Development of in vivo imaging probe specific for hypoxic diseases

• Project/Area Number: 21240049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Institute of Technology (2010-2011); Kyoto University (2009)
• Principal Investigator: KONDOH Shinae 東京工業大学, 大学院・生命理工学研究科, 教授 (40314182)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Fumihiko 東北薬科大学, 薬学部, 准教授 (40253471) ; UMEDA Izumi 国立がん研究センター, 臨床開発センター, 室長 (40160791) ; KONDOH Gen 京都大学, 再生医科学研究所, 准教授 (40243258)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000); Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2009: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
• Keywords: バイオイメージング / 低酸素 / PETS / PECT / HIF-1 / PET / SPECT / 分子プローブ / 膜透過ドメイン / 虚血性疾患

Research Abstract

A tumor-specific microenvironment is characterized by hypoxia. The hypoxic status of various solid tumors has been attributed as an indicator of adverse prognosis due to tumor progression toward a more malignant phenotype with increased metastatic potential and resistance to treatment. We have been developing a fusion protein that is specifically stabilized in hypoxic tumors. In this study, we had attempted to construct PET/SPECT probes with the fusion protein and explored the possibility of clinical application.

Research Products

• [Journal Article] 2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for in Vivo Imaging of Tumor Hypoxia (2012)
  • Author(s): Okuda K, Okabe Y, Kadonosono T, Ueno T, Youssif BG, Kizaka-Koadoh S, Nagasawa H
  • Journal Title: Bioconjug Chem. Volume: 22 Issue: 11 Pages: 324-329
  • DOI: 10.1111/j.1349-7006.2011.02057.x
  • Peer Reviewed
• [Journal Article] Development of a hy poxia-selective near-infrared fluorescent probe for non-invasive tumor imaging (2012)
  • Author(s): Youssif BG, Okuda K, Kadonosono T, Salem OI, Hayallah AA, Hussein MA, Kizaka-Kondoh S, Nagasawa H.
  • Journal Title: Chem Pharm Bull Volume: 60(3) Pages: 402-407
  • Peer Reviewed
• [Journal Article] Mammmalian carboxylesterase (CES) releases GPI-anchored proeins from the cell surface upon raft fluidization (2012)
  • Author(s): Orihashi, K., H.Tojo, K.Okawa, Y.Tashima, T.Morita, G.Kondoh
  • Journal Title: Biol.Chem. Volume: 393 Pages: 169-176
  • Peer Reviewed
• [Journal Article] Molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation (2012)
  • Author(s): Y. Masago, A. Hosoya, S. Kawano, A. Nasu, J. Toguchida, K. Fujita, H. Nakamura, G. Kondoh and K. Nagata
  • Journal Title: J. Cell Sci. Volume: 125(5) Issue: 5 Pages: 1118-1128
  • DOI: 10.1242/jcs.089748
  • Peer Reviewed
• [Journal Article] Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdknla expression (2012)
  • Author(s): Ishimura, A., K-I. Minehata, M.Terashima, G.Kondoh, T.Hara, T. Suzuki
  • Journal Title: Development Volume: 139 Issue: 4 Pages: 749-759
  • DOI: 10.1242/dev.074138
  • Peer Reviewed
• [Journal Article] 5-O-(4-[^<125>I]Iodobenzyl)-L-ascorbic acid : Electrophilic Radioiodination and Biodistribution in Mice (2012)
  • Author(s): J.Kim, T.Kino, H.Kato, F.Yamamoto, K.Sano, T.Mukai, M.Maeda
  • Journal Title: Chem.Pharm.Bull. Volume: 60(2) Pages: 235-240
  • NAID: 130001852401
  • Peer Reviewed
• [Journal Article] Evaluation of <125>^I-POS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor : Comparison among SPECT/CT imaging, autoradiography, and immune-histochemistry (2011)
  • Author(s): Ueda M, Kudo T, Mutou Y, Umeda IO, Miyano A, Ogawa K, Ono M, Fujii H, Kizaka-Kondoh S, Hiraoka M, Saji H.
  • Journal Title: Cancer Sci Volume: 102(11) Pages: 2090-6
  • Peer Reviewed
• [Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel(18) F-labeled biotin derivative (2011)
  • Author(s): Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
  • Journal Title: Mol Imaging Biol Volume: 13(5) Pages: 1003-10
  • Peer Reviewed
• [Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging (2011)
  • Author(s): Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y. Murakami A, Watanabe H, Tani T, Inoue M, Tsukamoto T, Toyoda T, Tanaka T, Hirota K, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S
  • Journal Title: PLoS ONE Volume: 6(11) Issue: 11 Pages: e26640-e26640
  • DOI: 10.1371/journal.pone.0026640
  • Peer Reviewed
• [Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel (18)F-labeled biotin derivative (2011)
  • Author(s): Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
  • Journal Title: Mol Imaging Biol. Volume: 13(5) Issue: 5 Pages: 1003-1010
  • DOI: 10.1007/s11307-010-0418-6
  • Peer Reviewed
• [Journal Article] Pathophysiological Response to Hypoxia - From the Molecular Mechanisms of Malady to Drug Discovery:Hypoxia-Inducible Factor-1 (HIF-1)-Active Cells as a Target for Cancer Therapy (2011)
  • Author(s): Kizaka-Kondoh S, Kuchimaru T, Kadonosono T.
