Design of Biomaterials Platform which responds to Oxidative Stress

• Project/Area Number: 21240050
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: University of Tsukuba
• Principal Investigator: NAGASAKI Yukio 筑波大学, 数理物質系, 教授 (90198309)
• Co-Investigator(Kenkyū-buntansha): YOSHITOMI Toru 筑波大学, 数理物質系, 研究員 (20585799) ; 阿部 康二 岡山大学, 医歯薬学部, 教授 (20212540) ; 鈴木 謙介 獨協医科大学, 医学部, 准教授 (20400674) ; 松井 裕史 筑波大学, 大学院・人間総合科学研究科, 講師 (70272200)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000); Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2010: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000); Fiscal Year 2009: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
• Keywords: ナノメディシン / DDS / イメージング / 細胞培養床 / 活性酸素種 / 酸化ストレス / 活性酸素 / 安定ラジカル / RNP / 脳梗塞再灌流 / 血液適合性 / 透析 / 反応性酸素種 / ニトロキシラジカル含有ナノ粒子 / 生体低合成表面 / バイオイメージング / MRI / EPRI

Research Abstract

Stable nitroxide radical-containing redox polymers, which we designed in this study, were found to effectively scavenge excessively generated reactive oxygen species and can be regarded as one of candidates for novel biomaterials.

Research Products

• [Journal Article] Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells (2013)
  • Author(s): 長崎幸夫
  • Journal Title: Biomaterials Science Volume: 1 Issue: 4 Pages: 361-367
  • DOI: 10.1039/c2bm00156j
  • Peer Reviewed
• [Journal Article] Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate (2013)
  • Author(s): 長崎幸夫
  • Journal Title: Journal of Materials Chemistry B Volume: 1 Issue: 4 Pages: 529-535
  • DOI: 10.1039/c2tb00031h
  • Peer Reviewed
• [Journal Article] The glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPAR gamma in breast cancer pathophysiology (2013)
  • Author(s): 長崎幸夫
  • Journal Title: Journal of Drug Targeting Volume: 21 Issue: 2 Pages: 161-174
  • DOI: 10.3109/1061186x.2012.736998
  • Peer Reviewed
• [Journal Article] Novel Biocompatible Nanoreactor for Silica/Gold Hybrid Nanoparticles Preparation (2013)
  • Author(s): 長崎幸夫
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 102 Pages: 778-782
  • DOI: 10.1016/j.colsurfb.2012.09.034
  • NAID: 120007137069
  • Peer Reviewed
• [Journal Article] An Orally Administered Redox Nanoparticle that Accumlates in the Colonic Mucosa and Reduces Colitis in Mice (2012)
  • Author(s): Long Binh Vong, Tsutomu Tomita, Toru Yoshitomi, Hirofumi Matsui, Yukio Nagasaki
  • Journal Title: Gastroenterology Volume: Vol.143, No.4 Issue: 4 Pages: 1027-1036
  • DOI: 10.1053/j.gastro.2012.06.043
  • Peer Reviewed
• [Journal Article] Redox Nanoparticle Treatment Protects Against Neurological Deficit in Focused Ultrasound-Induced Intracerebral Hemorrhage (2012)
  • Author(s): Pennapa Chonpathompikunlert, Ching-Hsiang Fan, Yuki Ozaki, Toru Yoshitomi, Chih-Kuang Yeh, Yukio Nagasaki
  • Journal Title: Nanomedicine Volume: Vol.7, No.7 Issue: 7 Pages: 1029-1043
  • DOI: 10.2217/nnm.12.2
  • Peer Reviewed
• [Journal Article] Design and preparation of a nanoprobe for imaging inflammation sites (2012)
  • Author(s): Toru Yoshitomi, Yukio Nagasaki
  • Journal Title: Biointerphase Volume: 7 Issue: 1 Pages: 7-7
  • DOI: 10.1007/s13758-011-0007-5
  • Peer Reviewed
• [Journal Article] Amemiya: Dependence of Swelling Behavior of pH-responsive PEG-modified Nanogel on Cross-link Density (2012)
  • Author(s): Goshu Tamura, Yuya Shinohara, Atushi Tamura, Yusuke Sanada, Motoi Oishi, Isamu Akiba, Yukio Nagasaki, Kazuo Sakurai, and Yoshiyuki
  • Journal Title: Polymer Journal Volume: Vol.44,No.3 Issue: 3 Pages: 240-244
  • DOI: 10.1038/pj.2011.123
  • Peer Reviewed
• [Journal Article] PEGylation Technology in Nanomedicine (2012)
  • Author(s): Yutaka Ikeda, Yukio Nagasaki
  • Journal Title: Advances in Polymer Science Volume: Volume 247, Polymers in Nanomedicine Pages: 115-140
  • DOI: 10.1007/12_2011_154
  • ISBN: 9783642278556, 9783642278563
  • Peer Reviewed
• [Journal Article] Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using nitroxide radical-containing polymer with reactive oxygen species scavenging activity (2012)
  • Author(s): Toru Yoshitomi, Yu Yamaguchi, Akihiko Kikuchi, Yukio Nagasaki
  • Journal Title: Acta Biomaterialia Volume: 8 Issue: 3 Pages: 1323-1329
  • DOI: 10.1016/j.actbio.2011.11.029
  • NAID: 120007130697
  • Peer Reviewed
• [Journal Article] High PEGylation Efficiency of Pentaethylenehexamine-end Poly(ethyleneglycol) (mPEG-N6) for Active-ester Surface (2012)
  • Author(s): Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto and Yukio Nagasaki
  • Journal Title: Colloid and Surface B: Biointerface Volume: 92 Issue: 2 Pages: 25-29
  • DOI: 10.4155/tde.11.153
  • Peer Reviewed
• [Journal Article] Different mechanisms of action of poly(ethylene glycol) and arginine on thermal inactivation of lysozyme and ribonuclease A (2012)
  • Author(s): Shunsuke Tomita
  • Journal Title: Biotechnology and Bioengineering Volume: 109 Issue: 10 Pages: 2543-2552
