journal Title

      Am J Physiol Endoc Metab

      Volume: 302

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptors in the pathophysiology of chronic kidney diseases and the metabolic syndrome2012

    • Author(s)
      Shibata S, Fujita T
    • Journal Title

      Mol Cell Endocrinol

      Volume: 350(2)

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
  • [Journal Article] Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes: role of small GTPase Rac12012

    • Author(s)
      Nagase M, Ayuzawa N, Kawarazaki W, Ishizawa K, Ueda K, Yoshida S, Fujita T.
    • Journal Title

      Hypertension

      Volume: 59 Issue: 2 Pages: 500-6

    • DOI

      10.1161/hypertensionaha.111.185520

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus2012

    • Author(s)
      Kawakami-Mori F, Shimosawa T, Mu S, Wang H, Ogura S, Yatomi Y, Fujita T.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302 Issue: 4 Pages: E425-E432

    • DOI

      10.1152/ajpendo.00227.2011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation2012

    • Author(s)
      Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ihizawa N, Ueda K, Fujita T
    • Journal Title

      J Am Soc Nephrol

      Volume: 23 Issue: 6 Pages: 997-1007

    • DOI

      10.1681/asn.2011070734

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptor-Rac1 activation and oxidative stress play major roles in salt-induced hypertension and kidney injury in prepubertal rats2012

    • Author(s)
      Kawarazaki H, Ando K, Shibata S, Muraoka K, Fujita M, Kawarasaki C, Fujita T
    • Journal Title

      J Hypertens

      Volume: 30 Issue: 10 Pages: 1977

    • DOI

      10.1097/hjh.0b013e3283576904

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiology of salt sensitivity hypertension.2012

    • Author(s)
      Ando K, Fujita T
    • Journal Title

      Ann Med

      Volume: 44 Issue: sup1 Pages: S119-S126

    • DOI

      10.3109/07853890.2012.671538

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The kidney and hypertension: Pathogenesis of salt-sensitive hypertension2012

    • Author(s)
      Shimosawa T, Mu S, Shibata S, Fujita T
    • Journal Title

      Curr Hypertens Rep

      Volume: 14 Issue: 5 Pages: 468

    • DOI

      10.1007/s11906-012-0284-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reply to: Does a beta(2)-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney?2012

    • Author(s)
      Mu S, Shimosawa T, Fujita T
    • Journal Title

      Nat Med

      Volume: 18 Pages: 1325-1327

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation2012

    • Author(s)
      Kawarazaki W, Fujita T, et al.
    • Journal Title

      J Am Soc Nephrol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrantly glycosylated IgA1 as a factor in the pathogenesis of IgA nephropathy2012

    • Author(s)
      Tanaka M, Fujita T, et al.
    • Journal Title

      Clin Dev Immunol

      Volume: (in press) Issue: 2 Pages: 198-199

    • DOI

      10.1111/j.1744-9987.2011.01041.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease2012

    • Author(s)
      Fujita M, Fujita T, et al.
    • Journal Title

      Hypertension

      Volume: 59 Pages: 105-112

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists2012

    • Author(s)
      Takahashi K, Fujita T, et al.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 2099-2106

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus2012

    • Author(s)
      Kawakami-Mori F, Fujita T, et al.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes : role of small GTPase Rac12012

    • Author(s)
      Nagase M, Fujita T, et al.
    • Journal Title

      Hypertension

      Volume: 59 Pages: 500-506

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans2012

    • Author(s)
      Hasegawa Y, Fujita T, et al.
    • Journal Title

      Circulation

      Volume: 125 Issue: 9 Pages: 1122

    • DOI

      10.1161/circulationaha.111.054346

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New short interfering RNA-based therapies for glomerulonephritis2011

    • Author(s)
      Shimizu H, Fujita T
    • Journal Title

      Nat RevNephrol

      Volume: 7 Pages: 407-415

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension2011

    • Author(s)
      Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T
    • Journal Title

      Nat Med

      Volume: 17 Pages: 573-580

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway2011

    • Author(s)
      Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayusawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 3233-3243

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common variation in GPC5 is associated with acquired nephrotic syndrome2011

