Clarification of the pathogenesis of the neurological disorders caused by impaired neuronal leucine-rich-repeat-containing transmembrane proteins.

• Project/Area Number: 21240031
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ARUGA Jun 独立行政法人理化学研究所, 行動発達障害研究チーム, チームリーダー (10232076)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000); Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
• Keywords: 比較ゲノム解析 / LRR膜タンパク質 / 疾患モデル動物 / 神経発達障害 / 精神神経疾患 / シナプス形成 / 抑制性シナプス / グルタミン酸受容体 / てんかん / 統合失調症 / 認知障害 / 空間記憶 / 膜貫通タンパク質 / 遺伝子ターゲッティング / 行動解析 / 神経回路形成 / 高次脳機能障害

Research Abstract

We developed animal models for neurological disorders including autism and schizophrenia by utilizing comparative genomics. Focusing brain-enriched Leucine-rich repeat containing transmembrane proteins with unknown functions, we successfully generated new 15 strains of mouse mutants exhibiting neurological abnormalities. We collected important facts that underlie the pathogenesis of autism, schizophrenia, anxiety disorders and sensory disturbance through morphological, neurochemical, electrophysiological and pharmacological analyses.

Research Products

• [Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction (2012)
  • Author(s): Hideto Takahashi, Kei-ichi Katayama, Kazuhiro Sohya, Hiroyuki Miyamoto, Tuhina Prasad, Yoshifumi Matsumoto, Maya Ota, Hiroki Yasuda, Tadaharu Tsumoto, Jun Aruga, Ann Marie Craig
  • Journal Title: Nature Neuroscience Volume: 15 Issue: 3 Pages: 389-398
  • DOI: 10.1038/nn.3040
  • Peer Reviewed
• [Journal Article] Comparative anatomy of marmoset and mouse cortex from genomic expression (2012)
  • Author(s): H. Mashiko, A. Yoshida, S. Kikuchi, K. Niimi, E. Takahashi, J. Aruga, H. Okano, T. Shimogori
  • Journal Title: J. Neurosci Volume: 32 Pages: 5039-5053
• [Journal Article] Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway (2012)
  • Author(s): T. J. Fujimi, M. Hatayama, J. Aruga
  • Journal Title: Dev. Biol Volume: 361 Pages: 220-231
• [Journal Article] GLI protein nuclear localization signal (2012)
  • Author(s): M. Hatayama, J. Aruga
  • Journal Title: Vitamins and Hormones Volume: (in press) Pages: 88-88
• [Journal Article] Lrrtm1と統合失調症 (2012)
  • Author(s): 佐郡和人、有賀純
  • Journal Title: 分子精神医学 Volume: 12 Pages: 47-49
• [Journal Article] LRRシナプスオーガナイザーと神経疾患 (2012)
  • Author(s): 有賀純、松本圭史
  • Journal Title: 実験医学 Volume: 30 Pages: 364-369
• [Journal Article] Comparative anatomy of marmoset and mouse cortex from genomic expression (2012)
  • Author(s): H.Mashiko, A.Yoshida, S.Kikuchi, K.Niimi, E.Takahashi, J.Aruga, H.Okano, T.Shimogori
  • Journal Title: J.Neurosci. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway (2012)
  • Author(s): T.J.Fujimi, M.Hatayama, J.Aruga
  • Journal Title: Dev.Biol. Volume: 361 Issue: 2 Pages: 220-231
  • DOI: 10.1016/j.ydbio.2011.10.026
  • Peer Reviewed
• [Journal Article] GLI protein nuclear localization signal (2012)
  • Author(s): M.Hatayama, J.Aruga
  • Journal Title: Vitamins and Hormones Volume: 88(In press)
  • Peer Reviewed
• [Journal Article] Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia (2011)
  • Author(s): N. Takashima, Y. S. Odaka, K. Sakoori, T. Akagi, T. Hashikawa, N. Morimura, K. Yamada, J. Aruga
  • Journal Title: Plos One Volume: 6
• [Journal Article] A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis (2011)