  • Journal Title: Journal of Pharmacological Sciences Volume: 115 Issue: 4 Pages: 440-445
  • DOI: 10.1254/jphs.10R20FM
  • NAID: 10029893111
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Mouse sperm undergo GPI-anchored protein release associated with lipid raft reorganization and acrosome reaction to acquire fertility (2011)
  • Author(s): Watanabe, H., G. Kondoh
  • Journal Title: J.Cell Sci Volume: 124 Issue: 15 Pages: 2573-2581
  • DOI: 10.1242/jcs.086967
  • Peer Reviewed
• [Journal Article] Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleop rotein (RNP) remodeling of chromatid bodies during spermatogenesis (2011)
  • Author(s): Tanaka, T., M.Hosokawa, V-V.Vagin, M.Reuter, E.Hayashi, A-L.Mochizuki, K.Kitamura, H.Yamanaka, G.Kondoh, K.Okawa, S.Kuramochi-Miyagawa, T.Nakano, R.Sachidanandam, G-J.Hannon, R-S.Pillai, N.Nakatsuji, S.Chuma
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108-26 Pages: 10579-10584
  • Peer Reviewed
• [Journal Article] ^<11>C-Labeled Analogs of Indomethacin Esters and Amides for Brain Cyclooxygenase-2 Imaging : Radiosynthesis, In Vitro Evaluation and In Vivo Characteristics in Mice (2011)
  • Author(s): Y.Yamamoto, J.Toyohara, K.Ishiwata, K.Sano, F.Yamamoto, T.Mukai, M.Maeda
  • Journal Title: Chem.Pharm.Bull. Volume: 59(8) Pages: 938-946
  • NAID: 130000960923
  • Peer Reviewed
• [Journal Article] HIF-1-active cells as a target for cancer therapy. (2011)
  • Author(s): Kizaka-Kondoh S, Kuchimaru T, Kadonosono T.
  • Journal Title: J Pharmacol Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel (18)F-labeled biotin derivative. (2011)
  • Author(s): Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H.
  • Journal Title: Mol Imaging Biol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Mouse sperm undergo GPI-anchored protein release associated with lipid raft reorganization and acrosome reaction for acquiring fertility. (2011)
  • Author(s): Watanabe, H., G.Kondoh
  • Journal Title: Journal of Cell Science Volume: (in press)
  • Peer Reviewed
• [Journal Article] Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. (2010)
  • Author(s): Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 107 Pages: 13063-13068
  • Peer Reviewed
• [Journal Article] Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation. (2010)
  • Author(s): Ushiki T, Kizaka-Kondoh S, Ashihara E, Tanaka S, Masuko M, Hirai H, Kimura S, Aizawa Y, Maekawa T. Hiraoka M.
  • Journal Title: PLoS One Volume: 5
  • NAID: 120002511315
  • Peer Reviewed
• [Journal Article] Rapid detection of hypoxia-inducible factor-1-active tumours : pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha. (2010)
  • Author(s): Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 37 Pages: 1566-1574
  • Peer Reviewed
• [Journal Article] Functional molecular imaging of integrin-linked kinase-Akt/PKB-mediated signaling and associated role of beta-parvin. (2010)
  • Author(s): Kimura M, Murakami T, Kizaka-Kondoh S, Itoh M, Yamamoto K, Hojo Y, Takano M, Kario K, Shimada K, Kobayashi E.
  • Journal Title: J Cell Sci. Volume: 123 Pages: 747-755
  • Peer Reviewed
• [Journal Article] Persisting mild hypothermia suppresses hypoxia-inducible factor 1{alpha} protein synthesis and HIF-1-mediated geneexpression. (2010)
  • Author(s): Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, Kizaka-Kondoh S, Fukuda K, Hirota K.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. Volume: 298
  • Peer Reviewed
• [Journal Article] 1-(3'-[^<125>I]Iodophenyl)-3-methy-2-pyrazolin-5-one : Preparation, Solution Stability, and Biodistribution in Normal Mice (2010)
  • Author(s): Yuuhei Sano, Tomokazu Motomura, Fumihiko Yamamoto, Miki Fukuda, Takahiro Mukai, Minoru Maeda
  • Journal Title: Chem.Pharm.Bull. Volume: 58 Pages: 1020-1025
  • NAID: 130000299808
  • Peer Reviewed
• [Journal Article] Norepinephrine Modulates the Zonally Different Hepatocyte Proliferation through the Regulation of Transglutaminase Activity (2010)
  • Author(s): Ohtake Y., Kobayashi T., Maruko A., Ohishi N., Yamamoto F., Katoh S., Ohkubo Y.
  • Journal Title: Am.J.Physiol. Volume: 299
  • Peer Reviewed
• [Journal Article] Development and initial evaluation of novel fluorine-18 labeled nanocarrier "lactosome" as a tumor imaging probe for PET (2010)
  • Author(s): Fumihiko Yamamoto, Ryo Yamahara, Kensuke Kurihara, Hideo Tsukada, Eri Takeuchi, Isao Hara, Akira Makino, Shinae Kizaka-Kondoh, Eiichi Ozeki, Shunsaku Kimura
  • Journal Title: J.Nucl.Med. Volume: 51(Suppl.2) Pages: 304-304
  • Peer Reviewed
• [Journal Article] The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. (2010)
  • Author(s): Omatsu, Y., T.Sugiyama, H.Kohara, G.Kondoh, N.Fujii, K.Kohno, T.Nagasawa
  • Journal Title: Immunity Volume: 33 Pages: 387-399
  • Peer Reviewed
• [Journal Article] 小動物を用いた生体光イメージング (2010)
  • Author(s): 近藤科江
  • Journal Title: 関西実験動物研究会会報 Volume: 32 Pages: 27-35
• [Journal Article] すい臟がん治療効果の経時的光イメージング (2010)
  • Author(s): 門之園哲哉、口丸高弘、近藤科江
  • Journal Title: PET journal Volume: 11 Pages: 22-23
• [Journal Article] がん低酸素微小環境を標的とする治療薬・可視化プローブの開発 (2010)
  • Author(s): 門之園哲哉、口丸高弘、近藤科江
  • Journal Title: 臨床放射線 Volume: 56 Pages: 329-338
• [Journal Article] 癌微小環境における低酸素癌細胞のライブイメージング (2010)
  • Author(s): 口丸高弘、門之園哲哉、近藤科江
  • Journal Title: Surgery Frontier Volume: 18 Pages: 36-43
• [Journal Article] 低線量の放射線・放射能は害なのか益なのか? (2010)
  • Author(s): 山本文彦
  • Journal Title: Rika Tan(理科の探検) Volume: 4(12) Pages: 16-19
• [Journal Article] 放射線の医学への利用 (2010)
  • Author(s): 山本文彦
  • Journal Title: Rika Tan(理科の探検) Volume: 4(12) Pages: 20-23
• [Journal Article] Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin. (2010)
  • Author(s): Kimura M., et al.
