Representation of time in the brain

• Project/Area Number: 21240029
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Osaka University (2011); Juntendo University (2009-2010)
• Principal Investigator: KITAZAWA Shigeru 大阪大学, 生命機能研究科, 教授 (00251231)
• Co-Investigator(Kenkyū-buntansha): UKA Takanori 順天堂大学, 医学研究科, 准教授 (50372933) ; KANSAKU Kenji 国立障害者リハビリテーションセンター(研究所), 脳機能系障害研究部, 室長 (60399318)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000); Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000); Fiscal Year 2010: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000); Fiscal Year 2009: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
• Keywords: 時間順序判断 / サッカード / 動き投影仮説 / 動き逆相関法 / MT野 / MST野 / サッケード / 固有知覚 / 経頭蓋交流刺激 / TMS / 腕交差 / 経頭蓋磁気刺激 / 空間座標系

Research Abstract

We studied how the brain orders events in time by applying methods in psychophysics and neuroimaging. We also recorded neural activities from behaving monkeys to elucidate why temporal order judgment is reversed when two successive visual stimuli are delivered just prior to the onset of saccadic eye movements. Results generally agreed with our hypothesis(motion projection hypothesis) that the temporal order of events is determined by combining spatial representations of stimuli in the parietal and prefrontal cortices with representations of" motion" or" changes" in the multisensory perisylvian cortex.

Research Products

• [Journal Article] Origins of superior dynamic visual acuity in baseball players : superior eye movements or superior image processing (2012)
  • Author(s): Uchida, Y, Kudoh, D., Murakami, A., Honda, M., Kitazawa, S.
  • Journal Title: PLoS One Volume: 7 Issue: 2 Pages: e31530-e31530
  • DOI: 10.1371/journal.pone.0031530
  • Peer Reviewed
• [Journal Article] Superior haptic-to-visual shape matching in autism spectrum disorders (2012)
  • Author(s): Nakano, T., Kato, N., Kitazawa, S.
  • Journal Title: Neuropsychologia Volume: 50 Pages: 696-703
  • Peer Reviewed
• [Journal Article] Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes (2011)
  • Author(s): Yoshimi K, Naya Y, Mitani N, Kato T, Inoue M, Natori S, Takahashi T, Weitemier A, Nishikawa N, McHugh T, Einaga Y, Kitazawa S
  • Journal Title: Neurosci Res Volume: 71 Issue: 1 Pages: 49-62
  • DOI: 10.1016/j.neures.2011.05.013
  • Peer Reviewed
• [Journal Article] Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task (2011)
  • Author(s): Takahashi T, Takikawa Y, Kawagoe R, Shibuya S, Iwano T, Kitazawa S
  • Journal Title: NeuroImage Volume: 57 Issue: 3 Pages: 991-1002
  • DOI: 10.1016/j.neuroimage.2011.05.012
  • Peer Reviewed
• [Journal Article] Shortening of subjective visual intervals followed by repetitive stimulation (2011)
  • Author(s): Ono F, Kitazawa S
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Lack of eyeblink entrainments in autism spectrum disorders (2011)
  • Author(s): Nakano T, Kato N, Kitazawa S
  • Journal Title: Neuropsychologia Volume: 49 Issue: 9 Pages: 2784-2790
  • DOI: 10.1016/j.neuropsychologia.2011.06.007
  • Peer Reviewed
• [Journal Article] Applying independent component analysis to detect silent speech in magnetic resonance imaging signals (2011)
  • Author(s): Abe K, Takahashi T, Takikawa Y, Arai H, Kitazawa S
  • Journal Title: Eur J Neurosci Volume: 34 Issue: 8 Pages: 1189-1199
  • DOI: 10.1111/j.1460-9568.2011.07856.x
  • Peer Reviewed
• [Journal Article] Towards intelligent environments : an augmented reality-brain-machine interface operated with a see-through head-mount display (2011)
  • Author(s): Takano, K., Hata, N., Kansaku, K.
