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DEVELOPMENT OF A TIME-DEPENDENT LIQUID MICRO-JET SPECTROSCOPY FOR RADIATION-INDUCED ANORMALY IN MIMETIC BIO-CELL MOLECULES

Research Project

Project/Area Number 21241017
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

UKAI Masatoshi  東京農工大学, 大学院・工学研究院, 教授 (80192508)

Co-Investigator(Kenkyū-buntansha) YOKOYA Akinari  日本原子力研究開発機構, 先端基礎研究センター, 研究主幹 (10354987)
Research Collaborator FUJII Kentaro  日本原子力研究開発機構, 先端基礎研究センター, 研究副主幹
SAITOH Yuji  日本原子力研究開発機構, 放射光科学研究ユニット, 研究副主幹
FUKUDA Yoshihiro  日本原子力研究開発機構, 放射光科学研究ユニット, 技術職員
SHIMADA Hiroyuki  東京農工大学, 大学院・工学研究院, 助教
SUMIYA Ryosuke  東京農工大学, 大学院・工学府, 博士前期課程
YASUHIRO Satoshi  東京農工大学, 大学院・工学府, 博士前期課程
FUKAO Taishi  東京農工大学, 大学院・工学府, 博士前期課程
MINAMI Hirotake  東京農工大学, 大学院・工学府, 博士前期課程
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
KeywordsDNA放射線損傷 / 化学的損傷修復 / シンクロトロン放射光電子分光 / 電子エネルギー損失分光 / 時間相関分光 / 液体分子線 / 超励起分子のダイナミクス / 水素結合ネットワーク
Research Abstract

To investigate the radiation-induced damage on DNA and its self-assembled repair both as the alternative thermo-dynamical restoration processes of bio-cells, we have developed a novel spectroscopic method for damage in bio-molecules under mimetic cell condition by combining a liquid-micro-jet synchrotron-radiation photoelectron spectroscopy and a newly built high energy electron energy loss spectroscopy. To observed time-dependent appearance of anomalous molecular species following irradiation, a high resolution mass spectrometry has also been developed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (97 results)

All 2012 2011 2010 2009

All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (59 results) Book (5 results)

  • [Journal Article] Lifetime of the unpaired electron species in calf thymus DNA thin films induced by nitrogen and oxygen K-shell photoabsorption2012

    • Author(s)
      T. Oka, A. Yokoya, and K. Fujii
    • Journal Title

      Int. J. Radiat. Biol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yield of single-, double-strandbreaks and nucleobase lesions in fully hydratedplasmid DNA films irradiated with high-LETcharged particles2012

    • Author(s)
      T. Ushigome, N. Shikazono, K. Fujii, R. Watanabe, M. Suzuki, C. Tsuruoka, H. Tauchi, and A. Yokoya
    • Journal Title

      Yield of single-, double-strandbreaks and nucleobase lesions in fully hydratedplasmid DNA films irradiated with high-LETcharged particles

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

    • Author(s)
      M. Noguchi, A. Urushibara, A. Yokoya, P. O' Neill, and N. Shikazono
    • Journal Title

      Mutat. Res

      Volume: 732 Pages: 34-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions2012

    • Author(s)
      M.Noguchi
    • Journal Title

      Mutation Research

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yield of single-, double-strand breaks and nucleobase lesions in fully hydrated plasmid DNA films irradiated with high-LET charged particles2012

    • Author(s)
      T.Ushigome
    • Journal Title

      Radiation Research

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electron para-magnetic resonance study of unpaired electron species in thin films of pyrimidine bases in-duced by nitrogen and oxygen K-shell photo-absorption2011

    • Author(s)
      T. Oka, A. Yokoya, and K. Fujii
    • Journal Title

      Appl. Phys. Lett

      Volume: 98 Pages: 1-3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and^4He^<2+> ion irradi-ation2011

    • Author(s)
      A. Yokoya, N. Shikazono, K. Fujii, M. Noguchi, and A. Urushibara
    • Journal Title