  • DOI: 10.1002/bit.24531
  • Peer Reviewed
• [Journal Article] Development of a high-performance immunolatex based on "soft landing" antibody immobilization mechanism (2012)
  • Author(s): Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto and Yukio Nagasaki
  • Journal Title: Colloid and Surface B: Biointreface Volume: Vol.99 Pages: 45-52
  • DOI: 10.1016/j.colsurfb.2011.09.040
  • NAID: 120007137228
  • Peer Reviewed
• [Journal Article] Boron Neutron Capture Therapy Assisted by Boron-conjugated Nanoparticles (2012)
  • Author(s): Shogo Sumitani, Yukio Nagasaki
  • Journal Title: Polymer Journal Volume: Vol.44, No.6 Issue: 6 Pages: 522-530
  • DOI: 10.1038/pj.2012.30
  • Peer Reviewed
• [Journal Article] Block Ionomer Complexes of PEG-block-poly(4-vinylbenzylphosphonate) and Cationic Surfactants as Highly Stable, pH Responsive Drug Delivery System (2012)
  • Author(s): Masao Kamimura, Jong Oh Kim, Alexander V. Kabanov, Tatiana K. Bronich, and Yukio Nagasaki
  • Journal Title: Journal of Controlled Release Volume: Vol.160 Issue: 3 Pages: 486-494
  • DOI: 10.1016/j.jconrel.2012.04.027
  • NAID: 120007137277
  • Peer Reviewed
• [Journal Article] Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array (2012)
  • Author(s): Yutaka Ikeda, Tomoko Jomura, Umeko Horiuchi, Junko Saeki, Keitaro Yoshimoto, Takeshi Ikeya, Yukio Nagasaki
  • Journal Title: Colloid and Surface, B, Biointerface Volume: 97 Pages: 97-100
  • DOI: 10.1016/j.colsurfb.2012.04.022
  • Peer Reviewed
• [Journal Article] Improved Complementary Polymer Pair System: Switching for Enzyme Activity by PEGylated Polymers (2012)
  • Author(s): Takaaki Kurinomaru, Shunsuke Tomita, Shinpei Kudo, Sumon Ganguli, Yukio Nagasaki, Kentaro Shiraki
  • Journal Title: Langmuir Volume: Vol.28, No.9 Issue: 9 Pages: 4334-4338
  • DOI: 10.1021/la2043312
  • Peer Reviewed
• [Journal Article] Pharmacokinetics of core-polymerized, boron-conjugated micell es designed for boron neutron capture therapy for cancer (2012)
  • Author(s): Shogo Sumitani, Motoi Oishi, Tatsuya Yaguchi, Hiroki Murotani, Yukichi, Horiguchi, Minoru Suzuki, Koji Ono, Hironobu Yanagie, Yukio Nagasaki
  • Journal Title: Biomaterials Volume: 33 Issue: 13 Pages: 3568-3577
  • DOI: 10.1016/j.biomaterials.2012.01.039
  • Peer Reviewed
• [Journal Article] High PEGylation Efficiency of Pentaethylenehexamine-end Poly(ethyleneglycol) (mPEG-N6) for Active-ester Surface (2012)
  • Author(s): 長崎幸夫
  • Journal Title: Colloid and Surface B: Biointerface Volume: 92 Pages: 25-29
  • DOI: 10.1016/j.colsurfb.2011.11.013
  • Peer Reviewed
• [Journal Article] 生体適合性ポリエチレングリコール表面の構築 (2012)
  • Author(s): 長崎幸夫
  • Journal Title: 高分子 Volume: 61 Pages: 77-82
  • NAID: 10030169568
  • Peer Reviewed
• [Journal Article] Novel redox nanomedicine improves gene expression of polyion complex vector (2011)
  • Author(s): KazukoToh, Toru Yoshitomi, Yutaka Ikeda, Yukio Nagasaki
  • Journal Title: Science and Technology of Advanced Materials Volume: 12 Issue: 6 Pages: 65001-65001
  • DOI: 10.1088/1468-6996/12/6/065001
  • NAID: 120007130770
  • Peer Reviewed
• [Journal Article] The Use of Nitroxide Radical-containing Nanoparticles Coupled with Piperine to Protect Neuroblastoma SH-SY5Y cells from Aβ-Induced Oxidative Stress (2011)
  • Author(s): Chonpathompikunlert Pennapa, Toru Yoshitomi, Han Junkyu, Hiroko Isoda, Yukio Nagasaki
  • Journal Title: Biomaterials Volume: 32 Issue: 33 Pages: 8605-8612
  • DOI: 10.1016/j.biomaterials.2011.07.024
  • Peer Reviewed
• [Journal Article] The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles (2011)
  • Author(s): Toru Yoshitomi, Aki Hirayama, Yukio Nagasaki
  • Journal Title: Biomaterials Volume: 32 Issue: 31 Pages: 8021-8028
  • DOI: 10.1016/j.biomaterials.2011.07.014
  • NAID: 120007137437
  • Peer Reviewed
• [Journal Article] Gd@C_<82> metallofullerenes for neutron capture therapy-Fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N,N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro (2011)
  • Author(s): Yukichi Horiguchi, Shinpei Kudo, Yukio Nagasaki
  • Journal Title: Science and Technology of Advanced Materials Volume: 12 Issue: 4 Pages: 44607-44614
  • DOI: 10.1088/1468-6996/12/4/044607
  • Peer Reviewed
• [Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid (2011)
  • Author(s): Hiroto Hatakeyama, Hidetaka Akita, Erika Itoh, Yasuhiro Hayashi, Motoi Oishi, Yukio Nagasaki, R. Danev, K. Nagayama, N. Kaji, H. Kikuchi, Y. Baba, Harashima H
  • Journal Title: Biomaterials Volume: 32(18) Issue: 18 Pages: 4-4
  • DOI: 10.1016/j.biomaterials.2011.02.045
  • Peer Reviewed
• [Journal Article] Chemical Nanotherapy-Nitroxyl Radical-containing Nanoparticle (RNP) Protects Neuroblastoma SH-SY5Y cells from Aβ-induced Oxidative Stress (2011)
  • Author(s): Chonpathompikunlert Pennapa , Toru Yoshitomi, Han Junkyu, Kazuko Toh, Hiroko Isoda, Yukio Nagasaki