  • Journal Title: Frontiers in Neuroscience Volume: 5:60 Pages: 1-5
  • DOI: 10.3389/fnins.2011.00060
  • Peer Reviewed
• [Journal Article] Psychophysical evidence for contraction of the range of spatial integration as a mechanism for filtering out spatial noise in a random dot motion display (2011)
  • Author(s): Sasaki R, Uka T
  • Journal Title: Vision Research Volume: 51 Issue: 17 Pages: 1979-1985
  • DOI: 10.1016/j.visres.2011.07.011
  • Peer Reviewed
• [Journal Article] The spatial profile of macaque MT neurons is consistent with Gaussian sampling of logarithmically coordinated visual representation (2010)
  • Author(s): Kumano, H. & Uka, T
  • Journal Title: J Neurophysiol Volume: 104 Pages: 61-75
  • Peer Reviewed
• [Journal Article] c-Fos expression during temporal order judgment in mice (2010)
  • Author(s): Wada, M., Higo, N., Moizumi, S. & Kitazawa, S.
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] The effect of perceived motion-in-depth on time perception (2010)
  • Author(s): Ono, F. & Kitazawa, S
  • Journal Title: Cognition Volume: 115 Pages: 140-146
  • Peer Reviewed
• [Journal Article] c-Fos expression during temporal order judgment in mice. (2010)
  • Author(s): Wada M, Higo N, Moizumi S, Kitazawa S
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] The effect of perceived motion-in-depth on time perception. (2010)
  • Author(s): Ono F, Kitazawa S
  • Journal Title: Cognition Volume: 115 Pages: 140-146
  • Peer Reviewed
• [Journal Article] Eyeblink entrainment at breakpoints of speech. (2010)
  • Author(s): Nakano T, Kitazawa S
  • Journal Title: Exp Brain Res. Volume: 205 Pages: 577-581
  • Peer Reviewed
• [Journal Article] Deficit in visual temporal integration in autism spectrum disorders (2010)
  • Author(s): Nakano T, Ota H, Kato N, Kitazawa S
  • Journal Title: Proc.R.Soc.B Volume: 277 Pages: 1027-1030
  • Peer Reviewed
• [Journal Article] Atypical gaze patterns in children and adults with autism spectrum disorders dissociated from developmental changes in gaze behaviour. (2010)
  • Author(s): Nakano T, Tanaka K, Endo Y, Yamane Y, Yamamoto T, Nakano Y, Ohta H, Kato N, Kitazawa S
  • Journal Title: Proc.R.Soc.B Volume: 277 Pages: 2935-2943
  • Peer Reviewed
• [Journal Article] My thoughts through a robot's eyes : an augmented reality-brain-machine interface. (2010)
  • Author(s): Kansaku, K., Hata, N., Takano, K.
  • Journal Title: Neuroscience Research Volume: 66 Pages: 219-222
  • Peer Reviewed
• [Journal Article] ブレイン・リーディング (2010)
  • Author(s): 神作憲司
  • Journal Title: Clinical Neuroscience Volume: 28(9) Pages: 1069-1071
• [Journal Article] 目を動かしてもぶれて見えないのはなぜか? (2010)
  • Author(s): 北澤茂
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 1073-1073
• [Journal Article] The spatial profile of macaque MT neurons is consistent with Gaussian sampling of logarithmically coordinated visual representation. (2010)
  • Author(s): Kumano H, Uka T.
  • Journal Title: J Neurophysiol Volume: 104 Pages: 61-75
  • Peer Reviewed
• [Journal Article] Shortening of subjective tone intervals followed by repetitive tone stimuli (2010)
  • Author(s): Ono F, Kitazawa S
  • Journal Title: Attention, perception & psychophysics 72 Pages: 492-500
  • Peer Reviewed
• [Journal Article] Deficit in visual temporal integration in autism spectrum disorders (2010)
  • Author(s): Nakano T, Ota H, Kato N, Kitazawa S
  • Journal Title: Proc.R.Soc.B (in press)
  • Peer Reviewed
• [Journal Article] The effect of perceived motion-in-depth on time perception (2010)
  • Author(s): Ono F, Kitazawa S
  • Journal Title: Cognition (in press)
  • Peer Reviewed
• [Journal Article] Noninvasive bioluminescence imaging of c-fos expression in the mouse barrel cortex (2010)
  • Author(s): Wada M, Watanabe S, Chung U, Higo N, Taniguchi T, Kitazawa S
  • Journal Title: Behavioural Brain Research 208 Pages: 158-162
  • Peer Reviewed
• [Journal Article] Synchronization of spontaneous eyeblinks while viewing video stories (2009)
  • Author(s): Nakano T, Yamamoto Y, Kitajo K, Takahashi T, Kitazawa S
  • Journal Title: Proc.R.Soc.B 276 Pages: 3635-3644
  • Peer Reviewed
• [Journal Article] Neural correlates of tactile temporal-order judgment in humans : an fMRI study
  • Author(s): Takahashi, T., Kansaku, K., Wada, M., Shibuya, S. & Kitazawa, S.