    • Author(s)
      Okamoto K, Tokunaga K, Doi K, Fujita T, Suzuki H, Katoh T, Watanabe T, Nishida N, Mabuchi A, Takahashi A, Kubo M, Maeda S, Nakamura Y, Noiri E
    • Journal Title

      Nat Genet

      Volume: 43(5) Pages: 459-63

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARγ-Dependent Nongenomic Signaling2011

    • Author(s)
      Endo Y, Suzuki M, Yamada H, Horita S, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T
    • Journal Title

      Cell Metab

      Volume: 13(5) Pages: 550-61

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptor activation : a major contributor to salt-induced renal injury and hypertension in young rats2011

    • Author(s)
      Kawarazaki H, Fujita T, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 300

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension2011

    • Author(s)
      Shibata S, Fujita T
    • Journal Title

      Curr Hypertens Rep

      Volume: 13 Pages: 109-115

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway2011

    • Author(s)
      Shibata, S. et al.
    • Journal Title

      J Clin Invest.

      Volume: 121 Issue: 8 Pages: 3233

    • DOI

      10.1172/jci43124

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New short interfering RNA-based therapies for glomerulonephritis2011

    • Author(s)
      Shimizu H, Fujita T
    • Journal Title

      Nat Rev Nephrol

      Volume: 7 Issue: 7 Pages: 407-415

    • DOI

      10.1038/nrneph.2011.61

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPAR_Y-dependent non-genomic signaling2011

    • Author(s)
      Endo Y, Fujita T, et al.
    • Journal Title

      Cell Metab

      Volume: 13 Pages: 550-561

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glypican 5 predisposes podocytes to nephrotic proteinuria2011

    • Author(s)
      Okamoto K, Fujita T, et al.
    • Journal Title

      Nat Genet

      Volume: 43 Pages: 459-463

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic modulation of the renal ss-adrenergic-WNK4 pathway in salt-sensitive hypertension2011

    • Author(s)
      Mu SY, Fujita T, et al.
    • Journal Title

      Nat Med

      Volume: 17 Pages: 573-580

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relative role of fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia after living donor kidney transplantation : a 1-year prospective observational study2011

    • Author(s)
      Kawarazaki H, Fujita T, et al.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Pages: 2691-2695

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of myeloperoxidase in membranous nephropathy-like deposits in patients with anti-neutrophil cytoplasmic antibody-associated glomerul onephritis2011

    • Author(s)
      Hanamura K, Fujita T, et al.
    • Journal Title

      Hum Pathol

      Volume: 42 Pages: 649-658

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-FGF23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice2011

    • Author(s)
      Aono Y, Fujita T, et al.
    • Journal Title

      J Bone Miner Res

      Volume: 26 Issue: 4 Pages: 803-810

    • DOI

      10.1002/jbmr.275

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of a putative carbonic anhydrase II-binding domain in the electrogenic Na(+)-HCO3(-)cotransporter NBCel expressed in Xenopus oocytes2011

    • Author(s)
      Yamada H, Fujita T, et al.
    • Journal Title

      Channels

      Volume: 5 Pages: 106-109

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions2011

    • Author(s)
      Nishi H, Fujita T, et al.
    • Journal Title

      Am J Pathol

      Volume: 17 Pages: 128-139

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New short interfering RNA-based therapies for glomerulonephritis. Functional characterization of nonsynonymous single nucleotide polymorphisms in the electrogenic Na+-HCO3- cotransporter NBCe1A2011

    • Author(s)
      Yamazaki O, Fujita T, et al.
    • Journal Title

      Pflugers Arch.

      Volume: 461 Pages: 249-259

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrinological aspects of proteinuria and podocytopathy in diabetes : role of the aldosterone/mineralocorticoid receptor system2011

    • Author(s)
      Nagase M, Fujita T
    • Journal Title

      Curr Diabetes Rev

      Volume: 7 Pages: 8-16

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GADD45SS Determines Chemoresistance and invasive Growth of Side Population Cells of Human Embryonic Carcinoma2011

    • Author(s)
      Inowa T, Fujita T, et al.
    • Journal Title

      Stem Cells Int

      Volume: 14 Pages: 782967-782967

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-200b precursor can ameliorate renal tubulointerstitial fibrosis2011

    • Author(s)
      Oba S, Fujita T, et al.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silver-enhanced immunogold scanning electron microscopy using vibratome sections of rat kidneys : detection of albumin filtration and reabsorption2011

    • Author(s)
      Kinugasa S, Fujita T, et al.
    • Journal Title

      Med Mol Morphol

      Volume: 43 Pages: 218-225

    • NAID

      10027752382

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective albuminuria via podocyte albumin transport in puromycin nephrotic rats is attenuated by an inhibitor of NADPH oxidase2011

    • Author(s)
      Kinugasa S, Fujita T, et al.
    • Journal Title

      Kidney Int.

