| Project/Area Number |
21240055
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Masaaki 東京医科大学, 医学部, 教授 (70129526)
OOHORI Makoto 東京医科大学, 医学部, 教授 (50203930)
HANDA Hiroshi 東京工業大学, 統合研究院, 教授 (80107432)
UEDA Tomoaki 東京工業大学, 統合研究院, 特任教授 (50456258)
YAMAMOTO Takao 大阪大学, 大学院・工学研究科, 教授 (00174798)
SEINO Satoshi 大阪大学, 大学院・工学研究科, 講師 (90432517)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2009: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | 低侵襲治療システム / 前立腺がん / 磁気温熱療法 / 高周波磁場発生装置 / 密封小線源 / 高周波コイル / 自己温度制御発熱体 / 磁気回路 / 生体内実験 / チタン / 自己温度制御夏熱体 / Ti針 |
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| Research Abstract |
Basic studies were performed to realize the combined therapy of the local radiation and the local hyperthermic treatments with less side-effects and high curative effect utilizing small seeds used for prostate cancer treatment also as heating mediators in magnetic hyperthermia. When applying the exchange magnetic field of 1 MHz and 50 Oe-rms, Ti needles, used as cold dummy of small seeds, functioned enough as heating mediators of magnetic hyperthermia through in-vivo tests. Moreover, it was found that the heat-shock protein(said to heighten the immunity effect) concentration in blood became high intentionally. This means that not only radiation and hyperthermia but also immune-therapies were expected when small seeds were used as heating mediators.
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