Systems biology of AKT signaling
Project/Area Number |
21240025
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bioinformatics/Life informatics
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Research Institution | The University of Tokyo |
Principal Investigator |
KURODA Shinya 東京大学, 大学院・理学系研究科, 教授 (50273850)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
Keywords | Akt / シグナル伝達 / システム生物学 / 周波数応答 / ローパスフィルタ / ローバスフィルタ |
Research Abstract |
In cellular signal transduction, information in an external stimulus is coded as temporal patterns of signaling activities; however, the temporal coding mechanism has been poorly investigated. In this study, we modeled the epidermal growth factor (EGF)-dependent Akt pathway in PC12 cells based on experimental results, and found how the Akt pathway, which is involved in cell growth, specifically transfers temporal information of upstream signals to downstream. In addition, we theoretically analyzed a simple biochemical reaction and found that signal transfer efficiency of transient peak amplitude attenuates depending on the strength of negative regulation, and found that cells can control downstream sensitivity through attenuation of signal transfer efficiency by changing the expression level of negative regulators.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Latent process genes for cell differentiation are common decoders of neurite extension length2012
Author(s)
Watanabe, K., Akimoto, Y., Yugi, K., Uda, S., Chung, J., Nakamuta, S., Kaibuchi K., Kuroda, S.
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Journal Title
Journal of Cell Science
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics.2010
Author(s)
Fujita, K., Toyoshima, Y., Uda, S., Ozaki, Y., Kubota, H. and Kuroda, S.
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Journal Title
Science Signaling
Volume: 3(132)
Issue: 132
Pages: 56-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics.2010
Author(s)
Fujita, K., Toyoshima, Y., Uda, S., Ozaki, Y., Kubota, H., Kuroda, S.
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Journal Title
Science Signaling
Volume: 3(132)
Related Report
Peer Reviewed
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