Elucidating the mechanism of human cancer metastasis using a humanized cancer metastasis model.
| Project/Area Number |
21240042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | 実験動物中央研究所 (2011)
Central Institute for Experimental Animals (2009-2010) |
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Principal Investigator |
SUEMIZU Hiroshi 実験動物中央研究所, バイオメディカル研究部, 部長 (40332209)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 免疫不全マウス / ヒューマナイズドマウス / ヒト化肝臓 / uPA-NOGマウス / TK-NOGマウス / がん転移 / 膵臓がん / 大腸がん / がん / 細胞・組織 / 転移モデル / ヒューマナイズド / ヒューマナィズドマウス / ヒト化肝臓モデル / ガン転移 |
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| Research Abstract |
When immunodeficient mice are used as a human cancer metastasis model, the metastatic potential of cell lines is evaluated in a microenvironment that differs from that of humans. To develop a model that reflects the phenomenon of human cancer metastasis in vivo more accurately, humanized mice in which the liver was reconstituted with human liver cells were used as the host animals to examine the relationship between host target tissue and transplanted cells in an allogeneic microenvironment. Even cell lines with no or extremely low metastatic potential in traditional xeno-transplantation models metastasized in this model. The results suggest the importance of allogeneic relationships in transplant models.
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Report
(4 results)
Research Products
(44 results)
