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Basic study on detecting strategy for drug/gene doping for athlete

Research Project

Project/Area Number 21240062
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEMASA Tohru  筑波大学, 体育系, 教授 (50236501)

Co-Investigator(Kenkyū-buntansha) KIYOSAWA Hidenori  高知大学, 医学部, 特任准教授 (30295422)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2009: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Keywords運動生理学 / 分子生物学 / 筋肥大 / ミオスタチン / 遺伝子ノックダウン / 薬剤ドーピング / 遺伝子ドーピング / ドーピング検出技術 / アスリート / 骨格筋 / 分子筋生理学 / ワンチップ型センサー / マイクロアレイ解析 / プラスミドベクター / ウィルスベクター / マイクロアレイ / カーボンペースト / 国際研究者交流 / フィリピン:ブルネイダルサラーム
Research Abstract

To investigate the feasibility of developing a method for detecion of gene doping in power-athletes, we devised an experimental model system. Myostatin is a potent negative regulator of skeletal muscle development and growth, and myostatinknockout mice exhibit a double-muscle phenotype. To achieve knockdown, we constructed plasmids expressing short hairpin interfering RNAs (shRNAs) against myostatin. These shRNAs were transfected into C2C12 cultured cells or injected into the tibialis anterior (TA) muscle of adult mice. By performing in vitro and in vivo experiments, we found that some shRNAs effectively reduced the expression of myostatin, and that the TA muscle showed hypertrophy of up to 27.9%. Then, using real- time PCR, we tried to detect the shRNA plasmid in the serum or muscles of mice into which it had been injected. Although we were unable to detect the plasmid in serum samples, it was detectable in the treated muscle at least four weeks after induction. We were also able to detect the plasmid in muscle in the vicinity of the TA. This gene doping model system will be useful for further studies aimed at doping control.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (97 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (29 results) (of which Peer Reviewed: 27 results) Presentation (64 results) (of which Invited: 2 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Effects of high-intensity training on lipid metabolism in Thoroughbreds.2012

    • Author(s)
      Kitaoka Y, Mukai K, Aida H, Hiraga A, Masuda H, Takemasa T, Hatta H.
    • Journal Title

      Am J Vet Res

      Volume: 73 Pages: 1813-1818

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundamental study of detection of muscle hypertrophy-oriented gene doping by myostatin knock down using RNA interference.2012

    • Author(s)
      Tohru Takemasa, Naohisa Yakushiji, Dale Manjiro Kikuchi,Custer Deocaris, Widodo, Masanao Machida, Hidenori Kiyosawa
    • Journal Title

      J. Sport. Sci. Med.

      Volume: 11 Pages: 294-303

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of microRNA-21 in skeletal muscle hypertrophy.2012

    • Author(s)
      Tohru Takemasa, Yousuke Abe, Chiaki Kumagai, Hidenori Kiyosawa
    • Journal Title

      Adv. Exerc. Sports Physiol

      Volume: 18 Pages: 5-15

    • NAID

      110009470522

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of ribosome biogenesis with activation of the mTOR pathway in denervated atrophic muscle2012

    • Author(s)
      Masanao Machida, Kohei Takeda, HiroyukiYokono, Sachiko Ikemune, Yuka Taniguchi, Hidenori Kiyosawa, Tohru Takemasa
    • Journal Title

      J. Cell Physiol.

      Volume: 227 Pages: 1569-1576

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner.2012

    • Author(s)
      Chihiro Kohama, Hidemasa Kato, Koji Numata, Michiko Hirose, Tohru Takemasa, Atsuo Ogura, Hidenori Kiyosawa
    • Journal Title

      Hum. Mol. Genet

      Volume: 21 Pages: 1391-1401

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of ribosome biogenesis with activation of the mTOR pathway in denervated atrophic muscle.2012

    • Author(s)
      Machida M, Takeda K, Yokono H, Ikemune S, Taniguchi Y, Kiyosawa H, Takemasa T.
    • Journal Title

      J Cell Physiol.

      Volume: 227 Issue: 4 Pages: 1569-1576

    • DOI

      10.1002/jcp.22871

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of microRNA-21 in skeletal muscle hypertrophy.2012

    • Author(s)
      Tohru Takemasa, Yousuke Abe, Chiaki Kumagai, Hidenori Kiyosawa
    • Journal Title

      Adv. Exerc. Sports Physiol.