  • Journal Title: Cereb Cortex Volume: (in press)
  • Peer Reviewed
• [Journal Article] Bayesian calibration of simultaneity in audiovisual temporal order judgments
  • Author(s): Yamamoto, S., Miyazaki, M., Iwano, T. & Kitazawa, S.
  • Journal Title: Plos One Volume: (in press)
  • NAID: 120004680893
  • Peer Reviewed
• [Presentation] Functional connectivity of the left posterior parietal cortex during arm crossing (2012)
  • Author(s): Ora, H., Wada, M., Salat, D.H., Kansaku, K.
  • Organizer: The 89th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Matsumoto
  • Year and Date: 2012-03-31
• [Presentation] 脳の中の時間 (2012)
  • Author(s): 北澤茂
  • Organizer: 第9回感性学研究会
  • Place of Presentation: 九州大学、福岡(招待講演)
  • Year and Date: 2012-03-05
• [Presentation] 脳の中の時間 (2012)
  • Author(s): 北澤茂
  • Organizer: 大阪大学生命機能研究科GCOEシンポジウム
  • Place of Presentation: 大阪大学、吹田(招待講演)
  • Year and Date: 2012-01-31
• [Presentation] 脳の中の時間:腕の交差や目の動きで逆転する時間 (2011)
  • Author(s): 北澤茂
  • Organizer: 身体性情報学研究会
  • Place of Presentation: 芝蘭会館,京都(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] Temporo-spatial dynamics of perisaccadic directional selectivity in areas MT and MST of the macaque monkey revealed by motion reverse correlation (2011)
  • Author(s): Saruwatari, M., Uka, T., Kitazawa, S.
  • Organizer: The 41^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-15
• [Presentation] Temporo-spatial dynamics of perisaccadic directional selectivity in areas MT and MST of the macaque monkey revealed by motion reverse correlation (2011)
  • Author(s): Saruwatari, M., Uka, T., Kitazawa, S.
  • Organizer: The 41st Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2011-11-15
• [Presentation] Mapping functional connectivity during P300-BCI : an MEG study (2011)
  • Author(s): Takano, K., Sekihara, K., Iwaki, S., Kansaku, K.
  • Organizer: The 41st Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2011-11-15
• [Presentation] Transfer of choice-related response modulation across visual fields during learning of a depth-discrimination task (2011)
  • Author(s): Kumano H, Uka T
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Temporo-spatial dynamics of perisaccadic directional selectivity in the medi al temporal area of the macaque monkey : application of a motion reverse corr elation method (2011)
  • Author(s): Saruwatari,M., Uka, T., Kitazawa, S.
  • Organizer: The 34th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Year and Date: 2011-09-15
• [Presentation] FMRI activities in the left inferior parietal lobule with left arm over right arm crossing (2011)
  • Author(s): Wada, M., Takano, K., Ikegami, S., Kansaku, K.
  • Organizer: The 34th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Year and Date: 2011-09-15
• [Presentation] A bounded leaky integrator model can explain variations in reaction time during task switching (2011)
  • Author(s): Mitani A, Oizumi M, Sasaki R, Uka T
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Using eye movements and blinks to probe social impairments in autism (2011)
  • Author(s): Kitazawa, S.
  • Organizer: 34th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] Using eye tracking to quantify social impairments in autism : Any difference between children and adults? (2011)
  • Author(s): Kitazawa, S.
