Development of in vivo imaging probe specific for hypoxic diseases
| Project/Area Number |
21240049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Institute of Technology (2010-2011)
Kyoto University (2009) |
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Principal Investigator |
KONDOH Shinae 東京工業大学, 大学院・生命理工学研究科, 教授 (40314182)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Fumihiko 東北薬科大学, 薬学部, 准教授 (40253471)
UMEDA Izumi 国立がん研究センター, 臨床開発センター, 室長 (40160791)
KONDOH Gen 京都大学, 再生医科学研究所, 准教授 (40243258)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Keywords | バイオイメージング / 低酸素 / PETS / PECT / HIF-1 / PET / SPECT / 分子プローブ / 膜透過ドメイン / 虚血性疾患 |
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| Research Abstract |
A tumor-specific microenvironment is characterized by hypoxia. The hypoxic status of various solid tumors has been attributed as an indicator of adverse prognosis due to tumor progression toward a more malignant phenotype with increased metastatic potential and resistance to treatment. We have been developing a fusion protein that is specifically stabilized in hypoxic tumors. In this study, we had attempted to construct PET/SPECT probes with the fusion protein and explored the possibility of clinical application.
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Report
(4 results)
Research Products
(143 results)
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[Journal Article] Evaluation of <125>^I-POS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor : Comparison among SPECT/CT imaging, autoradiography, and immune-histochemistry2011
Author(s)
Ueda M, Kudo T, Mutou Y, Umeda IO, Miyano A, Ogawa K, Ono M, Fujii H, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Cancer Sci
Volume: 102(11)
Pages: 2090-6
Related Report
Peer Reviewed
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[Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel(18) F-labeled biotin derivative2011
Author(s)
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Mol Imaging Biol
Volume: 13(5)
Pages: 1003-10
Related Report
Peer Reviewed
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[Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging2011
Author(s)
Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y. Murakami A, Watanabe H, Tani T, Inoue M, Tsukamoto T, Toyoda T, Tanaka T, Hirota K, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S
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Journal Title
PLoS ONE
Volume: 6(11)
Issue: 11
Pages: e26640-e26640
DOI
Related Report
Peer Reviewed
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[Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel (18)F-labeled biotin derivative2011
Author(s)
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Mol Imaging Biol.
Volume: 13(5)
Issue: 5
Pages: 1003-1010
DOI
Related Report
Peer Reviewed
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[Journal Article] Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleop rotein (RNP) remodeling of chromatid bodies during spermatogenesis2011
Author(s)
Tanaka, T., M.Hosokawa, V-V.Vagin, M.Reuter, E.Hayashi, A-L.Mochizuki, K.Kitamura, H.Yamanaka, G.Kondoh, K.Okawa, S.Kuramochi-Miyagawa, T.Nakano, R.Sachidanandam, G-J.Hannon, R-S.Pillai, N.Nakatsuji, S.Chuma
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Journal Title
Proc.Natl.Acad.Sci.USA
Volume: 108-26
Pages: 10579-10584
Related Report
Peer Reviewed
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[Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel (18)F-labeled biotin derivative.2011
Author(s)
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Mol Imaging Biol.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Rapid detection of hypoxia-inducible factor-1-active tumours : pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha.2010
Author(s)
Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H.
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 37
Pages: 1566-1574
Related Report
Peer Reviewed
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[Presentation] 炎症性病変モデルにおけるヨウ素125標識ラクトソームの生体内分布と分子イメージングプローブとしての基礎評価2012
Author(s)
木村光晴, 山本文彦, 大西いぶき, 牧野顕, 山原亮, 原功, 原恵理, 小関英一, 栗原研輔, 木村俊作, 山本由美, 齋藤陽平, 大久保恭仁
Organizer
日本薬学会第132年会
Place of Presentation
札幌
Year and Date
2012-03-30
Related Report
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[Presentation] 実験腫瘍および炎症病態モデルにおけるヨウ素125標識ラクトソームの生体内分布2011
Author(s)
木村光晴, 大西いぶき, 山本文彦, 牧野顕, 山原亮, 原功, 竹内恵理, 小関英一, 栗原研輔, 木村俊作, 山本由美、齋藤陽平、大久保恭仁
Organizer
第11回放射性医薬品・画像診断薬研究会
Place of Presentation
京都
Year and Date
2011-12-30
Related Report
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[Presentation] Development and initial evaluation of novel fluorine-18 labeled nanocarrier "Lactosome"as a tumor imaging probe for PET2010
Author(s)
Yamamoto F, Yamahara R, Kurihara K, Tsukada H, Takeuchi E, Hara I, Makino A, Kizaka-Kondoh S, Ozeki E, Kimura S
Organizer
The Society of Nuclear Medicine 57^<th> Annual Meeting
Place of Presentation
Salt Lake City, USA
Year and Date
2010-06-08
Related Report
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[Presentation] Development of a novel radioisotope labeled tumor imaging probe for PET "^<18>F-Lactosome"2010
Author(s)
Yamamoto F, Yamahara R, Kurihara K, Tsukada H, Takeuchi E, Hara I, Makino A, Shimizu A, Kizaka-Kondoh S, Ozeki E, Kimura S
Organizer
2010 World Molecular Imaging Congress
Place of Presentation
Kyoto
Related Report
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[Presentation] A fluorescent imaging of the murine orthotopic brain tumor, using new nanocarrier "Lactosome"2010
Author(s)
Kurihara K, Yamanoto F, Yamaguchi M, Arakawa Y, Hara I, Ozeki E, Makino A, Togashi K, Shimizu A, Kimura S
Organizer
2010 World Molecular Imaging Congress
Place of Presentation
Kyoto
Related Report
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