  • Journal Title: J Cell Sci. 123 Pages: 747-755
  • Peer Reviewed
• [Journal Article] Persisting mild hypothermia suppersses hypoxia-inducible factor-lalpha protein synthesis and hypoxia-inducible factor-1-mediated gene expresion. (2010)
  • Author(s): Tanaka T., et al.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 298(3)
  • Peer Reviewed
• [Journal Article] Physical and Functional Interaction of Transmembrane Thioredoxin-related Protein (TMX) with MHC Class I Heavy Chain : Redox-based Protein Quality Control and Its Potential Relevance to Immune Responses. (2009)
  • Author(s): Matsuo Y., et al.
  • Journal Title: Mol Biol Cell 20(21) Pages: 4552-4562
  • Peer Reviewed
• [Journal Article] Near-infrared fluorescence tumor imaging using nanocarrire composed of poly (L-lactic acid)-block-poly (sarcosine) amphiphilic polydepsipeptide. (2009)
  • Author(s): Makino A., et al.
  • Journal Title: Biomaterials 30(28) Pages: 5156-5160
  • Peer Reviewed
• [Journal Article] Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles. (2009)
  • Author(s): Han M., et al.
  • Journal Title: Molecular Therapy 17(8) Pages: 1404-1410
  • Peer Reviewed
• [Journal Article] Significance of nitroimidazole compounds and HIF-1 for imaging tumor hypoxia. (2009)
  • Author(s): Kizaka-Kondoh S., et al.
  • Journal Title: Cancer Sci 100(8) Pages: 1366-1373
  • Peer Reviewed
• [Journal Article] Selective killing of hypoxia-inducible factor-1-active cell improves survival in a mouse model of invasive and metastatic pancreatic cancer. (2009)
  • Author(s): Kizaka-Kondoh S., et al.
  • Journal Title: Clin Cancer Res 15(10) Pages: 3433-3441
  • Peer Reviewed
• [Journal Article] Imaging of HIF-1-Active Tumor Hypoxia Using a Protein Effectively Delivered to and Specifically Stabilized in HIF-1-Active Tumor Cells. (2009)
  • Author(s): Kudo T., et al.
  • Journal Title: J Nucl Med 50(6) Pages: 942-949
  • Peer Reviewed
• [Journal Article] Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. (2009)
  • Author(s): Sarkar SA., et al.
  • Journal Title: Diabetologia 52(6) Pages: 1092-1101
  • Peer Reviewed
• [Journal Article] The HIF-1 active microenvironment : an environmental target for cancer therapy. (2009)
  • Author(s): Kizaka-Kondoh S., et al.
  • Journal Title: Advanced Drug Delivery Reviews 61(7-8) Pages: 623-632
  • Peer Reviewed
• [Journal Article] Imaging and targeting of HIF-1 active microenvironment. (2009)
  • Author(s): Kizaka-Kondoh S., et al..
  • Journal Title: Journal of Toxicologic Pathology 22 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Imaging probe for tumor malignancy. (2009)
  • Author(s): Tanaka S., et al.
  • Journal Title: Progress in Biomedical Optics and Imaging 10(30)
  • Peer Reviewed
• [Journal Article] 低酸素誘導因子(HIF-1)と低酸素標的創薬 (2009)
  • Author(s): 永澤秀子, 他
  • Journal Title: ファルマシア 45(4) Pages: 321-36
  • Peer Reviewed
• [Journal Article] バイオインターフェースの医療応用 (2009)
  • Author(s): 菅谷博之, 他
  • Journal Title: 表面科学 30(4) Pages: 236-47
  • Peer Reviewed
• [Journal Article] 分子イメージング-イメージングで機能を診る-特集 : ナノテクノロジーの癌医療への応用 (2009)
  • Author(s): 近藤科江, 他
  • Journal Title: がんと化学療法 36(3) Pages: 366-371
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 田中正太郎
  • Journal Title: 癌分子標的治療研究マニュアル(金芳堂) Pages: 224-232
• [Presentation] 炎症性病変モデルにおけるヨウ素125標識ラクトソームの生体内分布と分子イメージングプローブとしての基礎評価 (2012)
  • Author(s): 木村光晴, 山本文彦, 大西いぶき, 牧野顕, 山原亮, 原功, 原恵理, 小関英一, 栗原研輔, 木村俊作, 山本由美, 齋藤陽平, 大久保恭仁
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] HIF-1α陽性領域のイメージングを目指した放射性ヨウ素標識融合タンパク質の合成 (2012)
  • Author(s): 大西いぶき、山本文彦、小原さとみ、佐藤史弥、佐藤美輪子、木村光晴、口丸高弘、近藤科江、山本由美、齋藤陽平、大久保恭仁
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] In vivo imaging of HIFs-active tumors by optical protein probes (2012)
  • Author(s): Tetsuya Kadonosono, Takahiro Kuchimaru, Shinae Kondoh