  • Author(s): H. Pan, M. K. Gustafsson, J. Aruga, J. J. Tiedken, J. C. J. Chen, C. P. Emerson, Jr
  • Journal Title: Dev. Biol Volume: 351 Pages: 120-127
• [Journal Article] Impaired Auditory-Vestibular Functions and Behavioral Abnormalities of Slitrk6-Deficient Mice (2011)
  • Author(s): Y. Matsumoto, K.-i. Katayama, T. Okamoto, K. Yamada, N. Takashima, S. Nagao, J. Aruga
  • Journal Title: Plos One Volume: 6
• [Journal Article] Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients (2011)
  • Author(s): M. Hatayama, A. Ishiguro, Y. Iwayama, N. Takashima, K. Sakoori, T. Toyota, Y. Nozaki, Y. S. Odaka, K. Yamada, T. Yoshikawa, J. Aruga
  • Journal Title: Scientific Reports Volume: 1
• [Journal Article] IP(3) signaling is required for cilia formation and left-right body axis determination in Xenopus embryos (2011)
  • Author(s): M. Hatayama, K. Mikoshiba, J. Aruga
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 410 Pages: 520-524
• [Journal Article] Role of BMP, FGF, Calcium Signaling, and Zic Proteins in Vertebrate Neuroectodermal Differentiation (2011)
  • Author(s): J. Aruga, K. Mikoshiba
  • Journal Title: Neurochem. Res Volume: 36 Pages: 1286-1292
• [Journal Article] 統合失調症モデルとしてのZic2低発現マウスと統合失調症患者にみられるZIC2の変異 (2011)
  • Author(s): 有賀純
  • Journal Title: 分子精神医学 Volume: 11 Pages: 47-49
• [Journal Article] Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients (2011)
  • Author(s): M.Hatayama, A.Ishiguro, Y.Iwayama, N.Takashima, K.Sakoori, T.Toyota, Y.Nozaki, Y.S.Odaka, K.Yamada, T.Yoshikawa, J.Aruga
  • Journal Title: Scientific Reports Volume: 1 Issue: 1 Pages: 16-16
  • DOI: 10.1038/srep00016
  • Peer Reviewed
• [Journal Article] Impaired Auditory-Vestibular Functions and Behavioral Abnormalities of Slitrk6-Deficient Mice (2011)
  • Author(s): Y.Matsumoto, K.-i.Katayama, T.Okamoto, K.Yamada, N.Takashima, S.Nagao, J.Aruga
  • Journal Title: Plos One Volume: 6 Issue: 1 Pages: e16497-e16497
  • DOI: 10.1371/journal.pone.0016497
  • Peer Reviewed
• [Journal Article] Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia (2011)
  • Author(s): N.Takashima, Y.S.Odaka, K.Sakoori, T.Akagi, T.Hashikawa, N.Morimura, K.Yamada, J.Aruga
  • Journal Title: Plos One Volume: 6 Issue: 7 Pages: e22716-e22716
  • DOI: 10.1371/journal.pone.0022716
  • Peer Reviewed
• [Journal Article] A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis (2011)
  • Author(s): H.Pan, M.K.Gustafsson, J.Aruga, J.J.Tiedken, J.C.J.Chen, C.P.Emerson, Jr.
  • Journal Title: Dev.Biol. Volume: 351 Issue: 1 Pages: 120-127
  • DOI: 10.1016/j.ydbio.2010.12.037
  • Peer Reviewed
• [Journal Article] IP_3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos (2011)
  • Author(s): Hatayama M
  • Journal Title: Biochem Biophys Res Commun Volume: 410(3) Issue: 3 Pages: 520-524
  • DOI: 10.1016/j.bbrc.2011.06.014
  • Peer Reviewed
• [Journal Article] Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation (2011)
  • Author(s): Aruga J
  • Journal Title: Neurochem Res Volume: 36(7) Issue: 7 Pages: 1286-92
  • DOI: 10.1007/s11064-011-0422-5
  • Peer Reviewed
• [Journal Article] Impaired Auditory-Vestibular Functions and Behavioral Abnormalities of Slitrk6-Deficient Mice. (2011)
  • Author(s): Matsumoto Y, et al.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. (2011)
  • Author(s): Pan H, et al.