      Volume: 80 Issue: 12 Pages: 1328-1338

    • DOI

      10.1038/ki.2011.282

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease2011

    • Author(s)
      Hasegawa H, Fujita T, et al.
    • Journal Title

      Kidney Int.

      Volume: 78 Pages: 975-980

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate2011

    • Author(s)
      Jutabha P, Fujita T, et al.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 35123-35132

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective membrane expression of the Na(+)-HCO(3)(-)cotransporter NB Ce1 is associated with familial migraine2011

    • Author(s)
      Suzuki M, Fujita T, et al.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Pages: 15963-15968

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil elastase contribute to acute lung injury induced by bilateral nephrectomy2011

    • Author(s)
      Ishii T, Fujita T, et al.
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 1665-1673

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibrobl asts against oxidative stress under ischemic conditions.2011

    • Author(s)
      Nishi H, Fujita T, et al.
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 128-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrinological aspects of proteinuria and podocytopathy in diabetes : role of the aldosterone/mineralocorticoid receptor system.2011

    • Author(s)
      Nagase M, Fujita T.
    • Journal Title

      Curr Diabetes Rev

      Volume: 7 Pages: 8-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of nonsynonymous single nucleotide polymor phisms in the electrogenic Na+-HCO3-cotransporter NBCe1A.2011

    • Author(s)
      Yamazaki 0, Fujita T, et al.
    • Journal Title

      Pflugers Arch

      Volume: 461 Pages: 249-259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum biological antioxidant potential predicts the prognosis of hemodialysis patients.2011

    • Author(s)
      Ishii T, Fujita T, et al.
    • Journal Title

      Nephron Clin Pract

      Volume: 117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of leukotriene B4 in accelerated hyperhpidaemic renal injury.2011

    • Author(s)
      Doi K, Fujita T, et al
    • Journal Title

      Nephrology(Carlton)

      Volume: 16 Pages: 304-309

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of a putative carbonic anhydrase II-binding domain in t2011

    • Author(s)
      Yamada H, Fujita T, et al.
    • Journal Title

      Channels (Austin)

      Volume: 5 Pages: 106-109

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis.2011

    • Author(s)
      Lo YF, Fujita.T, et al.
    • Journal Title

      Kidney Int

      Volume: 79 Pages: 730-741

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-FGF23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice.2011

    • Author(s)
      Aono Y, Fujita T, et al.
    • Journal Title

      J Bone Miner Res

      Volume: 26 Pages: 803-810

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of myeloperoxidase in membranous nephropathy-like deposits in patients with anti-neutrophil cytoplasmic antibody-associated glomerul onephritis.2011

    • Author(s)
      Hanamura K, Fujita T, et al.
    • Journal Title

      Hum Pathol

      Volume: 42 Pages: 649-658

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats.2011

    • Author(s)
      Kawarazaki H, Fujita T, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: (掲載確定)(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relative role of, fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia after living donor kidney transplantation : a 1-year prospective observational study.2011

    • Author(s)
      Kawarazaki H, Fujita T, et al.
    • Journal Title

      Nephrol Dial Transplant

      Volume: (掲載確定)(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.2011

    • Author(s)
      Mu SY, Fujita T, et al.
    • Journal Title

      Nat Med

      Volume: (掲載確定)(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARy-dependent non-genomic signaling.2011

    • Author(s)
      Endo Y, Fujita T, et al.
    • Journal Title

      Cell Metab

      Volume: (掲載確定)(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variation in GPC5 is associated with acquired nephrotic syndrome.2011

    • Author(s)
      Okamoto K, Fujita T, et al.
    • Journal Title

      Nat Genet

      Volume: (掲載確定)(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrantly glycosylated IgAl as a factor in the pathogenesis of IgA nephropathy.2011

