Clarification of the pathogenesis of the neurological disorders caused by impaired neuronal leucine-rich-repeat-containing transmembrane proteins.
| Project/Area Number |
21240031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ARUGA Jun 独立行政法人理化学研究所, 行動発達障害研究チーム, チームリーダー (10232076)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 比較ゲノム解析 / LRR膜タンパク質 / 疾患モデル動物 / 神経発達障害 / 精神神経疾患 / シナプス形成 / 抑制性シナプス / グルタミン酸受容体 / てんかん / 統合失調症 / 認知障害 / 空間記憶 / 膜貫通タンパク質 / 遺伝子ターゲッティング / 行動解析 / 神経回路形成 / 高次脳機能障害 |
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| Research Abstract |
We developed animal models for neurological disorders including autism and schizophrenia by utilizing comparative genomics. Focusing brain-enriched Leucine-rich repeat containing transmembrane proteins with unknown functions, we successfully generated new 15 strains of mouse mutants exhibiting neurological abnormalities. We collected important facts that underlie the pathogenesis of autism, schizophrenia, anxiety disorders and sensory disturbance through morphological, neurochemical, electrophysiological and pharmacological analyses.
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction2012
Author(s)
Hideto Takahashi, Kei-ichi Katayama, Kazuhiro Sohya, Hiroyuki Miyamoto, Tuhina Prasad, Yoshifumi Matsumoto, Maya Ota, Hiroki Yasuda, Tadaharu Tsumoto, Jun Aruga, Ann Marie Craig
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Journal Title
Nature Neuroscience
Volume: 15
Issue: 3
Pages: 389-398
DOI
Related Report
Peer Reviewed
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[Journal Article] Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients2011
Author(s)
M. Hatayama, A. Ishiguro, Y. Iwayama, N. Takashima, K. Sakoori, T. Toyota, Y. Nozaki, Y. S. Odaka, K. Yamada, T. Yoshikawa, J. Aruga
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Journal Title
Scientific Reports
Volume: 1
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[Journal Article] Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients2011
Author(s)
M.Hatayama, A.Ishiguro, Y.Iwayama, N.Takashima, K.Sakoori, T.Toyota, Y.Nozaki, Y.S.Odaka, K.Yamada, T.Yoshikawa, J.Aruga
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Journal Title
Scientific Reports
Volume: 1
Issue: 1
Pages: 16-16
DOI
Related Report
Peer Reviewed
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[Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain-and sex-dependent eye abnormalities in mice2010
Author(s)
M. Maekawa, Y. Iwayama, A. Watanabe, Y. Nozaki, T. Ohnishi, H. Ohba, M. Toyoshima, K. Hamazaki, N. Osumi, J. Aruga, T. Yoshikawa
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 402
Pages: 431-437
Related Report
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[Presentation] Molecular and pathological characterisation of an inherited condition amongst the Amish involving high myopia and sensaorineural hearing loss2011
Author(s)
Moore-Barton H., Chioza B. A., Matsumoto Y., Cross H., E., Sakoori K., Odagawa M., Gurtz K., Patton M. A., Aruga J., and Crosby A. H.
Organizer
British Human Genetics Conference 2011
Place of Presentation
Coventry, UK
Related Report
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[Presentation] Molecular and pathological characterisation of an inherited condition amongst the Amish involving high myopia and sensorineural hearing loss2011
Author(s)
Moore-Barton, H., Chioza, BA., Matsumoto, Y., Cross, HE., Sakoori, K., Ota, M., Gurtz, K., Patton, MA., Aruga, J., Crosby, AH
Organizer
British Human Genetics Conference 2011
Place of Presentation
Coventry, UK
Related Report
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[Presentation] Characterisation of Slitrk2-deficient mice2010
Author(s)
Corbett D. C., Katayama K., Matsumoto Y., Morimura, N., Yamada K., Ota M., Ornthanalai V., Honma C., Murphy N. P., and Aruga J.
Organizer
40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
Place of Presentation
San Diego, USA
Related Report
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