  • Organizer: 5th International Symposium on Nanomedicine
  • Place of Presentation: 名古屋大学(名古屋)(招待講演)
  • Year and Date: 2012-03-16
• [Presentation] 悪性化に関与する低酸素誘導因子特異的イメージングプローブの開発 (2012)
  • Author(s): 近藤科江、口丸高弘、門之園哲哉
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都国際会議場、京都(招待講演)
  • Year and Date: 2012-03-14
• [Presentation] 腫瘍の低酸素環境応答とその可視化 (2012)
  • Author(s): 近藤科江
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 千里ライフサイエンスセンター、大阪
  • Year and Date: 2012-02-24
• [Presentation] 腫瘍の低酸素環境応答とその可視化 (2012)
  • Author(s): 近藤科江
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 千里ライフサイエンスセンター、大阪(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] 環境に順応する細胞機能 (2012)
  • Author(s): 近藤科江
  • Organizer: 第18回肝血流動態イメージ研究会
  • Place of Presentation: 神戸国際会議場、神戸(招待講演)
  • Year and Date: 2012-01-29
• [Presentation] 実験腫瘍および炎症病態モデルにおけるヨウ素125標識ラクトソームの生体内分布 (2011)
  • Author(s): 木村光晴, 大西いぶき, 山本文彦, 牧野顕, 山原亮, 原功, 竹内恵理, 小関英一, 栗原研輔, 木村俊作, 山本由美、齋藤陽平、大久保恭仁
  • Organizer: 第11回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都
  • Year and Date: 2011-12-30
• [Presentation] Zonal differences of growth factor-related receptors expressionin hepatocytes after partial hepatectomy (2011)
  • Author(s): T.Kobayashi, Y.Saito, M.Matsuura, Y.Yamamoto, F.Yamamoto, Y.Ohkubo
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] HIF-1活性化腫瘍細胞内を標的とするドラッグデリバリーシステムの構築 (2011)
  • Author(s): 門之園哲哉、山野晃弘、後藤俊樹、口丸高弘、近藤科江
  • Organizer: 日本分子生物学会第34回年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-14
• [Presentation] In vivo imaging of HIF-active tumors with a fusion protein probe based on BRET (2011)
  • Author(s): Keisuke Hirota, Takahiro Kuchimaru, Tomoya Suka, Tetsuya Kadonosono, Shinae Kizaka-Kondoh
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-12-14
• [Presentation] Sperm membrane remodeling in the female reproductive tract to acquire fertility (2011)
  • Author(s): 近藤玄、渡邊仁美
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-12-13
• [Presentation] PEIT併用によるI-131標識ラクトソームを用いた内用療法 (2011)
  • Author(s): 竹内恵理、原功、山原亮、牧野顕、栗原研輔、木村光晴、大西いぶき、山本文彦、大久保恭仁、清水章、小関英一、木村俊作
  • Organizer: 第11回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都
  • Year and Date: 2011-12-03
• [Presentation] 低酸素環境を標的としたがん治療とイメージングに関するモデル (2011)
  • Author(s): 近藤科江、口丸高弘、門之園哲哉
  • Organizer: 第4回疾患モデルシンポジウム
  • Place of Presentation: 癌研究会癌研究所吉田富三記念講堂、東京(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Novel strategies for targeting hypoxic cancer cells (2011)
  • Author(s): 近藤科江、口丸高弘、門之園哲哉
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場、名古屋(招待講演)
  • Year and Date: 2011-10-04
• [Presentation] In vivo bioluminescence imaging of HIF-active tumors using HOL transgenic mice (2011)
  • Author(s): Ttetsuya Kadonosono, Takahiro Kuchimaru, Koji Urano, Gen Kondoh, Shinae Kondoh
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-03
• [Presentation] Construction of a short-term bone metastasis model and its functional analysis with 3D-bioluminescence and μCT imaging (2011)
  • Author(s): Takahiro Kuchimaru, Takuya Hoshino, Tetsuya Kadonosono, Shinae Kondoh
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-03
• [Presentation] 加齢による肝臓時計同調障害におけるアドレナリンα1受容体シグナル低下の関与 (2011)
  • Author(s): 守屋孝洋、中島伸吾、小野塚寛、齋藤陽平、小林智徳、山本文彦、大田英伸、程肇、大久保恭仁、中畑則道
  • Organizer: 第62回日本薬理学会北部会
  • Place of Presentation: 仙台市
  • Year and Date: 2011-09-29
• [Presentation] Evasion from the accelerated blood clearance (ABC) phenomenon of "Lactosome" by micelle size control (2011)
  • Author(s): A.Makino, E.Takeuchi,I.Hara, R.Yamahara, E.Ozeki, K.Kurihara, F.Yamamoto, S.Kimura
  • Organizer: 2011 World Molecular Imaging Congress
  • Place of Presentation: San Diego
  • Year and Date: 2011-09-09
• [Presentation] 低酸素誘導因子HIF活性のインビボイメージング (2011)
  • Author(s): 近藤科江
  • Organizer: 平成23年度遺伝子病制御研究所共同研究集会
  • Place of Presentation: 北海道大学医学部フラテホール、札幌(招待講演)
