| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Research Abstract |
When immunodeficient mice are used as a human cancer metastasis model, the metastatic potential of cell lines is evaluated in a microenvironment that differs from that of humans. To develop a model that reflects the phenomenon of human cancer metastasis in vivo more accurately, humanized mice in which the liver was reconstituted with human liver cells were used as the host animals to examine the relationship between host target tissue and transplanted cells in an allogeneic microenvironment. Even cell lines with no or extremely low metastatic potential in traditional xeno-transplantation models metastasized in this model. The results suggest the importance of allogeneic relationships in transplant models.
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