• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clarification of the molecular and cellular mechanisms of central and peripheral tolerance to pemphigus autoantigen

Research Project

Project/Area Number 21229014
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

AMAGAI Masayuki  慶應義塾大学, 医学部, 教授 (90212563)

Co-Investigator(Kenkyū-buntansha) NAGAO Keisuke  慶應義塾大学, 医学部, 講師 (40286521)
KUBO Akiharu  慶應義塾大学, 医学部, 講師 (70335256)
Project Period (FY) 2009-05-11 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥210,340,000 (Direct Cost: ¥161,800,000、Indirect Cost: ¥48,540,000)
Fiscal Year 2013: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2012: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2011: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2010: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2009: ¥56,420,000 (Direct Cost: ¥43,400,000、Indirect Cost: ¥13,020,000)
Keywords皮膚免疫学 / 免疫寛容 / 自己免疫 / モデルマウス / 樹状細胞 / 天疱瘡 / Interface Dermatitis / 乾癬 / デスモグレイン / 気管支炎 / 免役寛容
Research Abstract

The purpose of this study is to clarify the pathogenic roles of T cells specific for desmoglein 3 (Dsg3), the autoimmune target antigen in pemphigus vulgaris, and the mechanisms of tolerance to Dsg3 in vivo. Dsg3-specific T cells were able to induce not only pemphigus vulgaris, but also unexpectedly interface dermatitis and psoriasis-like skin lesions. This model provides an important tool to dissect the pathophysiological mechanisms for interface dermatitis as experimental autoimmune dermatitis (EAD). While Dsg3-specific T cells are usually deleted in the thymus (central tolerance), it was demonstrated that these T cells could be deleted solely in the periphery (peripheral tolerance) when thymic epithelial cells did not express Dsg3. Further dissection of the mechanisms for peripheral tolerance will lead us to develop a novel therapeutic strategy for antigen-specific immune suppression.

Assessment Rating
Verification Result (Rating)

A-

Report

(6 results)
  • 2014 Research Progress Assessment (Verification Result) ( PDF )
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (84 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (48 results) (of which Invited: 7 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus2013

    • Author(s)
      Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Makni S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M
    • Journal Title

      J Dermatol Sci

      Volume: 70(1) Issue: 1 Pages: 19-25

    • DOI

      10.1016/j.jdermsci.2013.02.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation2013

    • Author(s)
      Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A
    • Journal Title

      J Immunol

      Volume: 191(6) Issue: 6 Pages: 3065-3672

    • DOI

      10.4049/jimmunol.1300348

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus2013

    • Author(s)
      Hata T, Nishimoto S, Nagao K, Takahashi H, Yoshida K, Ohyama M, Yamada T, Asano K, Amagai M
    • Journal Title

      J Immunol

      Volume: 191(1) Issue: 1 Pages: 83-90

    • DOI

      10.4049/jimmunol.1203536

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pathophysiologic role for epidermal growth factor receptor in pemphigus acantholysis2013

    • Author(s)
      Bektas, M. Jolly, P. S. Berkowitz, P. Amagai, M. Rubenstein, D. S.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 13 Pages: 9447-5946

    • DOI

      10.1074/jbc.m112.438010

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus2013

    • Author(s)
      Ishii, K.
    • Journal Title

      Methods Mol Biol

      Volume: 961 Pages: 219-225

    • DOI

      10.1007/978-1-62703-227-8_13

    • ISBN
      9781627032261, 9781627032278
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D visualization of epidermal langerhans cells2013

    • Author(s)
      Kubo, A.
    • Journal Title

      Methods Mol Biol

      Volume: 961 Pages: 119-127

    • DOI

      10.1007/978-1-62703-227-8_5

    • ISBN
      9781627032261, 9781627032278
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display2012

    • Author(s)
      Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M
    • Journal Title

      J Invest Dermatol

      Volume: 132(4) Issue: 4 Pages: 1141-1148

    • DOI

      10.1038/jid.2011.449

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin2012

    • Author(s)
      Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M
    • Journal Title

