| Budget Amount *help |
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
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| Outline of Final Research Achievements |
Chemical compounds in breath originate mainly from volatile metabolic products in health and diseases. Fasted 1011 subjects aged from 20 to 88 years old volunteered for the study. Minute ventilation volumes of carbon dioxide (CO2), oxygen (O2), hydrogen (H2), methane (CH4), carbon monoxide (CO), nitric oxide (NO) and nitrogen oxide (NOX) were measured by the standard methods. VO2, VCO2 and VH2 were significantly decreased in age-dependent manner. Contrarily, VCH4 was increased in aged subjects. VCO was significantly increased to aging especially in women, while VNO did not significantly changed. Significant increases in VCO and decrease in VNO were observed in heavy smokers. VCO was increased in the 4th week after the starting date of menstruation. Futhermore, we developed the analytical method for non-invasive direct measurement of OH radicals emanated from the human skin, indirect methods by ingestion or inhalation of H2 and convienent breath H2 analyser.
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