  • Journal Title: Dev Biol.
  • Peer Reviewed
• [Journal Article] Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation (2011)
  • Author(s): Aruga J, et al
  • Journal Title: Neurochem Res
  • Peer Reviewed
• [Journal Article] Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities (2010)
  • Author(s): K. Katayama, K. Yamada, V. G. Ornthanalai, T. Inoue, M. Ota, N. P. Murphy, J. Aruga
  • Journal Title: Mol. Psychiatry Volume: 15 Pages: 177-184
• [Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain-and sex-dependent eye abnormalities in mice (2010)
  • Author(s): M. Maekawa, Y. Iwayama, A. Watanabe, Y. Nozaki, T. Ohnishi, H. Ohba, M. Toyoshima, K. Hamazaki, N. Osumi, J. Aruga, T. Yoshikawa
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 402 Pages: 431-437
• [Journal Article] Characterization of the tandem CWCH2 sequence motif : a hallmark of inter-zinc finger interactions (2010)
  • Author(s): M. Hatayama, J. Aruga
  • Journal Title: BMC Evol.Biol Volume: 10
• [Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors (2010)
  • Author(s): J. Aruga, Y. Nozaki, M. Hatayama, Y. S. Odaka, N. Yokota
  • Journal Title: BMC Cancer Volume: 10
• [Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors (2010)
  • Author(s): Aruga J, et al
  • Journal Title: BMC Cancer Volume: 10
  • Peer Reviewed
• [Journal Article] Characterization of the tandem CWCH2 sequence motif : a hallmark of inter-zinc finger interactions. (2010)
  • Author(s): Hatayama M, et al
  • Journal Title: BMC Evol Biol Volume: 10
  • Peer Reviewed
• [Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice. (2010)
  • Author(s): Maekawa M
  • Journal Title: Biochem Biophys Res Commun. Volume: 402 Pages: 431-437
  • Peer Reviewed
• [Journal Article] Characterization of the tandem CWCH2 sequence motif : a hallmark of inter-zinc finger interactions (2010)
  • Author(s): Minoru Hatayama
  • Journal Title: BMC Evol.Biol. 10(印刷中)
  • Peer Reviewed
• [Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors (2010)
  • Author(s): 有賀純
  • Journal Title: BMC Cancer (印刷中)
  • Peer Reviewed
• [Journal Article] Stability of folding structure of Zic zinc finger proteins (2009)
  • Author(s): K. Sakai-Kato, Y. Umezawa, K. Mikoshiba, J. Aruga, N. Utsunomiya-Tate
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 384 Pages: 362-365
• [Journal Article] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice (2009)
  • Author(s): K.-i. Katayama, A. Zine, M. Ota, Y. Matsumoto, T. Inoue, B. Fritzsch, J. Aruga
  • Journal Title: Plos One Volume: 4
• [Journal Article] Disorganized innervation neuronal loss in the inner ear of Slitrk6-deficient mice (2009)
  • Author(s): Kei-ichi Katayama
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Stability of folding structure of Zic zinc finger proteins (2009)
  • Author(s): Kumiko Sakai-Kato
  • Journal Title: Biochem Biophys Res Commun. 384 Pages: 362-365
  • Peer Reviewed
• [Journal Article] トゥレット症候群とSLITRK1 (2009)
  • Author(s): 有賀純
  • Journal Title: 分子精神医学 9 Pages: 254-261
• [Presentation] Molecular and pathological characterisation of an inherited condition amongst the Amish involving high myopia and sensaorineural hearing loss (2011)
  • Author(s): Moore-Barton H., Chioza B. A., Matsumoto Y., Cross H., E., Sakoori K., Odagawa M., Gurtz K., Patton M. A., Aruga J., and Crosby A. H.