      Radiat. Protect. Dosim

      Volume: 143 Pages: 219-255

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A model for analysis of the yield and the level of clustering of radia-tion-induced DNA strand breaks in hydrated plasmids2011

    • Author(s)
      N. Shikazono, A. Yokoya, A. Urushibara, M. Noguchi, and K. Fujii
    • Journal Title

      Radiat. Protect. Dosim

      Volume: 143 Pages: 181-185

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electron paramagnetic resonance study of unpaired electron species in thin films of pyrimidine bases induced by nitrogen and oxygen K-shell photoabsorption2011

    • Author(s)
      T.Oka
    • Journal Title

      Applied Physics Letters

      Volume: 98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated olasmid DNA molecule by X-ray and ^4He^<2+>2011

    • Author(s)
      A.Yokoya
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Pages: 219-225

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A model for analysis of the yield and the level of clustering of radiation-induced DNA strand breaks in hydrated plasmids2011

    • Author(s)
      N.Shikazono
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 143 Pages: 181-185

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of silybin and analogues against X-ray radiation-induced damage2010

    • Author(s)
      H. Fu, M. Lin, Y. Muroya, Y. Katsumura, A. Yokoya, K. Hata, K. Fujii, and N. Shikazono
    • Journal Title

      Acta Biochim. Biophys. Sin

      Volume: 42 Pages: 485-495

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray absorption spectra for nucleotides(AMP, GMP, and CMP) in liquid water solutions near the nitrogen K-edge2010

    • Author(s)
      M. Ukai, A. Yokoya, K. Fujii, and Y. Saitoh
    • Journal Title

      Chem. Phys. Let

      Volume: 495 Pages: 90-95

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray absorption spectra for nucleotides (AMP, GMP, and CMP) in liquid water solutions near the nitrogen K-edge2010

    • Author(s)
      M.Ukai
    • Journal Title

      Chemical Physics Letters

      Volume: 495 Pages: 90-95

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A model for analysis of the yield and the level of clustering of radiation-induced DNA strand breaks in hydrated nlasmids2010

    • Author(s)
      H.Fu
    • Journal Title

      Acta Biochimica et Biophysica Sinica

      Volume: 42 Pages: 489-495

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集記事「後書き:"放射線"をピボットとする化学と生物学」2010

    • Author(s)
      横谷明徳
    • Journal Title

      放射線化学

      Volume: 89 Pages: 36-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleo-base lesions and strand breaks in dry DNA thin film selectively induced by monochromatic soft X-rays2009

    • Author(s)
      K. Fujii, N. Shikazono, and A. Yokoya
    • Journal Title

      J. Phys. Chem. B

      Volume: 113 Pages: 16007-16015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenging reactions and antioxidant activities of silybin : mechanistic aspects and pulse radiolytic studies2009

    • Author(s)
      H. Fu, M. Lin, Y. Muroya, K. Hata, Y. Katsumura, A. Yokoya, N. Shikazono, and Y. Hatano
    • Journal Title

      Free Radic. Res

      Volume: 43 Pages: 887-897

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenging and radioprotective effects of carnosine and anserine2009

    • Author(s)
      H. Fu, Y. Katsumura, M. Lin, Y. Muroya, K. Hata, K. Fujii, A. Yokoya, and Y. Hatano
    • Journal Title

      Radiat, Phys. Chem

      Volume: 78 Pages: 1192-1197

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of DNA strand breaks, base lesions and clustered dam-age sites in hydrated plasmid DNA films by ultrasoft X-rays around the phosphorus K-edge2009

    • Author(s)
      A. Yokoya, S. M. T. Cunniffe, R. Watanabe, K. Kobayashi, and P. O' Neill
    • Journal Title

      Radiat. Res

      Volume: 172 Pages: 296-365

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spectral change in X-ray absorption near edge structure of DNA thin films irradiated with monochromatic soft X-rays2009