      Volume: 18 Pages: 5-15

    • NAID

      110009470522

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of high-intensity training on lipid metabolism in Thoroughbreds.2012

    • Author(s)
      Kitaoka Y, Mukai K, Aida H, Hiraga A, Masuda H, Takemasa T, Hatta H
    • Journal Title

      Am J Vet Res.

      Volume: 73 Issue: 11 Pages: 1813-1818

    • DOI

      10.2460/ajvr.73.11.1813

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle2011

    • Author(s)
      Yu Kitaoka, Masanao Machida, Tohru Takemasa, Hideo Hatta
    • Journal Title

      J. Physiol. Sci.

      Volume: 61 Pages: 467-472

    • NAID

      10030350936

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds.2011

    • Author(s)
      Kitaoka Y, Hoshino D, Mukai K, Hiraga A, Takemasa T, Hatta H.
    • Journal Title

      Am. J. Vet. Res.

      Volume: 72 Pages: 1107-1111

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ctrulline supplementation on fatigue and exercise performance in mice.2011

    • Author(s)
      Kohei Takeda, Masanao Machida, Akiko Kohara, Naomi Omi, Tohru Takemasa
    • Journal Title

      J. Nutr. Sci. Vitaminol

      Volume: 57 Pages: 246-250

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of training and detraining on monocarboxylate transporter (MCT) 1 and MCT4 in Thoroughbred horses.2011

    • Author(s)
      Yu Kitaoka, Hiroyuki Masuda, Kazutaka Mukai, Atsushi Hiraga, Tohru Takemasa, Hideo Hatta
    • Journal Title

      Exp. Physiol.

      Volume: 96 Pages: 348-355

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of training and detraining on monocarboxylate transporter (MCT) 1 and MCT4 in Thoroughbred horses2011

    • Author(s)
      Yu Kitaoka, Hiroyuki Masuda, Kazutaka Mukai, Atsushi Hiraga, Tohru Takemasa, Hideo Hatta
    • Journal Title

      Exp Physiol

      Volume: 96 Pages: 348-355

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Ctrulline Supplementation on Fatigue and Exercise Performance in Mice2011

    • Author(s)
      Kohei TAKEDA, Masanao MACHIDA, Akiko KOHARA, Naomi OMI, Tohru TAKEMASA
    • Journal Title

      Journal of Nutrition Science Vitaminology

      Volume: 57 Pages: 246-250

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds2011

    • Author(s)
      Kitaoka Y, Hoshino D, Mukai K, Hiraga A, Takemasa T, Hatta H
    • Journal Title

      Am J Vet Res

      Volume: 72 Pages: 1107-1111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle2011

    • Author(s)
      Yu Kitaoka, Masanao Machida, Tohru Takemasa, Hideo Hatta
    • Journal Title

      J Physiol Sci

      Volume: 61 Pages: 467-472

    • NAID

      10030350936

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner2011

    • Author(s)
      Chihiro Kohama, Hidemasa Kato, Koji Numata, Michiko Hirose, Tohru Takemasa, Atsuo Ogura, Hidenori Kiyosawa
    • Journal Title

      Hum Mol Genet

      Volume: 21 Pages: 1391-1401

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription2011

    • Author(s)
      Numata K, Kohama C, Abe K, Kiyosawa H
    • Journal Title

      Nucleic Acids Res

      Volume: 39 Pages: 2649-2657

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive expressional analyses of antisense transcripts in colon cancer tissues using artificial antisense probes2011

    • Author(s)
      Saito R, Kohno K, Okada Y, Osada Y, Numata K, Kohama C, Watanabe K, Nakaoka H, Yamamoto N, Kanai A, Yasue H, Murata S, Abe K, Tomita M, Ohkohchi N, Kiyosawa H
    • Journal Title

      BMC Medical Genomics

      Volume: 4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ibuprofen administration during endurance training cancels running-distance-dependent adaptations of skeletal muscle in mice.2010

    • Author(s)
      Masanao Machida, Tohru Takemasa
    • Journal Title

      J. Physiol. Pharmacol

      Volume: 61 Pages: 559-563

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased macrophages following endurance exercise without severe injury play a role in angiogenesis in skeletal muscle.2010

    • Author(s)
      Masanao Machida, Tohru Takemasa
    • Journal Title

      Adv. Exerc. Sports Physiol

      Volume: 15 Pages: 39-44

    • NAID

      110007573236

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased macrophages following endurance exercise without severe injury play a role in angiogenesis in skeletal muscle2010

    • Author(s)
      Masanao Machida, Tohru Takemasa
    • Journal Title

      Adv.Exerc.Sports Physiol.