  • Organizer: British Human Genetics Conference 2011
  • Place of Presentation: Coventry, UK
• [Presentation] Characterization on Elfn family in the central nervous system (2011)
  • Author(s): Tomioka-Hara N., Yamada K., Odagawa M., Odaka Y., and Aruga J.
  • Organizer: 41st Annual Meeting of the Society for Neuroscience(Neuroscience 2011)
  • Place of Presentation: Washington DC, USA
• [Presentation] Executive function deficits and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia (2011)
  • Author(s): Aruga J., Takashima N., Odaka Y., Sakoori K., Akagi T., Hashikawa T., Morimura N., and Yamada K
  • Organizer: 41st Annual Meeting of the Society for Neuroscience(Neuroscience 2011)
  • Place of Presentation: Washington DC, USA
• [Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN (2011)
  • Author(s): Matsumoto Y., Takashima N., Nozaki Y., Nishioka C., Kudoh M., and Aruga J.
  • Organizer: 41st Annual Meeting of the Society for Neuroscience(Neuroscience 2011)
  • Place of Presentation: Washington DC, USA
• [Presentation] 統合失調症モデルとしてのZic2低発現変異マウスと統合失調症患者に見られるZIC2の変異 (2011)
  • Author(s): 畑山実
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Characterization of Elfn family in the central nervous system (2011)
  • Author(s): 富岡-原直子
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Lrrtmシナプスオーガナイザーファミリー欠損マウスに見られた行動およびシナプスの異常 (2011)
  • Author(s): 有賀純
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Zic2の聴覚神経回路形成における役割 (2011)
  • Author(s): 有賀純
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 統合失調症患者におけるZIC2の変異解析とZic2ノックダウンマウスの行動異常 (2011)
  • Author(s): 畑山実
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Lrfn2/SALM1による海馬興奮性シナプスの機能制御とその遺伝子欠損マウスにみられた行動異常 (2011)
  • Author(s): 守村直子
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Slitrk6欠損マウスの聴覚および前庭機能異常について (2011)
  • Author(s): 松本圭史
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Lrrtm1欠損マウスの新規環境における遂行機能障害と海馬シナプス形態異常 (2011)
  • Author(s): 高嶋記子
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Executive function deficits and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia (2011)
  • Author(s): 有賀純
  • Organizer: 41st Annual Meeting of the Society for Neuroscienee (Neuroscience 2011)
  • Place of Presentation: Washington DC
• [Presentation] Characterization on Elfn family in the central nervous system (2011)
  • Author(s): 富岡-原直子
  • Organizer: 41st Annual Meeting of the Society for Neuroscienee (Neuroscience 2011)
  • Place of Presentation: Washington DC
• [Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN (2011)
  • Author(s): 松本圭史
  • Organizer: 41st Annual Meeting of the Society for Neuroscienee (Neuroscience 2011)
  • Place of Presentation: Washington DC
• [Presentation] Molecular and pathological characterisation of an inherited condition amongst the Amish involving high myopia and sensorineural hearing loss (2011)
  • Author(s): Moore-Barton, H., Chioza, BA., Matsumoto, Y., Cross, HE., Sakoori, K., Ota, M., Gurtz, K., Patton, MA., Aruga, J., Crosby, AH
  • Organizer: British Human Genetics Conference 2011
  • Place of Presentation: Coventry, UK
• [Presentation] 分子内相互作用するC2H2型亜鉛フィンガーの機能的意義の解明 (2010)
  • Author(s): 畑山実
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice (2010)
  • Author(s): Matsumoto Yoshifumi
  • Organizer: 40th Annual Meeting of the Society for Neuroscienee (Neuroscience 2010)
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-17
• [Presentation] A role of Rines, a neuronal membrane-bound ubiquitin ligase in higher brain function (2010)
  • Author(s): Kabayama-Ogawa Miyuki
  • Organizer: 40th Annual Meeting of the Society for Neuroscienee (Neuroscience 2010)
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-17
• [Presentation] Characterisation of Slitrk2-deficient mice (2010)
  • Author(s): Corbett Daniel C
  • Organizer: 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-17
• [Presentation] Zic2 hypomorphic mutant mice exhibit cognitive impairment and social behavior abnormalities with an altered distribution of basal forebrain cholinergic neurons (2010)
  • Author(s): Aruga Jun
  • Organizer: 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-15
• [Presentation] 膜結合型ユビキチンリガーゼRinesの高次脳機能における役割 (2010)
  • Author(s): 樺山-小川実幸
  • Organizer: Neuro2010(第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] A role of Rines, a neuronal membrane-bound ubiquitin ligase in higher brain function (2010)
  • Author(s): Kabayama-Ogawa M., Ornthanalai V., Yamada K., Murphy N. P., Katayama K., and Aruga J.