  • Year and Date: 2011-09-06
• [Presentation] HIF活性化細胞標的タンパク質による腫瘍組織の光イメージング (2011)
  • Author(s): 門之園哲哉、口丸高弘、平岡眞寛、近藤科江
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-22
• [Presentation] 低酸素誘導因子HIF関連疾患のイメージング・ターゲティング (2011)
  • Author(s): 近藤科江、口丸高弘、門之園哲哉
  • Organizer: 第27回DDS学会
  • Place of Presentation: 東京大学(東京)(招待講演)
  • Year and Date: 2011-06-10
• [Presentation] 可溶性RANKLを用いた短期骨転移モデルの構築とインビボイメージング評価 (2011)
  • Author(s): 口丸高弘、星野卓哉、門之園哲哉、保田尚孝、近藤科江
  • Organizer: 第6回日本分子イメージング学会総会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2011-05-27
• [Presentation] トランスジェニックマウスを用いた腫瘍内HIF活性の生体イメージング (2011)
  • Author(s): 門之園哲哉、口丸高弘、浦野浩司、近藤玄、近藤科江
  • Organizer: 第6回日本分子イメージング学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2011-05-26
• [Presentation] X線照射によるEGF受容体機能変化に及ぼす加齢の影響 (2011)
  • Author(s): 小林智徳, 飯田奈紀沙, 大竹洋輔, 桑原義和, 福本学, 山本文彦, 大久保恭仁
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] ナノキャリア"ラクトソーム"の^<125>I標識体の合成と炎症病態モデル動物における生体内分布 (2011)
  • Author(s): 木村光晴, 山本文彦, 大西いぶき, 牧野顕, 山原亮, 小関英一, 栗原研輔, 木村俊作, 大久保恭仁
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 融合タンパク質多機能性ラベリングシステムを応用したHIF-1α陽性領域可視化SPECTプローブの開発 (2011)
  • Author(s): 柿島祐^2, 梅田泉, 楽ヒョウ, 木村禎亮, 口丸高弘, 近藤科江, 谷中昭典, 藤井博史
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] ラクトソームにおけるABC現象の抑制に関する検討 (2011)
  • Author(s): 竹内恵理, 原功, 山原亮, 牧野顕, 栗原研輔, 山本文彦, 清水章, 小関英一, 木村俊作
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-29
• [Presentation] 低酸素誘導因子HIF活性を有する細胞のイメージング・ターゲッティング (2011)
  • Author(s): 近藤科江
  • Organizer: 発生工学・疾患モデル研究会
  • Place of Presentation: 国立がんセンター 国際研究交流会館、東京
  • Year and Date: 2011-02-10
• [Presentation] がんの進行を可視化するトランスジェニックマウスの構築 (2011)
  • Author(s): 近藤科江、門之園哲哉、口丸高弘、伊藤守
  • Organizer: 「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 琵琶湖ホテル、滋賀県大津
  • Year and Date: 2011-02-04
• [Presentation] HIF活性化細胞特異的プローブを用いた腫瘍組織の光イメージング (2011)
  • Author(s): 門之園哲哉、口丸高弘、牛木隆志、平岡眞寛、近藤科江
  • Organizer: ワークショップ「個体レベルのがん研究の魅力:培養細胞と臨床研究をつなぐマトリクス」
  • Place of Presentation: 滋賀県・琵琶湖ホテル
  • Year and Date: 2011-02-03
• [Presentation] In vivo imaging of HIF- active cancer cells using a fusion protein probes (2011)
  • Author(s): Kuchimaru T, Kadonosono T, Ushiki T, Kizaka-Kondoh S, Hiraoka M.
  • Organizer: ワークショップ「個体レベルのがん研究の魅力:培養細胞と臨床研究をつなぐマトリクス」
  • Place of Presentation: 滋賀県・琵琶湖ホテル
  • Year and Date: 2011-02-03
• [Presentation] HIF-1 存在低酸素腫瘍イメージングのためのRI/蛍光デュアル標識タンパク質プローブの開発 (2011)
  • Author(s): 上田真史、宮野梓、工藤喬、小川京、小野正博、近藤科江、佐治英郎
  • Organizer: がんとハイポキシア研究会
  • Place of Presentation: 北海道大学学術交流会館、札幌
  • Year and Date: 2011-01-30
• [Presentation] 腫瘍内低酸素誘導因子活性をモニターするトランスジェニックマウス (2011)
  • Author(s): 門之園哲哉、口丸高弘、伊藤守、井上正宏、田中具治、広田喜一、近藤科江
  • Organizer: 第8回がんとハイポキシア研究会
  • Place of Presentation: 北海道・北海道大学学術交流会館
  • Year and Date: 2011-01-30
• [Presentation] マウス骨転移モデルにおけるHIF-1活性と腫瘍亢進のマルチモダリティイメージング (2011)
  • Author(s): 星野卓哉、口丸高弘、門之園哲哉、近藤科江
  • Organizer: 第8回がんとハイポキシア研究会
  • Place of Presentation: 北海道・北海道大学学術交流会館
  • Year and Date: 2011-01-30
• [Presentation] がん微小環境特異的シグナルネットワークのモニターするレポーターシステムの構築 (2011)
  • Author(s): 廣田圭佑、口丸高弘、門之園哲哉、近藤科江
  • Organizer: 第8回がんとハイポキシア研究会
  • Place of Presentation: 北海道・北海道大学学術交流会館
  • Year and Date: 2011-01-30
• [Presentation] テレピン油誘発性炎症病態モデルにおける放射性ヨウ素標識ラクトソームの生体内分布 (2011)
  • Author(s): 木村光晴, 山本文彦, 大西いぶき, 牧野顕, 山原亮, 竹内恵理, 小関英一, 栗原研輔, 木村俊作, 山本由美、齋藤陽平、大久保恭仁
  • Organizer: 第50回日本薬学会東北支部大会
  • Place of Presentation: 仙台
• [Presentation] COX-2イメージングを目的としたnimesulide誘導体の合成 (2011)
  • Author(s): 山本由美、長島春香、森本浩之、向高弘、大嶋孝志、齋藤陽平、山本文彦、大久保恭仁、前田稔
  • Organizer: 第50回日本薬学会東北支部大会
  • Place of Presentation: 仙台
• [Presentation] 再生肝におけるErbB familyおよびMetの変動 (2011)
  • Author(s): 小林智徳、齋藤陽平、山本由美、山本文彦、大久保恭仁
  • Organizer: 第50回日本薬学会東北支部大会
  • Place of Presentation: 仙台
• [Presentation] 高分子ミセル"ラクトソーム"の構造制御と体内動態解析 (2011)
  • Author(s): 牧野顕、山原亮、原功、竹内恵理、小関英一、栗原研輔、塚田秀夫、山本文彦、佐治英郎、清水章、木村俊作