      Nat Immunol

      Volume: 13(8) Pages: 744-752

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases2012

    • Author(s)
      Kubo A, Nagao K, Amagai M
    • Journal Title

      J Clin Invest

      Volume: 122(2) Issue: 2 Pages: 440-447

    • DOI

      10.1172/jci57416

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface2012

    • Author(s)
      Di Zenzo G, Di Lullo G, Corti D, Calabresi V, Sinistro A, Vanzetta F, Didona B, Cianchini G, Hertl M, Eming R, Amagai M, Ohyama B, Hashimoto T, Sloostra J, Sallusto F, Zambruno G, Lanzavecchia A
    • Journal Title

      J Clin Invest

      Volume: 122(10) Issue: 10 Pages: 3781-3790

    • DOI

      10.1172/jci64413

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desmoglein as a target in skin disease and beyond2012

    • Author(s)
      Amagai M, Stanley JR
    • Journal Title

      J Invest Dermatol

      Volume: 132(3) Issue: 3 Pages: 776-784

    • DOI

      10.1038/jid.2011.390

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.2012

    • Author(s)
      Keisuke Nagao
    • Journal Title

      Nature Immunology

      Volume: 13(8) Issue: 8 Pages: 744-752

    • DOI

      10.1038/ni.2353

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epitope spreading is rarely found in pemphigus vulgaris by large-scale longitudinal study using desmoglein 2-based swapped molecules2012

    • Author(s)
      Ohyama, B.
    • Journal Title

      J Invest Dermatol

      Volume: 132 Issue: 4 Pages: 1158-1168

    • DOI

      10.1038/jid.2011.448

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmunity against M(2) muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype2012

    • Author(s)
      Yoshizawa, A.
    • Journal Title

      Eur J Immunol

      Volume: 42 Issue: 5 Pages: 1152-1163

    • DOI

      10.1002/eji.201142104

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice2012

    • Author(s)
      Kawasaki H
    • Journal Title

      J Allergy Clin Immunol

      Volume: (Epub) Issue: 6 Pages: 1538-1546

    • DOI

      10.1016/j.jaci.2012.01.068

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris2011

    • Author(s)
      Yokoyama T, Matsuda S, Takae Y, Wada N, Nishikawa T, Amagai M, Koyasu S
    • Journal Title

      Int Immunol

      Volume: 23(6) Issue: 6 Pages: 365-373

    • DOI

      10.1093/intimm/dxr020

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance2011

    • Author(s)
      Wada N, Nishifuji K, Yamada T, Kudoh J, Shimizu N, Matsumoto M, Peltonen L, Nagafuchi S, Amagai M
    • Journal Title

      J Invest Dermatol

      Volume: 131(2) Issue: 2 Pages: 410-417

    • DOI

      10.1038/jid.2010.330

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris2011

    • Author(s)
      Tsunoda K, Ota T, Saito M, Hata T, Shimizu A, Ishiko A, Yamada T, Nakagawa T, Kowalczyk AP, Amagai M
    • Journal Title

      Am J Pathol

      Volume: 179(2) Issue: 2 Pages: 795-806

    • DOI

      10.1016/j.ajpath.2011.04.015

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice2011

    • Author(s)
      Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, 他
    • Journal Title

      J Clin Invest

      Volume: 121 Issue: 9 Pages: 3677-3688

    • DOI

      10.1172/jci57379

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris2011

    • Author(s)
      Hata T, Nishifuji K, Shimoda K, Sasaki T, Yamada T, Nishikawa T, Koyasu S, Amagai M
    • Journal Title

      J Dermatol Sci

      Volume: 63(1) Issue: 1 Pages: 33-39

    • DOI

      10.1016/j.jdermsci.2011.04.010

    • NAID

      10030891768

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients2011

    • Author(s)
      Saleh MA
    • Journal Title

      J Dermatol Sci

      Volume: 62 Issue: 3 Pages: 169-175

    • DOI

      10.1016/j.jdermsci.2011.03.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome2011

    • Author(s)
      Ouchi T
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 13 Pages: 2607-2613

    • DOI

      10.1084/jem.20111718

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell toleranc2011

    • Author(s)
      Wada N
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 410-417