      Volume: 15 Pages: 39-44

    • NAID

      110007573236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ibuprofen administration during endurance training cancels running-distance-dependent adaptations of skeletal muscle in mice2010

    • Author(s)
      Masanao Machida, Tohru Takemasa
    • Journal Title

      J.Physiol.Pharmacol.

      Volume: 61 Pages: 559-563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 後肢懸垂により引き起される筋萎縮の回復過程における鍼通電刺激の効果2010

    • Author(s)
      池宗佐知子, 大田美香, 町田正直, 武政徹, 高岡裕, 宮本俊和
    • Journal Title

      全日本鍼灸学会雑誌

      Volume: 60 Pages: 707-715

    • NAID

      10031188701

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of expression modes and DNA methylation status at sense-antisense transcript loci in mouse2010

    • Author(s)
      Watanabe Y, Numata K, Murata S, Osada Y, Saito R, Nakaoka H, Yamamoto N, Watanabe K, Kato H, Abe K, Kiyosawa H
    • Journal Title

      Genomics

      Volume: 96 Pages: 333-341

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swimming Training Prevents Induction of Suppressor Macrophages in Mice during Acute Exposure to Cold2009

    • Author(s)
      Hideki OHNO, Shukoh HAGA, Tohru TAKEMASA, Takuya SAKURAI, Jun-Etsu OGASAWARA, Ken SHIRATO, Yoshinaga ISHIBASHI, Kazuhiko IMAIZUMI, Takako KIZAKI
    • Journal Title

      Adv.Exerc.Sports Physiol. 15

      Pages: 1-7

    • NAID

      110007330710

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動による骨格筋の可塑性に関わる分子の研究2009

    • Author(s)
      武政徹
    • Journal Title

      体育の科学 59

      Pages: 623-630

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 柔道における持久力および筋力トレーニングとしての打ち込みの効果-運動生理・生化学的観点からの検討-2009

    • Author(s)
      増地克之, 町田正直, 松井崇, 薬師寺巨久, 金野潤, 小山勝弘, 岡田弘隆, 金丸雄介, 小俣幸嗣, 武政徹
    • Journal Title

      武道学研究 42

      Pages: 1-11

    • NAID

      130004565498

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      町田正直, 武政徹(分担)
    • Journal Title

      運動と骨格筋と免疫運動と免疫-からだをまもる運動の不思議-(木崎節子,大野秀樹編著)(ナップ)

      Pages: 9-420

    • Related Report
      2009 Annual Research Report
  • [Presentation] 筋肥大の分子メカニズム-遺伝子ドーピング検出技術創成の試み-.2013

    • Author(s)
      武政徹
    • Organizer
      第157回日本体力医学会関東地方会
    • Place of Presentation
      日本体育大学(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] シトルリン摂取による廃用性筋萎縮の抑制効果の検討.2013

    • Author(s)
      福田麦穂, 武政徹
    • Organizer
      第157回日本体力医学会関東地方会
    • Place of Presentation
      日本体育大学(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] スプリントトレーニングと持久性トレーニングが乳酸脱水素酵素に及ぼす影響2012

    • Author(s)
      駒形康文,北岡祐,菊池デイル万次郎,武田紘平,武政徹
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ドーピング研究最前線 迫りくる危機に研究者はどう立ち向かうのか?周辺研究領域の専門家がアスリートのドーピングの今と今後を考える(シンポジウム3)2012

    • Author(s)
      武政徹
    • Organizer
      第20回日本運動生理学会
    • Place of Presentation
      つくば
    • Year and Date
      2012-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] High-Frequency Acupuncture Represses the Atrophy of Fast-Fiber Rich Skeletal Muscle.2012