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば
• [Presentation] I-131標識ラクトソームを用いた内用療法 (2011)
  • Author(s): 竹内恵理、原功、山原亮、牧野顕、栗原研輔、木村光晴、大西いぶき、山本文彦、清水章、小関英一、木村俊作
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば
• [Presentation] 放射線耐性肝がん細胞のEGF誘導性細胞増殖促進の作用機序の解明 (2011)
  • Author(s): 小林智徳、齋藤陽平、桑原義和、福本基、山本由美、山本文彦、福本学、大久保恭仁
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 京都
• [Presentation] 電離放射線によるEGF誘導性DNA合成能変化に及ぼす加齢の影響 (2011)
  • Author(s): 小林智徳、齋藤陽平、山本文彦、山本由美、大久保恭仁
  • Organizer: 第18回肝細胞研究会
  • Place of Presentation: 東京
• [Presentation] 新規GPlase活性を有する分子の同定 (2010)
  • Author(s): 折橋郁、森田隆、東城博雅、近藤玄
  • Organizer: 第33回日本分子生物学会、第83回日本生化学会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-09
• [Presentation] 遺伝子改変マウスを用いたホスホリパーゼB/リパーゼの生理的機能の解析 (2010)
  • Author(s): 竹村浩昌、東城博雅、近藤玄
  • Organizer: 第33回日本分子生物学会、第83回日本生化学会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-09
• [Presentation] Increasing of transglutaminase 2 activity with aging down-regulates the affinity of EGF receptor to EGF in periportal and perivenous hepatocytes (2010)
  • Author(s): Tomonori Kobayashi, Yosuke Ohtake, Akiko Maruko, Fumihiko Yamamoto, Yasuhito Ohkubo
  • Organizer: 第33回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Effect of aging on norepinephrine-induced amplification of EGF-induced DNA synthesis in rat hepatocytes (2010)
  • Author(s): Yosuke Ohtake, Tomonori Kobayashi, Akiko Maruko, Fumihiko Yamamoto, Yasuhito Ohkubo
  • Organizer: 第33回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] In vivo Imaging of HIF-active Cancers by an Oxygen-Dependent Degradative Probe with an Interchangeable Labeling System (2010)
  • Author(s): Kizaka-Kondoh S, Takahiro Kuchimaru and Tetsuya Kadonosono.
  • Organizer: 4th International Symposium on Nanomedicine(ISNM2010)
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2010-11-29
• [Presentation] In vivo Imaging of HIF-active Cancers by an Oxygen-Dependent Degradative Probe with an Interchangeable Labeling System. (2010)
  • Author(s): Kizaka-Kondoh S, Kuchimaru T, Tetsuya Kadonosono.
  • Organizer: 4th International Symposium on Nanomedicine
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2010-11-29
• [Presentation] 肝臓の領域差に着目した体内時計同調能における加齢の影響 (2010)
  • Author(s): 中島伸吾、守屋孝洋、小野塚寛、大竹洋輔、小林智徳、山本文彦、大田英伸、程肇、大久保恭仁、中畑則道
  • Organizer: 第17回日本時間生物学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-20
• [Presentation] 初代培養肝細胞におけるノルエピネフリン関連増殖応答に及ぼす加齢の影響 (2010)
  • Author(s): 小林智徳、大竹洋輔、円子顕子、山本文彦、大久保恭仁
  • Organizer: 第49回日本薬学会東北支部大会及び東北病院薬剤師会総会
  • Place of Presentation: 郡山
  • Year and Date: 2010-10-24
• [Presentation] In vivo imaging of tumor hypoxia (2010)
  • Author(s): 近藤科江
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2010-09-24
• [Presentation] Molecular evaluation of imaging probe specific to HIF-active cancer cells and influence of cell permeable property of flurescent dye on in vivo optical imaging (2010)
  • Author(s): Kadonosono T, Kuchimaru T, Ushiki T, Kizaka-Kondoh S, Hiraoka M.
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: 京都府・国立京都国際会館
  • Year and Date: 2010-09-10
• [Presentation] Development of fusion protein probes for in vivo imaging of HIF-active cancer cells (2010)
  • Author(s): Kuchimaru T, Kadonosono T, Ushiki T, Kizaka-Kondoh S, Hiraoka M.
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: 京都府・国立京都国際会館
  • Year and Date: 2010-09-10
• [Presentation] 近赤外光プローブを用いた低酸素がん細胞のin vivoイメージング (2010)
  • Author(s): 口丸高弘、門之園哲哉、牛木隆、平岡真寛、近藤科江
  • Organizer: 平成22年度 がん若手研究者ワークショップ
  • Place of Presentation: 長野県・アートランドホテル蓼科
  • Year and Date: 2010-09-03
• [Presentation] Lipid raft mobility-associated GPI-anchored protein release for sperm capacitation in mouse. (2010)
  • Author(s): Kondoh, G., Watanabe, H., Orihashi, H.
  • Organizer: 11th International Symposium on Spermatology.