    • Author(s)
      K. Fujii and A. Yokoya
    • Journal Title

      Radiat. Phys. Chem

      Volume: 78 Pages: 1188-1191

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotron radiation photoelectron studies for primary radiation effects using a liquid water jet in vacuum : total and partial photoelectron yields for liquid water near the oxygen K-edge2009

    • Author(s)
      M. Ukai, A. Yokoya, Y. Nonaka, K. Fujii, and Y. Saitoh
    • Journal Title

      Radiat. Phys. Chem

      Volume: 78 Pages: 1202-1206

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] EPR study of radiation damage to DNA irradiated with synchrotron soft X-rays around nitrogen and oxygen K-edge2009

    • Author(s)
      A. Yokoya, K. Fujii, Y. Fukuda, and M. Ukai
    • Journal Title

      Radiat. Phys

      Volume: 78 Pages: 1211-1215

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The yield, processing, and biological consequences of clustered DNA2009

    • Author(s)
      N. Shikazono, M. Noguchi, K. Fujii, A. Urushibara, and A. Yokoya
    • Journal Title

      J. Radiat. Res

      Volume: 50 Pages: 27-36

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotron radiation photoelectron studies for primary radiation effects using a liquid water jet in vacuum : Total and partial photoelectron yields for liquid water near the oxygen K-edge2009

    • Author(s)
      M.Ukai
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1202-1206

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 基礎から学ぶマススペクトロメトリー/質量分析の源流第3回ペニングイオン化2009

    • Author(s)
      鵜飼正敏
    • Journal Title

      Journal of Mass Spectrometry Society of Japan 57

      Pages: 393-404

    • NAID

      10026278705

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleobase Lesions and Strand Breaks in Dry DNA Thin Film selectively induced by Monochromatic Soft X-rays2009

    • Author(s)
      K.Fujii
    • Journal Title

      Jounral of Physical Chemistry B 113

      Pages: 16007-16015

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenging reactions and antioxidant activities of silybin : mechanistic aspects and pulse radiolytic studies2009

    • Author(s)
      H.Fu
    • Journal Title

      Radiation Research 43

      Pages: 887-897

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenging and radioprotective effects of carnosine and anserine2009

    • Author(s)
      H.Fu
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1192-1197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of DNA strand breaks, base lesions and clustered damage sites in hydrated plasmid DNA films by ultrasoft X-rays around the phosphorus K edge2009

    • Author(s)
      A.Yokoya
    • Journal Title

      Radiation Research 172

      Pages: 296-365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EPR study of radiation damage to DNA irradiated with synchrotron soft X-rays around nitrogen and oxygen K-edge2009

    • Author(s)
      A.Yokoya
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1211-1215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spectral change in X-ray absorption near edge structure of DNA thin films irradiated with monochromatic soft X-rays2009

    • Author(s)
      K.Fujii
    • Journal Title

      Radiation Physics and Chemistry 78

      Pages: 1188-1191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The yield, processing, and biological consequences of clustered DNA.(Invited Review)2009

    • Author(s)
      N.Shikazono
    • Journal Title

      Journal of Radiation Research 50

      Pages: 27-36

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Unpaired electron species induced in DNA thin films during monochoromatic soft X-ray irradiation2012

    • Author(s)
      T. Oka, A. Yokoya, K. Fujii, Y. Fukuda, and M. Ukai
    • Organizer
      XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2012-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Variation in DNA damage induced by mono-chromatic soft X-rays in the energy region of oxygen K-edge2012

    • Author(s)
      Y. Sugaya, T. Shiina, I. Shiraishi, and A. Yokoya
    • Organizer
      XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2012-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Order effects of base excision processes to repair clustered DNA damage2012

    • Author(s)
      I. Shiraishi, T. Shiina, Y. Sugaya, N. Shikazono, and A. Yokoya
    • Organizer
      XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Czech Republic
    • Year and Date
      2012-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] DNA damage caused by UV-A irradiation induces genetic instabilit2012

    • Author(s)
      A. Urushibara, S. Kodama, and A. Yokoya
    • Organizer
      XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2012-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Simula-tion study of microdosimetry and distribution of DNA damage inducing base damage2012