    • Author(s)
      Shin Fujimaki, Masanao Machida, Kohei Takeda, Tohru Takemasa
    • Organizer
      59thAnnual Meeting of American College of Sports Medicine in San Francisco
    • Place of Presentation
      California/USA
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 筋萎縮時におけるリボソームRNAの合成とmTOR経路の変化2012

    • Author(s)
      町田正直,武田紘平,横野裕行,武政徹
    • Organizer
      2012年生体運動研究合同班会議
    • Place of Presentation
      つくば
    • Year and Date
      2012-01-06
    • Related Report
      2012 Final Research Report
  • [Presentation] ドーピング研究最前線 迫りくる危機に研究者はどう立ち向かうのか?周辺研究領域の専門家がアスリートのドーピングの今と今後を考える2012

    • Author(s)
      武政徹
    • Organizer
      第20回日本運動生理学会
    • Place of Presentation
      筑波大学(茨城県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] スプリントトレーニングと持久性トレーニングが乳酸脱水素酵素に及ぼす影響.2012

    • Author(s)
      駒形康文,北岡祐,菊池デイル万次郎,武田紘平,武政徹
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高分子ポリフェノールを含有する紅茶抽出物E80の非アルコール性脂肪肝に対する効果.2012

    • Author(s)
      佐藤海斗,武政徹,小澤哲夫,沼田治
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] High-Frequency Acupuncture Represses the Atrophy of Fast-Fiber Rich Skeletal Muscle.2012

    • Author(s)
      Shin Fujimaki, Masanao Machida, Kohei Takeda, Tohru Takemasa
    • Organizer
      American College of Sports Medicine (ACSM) 59th Annual Meeting
    • Place of Presentation
      Moscone Center (San Francisco, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高強度水泳トレーニングはマウス骨格筋においてHIF-1αを介して解糖系代謝を亢進する2011

    • Author(s)
      菊地デイル万次郎, 沼田治, 武政徹
    • Organizer
      BMB2011(第34回日本分子生物学会年会・第84回日本生化学会大会合同大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 紅茶由来高分子ポリフェノール(MAF)がAMPKを介して培養筋細胞C2C12の有酸素代謝を向上させるメカニズム2011

    • Author(s)
      新谷浩章, 小澤哲夫, 武政徹, 沼田治
    • Organizer
      BMB2011(第34回日本分子生物学会年会・第84回日本生化学会大会合同大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] An ES cell-differentiation system recapitulates a developmentally regulated neuron-specific parent-of-origin expressivity2011

    • Author(s)
      加藤英政、小濱千裕、沼田興治、清澤秀孔
    • Organizer
      BMB2011(第34回日本分子生物学会年会・第84回日本生化学会大会合同大会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 紅茶由来高分子ポリフェノール(MAF)がAMPKを介して培養筋細胞C2C12の有酸素代謝を向上させるメカニズム2011

    • Author(s)
      新谷浩章, 小澤哲夫, 武政徹, 沼田治
    • Organizer
      BMB2011(第34回日本分子生物学会年会・第84回日本生化学会大会合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 高強度水泳トレーニングはマウス骨格筋においてHIF-1αを介して解糖系代謝を亢進する2011

    • Author(s)
      菊地デイル万次郎, 沼田治, 武政徹
    • Organizer
      BMB2011(第34回日本分子生物学会年会・第84回日本生化学会大会合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] マウスSAT領域から発現する50-100残基RNAのクラスタリングと構造解析2011

    • Author(s)
      河合剛太、牛田千里、清澤秀孔
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋萎縮時におけるリボソームRNA合成低下を引き起こす因子の検討.2011

    • Author(s)
      町田正直, 武田紘平, 横野裕行, 池宗佐知子, 北岡祐, 大野秀樹, 武政徹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 打撲損傷後の早期運動介入が骨格筋再生と線維化に及ぼす影響.2011

    • Author(s)
      横野裕行, 町田正直, 武政徹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨格筋乳酸トランスポーターは一過性運動により増加する2011

    • Author(s)
      北岡祐, 遠藤友香里, 向井和隆, 間弘子, 武政徹, 八田秀雄
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 除神経モデルを用いた鍼通電刺激の筋萎縮抑制効果の検討2011

    • Author(s)
      藤巻慎, 町田正直, 武田紘平, 武政徹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      山口
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 打撲損傷後の早期運動介入が骨格筋再生と線維化に及ぼす影響2011