  • Place of Presentation: 那覇市
  • Year and Date: 2010-06-26
• [Presentation] 病的低酸素細胞の生体イメージング (2010)
  • Author(s): 近藤科江
  • Organizer: 第16回癌治療増感研究会
  • Place of Presentation: 県民文化ホール未来会館, 岐阜
  • Year and Date: 2010-06-19
• [Presentation] 放射線耐性肝がん細胞の細胞増殖能獲得メカニズムの解明 (2010)
  • Author(s): 小林智徳、大竹洋輔、桑原義和、福本基、円子顕子、山本文彦、福本学、大久保恭仁
  • Organizer: 第17回肝細胞研究会
  • Place of Presentation: 秋田
  • Year and Date: 2010-06-19
• [Presentation] 新規ナノキャリア、ラクトソームを用いた脳腫瘍同所移植モデルマウスにおける蛍光イメージングおよび病理組織との比較 (2010)
  • Author(s): 栗原研輔、山本文彦、山口真、荒川芳輝、原功、牧野顕、小関英一、富樫かおり、清水章、木村俊作
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-18
• [Presentation] 高分子ミセル型ナノキャリア「ラクトソーム」の放射性核種標識とこれを用いたIn vivoイメージングおよび生体内動態の検討 (2010)
  • Author(s): 山原亮、山本文彦、栗原研輔、原功、竹内恵理、牧野顕、近藤科江、塚田秀夫、小関英一、木村俊作
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-18
• [Presentation] Development and initial evaluation of novel fluorine-18 labeled nanocarrier "Lactosome"as a tumor imaging probe for PET (2010)
  • Author(s): Yamamoto F, Yamahara R, Kurihara K, Tsukada H, Takeuchi E, Hara I, Makino A, Kizaka-Kondoh S, Ozeki E, Kimura S
  • Organizer: The Society of Nuclear Medicine 57^<th> Annual Meeting
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2010-06-08
• [Presentation] 低酸素誘導因子 HIF-活性の生体イメージング (2010)
  • Author(s): 近藤科江、口丸高弘、門之園哲哉、平岡眞寛
  • Organizer: 日本分子生物学会第10回春季シンポジウム
  • Place of Presentation: ホテル松島大観荘, 仙台
  • Year and Date: 2010-06-07
• [Presentation] HIF活性化細胞特異的プローブの分子評価と標識蛍光色素の特性による生体イメージングの変化 (2010)
  • Author(s): 門之園哲哉、口丸高弘、牛木隆志、平岡眞寛、近藤科江
  • Organizer: 第5回日本分子イメージング学会学術集会
  • Place of Presentation: 滋賀県・ピアザ淡海
  • Year and Date: 2010-05-23
• [Presentation] 近赤外光プローブを用いたHIF活性細胞のin vivoイメージング (2010)
  • Author(s): 口丸高弘、門之園哲哉、牛木隆、平岡真寛、近藤科江
  • Organizer: 第5回日本分子イメージング学会学術集会
  • Place of Presentation: 滋賀県・ビアザ淡海
  • Year and Date: 2010-05-23
• [Presentation] ABC現象の可視化とその抑制方法の探究…近赤外蛍光剤標識された高分子ミセル型ナノキャリア「ICGラクトソーム」を用いて (2010)
  • Author(s): 栗原研輔、山本文彦、竹内恵理、原功、山原亮、小関英一、牧野顕、富樫かおり、清水章、木村俊作
  • Organizer: 第5回日本分子イメージング学会学術集会
  • Place of Presentation: 滋賀
  • Year and Date: 2010-05-23
• [Presentation] マウス精子におけるGPIアンカー型タンパク質遊離と受精能獲得との相関 (2010)
  • Author(s): 渡邊仁美、折橋郁、近藤玄
  • Organizer: 第57回日本実験動物学会
  • Place of Presentation: 京都市
  • Year and Date: 2010-05-12
• [Presentation] Influence of cell permeable property of fluorescent dye on the POH in vivo imaging probe specific to HIF-active cancer cells (2010)
  • Author(s): Kadonasono T, Kuchimaru K, Ushiki U, McDougall M, Kizaka-Kondoh S, Hiraoka M.
  • Organizer: American Association for Cancer Research 101st Annual Meeting 2010
  • Place of Presentation: Washington Convention Center, Washington DC
  • Year and Date: 2010-04-21
• [Presentation] Development of a fusion protein probe for in vivo imaging of HIF-active cancer cells (2010)
  • Author(s): Kuchimaru T, Kadonosono T, Ushiki T, McDougall M, Kizaka-Kondoh S, Hiraoka M.
  • Organizer: American Association for Cancer Research 101st Annual Meeting 2010
  • Place of Presentation: Washington Convention Center, Washington DC
  • Year and Date: 2010-04-21
• [Presentation] 低酸素誘導因子HIFを標的としたイメージング・ターゲティング (2010)
  • Author(s): 近藤科江、口丸高弘、門之園哲哉、平岡眞寛
  • Organizer: 第69回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2010-04-09
• [Presentation] 低酸素誘導因子HIFを標的としたイメージング・ターゲティング (2010)
  • Author(s): 近藤科江, 他
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16
• [Presentation] Development of a novel radioisotope labeled tumor imaging probe for PET "^<18>F-Lactosome" (2010)
  • Author(s): Yamamoto F, Yamahara R, Kurihara K, Tsukada H, Takeuchi E, Hara I, Makino A, Shimizu A, Kizaka-Kondoh S, Ozeki E, Kimura S
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] Development of novel radioiodine labeled nanocarrier "Lactosome" and initial evaluation as a tumor imaging probe (2010)
  • Author(s): Yamamoto F, Yamahara R, Kurihara K, Takeuchi E, Hara I, Makino A, Kizaka-Kondoh S, Ozeki E, Kimura S
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] Development of Near-Infrared Fluorescence Probes for In Vivo Tumor Imaging with Using an Amphiphilic Polydepsipeptide Micelle "Lactosome" (2010)
  • Author(s): Hara I, Yamahara R, Takeuchi E, Makino A, Kurihara K, Yamamoto F, Kizaka-Kondoh S, Ozeki E, Kimura S
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] A fluorescent imaging of the murine orthotopic brain tumor, using new nanocarrier "Lactosome" (2010)