  • Journal Title: Therapeutic Delivery Volume: 2(5) Issue: 5 Pages: 585-597
  • DOI: 10.4155/tde.11.27
  • Peer Reviewed
• [Journal Article] Nitroxyl radical-containing nanoparticles for novel nanomedicine against oxidative stress injury (2011)
  • Author(s): Toru Yoshitomi, Yukio Nagasaki
  • Journal Title: Nanomedicine Volume: April, Vol. 6, No. 3 Issue: 3 Pages: 509-518
  • DOI: 10.2217/nnm.11.13
  • Peer Reviewed
• [Journal Article] Newly Synthesized Radical-containing Nanoparticles (RNP)Enhance Neuroprotection after Cerebral Ischemia-reperfusion Injury (2011)
  • Author(s): Aiki Marushima, Hideo Tsurusima, Toru Yoshitomi, Kazuko Toh, Aki Hirayama, Yukio Nagasaki, Akira Matumura
  • Journal Title: Neurosurgery Volume: 68 Issue: 5 Pages: 1418-1426
  • DOI: 10.1227/neu.0b013e31820c02d9
  • Peer Reviewed
• [Journal Article] Noveloligonucleotide carrier possessing reactive oxygen species scaven gingability (2011)
  • Author(s): Yutaka Ikeda, Rie Suzuki, Toru Yoshitomi, Yukio Nagasaki
  • Journal Title: Macromolecular Bioscience Volume: 11 Issue: 3 Pages: 344-351
  • DOI: 10.1002/mabi.201000305
  • Peer Reviewed
• [Journal Article] TEMPOL Protects Human Neuroblastoma SH-SY5Ycells Against β-amyloid-induced Cell Toxicity (2011)
  • Author(s): Chonpathompikunlert Pennapa, Han Junkyu, Toh Kazuko, Hiroko Isoda ,Nagasaki Yukio
  • Journal Title: European Journal of Pharmacology Volume: 650 Issue: 2-3 Pages: 544-549
  • DOI: 10.1016/j.ejphar.2010.10.028
  • Peer Reviewed
• [Journal Article] TEMPOL Protects Human Neuroblastoma SH-SY5Ycells Against β-amyloid-induced Cell Toxicity (2011)
  • Author(s): Chonpathompikunlert Pennapa, Han Junkyu, Toh Kazuko, Hiroko Isoda, Nagasaki Yukio
  • Journal Title: European Journal of Pharmacology Volume: 650 Pages: 544-549
  • Peer Reviewed
• [Journal Article] Newly Synthesized Radical-containing Nanoparticles (RNP) Enhance Neuroprotection after Cerebral Ischemia-reperfusion Injury (2011)
  • Author(s): Aki Marushima, Hideo Tsurusima, Toru Yoshitomi, Kazuko Toh, Aki Hirayama, Yukio Nagasaki, Akira Matumura
  • Journal Title: Neurosurgery Volume: 68 Pages: 344-351
  • Peer Reviewed
• [Journal Article] Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly (ethylene glycol) tethered-chain layer (2011)
  • Author(s): Masaki Kubota, Keitaro Yoshimoto, Yuan Xiaofei, Yukio Nagasaki
  • Journal Title: Polymer Journal Volume: 43 Issue: 5 Pages: 493-496
  • DOI: 10.1038/pj.2011.5
  • NAID: 10028221047
  • Peer Reviewed
• [Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid (2011)
  • Author(s): Hiroto Hatakeyama, Hidetaka Akita, Erika Itoh, Yasuhiro Hayashi, Motoi Oishi, Yukio Nagasaki, R.Danev, K.Nagayama, N.Kaji, H.Kikuchi, Y.Baba, Harashima H.
  • Journal Title: Biomaterials Volume: 32(18) Pages: 4306-4316
  • Peer Reviewed
• [Journal Article] Carborane Confined Nanoparticle for Boron Neutron Capture Therapy : -Improved stability, Blood Circulation Time and Tumor Accumulation (2011)
  • Author(s): Shogo Sumitani, Motoi Oishi, Yukio Nagasaki
  • Journal Title: Reactive and Functional Polymers Volume: 71(7) Pages: 684-693
  • NAID: 120007130836
  • Peer Reviewed
• [Journal Article] In Vivo and In Vitro Characteristics of Core-Shell-Type Nanogel Particles : Optimization of Core Cross-Linking Density and Surface PEG Density in PEGylated Nanogels (2011)
  • Author(s): Masato Tamura, Satoshi Ichinohe, Atsushi Tamura, Yutaka Ikeda, Yukio Nagasaki
  • Journal Title: Acta Biomaterialia Volume: 7(9) Pages: 3354-3361
  • Peer Reviewed
• [Journal Article] Near infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly (4-vinylbenzylphosphonate) (2011)
  • Author(s): Masao Kamimura, Naoki Kanayama, Kimikazu Tokuzen, Kohei Soga, Yukio Nagasaki
  • Journal Title: Nanoscale Volume: 3 Issue: 9 Pages: 3705-3713
  • DOI: 10.1039/c1nr10466g
  • Peer Reviewed
• [Journal Article] Preparation of Highly Dispersible and Tumor-Accumulative, Iron Oxide Nanoparticles-Multi-point Anchoring of PEG-b-poly(4-vinylbenzylphosphonate) Improves Performance Significantly, Colloid and Surface B (2011)
  • Author(s): Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki
  • Journal Title: Biointreface Volume: 88 Pages: 771-778
  • Peer Reviewed
• [Journal Article] Construction of Densely Poly(ethylene glycol) Chain Tethered Surface and its Performance (2011)
  • Author(s): Yukio Nagasaki
  • Journal Title: Polymer Journal Volume: 43 Issue: 12 Pages: 949-958
  • DOI: 10.1038/pj.2011.93
  • Peer Reviewed
• [Journal Article] Engineering of poly(ethylene glycol)chain-tethered surfaces to obtain high-performance bionanoparticles (2010)
  • Author(s): 長崎幸夫
  • Journal Title: Science and Technology of Advanced Materials Volume: 11 Pages: 54505-54505
  • Peer Reviewed
• [Journal Article] TEMPOL Protects Human Neuroblastoma SH-SYSYcells Against o-amyloid-induced Cell Toxicity (2010)
  • Author(s): 長崎幸夫
  • Journal Title: European Journal of Pharmacology Volume: 650 Pages: 544-549
  • Peer Reviewed
• [Journal Article] Simple Solid-Phase Synthesis and Biological Properties of Carbohydrate-Oligonucleotide Conjugates Modified at the 3'-Terminus (2010)
  • Author(s): 長崎幸夫
  • Journal Title: Bioconjugate Chemistry Volume: 21 Pages: 1685-1690
  • Peer Reviewed
• [Journal Article] Efficient Inhibition of Interfacial Nonspecific Interaction to Create Practically Utilizable High Ferritin-Response Immunolatex, Analytical Chemistry, 81 10097-10105(2009). (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Analytical Chemistry 81 Pages: 10097-10105
  • Peer Reviewed
• [Journal Article] Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine] Modified Gold Surfaces Fabricated by the "Grafting to" Method : Comparison of its Protein Resistance with Poly (ethylene glycol) Modified Gold Surfaces. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Macromolecular Rapid Communications 30 Pages: 2136-2140
  • Peer Reviewed
• [Journal Article] pH-Sensitive Radical-Containing-Nanoparticle(RNP)for the L-Band-EPR Imaging of Low pH Circumstances. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Bioconjugate Chemistry 20 Pages: 1792-1798
  • Peer Reviewed
• [Journal Article] Spheroid Array of Fetal Mouse Liver Cells Constructed on a PEG-gel Micropatterned Surface : Upregulation of Hepatic Functions by Co-Culture with Nonparenchymal Liver Cells. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Lab on a Chip 9 Pages: 1991-1993
  • Peer Reviewed
• [Journal Article] Inverted Pattern Formation of Cell Microarrays on Poly(ethylene glycol)(PEG)Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Lab on a Chip 9 Pages: 1286-1289
  • NAID: 120007138167
  • Peer Reviewed
• [Journal Article] Regulation of Lysozyme Activity Based on Thermotolerant Protein/Smart Polymer Complex Formation. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Journal of the American Chemical Society 131 Pages: 6549-6553
  • Peer Reviewed
• [Journal Article] Design of Core-shell-type Nanoparticles Carrying Stable Radicals in the Core. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Biomacromolecules 10 Pages: 596-601
  • Peer Reviewed
• [Journal Article] Luminescence-based Colorimetric Discrimination of Single-nucleotide Transversions by the Combined Use of the Derivatives of DOTA-conjugated Naphthyridine and Its Terbium Complex. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Tetrahedron Letter 50 Pages: 2177-2180
  • NAID: 120007138274
  • Peer Reviewed
• [Journal Article] High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface : High Sensitive Ferritin Immunodiagnostics. (2009)
  • Author(s): 長崎幸夫
  • Journal Title: Analytical Chemistry 81 Pages: 1549-1556
  • Peer Reviewed
• [Presentation] Novel Redox Injectable Gel for Local Inflammation (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: New Innovations in Polymers And (bio)Materials(NIPAM-80)
  • Place of Presentation: Ka'anapali, Maui, Hawaii, USA
  • Year and Date: 2012-12-16
• [Presentation] Next generation of PEG modification technology on biomolecules (2012)
  • Author(s): Yutaka Ikeda, Jinya Katamachi, Hiromichi Kawasaki and Yukio Nagasaki
  • Organizer: The 9th SPSJ International Polymer Conference, (IPC2012)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2012-12-13
• [Presentation] Orally Administered Redox Nanoparticle Accumulates in the Colonic Mucosa and Reduces Colitis in Mice (2012)
  • Author(s): Long Binh Vong, Tsutomu Tomita, Toru Yoshitomi, Hirofumi Matsui and, Yukio Nagasaki
  • Organizer: The 9th SPSJ International Polymer Conference, (IPC2012)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2012-12-12
• [Presentation] Design of redox nanoparticle as an adjuvant to anticancer chemotherapy (2012)
  • Author(s): Toru Yoshitomi Yuki Ozaki and Yukio Nagasaki
  • Organizer: The 9th SPSJ International Polymer Conference, (IPC2012)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2012-12-12
• [Presentation] Redox Polymer Therapeutics (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: 6th International Symposium, on Nanomedicine , (ISNM2012)
  • Place of Presentation: Kunibiki Messe, Matsue, Shimane
  • Year and Date: 2012-11-30
• [Presentation] Redox nanoparticle avoids an uptake into blood cell and prevents blood coagulation, International Joint Symposium on Single-Cell Analysis (2012)
  • Author(s): Madoka Shimizu , Toru Yoshitomi and Yukio Nagasaki
  • Organizer: The 6th International Workshop on Approaches to Single-Cell Analysis & The 8th International Forum on Post-Genome Technologies
  • Place of Presentation: Kyoto Research Park, Kyoto,Japan
  • Year and Date: 2012-11-28
• [Presentation] 非ステロイド系抗炎症薬内包レドックスナノ粒子による消化管傷害の抑制と バイオアベイラビリティの向上 (2012)
  • Author(s): 沙 莎 、吉冨 徹 、Vong Long Binh 、Pennapa Chonpathompikunlert 、松 井裕史、 長崎幸夫
  • Organizer: 日本バイオマテリアル学会シンポジウム2012
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2012-11-27
• [Presentation] 局所的酸化ストレス障害を治療するレドックスインジェクタブルハイドロゲルの開発 (2012)
  • Author(s): プア ミン リー、吉冨 徹 、Pennapa Chonpathompikunlert、 平山 暁、 長崎幸夫
  • Organizer: 日本バイオマテリアル学会シンポジウム2012
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2012-11-26
• [Presentation] Develop a novel oral administration of indomethacin-loaded redox nanoparticles for enhancement of bioavailability and suppression of side effect (2012)
  • Author(s): Sha Sha, Long Binh Vong, Pennapa Chonpathompikunlert, Toru Yoshitomi,Hirofumi Matsui and Yukio Nagasaki
  • Organizer: International Workshop on Soft Interface Science for Young Scientists(SISYS2012)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-11-22
• [Presentation] Development and Evaluation of ROS-Scavenging Cigarette Filter prepared by Nitroxide Radicals Containing Polymer (2012)
  • Author(s): Kazuhiro Kuramochi, Toru Yoshitomi, Yu Yamaguchi, and Yukio Nagasaki
  • Organizer: International Workshop on Soft Interface Science for Young Scientists(SISYS2012)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-11-22
• [Presentation] Redox Injectable Gel (RIG) for Treatments of Local Inflammation -Carrageenan-induced Arthritis- (2012)
  • Author(s): Pua Min Ley, Toru Yoshitomi,Pennapa Chonpathompikunlert, Aki Hirayama and Yukio Nagasaki
  • Organizer: International Workshop on Soft Interface Science for Young Scientists(SISYS2012)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-11-22
• [Presentation] Redox nanoparticle improves chemotherapeutic effect and suppresses its adverse effects (2012)
  • Author(s): Long Binh Vong, Tsutomu Tomita, Toru Yoshitomi, Hirofumi Matsui, and Yukio Nagasaki
  • Organizer: International Workshop on Soft Interface Science for Young Scientists(SISYS2012)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-11-22
• [Presentation] Protein sensing on Aptamer/PEG hybrid surface by monolithic SiO2, waveguide sensing plate (2012)
  • Author(s): Thangavel Lakshmipriya, Makoto Fujimaki, Subash C.B. Gopinath, Koichi Awazu, Yukichi Horiguchi and Yukio Nagasaki
  • Organizer: International Workshop on Soft Interface Science for Young Scientists(SISYS2012)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-11-22
• [Presentation] HIGHLY CONTROLLED PEG/APTAMER HYBRID SURFACEFOR PROTEIN DETECTION ANALYSISBY SURFACE ACOUSTIC WAVE SENSOR (2012)
  • Author(s): Yukichi Horiguchi, Seigo Miyachi, Yukio Nagasaki
  • Organizer: International Workshop on Soft Interface Science for Young Scientists(SISYS2012)
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-11-22
• [Presentation] レドックスインジェクタブルゲルの設計と評価 (2012)
  • Author(s): 長崎幸夫
  • Organizer: 第51回電子スピンサイエンス学会年会 (SEST2012)
  • Place of Presentation: 札幌コンベンションセンター、札幌
  • Year and Date: 2012-11-03
• [Presentation] pH応答性ニトロキシドラジカル含有高分子ミセルの開発と腎虚血再灌流障害治療への展開 (2012)
  • Author(s): 吉冨 徹、平山 暁 、長崎幸夫
  • Organizer: 第51回電子スピンサイエンス学会年会 (SEST2012)
  • Place of Presentation: 札幌コンベンションセンター、札幌
  • Year and Date: 2012-11-03
• [Presentation] Fullerene as Nanobiomedicine (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: The 6th International Workshop on Advanced Materials Science IWAMSN 2012
  • Place of Presentation: Halong-Vietnam
  • Year and Date: 2012-11-01
• [Presentation] Conjugation chemistries for the development of next generation drugs (2012)
  • Author(s): Yutaka Ikeda Hiromichi Kawasaki Jinya Katamachi Yukio Nagasaki
  • Organizer: The 6th International Workshop on Advanced Materials Science IWAMSN 2012
  • Place of Presentation: Halong-Vietnam
  • Year and Date: 2012-10-31
• [Presentation] 新しいレドックス型ポリマードラッグによるアルツハイマー型障害治療 (2012)
  • Author(s): 長崎幸夫、ペンナッパチョンパソンピクンラート、吉冨 徹
  • Organizer: 第31回認知症学会学術集会
  • Place of Presentation: 筑波国際会議場、つくば
  • Year and Date: 2012-10-27
• [Presentation] Redox Polymer Nanoarchitectonics in vivo -Novel Oral Plymer Therapeutics- (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: PCCP Asian Symposium 2012
  • Place of Presentation: MANA, NIMS, Tsukuba
  • Year and Date: 2012-10-01
• [Presentation] 高性能な腹膜透析を目指したシリカ含有レドックスナノ粒子の開発 (2012)
  • Author(s): 吉冨 徹、矢口 達也、平山暁、植田 敦志、長崎 幸夫
  • Organizer: 第61回高分子学会高分子討論会
  • Place of Presentation: 名古屋工業大学、名古屋
  • Year and Date: 2012-09-21
• [Presentation] 局所的酸化ストレス障害の治療効果を高める新規ニトロキシドラジカル含有インジェクタブルハイドロゲルの開発 (2012)
  • Author(s): プア ミン リー、ペナパーションパトンピクンラット、吉冨 徹、長崎 幸夫
  • Organizer: 第61回高分子学会高分子討論会
  • Place of Presentation: 名古屋工業大学、名古屋
  • Year and Date: 2012-09-21
• [Presentation] アルツハイマー病に対するナノメディシンの設計 (2012)
  • Author(s): 長崎幸夫 、 Pennapa Chonpathompikunlert、今泉夏香、尾崎祐樹、吉冨 徹
  • Organizer: 第61回高分子学会高分子討論会
  • Place of Presentation: 名古屋工業大学、名古屋
  • Year and Date: 2012-09-21
• [Presentation] Design of Redox Polymer Nanotherapy (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: The Saudi International, Biotechnology Conference 2012
  • Place of Presentation: Ryado, Saudi Arabia
  • Year and Date: 2012-09-19
• [Presentation] Sha Sha Pennapa Chonpathompikunlert Toru YoshitomiHorifumi Matsui, Protection of NSAID-induced small intestinal mucosal injury by redox nanoparticle (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: 7th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2012-09-10
• [Presentation] Polymer nanoparticle-based nitric oxide(NO) photodonor for novel therapeutics (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: SPIE2012 Nanosystem, (the international society for optics and photonics)
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2012-09-10
• [Presentation] 経口投与によるレドックスポリマードラッグの開発 (2012)
  • Author(s): 長崎幸夫
  • Organizer: 日本バイオマテリアル学会第2回九州地区講演会
  • Place of Presentation: 九州大学、福岡
  • Year and Date: 2012-09-04
• [Presentation] Novel synthesized radical-containing nanoparticles augment cardioprotection after ischemia-reperfusion injury via nitric oxide in canine hearts (2012)
  • Author(s): Akemi Yoshida; Shoji Sanada; Hiroshi Asanuma; Hideyuki Sasaki; Hiroyuki Takahama; Masanori Asakura; Toru Yoshitomi; Yukio Nagasaki; Naoki Mochizuki; Masafumi Kitakaze
  • Organizer: ESC (European Society of Cardiology) Congress 2012
  • Place of Presentation: Munich, Germany
  • Year and Date: 2012-08-29
• [Presentation] Hybrid chemistry for nanomedicine (2012)
  • Author(s): Yutaka Ikeda
  • Organizer: Nanobio Seattle
  • Place of Presentation: Seattle, USA
  • Year and Date: 2012-07-24
• [Presentation] Oral nanotherapy for treatment of ulcerative colitis by redox nanoparticle (2012)
  • Author(s): Toru Yoshitomi, Long Binh Vong, Hirofumi Matsui, Yukio Nagasaki
  • Organizer: Nanobio Seattle
  • Place of Presentation: Seattle, USA
  • Year and Date: 2012-07-24
• [Presentation] Redox Nanomedicine for Cancer Chemotherapy (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: Nanobio Seattle
  • Place of Presentation: Seattle, USA
  • Year and Date: 2012-07-23
• [Presentation] Self-organizing Redox Polymer Therapy (2012)
  • Author(s): Yukio Nagasaki
  • Organizer: First Workshop between UdeM-MANA on Nano-life
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2012-07-19
• [Presentation] Nanotherapy of Renal Ischemia-reperfusion Injury by pH-responsive Redox Nanoparticle (2012)
  • Author(s): Toru Yoshitomi, Aki Hirayama and Yukio Nagasaki
  • Organizer: 2012 Korean Society of Biomaterials
  • Place of Presentation: Kyunghee University, Seoul, Korea
• [Presentation] 高性能な腹膜透析を目指したシリカナノゲル含有レドックスナノ粒子の設計と開発 (2012)
  • Author(s): 吉冨 徹、矢口 達也、平山 暁、植田 敦志、長崎 幸夫
  • Organizer: ゲルワークショップイン名古屋、KKRホテル名古屋
  • Place of Presentation: 名古屋
• [Presentation] 高い酵素残存活性を有する新しいタンパク質PEG 化試薬の開発 (2012)
  • Author(s): 片町 仁哉、河崎 弘道、池田 豊、長崎 幸夫
  • Organizer: 第61会高分子討論会
  • Place of Presentation: 名古屋工業大学、名古屋
• [Presentation] Evaluation of in vivo antioxidative activity of O-TEMPO-RNP using our newly developed chicken egg assay (2012)
  • Author(s): Yoshihiro Uto, Chiaki Abe, Toru Yoshitomi, Yukio Nagasaki, Yoshio Endo and Hitoshi Hori
  • Organizer: Society for Free Radical Research International 16TH BIENNIAL MEETING
  • Place of Presentation: Imperial College London, UK
• [Presentation] 次世代タンパク質PEG化技術の開発 (2012)
  • Author(s): 片町仁哉、河崎 弘道、 池田 豊、長崎幸夫
  • Organizer: 第3回ソフトインターフェースの分子科学ミニワークショップ
  • Place of Presentation: 東京医科歯科大、東京
• [Presentation] アプタマー/PEG-PAMA共吸着表面構築による高感度な表面弾性波センシングシステム (2012)
  • Author(s): 堀口諭吉、宮地正悟、 長崎幸夫
  • Organizer: 第8回ソフトインターフェースの分子科学公開シンポジウム
  • Place of Presentation: 米沢
• [Presentation] 高い酵素残存活性を有する新しいタンパク質PEG化技術の開発 (2012)
  • Author(s): 片町仁哉、河崎 弘道、池田 豊、長崎幸夫
  • Organizer: 第8回ソフトインターフェースの分子科学公開シンポジウム
  • Place of Presentation: 米沢
• [Presentation] 酵素-高分子電解質インターフェース形成を利用する酵素機能制御法 (2012)
  • Author(s): 冨田 峻介、栗之丸 隆章、工藤 心平、 Sumon Ganguli、 長崎 幸夫、白木賢太
  • Organizer: 第8回ソフトインターフェースの分子科学公開シンポジウム
  • Place of Presentation: 米沢
• [Presentation] Self-assembled Redox Polymer Drug -Synthesis, Physicochemical Characteristics and Nanotherapy (2011)
  • Author(s): Yukio Nagasaki
  • Organizer: Advanced ESR Studies for New Frontiers in Biofunctional Spin Science and Technology"(AEBST 2011)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2011-11-13
• [Presentation] SELF-ASSEMBLING REDOX POLYMER DRUG FOR ANTI-OXIDATIVE STRESS INJURY (2011)
  • Author(s): 長崎幸夫
  • Organizer: 2nd International School-Nano2011. Nanomaterials and Nanotechnologies in Living Systems. Safety and Nanomedicine
  • Place of Presentation: Moscow, Russia(招待講演)
  • Year and Date: 2011-09-19
• [Presentation] ニトロキシラジカルを利用した新しいバイオマテリアルの設計 (2010)
  • Author(s): 長崎幸夫
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜、横浜、日本
  • Year and Date: 2010-05-26
• [Presentation] DESIGN OF pH-SENSITIVE RADICAL-CONTAINING-NANOPARTICLE(RNP)FOR THE EPR IMAGING OF LOW pH ENVIRONMENTS (2010)
  • Author(s): 長崎幸夫
  • Organizer: Symposium on Biomedical Polymers for Drug Delivery
  • Place of Presentation: University of Utah, SALT LAKE CITY, Utah, USA
  • Year and Date: 2010-03-26
• [Presentation] Design of pH-sensitive polymeric micelle possessing reduced forms of TEMPO for imaging of ROS (2010)
  • Author(s): 長崎幸夫
  • Organizer: the 2010 World Congress of the Oxygen Club of California
  • Place of Presentation: Fess Parker's Double Tree Resort, Santa Barbara, California, USA
  • Year and Date: 2010-03-18
• [Presentation] Design of pH-sensitive polumeric micelle possessing reduced forms of TEMPO for imaging of ROS. Anti-oxidative stress nanoparticle for novel theranostics (2010)
  • Author(s): 長崎幸夫
  • Organizer: OCC 2010 World Congress
  • Place of Presentation: SANTA BARBARA, CALI FORNIA, USA
  • Year and Date: 2010-03-17
• [Presentation] Nanoparticles possessing Anti-oxidative Stress Activity for Ischemia Reperfusion Injury (2010)
  • Author(s): 長崎幸夫
  • Organizer: MANA International Symposium 2010
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2010-03-05
• [Presentation] Novel Nanosphere Theranostic for Anti-Oxidative Stress (2010)
  • Author(s): 長崎幸夫
  • Organizer: THE 1st INTERNATIONAL CONFERENCE FORGREEN TECHNOLOGIES
  • Place of Presentation: Ajou University, Suwon, Korea
  • Year and Date: 2010-02-18
• [Presentation] 酸化ストレスを制御するナノ粒子セラノティクス (2010)
  • Author(s): 長崎幸夫
  • Organizer: 第10回RGM1研究会
  • Place of Presentation: 大手町 トップオブザスクウェア
  • Year and Date: 2010-02-06
• [Presentation] 酸化ストレスをターゲットとした新しいナノ粒子セラノステイックス (2010)
  • Author(s): 長崎幸夫
  • Organizer: 第24回酸化ストレス学会関東支部会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2010-01-09
• [Presentation] 酸化ストレスの検出を目指したhydroxylamine内包pH応答性ナノ粒子の設計と評価 (2010)
  • Author(s): 長崎幸夫
  • Organizer: 第24回酸化ストレス学会関東支部会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2010-01-09
• [Presentation] Nitroxy Radicals Possessing Polymer Suppresses Blood Activation by Their Antioxidant Ability (2009)
  • Author(s): 長崎幸夫
  • Organizer: 19th Symposium of MRS-Japan
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2009-12-09
• [Presentation] ハイポキシアに基づくpH低下のイメージングを目指したpH応答性ナノ粒子の設計と機能 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第7回がんとハイポキシア研究会
  • Place of Presentation: 京都大学
  • Year and Date: 2009-12-05
• [Presentation] 5.2009.11.25 Nagasak Yukio : Hybridization of synthetic polymers and biopolymers for creation of high-performance biointerface (2009)
  • Author(s): 長崎幸夫
  • Organizer: Nano Europe 2009
  • Place of Presentation: Rapperswil, Switzerland
  • Year and Date: 2009-11-25
• [Presentation] 生体適合性金ナノ粒子を利用した診断技術 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第六回コロイド・界面新領域創造講座
  • Place of Presentation: 日本化学会館5階会議室
  • Year and Date: 2009-11-20
• [Presentation] Spheroid array chip of fetal liver cells on micropatterned PEG-gel surface for culture technique to regenerative medicine in liver : upregulation of liver function by co-culture's cell-cell contact (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 4th International Symposium on Atomic Technology (ISAT-4)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2009-11-19
• [Presentation] Novel Biocompatible Polymer Possessing Anti-Oxidative Stress Ability Nitroxy Radicals Containing Polymer(NRP)Suppresses Blood Activation (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 4th International Symposium on Atomic Technology (ISAT-4)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2009-11-19
• [Presentation] Carbohydrate-oligonucleotides conjugates : synthesis and application for the oligonucleotide delivery (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 4th International Symposium on Atomic Technology (ISAT-4)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2009-11-18
• [Presentation] Prevention of Heat-induced Inactivation of Enzymes Through Complexation with PEAMA-g-PEG (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 4th International Symposium on Atomic Technology (ISAT-4)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2009-11-18
• [Presentation] Enhanced Stability of Biodegradable Polymeric Micelles EncapsulatingBoron Cluster for Boron Neutron Capture Therapy (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 4th International Symposium on Atomic Technology (ISAT-4)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2009-11-16
• [Presentation] グルコーストランスポーターを介した核酸の細胞内取り込み評価 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都府民総合交流プラザ
  • Year and Date: 2009-11-16
• [Presentation] 高い安定性を有するホウ素含有ナノ粒子の調製とホウ素中性子捕捉療法への展開 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都府民総合交流プラザ
  • Year and Date: 2009-11-16
• [Presentation] Synthesis and Characterization of Highly PEGylated Nanogel (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 4th International Symposium on Atomic Technology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2009-11-08
• [Presentation] Development of TEMPOL-containing nano-particle for continuous superoxide scavenging and antihypertension (2009)
  • Author(s): 長崎幸夫
  • Organizer: ASN Renal Week 2009
  • Place of Presentation: Washington, DC Unitedstate of America
  • Year and Date: 2009-10-27
• [Presentation] 体内安定化を目指した架橋型ボロン含有ナノ粒子の設計 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第6回日本中性子捕捉療法学会学術大会
  • Place of Presentation: キャンパスプラザ京都
  • Year and Date: 2009-09-19
• [Presentation] バイオ環境を制御するナノゲルの設計 (2009)
  • Author(s): 長崎幸夫
  • Organizer: ゲルワークショップ イン 熊本
  • Place of Presentation: ホテル法華クラブ熊本
  • Year and Date: 2009-09-19
• [Presentation] pH応答性EPRプローブとして機能する安定ラジカル含有ナノ粒子(RNP)の調製と評価 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第58回 高分子討論会
  • Place of Presentation: 熊本大学 工学部黒髪キャンパス
  • Year and Date: 2009-09-18
• [Presentation] 金表面上に固定化した抗体フラグメントの抗原認識能に対するPEG密生層の役割 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第58回 高分子討論会
  • Place of Presentation: 熊本大学 工学部黒髪キャンパス
  • Year and Date: 2009-09-18
• [Presentation] 経口投与型胆汁酸吸着剤としてのPEG化4級ポリアミンナノゲルの設計と評価 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第58回 高分子討論会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-18
• [Presentation] 高感度免疫診断粒子の設計-実用化を目指したPEG/抗体密生層の表面構築 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第58回 高分子討論会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-17
• [Presentation] ナノリアクターとして機能するPEG化ナノゲル粒子によるナノ治療・診断 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第58回 高分子討論会
  • Place of Presentation: 熊本大学 工学部黒髪キャンパス
  • Year and Date: 2009-09-17
• [Presentation] Healingof Oxidative Stress in Brain on the Occasion of Cerebral Ischemia-Reperfusion (2009)
  • Author(s): 長崎幸夫
  • Organizer: The 6th International Forum on Post-Genome Technologies
  • Place of Presentation: Beijing, China
  • Year and Date: 2009-09-17
• [Presentation] Spheroid array chip of fetal liver cells for regenerative medicine constructed on micropatterned PEG-gel surface : control of liver cell spheroids functionsby hetero co-culture system (2009)
  • Author(s): 長崎幸夫
  • Organizer: Gordon Research Conference, Biomaterials : Biocompatibility
  • Place of Presentation: Tissue Engineering. Holderness School Holderness, NH United states of America
  • Year and Date: 2009-07-17
• [Presentation] 環境変化に応答するナノ粒子の設計とナノメディシンへの展開 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 徳島大学大学院ソシオテクノサイエンス研究部セミナー
  • Place of Presentation: 徳島大学
  • Year and Date: 2009-07-16
• [Presentation] バイオナノ粒子の魅力 (2009)
  • Author(s): 長崎幸夫
  • Organizer: ナノ科学・材料研究センター(N2RC)セミナー
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2009-07-08
• [Presentation] 環境に応答してシグナルを発信するバイオナノ粒子 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 高分子学会東海支部 東海高分子研究会
  • Place of Presentation: 中部大学 春日井キャンパス
  • Year and Date: 2009-06-20
• [Presentation] 生体内ROSの可視化を目指したEPRナノプローブの創製 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学
  • Year and Date: 2009-06-11
• [Presentation] 酸化ストレスの検出を目指した還元型TEMPO内包pH応答性ナノ粒子(RNP-H)の設計と評価 (2009)
  • Author(s): 長崎幸夫
  • Organizer: 第58回高分子学会年次大会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2009-05-29
• [Presentation] Stable Radical-containing Nanoparticles for Anti-oxydative Stress Disease (2009)
  • Author(s): 長崎幸夫
  • Organizer: FBPS2009
  • Place of Presentation: 静岡県三島東レ人的資源発展センター
  • Year and Date: 2009-05-20
• [Presentation] Novel Nanoparticle Therapy (2009)
  • Author(s): 長崎幸夫
  • Organizer: ISAP2009
  • Place of Presentation: Keio University
  • Year and Date: 2009-04-27
• [Presentation] Novel Redox Injectable Gel for Local Inflammation
  • Author(s): 長崎幸夫
  • Organizer: New Innovations in Polymers And (bio)Materials(NIPAM-80)（招待講演）
  • Place of Presentation: Ka'anapali, Maui, Hawaii, USA
  • Invited
• [Book] ナノ粒子アシスト型がん化学療法の開発、癌と人 (2012)
  • Author(s): 長崎幸夫
  • Publisher: 公益財団法人大阪癌研究会
• [Book] ガドリニウムフラーレンによる中性子捕捉療法、2013ナノカーボン技術大全 (2012)
  • Author(s): 長崎幸夫
  • Total Pages: 5
  • Publisher: Electric Journal
• [Book] ナノゲルによるピンポイント治療・診断システムへの展開、先端バイオマテリアルハンドブック (2012)
  • Author(s): 長崎幸夫
  • Total Pages: 6
  • Publisher: エヌ・ティー・エス
• [Book] ナノ粒子アシスト型がん化学療法の開発 (2012)
  • Author(s): 長崎幸夫
  • Total Pages: 7
  • Publisher: 公益財団法人大阪癌研究会
• [Book] 高分子材料が一番わかる (2011)
  • Author(s): 長崎幸夫
  • Total Pages: 20
  • Publisher: 技術評論社
• [Book] Biomaterials Chapter 13, pp 243-258 ACS Symposium Series, Vol.1054 (2010)
  • Author(s): 長崎幸夫
  • Total Pages: 15
  • Publisher: Design of Highly Functional Antiferritin-Immunolatex by Hybridization ofAntiferritin/Mixed-PEG Polymers onto Polystyrene Submicroparticles
• [Remarks]
  • URL: http://www.ims.tsukuba.ac.jp/~nagasaki_lab/index.htm
• [Patent(Industrial Property Rights)] 高分子化環状ニトロキシドラジカル化合物の潰瘍性消化管の炎症の処置剤 (2010)
  • Inventor(s): 長崎幸夫
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2010-260471
  • Filing Date: 2010-11-22