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous dsg32011

    • Author(s)
      Jennings JM
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 706-718

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus2010

    • Author(s)
      Chan PT, Ohyama B, Nishifuji K, Yoshida K, Ishii K, Hashimoto T, Amagai M
    • Journal Title

      Br J Dermatol

      Volume: 162(6) Issue: 6 Pages: 1242-1250

    • DOI

      10.1111/j.1365-2133.2010.09696.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune and infectious skin diseases that target desmogleins2010

    • Author(s)
      Amagai M
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 86 Issue: 5 Pages: 524-537

    • DOI

      10.2183/pjab.86.524

    • NAID

      130000258746

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus2010

    • Author(s)
      Chan PT
    • Journal Title

      Br J Dermatol

      Volume: 162 Pages: 1242-1250

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation2010

    • Author(s)
      Nishifuji K
    • Journal Title

      J Dermatol Sci

      Volume: 59 Pages: 184-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmunity to desmocollin 3 in pemphigus vulgaris2010

    • Author(s)
      Mao X
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 2724-2730

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers2009

    • Author(s)
      Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M
    • Journal Title

      J Exp Med

      Volume: 206(13) Issue: 13 Pages: 2937-2946

    • DOI

      10.1084/jem.20091527

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Humoral and cellular autoimmune response to desmoglein 3 in pemphigus and beyond2013

    • Author(s)
      Amagai M
    • Organizer
      International Symposium SFB 829 "Molecular Mechanism Regulating Skin Homeostasis"
    • Place of Presentation
      Cologne, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Humoral and cellular autoimmunity in pemphigus and other skin diseases2013

    • Author(s)
      Amagai M
    • Organizer
      9th Asian Dermatological Congress
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Final Research Report
  • [Presentation] Humoral and cellular autoimmune reaction to desmoglein 32013

    • Author(s)
      Amagai M
    • Organizer
      British Society for Investigative Dermatology (Satellite Meeting of the SID)
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Epidermotropic resident memory T cells require hair follicle-derived cytokines to reside in epidermis2013

    • Author(s)
      Adachi, T. Kobayashi, T. Amagai, M. Nagao, K.
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Autoimmunity against epidermal antigen by Th17 cells induces psoriasis-like skin inflammation2013

    • Author(s)
      Nishimoto, S. Takahashi, H. Amagai, M. Yoshimura, A.
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgG4 is the dominant subclass in Egypti an pemphigus vulgaris sera2013

    • Author(s)
      Saleh, M. A. Amagai, M. Yamagami, J.
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Low frequency of IgG autoanti bodies specifi c to the precursor form of desmoglein 1 and 3 in pati ents with sporadic pemphigus2013

    • Author(s)
      Yamagami, J. Saleh, M. A. Ohyama, M. Hachiya, T. Kuroda, K. Amagai, M.
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Skin inflammatory diseases caused by different subtypes of desmoglein 3-specific Th cells2013

    • Author(s)
      Amagai, M
    • Organizer
      the Joint international Meeting of the 78th Meeting of the Japanese Society of Interferon and Cytokine Research and the 21st International Symposium on Molecular Cell Biology of Macrophages 2013
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Humoral and cellular autoimmunity in pemphigus and other skin diseases2013

    • Author(s)
      Amagai, M
    • Organizer
      9th Asian Dermatological Congress
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immunology for pemphigus2013

    • Author(s)
      Amagai, M
    • Organizer
      9th Asian Dermatological Congress
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Humoral and cellular autoimmune response to desmoglein 3 in pemphigus and beyond2013

    • Author(s)
      Amagai, M.
    • Organizer
      International Symposium SFB 829 “Molecular Mechanism Regulating Skin Homeostasis”
    • Place of Presentation
      Cologne, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tolerance break by immunoglobulin class switch recombination induces the onset of pemphigus vulgaris2013

    • Author(s)
      Wada, N. Fuji, H. Ishikura, T. Koseki, H. Amagai, M. Koyasu, S.
    • Organizer
      42nd Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mechanisms in pemphigus2012