  • Organizer: 40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
  • Place of Presentation: San Diego, USA
• [Presentation] Characterisation of Slitrk2-deficient mice (2010)
  • Author(s): Corbett D. C., Katayama K., Matsumoto Y., Morimura, N., Yamada K., Ota M., Ornthanalai V., Honma C., Murphy N. P., and Aruga J.
  • Organizer: 40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
  • Place of Presentation: San Diego, USA
• [Presentation] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice (2010)
  • Author(s): Matsumoto Y., Katayama K., Zine A., Ota M., Inoue T., Fritzsch B., Yamada K., and Aruga J.
  • Organizer: 40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
  • Place of Presentation: San Diego, USA
• [Presentation] Zic2 hypomorphic mutant mice exhibit cognitive impairment and social behavior abnormalities with an altered distribution of basal forebrain cholinergic neurons (2010)
  • Author(s): Aruga J., Hatayama M., Takashima N., Sakoori K., Nozaki Y., Odaka Y., Yamada K., and Ishiguro A
  • Organizer: 40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
  • Place of Presentation: San Diego, USA
• [Presentation] タンデムCWCH2ドメイン:フィンガー間相互作用を生じる特殊なジンクフィンガーの in silico 解析 (2009)
  • Author(s): 畑山実
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] 膜結合型ユビキチンリガーゼ Rines ノックアウトマウスの行動および神経化学的解析 (2009)
  • Author(s): 小川実幸
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Xenopus Zic3 has an inhibitory role for beta-catenin dependent Transcription activation (2009)
  • Author(s): 藤見峰彦
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice (2009)
  • Author(s): 有賀純
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Slitrk5欠損マウスは不安様症状の亢進とセロトニン作動性神経の異常を示す (2009)
  • Author(s): 松本圭史
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] シナプス接着分子Lrfn2/SALM1は興奮性シナプスの機能制御および行動発現に重要である (2009)
  • Author(s): 守村直子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Slitrk6欠損マウスに見られた内耳の感覚神経発生異常 (2009)
  • Author(s): 有賀純
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Remarks] 機関および研究室ホームページでの研究成果紹介
  • URL: http://www.riken.jp/r-world/info/release/press/2012/120130/index.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Slitrk3_inhibitorysynapse.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Takashima_Lrrtm1.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Hatayama_Zic2_SCZ_2011.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Matsumoto_Slitrk6_vestibular_function.html
• [Remarks]
  • URL: http://www.riken.jp/r-world/info/release/press/2012/120130/index.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Slitrk3_inhibitorysynapse.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Takashima_Lrrtm1.html
• [Remarks]
  • URL: http://lcn.brain,riken.jp/Hatayama_Zic2_SCZ_2011.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/Matsumoto_Slitrk6_vestibular_function.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/advancesj.html
• [Remarks]
  • URL: http://www.riken.go.jp/r-world/info/release/press/2009/091111/detail.html
• [Remarks]
  • URL: http://lcn.brain.riken.jp/indexj.html