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京ベイ有明ワシントンホテル,台場(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] How sensory signals are ordered in time : lessons from judgment reversal due to arm crossing and saccades. (2011)
  • Author(s): Kitazawa S
  • Organizer: International Conference on Systems-neuroscience and Rehabilitation.
  • Place of Presentation: Research Institute of National Rehabilitation Center, Tokorozawa, Japan
  • Year and Date: 2011-03-10
• [Presentation] Quantitative evaluation of gaze and cognition in autism. (2010)
  • Author(s): Kitazawa S
  • Organizer: 41th NIPS International Symposium "Towards Systematic Understanding of Human Beings"
  • Place of Presentation: 生理学研究所、岡崎
  • Year and Date: 2010-12-16
• [Presentation] Temporo-spatial gaze patterns in children and adults with autism. (2010)
  • Author(s): Kitazawa S
  • Organizer: NUOVE TECNOLOGIE PER LA DIAGNOSI E L'INTERVENTO NEI DISTURBI DELLO SPETTRO AUTISTICO
  • Place of Presentation: Cagliari, Italy
  • Year and Date: 2010-10-12
• [Presentation] Quantification of direction-speed tuning and its relationship with pattern motion selectivity in macaque area MT. (2010)
  • Author(s): Kumano H, Uka T.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Role of the left temporoparietal junction for arm crossing. (2010)
  • Author(s): Wada, M., Takano, K., Ikegami, S., Kansaku, K.
  • Organizer: The 33rd Annual Meeting of Japan Neuroscience Society.
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] 発達と脳内機構 (2010)
  • Author(s): 神作憲司
  • Organizer: 第103回日本小児精神神経学会研究大会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-29
• [Presentation] Adaptations and illusions in conscious time perception (2010)
  • Author(s): Kitazawa, S.
  • Organizer: Rahmen des Schwerpunktkolloquuiums Neurowissenschaten der Universitat Hamburg
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2010-02-16
• [Presentation] Adaptations and iluusions in conscious time perception (2010)
  • Author(s): 北澤茂
  • Organizer: Rahmen des Schwerpunktkolloquuiums Neurowissenschaten der Universitat Hamburg
  • Place of Presentation: Hamburg, ドイツ
  • Year and Date: 2010-02-16
• [Presentation] 脳の中の時間 (2009)
  • Author(s): 北澤茂
  • Organizer: 名古屋大学環境医学研究所市民公開講座
  • Place of Presentation: 名古屋大学野依記念館
  • Year and Date: 2009-10-24
• [Presentation] Reciprocal roles for the right and left hemispheres in reversal of subjective temporal order due to arm crossing. (2009)
  • Author(s): Kansaku K, Takano T, Takahashi T, Kitazawa S.
  • Organizer: The 39th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-17
• [Presentation] Reciprocal roles for the right and left hemispheres in reversal of subjective temporal order due to arm crossing (2009)
  • Author(s): Kansaku K, Takano T, Takahashi T, Kitazawa S
  • Organizer: Program No.94.3/EE53 2009 Neuroscience Meeting Planner. Chicago, IL : Society for Neuroscience, 2009. Online
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-17
• [Presentation] Locating self and external events in time, space and social contexts (2009)
  • Author(s): 北澤茂
  • Organizer: RIKEN summer seminar 2009, Interacting Brains
  • Place of Presentation: 和光, RIKEN
  • Year and Date: 2009-07-21
• [Book] Multisensory timing. in The New Handbook of Multisensory Processes(ed B Stein) (2012)
  • Author(s): Fujisaki, W., Kitazawa, S. & Nishida, S.
  • Publisher: MIT press
• [Book] Multisensory timing. In : The New Handbook of Multisensory Processes(Stein B, editor.)
  • Author(s): Fujisaki W, Kitazawa S, Nishida S
  • Publisher: MIT Press(in press)
• [Book] Multisensory timing.(Stein B, ed.)(The New Handbook of Multisensory Processes)
  • Author(s): Fujisaki W, Kitazawa S, Nishida S
  • Publisher: MIT Press(in press)
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/jpn/general/lab/181/
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/jpn/general/lab/181/