    • Author(s)
      Amagai M
    • Organizer
      61st Annual Montagna Symposium on the Biology of Skin
    • Place of Presentation
      Oregon, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Desmogleins - Pathogenic and Therapeutic Targets in Pemphigus2012

    • Author(s)
      Amagai M
    • Organizer
      The 39th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung
    • Place of Presentation
      Marburg, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanisms in pemphigus2012

    • Author(s)
      Amagai, M.
    • Organizer
      61st Annual Montagna Symposium on the Biology of Skin
    • Place of Presentation
      Salishan Resort, Gleneden Beach
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 天疱瘡:最新の話題2012

    • Author(s)
      天谷雅行
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A key role for the polyclonal nature of pemphigus vulgaris IgG in p38 MAPK-dependent loss of keratinocyte adhesion2012

    • Author(s)
      Saito, M.
    • Organizer
      The 75th Annual Meeting of Society for Investigative Dermatology
    • Place of Presentation
      Ralegh, North Carolina, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Antibodies against desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus are mostly against the precursor molecule.2012

    • Author(s)
      Toumi, A.
    • Organizer
      The 75th Annual Meeting of Society for Investigative Dermatology
    • Place of Presentation
      Ralegh, North Carolina, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stress-induced chemokine production by hair follicles recruit Langerhans cell precursors to skin2012

    • Author(s)
      Nagao, K.
    • Organizer
      The 42nd Annual Meeting of European Society for Dermatological Research
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Langerhans cells suppress Th1-mediated autoimmunity against Desmoglein32012

    • Author(s)
      Kitashima, D.
    • Organizer
      The 42nd Annual Meeting of European Society for Dermatological Research
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Desmogleins-Pathogenic and Therapeutic Targets in Pemphigus2012

    • Author(s)
      Amagai M
    • Organizer
      The 39thAnnual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung
    • Place of Presentation
      Marburg, Germany(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular Mechanisms of Autoimmune Responses in Pemphigus2011

    • Author(s)
      Amagai M
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Langerhans cell dendrites penetrate through epidermal tight junction barrier during foreign antigen uptake2011

    • Author(s)
      Kubo A
    • Organizer
      The 70th Annual Meeting of Society for Investigative Dermatology
    • Place of Presentation
      Arizona, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Human epidermal tight junctions are functional and allow penetration of activated Langerhans cell dendrites2011

    • Author(s)
      Yoshida K
    • Organizer
      The 70th Annual Meeting of Society for Investigative Dermatology
    • Place of Presentation
      Arizona, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular Mechanisms of Autoimmune Responses in Pemphigus2011

    • Author(s)
      Amagai M
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Autoimmune Bullous Disease2011

    • Author(s)
      Amagai M
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Conventional Therapies for Pemphigus2011

    • Author(s)
      Amagai M
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms of epidermal barrier and its dysfunction in atopic diseases2011

    • Author(s)
      Amagai M
    • Organizer
      Gordon Research Conferences on Epithelial Defferentiation & Keratinization
    • Place of Presentation
      Vermont, USA(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Langerhans cells play an essential role in inducing protective humoral immune response subsequent to antigen uptake through tight junctions2011

    • Author(s)
      Ouchi T
    • Organizer
      The 41st Annual Meeting of European Society for Dermatological Research
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] Langerin-positive Langerhans cells but not Langerin-negative inflammatory dendritic epidermal cells penetrate epidermal tight junction barriers in atopic dermatitis2011

    • Author(s)
      Yoshida K
    • Organizer
      The 41st Annual Meeting of European Society for Dermatological Research
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] The establishment of the active mouse model for pemphigus vulgaris and updates2011

    • Author(s)
      Amagai M
    • Organizer
      The 3rd International Academic Meeting on Bullous Disease
    • Place of Presentation
      上海、中国(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] A key role for the polyclonal nature of pemphigus vulgaris IgG in p38 MAPK-dependent Dsg3 endocytosis and desmosome disassembly2011

    • Author(s)
      Saito M
    • Organizer
      The 3rd International Academic Meeting on Bullous Disease
    • Place of Presentation
      上海、中国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of pathogenic anti-desmoglein 3 monoclonal antibodies isolated from a paraneoplastic pemphigus patient by phage display technique2011