    • Author(s)
      Tanaka M, Fujita T, et al.
    • Journal Title

      Clin Dev Immunol

      Volume: (掲載確定)(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siRNA-based therapy for glomerulonephritis2010

    • Author(s)
      Shimizu H, Hori Y, Kaname S, Yamada K, Nishiyama N, Matsumoto S, Miyata K, Oba M, Yamada A, Kataoka K, Fujita T
    • Journal Title

      J Am Soc Nephrol

      Volume: 21(4) Pages: 622-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptors, saltsensitive hypertension, and metabolic syndrome2010

    • Author(s)
      Fujita T
    • Journal Title

      Hypertension

      Volume: 55(4) Pages: 813-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome.2010

    • Author(s)
      Fujita T
    • Journal Title

      Hypertension

      Volume: 53 Pages: 813-818

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siRNA-based therapy for glomerulonephritis.2010

    • Author(s)
      Shimizu H, Fujita T, et al.
    • Journal Title

      J Am Soc Nephrol

      Volume: 21 Pages: 622-633

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory and imaging features of kidney involvement in autoimmune pancreatitis : incidence, correlation, and steroid therapy response.2010

    • Author(s)
      Nishi H, Fujita T, et al.
    • Journal Title

      Clin Nephrol

      Volume: 73 Pages: 253-259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Very low but stable glomerular filtration rate after living kidney donation : is the concept of "chronic kidney disease" applicable to kidney donors2010

    • Author(s)
      Kido R, Fujita T, et al
    • Journal Title

      Clin Exp Nephrol

      Volume: 14 Pages: 356-362

    • NAID

      10027706776

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silver-enhanced immunogold scanning electron microscopy using vibr atome sections of rat kidneys : detection of albumin filtration and reabsorption.2010

    • Author(s)
      Kinugasa S, Fujita T, et al.
    • Journal Title

      Med Mol Morphol

      Volume: 43 Pages: 218-225

    • NAID

      10027752382

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of glyoxalase system in renal hypoxia.2010

    • Author(s)
      Inagi R, Fujita T, et al.
    • Journal Title

      Adv Exp Med Biol

      Volume: 662 Pages: 49-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization and mechanism of nephrocalcinosis in pseudo-Bartter's synd rome..2010

    • Author(s)
      Tojo A, Fujita T, et al.
    • Journal Title

      Kidney Int

      Volume: 77 Pages: 831-831

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect Study Investigators.Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial : a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria.2010

    • Author(s)
      Ando K, Fujita T, et al.
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 616-621

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virus removal and eradication by modified double filtration plasmapher esis decreases factor XIII levels.2010

    • Author(s)
      Hanafusa N, Fujita T, et al.
    • Journal Title

      Ther Apher Dial

      Volume: 14 Pages: 287-291

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term clinical course of IgG4-related systemic disease accompanied by hypophysitis.2010

    • Author(s)
      Hori M, Fujita T, et al.
    • Journal Title

      Endocr J

      Volume: 57 Pages: 485-492

    • NAID

      10029585054

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent glomerular hematuria in living kidney donors confers arisk of progressive kidney disease in donors after heminephrectomy.2010

    • Author(s)
      Kido R, Fujita T, et al.
    • Journal Title

      Am J Transplant

      Volume: 10 Pages: 1597-1604

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-derived microparticles are removed by a membrane plasma separator.2010

    • Author(s)
      Hanafusa N, Fujita T, et al.
    • Journal Title

      ASAIO J

      Volume: 56 Pages: 323-3325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress.2010

    • Author(s)
      Palm F, Fujita T, et al
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats.2010

    • Author(s)
      Kawarazaki H, Fujita T, et al.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25 Pages: 2879-2889

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trichostatin, a prevents TGF-betal-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells.2010

    • Author(s)
      Yoshikawa M, Fujita T, et al.
    • Journal Title

      Eur J Pharmacol

      Volume: 642 Pages: 28-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCel is associated with familial migraine.2010

    • Author(s)
      Suzuki M, Fujita T, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 15963-15968

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.2010

    • Author(s)
      Kawakami T, Fujita T, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.2010

    • Author(s)
      Ishii T, Fujita T, et al.
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 1665-1673

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-200b precursor can ameliorate renal tubulointerstitial fibrosis.2010