    • Author(s)
      横野裕行, 町田正直, 武政徹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋萎縮時におけるリボソームRNA合成低下を引き起こす因子の検討2011

    • Author(s)
      町田正直, 武田紘平, 横野裕行, 池宗佐知子, 北岡祐, 大野秀樹, 武政徹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 除神経モデルを用いた鍼通電刺激の筋萎縮抑制効果の検討2011

    • Author(s)
      藤巻慎, 町田正直, 武田紘平, 武政徹
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋乳酸トランスポーターは一過性運動により増加する2011

    • Author(s)
      北岡祐, 遠藤友香里, 向井和隆, 間弘子, 武政徹, 八田秀雄
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 代償性過負荷による乳酸トランスポーター(MCT)の増加2011

    • Author(s)
      北岡祐, 町田正直, 八田秀雄, 武政徹
    • Organizer
      第19回日本運動生理学会
    • Place of Presentation
      徳島
    • Year and Date
      2011-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] EMR(酵素処理ルチン)の摂取が協働筋切除による筋肥大モデルマウスに与える影響2011

    • Author(s)
      小原亜希子, 町田正直, 麻見直美, 武政徹
    • Organizer
      第19回日本運動生理学会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自発性走運動による骨格筋遅筋化に対するイブプロフェン摂取の影響2011

    • Author(s)
      町田正直, 武田紘平, 武政徹
    • Organizer
      第19回日本運動生理学会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 代償性過負荷による乳酸トランスポーター(MCT)の増加2011

    • Author(s)
      北岡祐, 町田正直, 八田秀雄, 武政徹
    • Organizer
      第19回日本運動生理学会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自発性走運動による骨格筋遅筋化に対するイブプロフェン摂取の影響2011

    • Author(s)
      町田正直, 武田紘平, 武政徹
    • Organizer
      第19回日本運動生理学会
    • Place of Presentation
      徳島
    • Year and Date
      2011-08-19
    • Related Report
      2012 Final Research Report
  • [Presentation] EMR(酵素処理ルチン)の摂取が協働筋切除による筋肥大モデルマウスに与える影響.2011

    • Author(s)
      小原亜希子, 町田正直, 麻見直美, 武政徹
    • Organizer
      第19回日本運動生理学会
    • Place of Presentation
      徳島
    • Year and Date
      2011-08-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of small RNAs from mouse SAT loci2011

    • Author(s)
      Ushida C, Ono T, Saito R, Osada Y, Shindo Y, Kaneko N, Kawai G, Kiyosawa H
    • Organizer
      16th Annual Meeting of The RNA Society
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of Small RNAs, with 50-100 nt Length, from the Loci of the Sense-Antisetise Transcription in Mouse Genome2011

    • Author(s)
      Kawai G, Ushida C, Kiyosawa H
    • Organizer
      16th Annual Meeting of The RNA Society
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Acute Exercise and Monocarboxylate Transporter (MCT)1 and MCT4 in Thoroughbred Horses2011

    • Author(s)
      Yu Kitaoka, Yukari Endo, Kazutaka Mukai, Atsushi Hiraga, Tohru Takemasa, Hideo Hatta
    • Organizer
      58thAnnual Meeting of American College of Sports Medicine in Denver
    • Place of Presentation
      USA
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Acute Exercise and Monocarboxylate Transporter (MCT)1 and MCT4 in Thoroughbred Horses2011

    • Author(s)
      Yu Kitaoka, Yukari Endo, Kazutaka Mukai, Atsushi Hiraga, Tohru Takemasa, Hideo Hatta
    • Organizer
      58th Annual Meeting of American College of Sports Medicine
    • Place of Presentation
      John B.Hynes Convention Center, Boston, (USA)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経細胞特異的なゲノム刷り込みにおけるエピジェネティックな発現制御とアンチセンスRNA発現解析2010

    • Author(s)
      小濱千裕, 加藤英政, 沼田興治, 武政徹, 清澤秀孔
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-intensity Training Increases Fatty Acid Oxidation In Thoroughbred Horses2010

    • Author(s)
      Yu Kitaoka, Yukari Endo, Kazutaka Mukai, Atsushi Hiraga, Tohru Takemasa, Hideo Hatta
    • Organizer
      ACSM Conference on Integrative Physiology of Exercise
    • Place of Presentation
      Florida Miami Beach, USA
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 除神経後の筋萎縮は、mTOR経路の活性化状況下でのリボソーム合成の低下とタンパク分解の促進により進行する.2010