    • Author(s)
      Saleh MA
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Langerhans cells confer pre-emptive immunity via antigen capture through tight junctions in experimental staphylococcal scalded skin syndrome2011

    • Author(s)
      Nagao K
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Langerhans cells but not Langerin-negative inflammatory dendritic epidermal cells gain access to the environment outside the tight junction barrier in atopic dermatitis skin2011

    • Author(s)
      Yoshida K
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Investigation of the tight junction barrier in hair follicles and sebaceous glands2011

    • Author(s)
      Kubo A
    • Organizer
      The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antigen capture through tight junctions by Langerhans cells confer pre-emptive immunity in experimental staphylococcal scaled skin syndrome2011

    • Author(s)
      Ouchi T
    • Organizer
      The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] A key role for the polyclonal nature of pemphigus vulgaris IgG in p38 MAPK-dependent Dsg3 endocytosis and desmosome disassembly2011

    • Author(s)
      Saito M
    • Organizer
      The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Autoimmunity and Tolerance in Pemphigus2010

    • Author(s)
      Amagai M
    • Organizer
      Cluster Lecture at the Manor House
    • Place of Presentation
      Borstel, Germany
    • Year and Date
      2010-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of pathogenic autoantibody production in pemphigus and pemphigoid2010

    • Author(s)
      Amagai M
    • Organizer
      JC Bystryn Pemphigus & Pemphigoid Meeting : From the Bench to the Bedside
    • Place of Presentation
      Bethesda, USA
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] Lessons from pemphigus to clarify fundamental autoimmune mechanisms2010

    • Author(s)
      Amagai M
    • Organizer
      The First Eastern Asia Dermatology Congress
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] Pemphigus vulgaris as a paradigm of autoimmune disease2010

    • Author(s)
      Amagai M
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Pemphigus vulgaris as a paradigm of autoimmune disease.2010

    • Author(s)
      Amagai M
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Overview on autoimmunity and autoinflammation2010

    • Author(s)
      Amagai M
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of monoclonal Desmoglein 3 autoantibodies isolated from a paraneoplastic pemphigus patient by phage display2010

    • Author(s)
      Saleh MA
    • Organizer
      The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Humoral and cellular autoimmune responses to desmoglein 3 in paraneoplastic pemphigus2009

    • Author(s)
      Amagai M
    • Organizer
      The 39th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] T cell immune responses in experimental pemphigus2009

    • Author(s)
      Amagai M
    • Organizer
      International Pemphigus Meeting
    • Place of Presentation
      Berne, Switzerland
    • Related Report
      2013 Final Research Report
  • [Presentation] Pemphigus : A Dynamic Model of Autoimmune Responses2009

    • Author(s)
      Amagai M
    • Organizer
      Gordon Research Conferences on Epithelial Defferentiation & Keratinization
    • Place of Presentation
      Les Diablerets, Switzerland
    • Related Report
      2013 Final Research Report
  • [Book] Methods Mol Biol2013

    • Author(s)
      Ishii, K. Amagai, M.
    • Publisher
      Humana Press
    • Related Report
      2013 Annual Research Report
  • [Book] Pemphigus. Dermatology 3rd edition2012

    • Author(s)
      Amagai M
    • Publisher
      Elsevier Saunders
    • Related Report
      2013 Final Research Report
  • [Book] Dermatology 3rd Edition2012

    • Author(s)
      Amagai, M.
    • Total Pages
      2776
    • Publisher
      Elsevier Saunders
    • Related Report
      2012 Annual Research Report
  • [Book] Asian Skin and Skin Diseases~Special book of the 22nd World Congress of Dermatology~2011

    • Author(s)
      Chan, P.T.
    • Publisher
      ILDS
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.sc.itc.keio.ac.jp/derma/r_research/index.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Pemphigus monoclonal antibody2009

    • Inventor(s)
      Kazuyuki Tsunoda, Masayuki Amagai, Takeji Nishikawa, Shigeo Koyasu
    • Industrial Property Rights Holder
      Keio University
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2009-06-23
    • Related Report
      2013 Final Research Report
    • Overseas

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi