Establishment of magnetic hyperthermic prostate cancer therapy using brachytherapy systems
| Project/Area Number |
21240055
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Masaaki 東京医科大学, 医学部, 教授 (70129526)
OOHORI Makoto 東京医科大学, 医学部, 教授 (50203930)
HANDA Hiroshi 東京工業大学, 統合研究院, 教授 (80107432)
UEDA Tomoaki 東京工業大学, 統合研究院, 特任教授 (50456258)
YAMAMOTO Takao 大阪大学, 大学院・工学研究科, 教授 (00174798)
SEINO Satoshi 大阪大学, 大学院・工学研究科, 講師 (90432517)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2009: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | 低侵襲治療システム / 前立腺がん / 磁気温熱療法 / 高周波磁場発生装置 / 密封小線源 / 高周波コイル / 自己温度制御発熱体 / 磁気回路 / 生体内実験 / チタン / 自己温度制御夏熱体 / Ti針 |
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| Research Abstract |
Basic studies were performed to realize the combined therapy of the local radiation and the local hyperthermic treatments with less side-effects and high curative effect utilizing small seeds used for prostate cancer treatment also as heating mediators in magnetic hyperthermia. When applying the exchange magnetic field of 1 MHz and 50 Oe-rms, Ti needles, used as cold dummy of small seeds, functioned enough as heating mediators of magnetic hyperthermia through in-vivo tests. Moreover, it was found that the heat-shock protein(said to heighten the immunity effect) concentration in blood became high intentionally. This means that not only radiation and hyperthermia but also immune-therapies were expected when small seeds were used as heating mediators.
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Report
(4 results)
Research Products
(27 results)
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[Presentation] Hyperthermic in vivo experiments using Ti needles as magnetic induction heating mediators2011
Author(s)
Nakagawa, T.; Yoshioka, T.; Horiki, M.; Seino, S.; Yamamoto, T. A.; Abe, M.; Gondo, T.; Hashimoto, T.; Tachibana, M.; Ohori, M.
Organizer
INTERMAG 2011 Conference
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] 密封小線源治療用チタンを用いた新しい前立腺磁気温熱治療の開発2010
Author(s)
権藤立男, 大堀理, 中川貴, 橋本剛, 清野智史, 阿部正紀, 山本孝夫, 上田智章, 半田宏, 秦野直, 橘政昭
Organizer
第69回日本癌学会学術総会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2010-09-23
Related Report
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[Presentation] 前立腺がん治療用密封小線源の磁気ハイパーサーミアへの応用2010
Author(s)
中川貴, 吉岡朋宏, 堀木麻由美, 清野智史, 山本孝夫, 権藤立男, 橋本剛, 橘政昭, 大堀理, 川島啓, 多田大, 半田宏, 阿部正紀
Organizer
第34回日本磁気学会学術講演会
Place of Presentation
つくば国際会議場(つくば市)
Year and Date
2010-09-04
Related Report
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[Presentation] 前立腺がん治療用密封小線源の磁気ハイパーサーミアへの応用2010
Author(s)
中川貴, 吉岡朋宏, 堀木麻由美, 清野智史, 山本孝夫, 権藤立男, 橋本剛, 橘政昭, 大堀理, 川島啓, 多田大, 半田宏, 阿部正紀
Organizer
第34回日本磁気学会学術講演会
Place of Presentation
つくば国際会議場
Related Report
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