  • Author(s): Kurihara K, Yamanoto F, Yamaguchi M, Arakawa Y, Hara I, Ozeki E, Makino A, Togashi K, Shimizu A, Kimura S
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] "Lactosome" a potential nano-ordered carrier for molecular imaging composed of a poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide and poly(lactic acid) derivatives. (2010)
  • Author(s): A.Makino, R.Yamahara, I.Hara, E.Takeuchi, E.Ozeki, K.Kurihara, S.Kizaka-Kondoh, F.Yamamoto, A.Shimizu, S.Kimura
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] ABC phenomenon with lactosome studied by in vivo NIRF imaging (2010)
  • Author(s): E.Takeuchi, I.Hara, R.Yamahara, A.Makino, K.Kurihara, F.Yamamoto, S.Kizaka-Kondoh, A.Shimizu, E.Ozeki, S.Kimura
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] "Lactosome" a Potential Nano-Ordered Carrier Composed of a Poly(L-latic acid)-block-Poly(sarcosine) Amphiphilic Polydepsipeptide and Poly(lactic acid) Derivatives (2010)
  • Author(s): A.Makino, R.Yamahara, I.Hara, E.Takeuchi, E.Ozeki, K.Kurihara, S.Kizaka-Kondoh, F.Yamamoto, A.Shimizu, S.Kimura
  • Organizer: International Symposium of "Development of Molecular Nanotechnology"
  • Place of Presentation: Nara
• [Presentation] 小動物を用いた生体光イメージング (2009)
  • Author(s): 近藤科江
  • Organizer: 第104回関西実験動物研究会
  • Place of Presentation: 京都
  • Year and Date: 2009-12-11
• [Presentation] 低酸素誘導転写因子HIF-1活性の生体光イメージング～癌化機構解析から創薬研究まで～ (2009)
  • Author(s): 近藤科江
  • Organizer: 第33回阿蘇シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2009-07-31
• [Presentation] すい臓がんでのHIF-1活性細胞の特異の細胞死誘導はがんの浸潤・転移を抑制する (2009)
  • Author(s): 近藤科江, 他
  • Organizer: 第13回日本癌分子標的治療学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2009-06-25
• [Presentation] 低酸素特異的アポトーシス誘導によるすい臓がん治療のイメージグ (2009)
  • Author(s): 近藤科江, 他
  • Organizer: 第4回日本分子イメージング学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14
• [Presentation] Imaging probe for tumor malignancy (2009)
  • Author(s): Kizaka-Kondoh S. Tanaka S
  • Organizer: SPIE 2009 BiOS Biomedical Optics Symposium
  • Place of Presentation: San Jose, CA, USA
  • Year and Date: 2009-01-29
• [Book] 医学のあゆみ:HIFs活性化細胞のバイオセンシングによる腫瘍内低酸素微小環境の可視化と治療薬開発 (2012)
  • Author(s): 門之園哲哉、近藤科江
  • Publisher: 医歯薬出版株式会社(in press)
• [Book] 薬学テキストシリーズ放射化学・放射性医薬品学 (2011)
  • Author(s): 小島周二、大久保恭仁編著/加藤真介、工藤なをみ、坂本光、佐々木徹、月本光俊、山本文彦
  • Total Pages: 264
  • Publisher: 朝倉書店
• [Book] がん幹細胞-ステムネス、ニッチ、標的的治療への理解第5章1.低酸素誘導因子HIFの機能と低酸素-幹細胞様形質と治療抵抗性のリンク (2011)
  • Author(s): 近藤科江
  • Publisher: 羊土社
• [Book] 臨床放射線:がん低酸素微小環境を標的とする治療薬・可視化プローブの開発 (2011)
  • Author(s): 門之園哲哉, 口丸高弘, 近藤科江
  • Publisher: 金原出版
• [Book] Surgery Frontier:癌微小環境における低酸素がん細胞のライブイメージング (2011)
  • Author(s): 口丸高弘、門之園哲哉、近藤科江
  • Publisher: メディカルレビュー社
• [Book] ドラッグデリバリーシステムの新展開II-核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術:膜透過性タンパク質を用いた低酸素誘導因子HIF関連疾患イメージング (2011)
  • Author(s): 口丸高弘、門之園哲哉、近藤科江
  • Publisher: シーエムシー出版
• [Book] 薬学テキストシリーズ放射化学・放射性医薬品学 (2011)
  • Author(s): 小島周二、大久保恭仁編著/加藤真介、工藤なをみ、坂本光、佐々木徹、月本光俊、山本文彦著
  • Total Pages: 264
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://www.kondohlab.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.kondohlab.bio.titech.ac.jp/
• [Patent(Industrial Property Rights)] Polypeptide unstablizing protein incells under aerobic conditions and DNA encoding the same (2012)
  • Inventor(s): 平岡真寛・近藤科江・原田浩
  • Industrial Property Rights Holder: オリエンタル酵母工業(株)
  • Filing Date: 2012-02-07
  • Overseas
• [Patent(Industrial Property Rights)] Polypeptide unstablizing protein incells under aerobic conditions and DNA encoding the same (2012)
  • Inventor(s): 平岡真寛・近藤科江・原田浩
  • Industrial Property Rights Holder: オリエンタル酵母工業(株)
  • Filing Date: 2012-02-07
  • Overseas
• [Patent(Industrial Property Rights)] Novel molecular assembly, molecular probe for molecularimaging and molecular probe fordrug delivery system using the same, and molecular imaging system and drugdelivery system (2011)
  • Inventor(s): 原功、山原亮、小関英一、木村俊作、近藤科江、牧野顕
  • Industrial Property Rights Holder: 株式会社島津製作所、国立大学法人京都大学
  • Filing Date: 2011-01-25
  • Overseas
• [Patent(Industrial Property Rights)] Polypeptide unstablizing protein incells under aerobic conditions and DNA encoding the same (2010)
  • Inventor(s): 平岡真寛・近藤科江・原田浩
  • Industrial Property Rights Holder: オリエンタル酵母工業(株)
  • Filing Date: 2010-04-20
  • Overseas