    • Author(s)
      Oba S, Fujita T, et al.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated- with acute kidney injury.2010

    • Author(s)
      Doi K, Fujita T, et al.
    • Journal Title

      Crit Care Med

      Volume: 38 Pages: 2037-2042

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a commonrenal secretory pathway for drugs and urate.2010

    • Author(s)
      Jutabha P, Fujita T, et al.
    • Journal Title

      J Biol Chem

      Volume: 285

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.2010

    • Author(s)
      Hasegawa H, Fujita T, et al.
    • Journal Title

      Kidney Int

      Volume: 78 Pages: 975-980

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resolution of Henoch-SchOnlein purpura nephritis after acquired IgA def_iciency.2010

    • Author(s)
      Tanaka M, Fujita T, et al.
    • Journal Title

      Pediatr Nephrol

      Volume: 125 Pages: 2355-2358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel globin, plays an antifibrotic role in the kidney.2010

    • Author(s)
      Mimura I, Fujita T, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal preservation effect of ubiquinol, the reduced form of coenzyme Q102010

    • Author(s)
      Ishikawa A, Fujita T, et al.
    • Journal Title

      Clin EXp Nephrol

      Volume: 15 Pages: 30-33

    • NAID

      10029004333

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptors, salt-sensitive hypertensions, and metabolic syndrome2010

    • Author(s)
      Fujita T
    • Journal Title

      Hypertension 55

      Pages: 813-818

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siRNA-based therapy ameliorates glomerulonephritis.2010

    • Author(s)
      Shimizu H, Fujita T, et al.
    • Journal Title

      J Am Soc Nephrol 21

      Pages: 622-633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension2009

    • Author(s)
      Nagae A, Fujita M, Kawarazaki H, Matsui H, Ando K, Fujita T
    • Journal Title

      Circulation

      Volume: 119(7) Pages: 978-86

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mac-1(CD11b/CD18)links inflammation and thrombosis after glomerular injury.2009

    • Author(s)
      Hirahashi J, Fujita T, et al.
    • Journal Title

      Circulation 120

      Pages: 1255-1265

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Mechanism for Activation of Mineralocorticoid Receptor in the Heart and Kidney2014

    • Author(s)
      Fujita T
    • Organizer
      Gordon Research Conference "The Renin-Angiotensin System Beyond Angiotensin II"
    • Place of Presentation
      Keynote Lecture
    • Related Report
      2013 Final Research Report
  • [Presentation] The Mechanism for Activation of Mineralocorticoid Receptor in the Heart and Kidney2014

    • Author(s)
      Fujita T
    • Organizer
      Gordon Research Conference “The Renin-Angiotensin System Beyond Angiotensin II”
    • Place of Presentation
      Lucca (Barga), Italy
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Epigenetic mechanism on hypertension-The vascular road to heart failure at 20132013

    • Author(s)
      Fujita T
    • Organizer
      2013 HFA Winter Research meeting ESH on translational Research
    • Place of Presentation
      Les Diablerets, Switzerland
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Salt, obesity and hypertension2013

    • Author(s)
      Fujita T
    • Organizer
      The 5th Pulse of Asia
    • Place of Presentation
      Plenary Lecture
    • Related Report
      2013 Final Research Report
  • [Presentation] The kidney and hypertension : The pathogenesis of Salt-Sensitive Hypertension2013

    • Author(s)
      Fujita T
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Final Research Report
  • [Presentation] Mineralocorticoid Receptor2013

    • Author(s)
      Fujita T
    • Organizer
      Cardiovascular Seminar "Fundamental Mechanisms of Hypertension", American Heart association (AHA)
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Rac1-mediated Activation of Mineralocorticoid Receptor in Pressure Overloaded Heart2013

    • Author(s)
      Ayuzawa N, Nagase M, Fujita T. et al
    • Organizer
      39th Meeting of the International Aldosterone Conference
    • Place of Presentation
      San Francisco, CA, USA (Young Investigator Award(YIA)
    • Related Report
      2013 Final Research Report
  • [Presentation] Salt, obesity and hypertension2013

    • Author(s)
      Fujita T
    • Organizer
      The 5th Pulse of Asia
    • Place of Presentation
      Seol, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The pathogenesis of Salt-sensitive hypertension2013