    • Author(s)
      町田正直, 北岡祐, 大野秀樹, 武政徹
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 高強度トレーニングがモノカルボン酸トランスポーター(MCT)および乳酸代謝に及ぼす影響2010

    • Author(s)
      北岡祐, 遠藤友香里, 向井和隆, 平賀敦, 武政徹, 八田秀雄
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-17
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 除神経後の筋萎縮は、mTOR経路の活性化状況下でのリボソーム合成の低下とタンパク分解の促進により進行する2010

    • Author(s)
      町田正直, 北岡祐, 大野秀樹, 武政徹
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 除神経による筋萎縮に伴うmTOR経路の活性化とリボソーム合成の低下2010

    • Author(s)
      町田正直, 武田紘平, 横野裕行, 北岡祐, 武政徹
    • Organizer
      第18回日本運動生理学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-08-01
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] シトルリンの摂取が運動による疲労および運動パフォーマンスに及ぼす影響.2010

    • Author(s)
      武田紘平, 町田正直, 武政徹
    • Organizer
      第18回日本運動生理学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-07-31
    • Related Report
      2012 Final Research Report
  • [Presentation] ノカルボン酸トランスポータ(MCT)は代償性筋肥大により増加する2010

    • Organizer
      第18回日本運動生理学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-07-31
    • Related Report
      2012 Final Research Report
  • [Presentation] モノカルボン酸トランスポータ(MCT)は代償性筋肥大により増加する2010

    • Author(s)
      北岡祐, 町田正直,八田秀雄, 武政徹
    • Organizer
      第18回日本運動生理学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] シトルリンの摂取が運動による疲労および運動パフォーマンスに及ぼす影響2010

    • Author(s)
      武田紘平, 町田正直, 武政徹
    • Organizer
      第18回日本運動生理学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ube3a遺伝子座におけるエピジェネティックな発現制御とアンチセンスRNA発現解析2010

    • Author(s)
      小濱千裕、加藤英政、沼田興治、清澤秀孔
    • Organizer
      第12回日本RNA学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-intensity Training Increases Fatty Acid Oxidation In Thoroughbred Horses.2010

    • Author(s)
      Yu Kitaoka, Yukari Endo, Kazutaka Mukai, Atsushi Hiraga, Tohru Takemasa, Hideo Hatta
    • Organizer
      57thAnnual Meeting of American College of Sports Medicine
    • Place of Presentation
      Florida Miami Beach, USA
    • Year and Date
      2010-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] High-resolution Landscape of Ube3a Allelic Exclusion by using Highly Parallel SNP Typing Platform2010

    • Author(s)
      Numata K, Kohama C, Abe K, Kiyosawa H
    • Organizer
      Cold Spring Harbor Laboratory Meeting
    • Place of Presentation
      NY,USA
    • Year and Date
      2010-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Black Tea High-Molecular-Weight Polyphenol(MAF; Mitochondria Activation Factor) Increases Oxidative Slow Muscle Fibers and Improves Endurance Capacity via AMPK in Mice.2009

    • Author(s)
      Tomoaki Eguchi, Tohru Takemasa, Tetsuo Ozawa, Osamu Numata
    • Organizer
      4thInternational Conference on Polyphenol and Health
    • Place of Presentation
      Yorkshire, England
    • Year and Date
      2009-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Black Tea High-Molecular-Weight Polyphenol(MAF ; Mitochondria Activation Factor)Increases Oxidative Slow Muscle Fibers and Improves Endurance Capacity via AMPK in Mice2009

    • Author(s)
      Tomoaki Eguchi, Tohru Takemasa, Tetsuo Ozawa, Osamu Numata
    • Organizer
      4th International Conference on Polyphenol and Health
    • Place of Presentation
      Yorkshire/England
    • Year and Date
      2009-12-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 代償性過負荷による筋肥大過程で起こる遺伝子発現の解析と新規経路の探索2009

    • Author(s)
      町田正直, 大野秀樹, 武政徹
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-19
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] トレーニングおよびデトレーニングがモノカルボン酸トランスポーター(MCT)タンパク質量に及ぼす影響2009

