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Systems biology of AKT signaling

Research Project

Project/Area Number 21240025
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionThe University of Tokyo

Principal Investigator

KURODA Shinya  東京大学, 大学院・理学系研究科, 教授 (50273850)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
KeywordsAkt / シグナル伝達 / システム生物学 / 周波数応答 / ローパスフィルタ / ローバスフィルタ
Research Abstract

In cellular signal transduction, information in an external stimulus is coded as temporal patterns of signaling activities; however, the temporal coding mechanism has been poorly investigated. In this study, we modeled the epidermal growth factor (EGF)-dependent Akt pathway in PC12 cells based on experimental results, and found how the Akt pathway, which is involved in cell growth, specifically transfers temporal information of upstream signals to downstream. In addition, we theoretically analyzed a simple biochemical reaction and found that signal transfer efficiency of transient peak amplitude attenuates depending on the strength of negative regulation, and found that cells can control downstream sensitivity through attenuation of signal transfer efficiency by changing the expression level of negative regulators.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway2012

    • Author(s)
      Hiroyuki Kubota, Rei Noguchi, Yu Toyoshima, Yu-ichi Ozaki, Shinsuke Uda, Kanako Watanabe, Wataru Ogawa and Shinya Kuroda
    • Journal Title

      Molecular Cell

      Volume: 46(6) Issue: 6 Pages: 820-832

    • DOI

      10.1016/j.molcel.2012.04.018

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Latent process genes for cell differentiation are common decoders of neurite extension length2012

    • Author(s)
      Watanabe, K.
    • Journal Title

      J Cell Sci

      Volume: 125 Pages: 2198-211

    • DOI

      10.1242/jcs.097709

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signaling2012

    • Author(s)
      Toyoshima, Y., Kakuda, H., Fujita, K.,Uda, S. and Kuroda, S.
    • Journal Title

      Nature.Communications

      Volume: 3(473) Issue: 1

    • DOI

      10.1038/ncomms1745

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signaling2012

    • Author(s)
      Toyoshima, Y., Kakuda, H., Fujita, K., Uda, S., Kuroda, S.
    • Journal Title

      Nature Communications

      Volume: 3 Pages: 743-743

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latent process genes for cell differentiation are common decoders of neurite extension length2012

    • Author(s)
      Watanabe, K., Akimoto, Y., Yugi, K., Uda, S., Chung, J., Nakamuta, S., Kaibuchi K., Kuroda, S.
    • Journal Title

      Journal of Cell Science

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics.2010

    • Author(s)
      Fujita, K., Toyoshima, Y., Uda, S., Ozaki, Y., Kubota, H. and Kuroda, S.
    • Journal Title

      Science Signaling

      Volume: 3(132) Issue: 132 Pages: 56-56

    • DOI

      10.1126/scisignal.2000810

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics.2010

    • Author(s)
      Fujita, K., Toyoshima, Y., Uda, S., Ozaki, Y., Kubota, H., Kuroda, S.
    • Journal Title

      Science Signaling

      Volume: 3(132)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] AKT経路の情報多重化によるインスリン作用の時間情報コード2012

    • Author(s)
      久保田浩行、野口怜、豊島有、尾崎裕一、 宇田新介、渡邊可奈子、小川渉、 黒田真也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2012-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] ERK経路の情報コード2012

    • Author(s)
      黒田真也
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋(名古屋大学)
    • Year and Date
      2012-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Temporal Cording of Insulin Action through Multiplexing of the AKT Pathway2012

    • Author(s)
      久保田浩行、野口怜、豊島有、尾崎裕一、 宇田新介、渡邊可奈子、小川渉、 黒田真也
    • Organizer
      Joint meeting of JSDB 45th & JSCB64th
    • Place of Presentation
      神戸(神戸国際会議場)
    • Year and Date
      2012-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] イ ンスリン作用の AKT 経路による多重情報 コード2011

    • Author(s)
      黒田真也
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] インスリン作用のAKT経路による多重情報コード2011

    • Author(s)
      黒田真也、久保田浩行
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temporal coding of ERK and AKT signaling networks2010

    • Author(s)
      黒田真也
    • Organizer
      2010年日本バイオインフォマティクス学会会
    • Place of Presentation
      福岡(九州大学医学部百年講堂)
    • Year and Date
      2010-12-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Temporal coding of ERK and AKT signaling networks2010

    • Author(s)
      黒田真也
    • Organizer
      2010年日本バイオインフォマティクス学会年会
    • Place of Presentation
      福岡(九州大学医学部百年講堂)
    • Year and Date
      2010-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

    • Author(s)
      久保田浩行、野口怜、豊島有、尾崎裕一、宇田新介、渡邉可奈子、小川渉、黒田真也
    • Organizer
      Joint meeting of JSDB 45th & JSCB 64th
    • Place of Presentation
      神戸・神戸国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] ERK経路の情報コード

    • Author(s)
      黒田真也
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋・名古屋大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] AKT経路の情報多重化によるインスリン作用の時間情報コード

    • Author(s)
      久保田浩行、野口怜、豊島有、尾崎裕一、宇田新介、渡邉可奈子、小川渉、黒田真也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡・福岡国際会議場
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://kurodalab.bi.s.u-tokyo.ac.jp/ja/index.html

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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