    • Author(s)
      Fujita T
    • Organizer
      Working group of kidney at ESH meeting
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The kidney and hypertension: The pathogenesis of Salt-Sensitive Hypertension2013

    • Author(s)
      Fujita T
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Epigenetics in salt-sensitive hypertension2013

    • Author(s)
      Fujita T
    • Organizer
      8th annual Winter Research Meeting on Translational Basic Science
    • Place of Presentation
      Les Diablerets- Switzerland
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Activation of Rac1-MR pathway in Salt-Sensitive Hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      American Society of Nephrology (ASN)
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] The Pathogenesis of Salt-Sensitive Hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      International Society of Hypertension (ISH)
    • Place of Presentation
      Sydney
    • Related Report
      2013 Final Research Report
  • [Presentation] Activation of Rac1-mineralocorticoid pathway in proteinuric kidney disease2012

    • Author(s)
      Fujita T
    • Organizer
      9th International Podocyte Conference
    • Place of Presentation
      Miami, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The mechanism of salt-sensitive hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      22nd European Society of Hypertension
    • Place of Presentation
      London, United Kingdom
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Role of Sympathetic nervous system in salt-sensitive hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      satellite meeting of ISH 2012
    • Place of Presentation
      Palm Cove, Queensland, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The mechanism of salt-sensitive hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      24th Scientific Meeting of the International Society of Hypertension (ISH)
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Rac1-MR activation in salt-sensitive hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      satellite meeting of ISH 2012
    • Place of Presentation
      Palm Cove, Queensland, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Activation of Rac1-MR pathway in salt-sensitive hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      45th annual meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Role of Rac1-MR pathway in salt-sensitive hypertension2012

    • Author(s)
      Fujita T
    • Organizer
      European Section of Aldosterone Council
    • Place of Presentation
      Hannover, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Pathogenesis of salt-sensitive hypertension2011

    • Author(s)
      藤田敏郎
    • Organizer
      American Society of Nephrology Kidney Week 2011
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, USA(招待講演)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activation of the Racl-MR Pathway in Saltsensitive Hypertension2011

    • Author(s)
      藤田敏郎
    • Organizer
      High Blood Presssure Research 2011 Scientific Sessions
    • Place of Presentation
      Walt Disney World Dolph in Resort, Florida, USA(招待講演)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aberrant Renal be-ta-adrenergic-WNK4 Pathway in Salt-sensitive Hypertension2011

    • Author(s)
      藤田敏郎
    • Organizer
      High Blood Presssure Research 2011 Scientific Sessions
    • Place of Presentation
      Walt Disney World Dolph in Resort, Florida, USA(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes : role of small GTPase Rac12011

    • Author(s)
      Nagase M, Fujita T. et al
    • Organizer
      High Blood Pressure Research
    • Place of Presentation
      Florida, USA (oral)
    • Related Report
      2013 Final Research Report
  • [Presentation] 栄誉賞受賞講演 「食塩感受性高血圧の発症機序に関する研究2010

    • Author(s)
      藤田敏郎
    • Organizer
      日本高血圧学会
    • Place of Presentation
      福岡国際会議場、福岡県
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Salt, hypertension and metabolic syndrome2010

    • Author(s)
      Toshiro Fujita
    • Organizer
      International Society of Hypertension
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activation of mineralocorticoid receptor in hypertension and metabolic syndrome2010

    • Author(s)
      Toshiro Fujita
    • Organizer
      European Society of Hypertension
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 教育講「食塩と高血圧」2010

    • Author(s)
      藤田敏郎
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議揚、兵庫県
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Salt, obesity and hypertension2010

    • Author(s)
      Toshiro Fujita
    • Organizer
      American Society of Hypertension
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-05-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] the Arthur C. Corcoran Memorial Lecture : Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome2009

    • Author(s)
      Fujita T
    • Organizer
      the 63rd High Blood Pressure Conference
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Antialbuminuric Effects of an Aldosterone Blocker in Hypertensive Patients with Albuminuria: A Double-Blinded, Randomized, Placebo-Controlled (EVALUATE) Trial

    • Author(s)
      Fujita T., Uchida S., Seki G. and Kaname S.
    • Organizer
      American Society of Nephrology Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.c-epi.rcast.u-tokyo.ac.jp

    • Related Report
      2013 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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