    • Author(s)
      北岡祐,向井和隆,平賀敦,武政徹,八田秀雄
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] 骨格筋運動適応メカニズムの分子レベルでの解明を目指して(シンポジウムThe Myogenesis -骨格筋の発生・分化・再生・適応の分子機構-オーガナイザー:竹倉宏明,町田修一)2009

    • Author(s)
      武政徹
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 紅茶ポリフェノール(MAF)がマウス骨格筋の遅筋化に及ぼす影響2009

    • Author(s)
      江口友昭, 武政徹, 小澤哲夫, 沼田治
    • Organizer
      日本動物学会第80回
    • Place of Presentation
      静岡
    • Year and Date
      2009-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 紅茶ポリフェノール(MAF)がマウス骨格筋の遅筋化に及ぼす影響2009

    • Author(s)
      江口友昭, 武政徹, 小澤哲夫, 沼田治
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨格筋運動適応メカニズムの分子レベルでの解明を目指してシンポジウムThe Myogenesis -骨格筋の発生・分化・再生・適応の分子機構-2009

    • Author(s)
      武政徹
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超音波刺激の温熱効果によるラット骨格筋Heat Shock Proteih発現量の増加2009

    • Author(s)
      大澤真, 大森肇, 町田正直, 池宗佐知子, 緒方知徳, 石倉恵介, 武政徹, 宮川俊平
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 代償性筋肥大におけるmiR-21 の動態とその特性2009

    • Author(s)
      熊谷千明,武政徹
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 代償性過負荷による筋肥大の過程における遺伝子発現の網羅的解析と重要経路の解析.2009

    • Author(s)
      町田正直,武政徹
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 超音波刺激の温熱効果によるラット骨格筋Heat Shock Protein発現量の増加.2009

    • Author(s)
      緒方知徳, 石倉恵介, 武政徹, 宮 川 俊 平
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 代償性筋肥大におけるmiR-21の動態とその特性2009

    • Author(s)
      熊谷千明, 武政徹
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 代償性過負荷による筋肥大の過程における遺伝子発現の網羅的解析と重要経路の解析2009

    • Author(s)
      町田正直, 武政徹
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reduced Leg Muscle Oxygenation During Underwater Treadmill Walking2009

    • Author(s)
      Kazuki Esaki, Koichi Kaneda, Daisuke Sato, Hitoshi Wakabayashi, Tohru Takemasa, Takeo Nomura, Takafumi Hamaoka, Toshihito Katsumura
    • Organizer
      56th Annual Meeting of American College of Sports Medicine
    • Place of Presentation
      Seattle/USA (アメリカ合衆国)
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] シトルリン摂取による廃用性筋萎縮の抑制効果の検討

    • Author(s)
      福田麦穂, 武政徹
    • Organizer
      第157回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 筋肥大の分子メカニズム-遺伝子ドーピング検出技術創成の試み-

    • Author(s)
      武政徹
    • Organizer
      第157回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Book] Genome-wide analysis of sense-antisense transcripts, in "Non-coding RNAs and Epigenetic Regulation of Gene Expression : Drivers of Natural Selection"2012

    • Author(s)
      Kohama C, Kiyosawa H
    • Total Pages
      216
    • Publisher
      Caister Academic Press, Norwich, U.K.
    • Related Report
      2011 Annual Research Report
  • [Book] 教科書:機能性RNAの分子生物学2010

    • Author(s)
      牛田千里、影山裕二、金井昭夫、河合剛太、清澤秀孔、黒崎直子、剣持直哉、坂本泰一、原田和雄
    • Total Pages
      287
    • Publisher
      クバプロ(編者:河合剛太、清澤秀孔)
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 筋肥大促進のための食品、補助食品、及びサプリメント2010

    • Inventor(s)
      小原亜希子、武政徹、麻見直美、後藤一成
    • Industrial Property Rights Holder
      小原亜希子、武政徹、麻見直美、後藤一成
    • Industrial Property Number
      2010-149911
    • Filing Date
      2010-06-30
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 特許2010

    • Inventor(s)
      小原亜希子、武政徹、麻見直美、後藤一成
    • Industrial Property Rights Holder
      森永製菓
    • Industrial Property Number
      2010-149911
    • Filing Date
      2010-06-30
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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