    • Author(s)
      R. Watanabe, T. Shiina, and A. Yokoya
    • Organizer
      XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2012-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線によるゲノムDNA損傷の初期過程と生体修復2012

    • Author(s)
      横谷明徳
    • Organizer
      日本物理学会第67回年次大会
    • Place of Presentation
      関西学院大,兵庫県
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線によるゲノムDNA損傷の初期過程と生体修復2012

    • Author(s)
      横谷明徳
    • Organizer
      日本物理学会第67回年次大会
    • Place of Presentation
      関西学院大学、兵庫県(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Soft X-ray absorption spectra of AMP and ATP in solutions2012

    • Author(s)
      H.Shimada
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Unpaired electron species induced in DNA thin films during monocnoro matic soft X-ray irradiation2012

    • Author(s)
      T.Oka
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dependence of the yields of AP sites and AP clustered produced in plasmid DNA on scavenging capacity and LET2012

    • Author(s)
      T. Shiina
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Variation in DNA damge induced by monochromatic soft X-rays in the energy region of Oxygen K-edge2012

    • Author(s)
      Y.Sugaya
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Order effects of base excision processes to repair clustered DNA damage2012

    • Author(s)
      I.Shiraishi
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA damage caused by UV-A irradiation induces genetic instability2012

    • Author(s)
      A.Urushibara
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Simulation stud of microdosimetry and distribution of DNA damage inducing base damage2012

    • Author(s)
      R.Watanabe
    • Organizer
      The XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      プラハ,チェコ共和国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Near Edge X-ray Absorption spectroscopy of DNA damage induced by soft X-rays2011

    • Author(s)
      K. Fujii and A. Yokoya
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Year and Date
      2011-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] EPR study of unpaired electron species in DNA film induced by nitrogen and oxygen K-shell photoabsorp-tion2011

    • Author(s)
      T. Oka, A. Yokoya, and K. Fujii
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Year and Date
      2011-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Significance of the repair synthesis in determining the biological consequences of clustered DNA damage2011

    • Author(s)
      N. Shikazono, M. Noguchi, A. Urishibara, P. O' Neill, and A. Yokoya
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Year and Date
      2011-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Dependence of the yields of AP sites and AP clustered produced in plasmid DNA on scavenging capacity and LET2011

    • Author(s)
      T. Shiina, Y. Sugaya, I. Shiraishi, R. Watanabe, M. Suzuki, and A. Yokoya
    • Organizer
      XII International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2011-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Introduction to synchrotron radia-tion and radiobiological studies, Surface2011

    • Author(s)
      A. Yokoya
    • Organizer
      Electro, Radiation, and Photo Chemistry International Master Course(SERP-Chem), EU Education & Training ERASUMUS MUNDUS
    • Place of Presentation
      Orsay, France
    • Related Report
      2011 Final Research Report
  • [Presentation] Order effect of base excision processes to repair clustered DNA damage2011

    • Author(s)
      A. Yokoya I. Shiraishi, and N. Shikazono
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      Warszawa, Poland
    • Related Report
      2011 Final Research Report
  • [Presentation] AP sites in plasmind DNA caused by Auger effect of oxygen2011

    • Author(s)
      A. Yokoya, Y. Sugaya, K. Fujii, T. Oka, R. Watanabe, T. Kai
    • Organizer
      7th Inter-national Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      Julich, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] X-ray absorption spectrosco pic analysis of DNA damage induced by soft X-rays2011

    • Author(s)
      K. Fujii and A. Yokoya
    • Organizer
      7th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      Julich, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Study of unpaired electron species in DNA film induced by nitrogen and oxygen K-shell photoabsorp-tion2011

    • Author(s)
      T. Oka, A. Yokoya, and K. Fujii
    • Organizer
      7th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      Julich, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] AP sites in Plasmind DNA Caused by Auger Effect of Oxygen2011

    • Author(s)
      A.Yokoya
    • Organizer
      7th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      ユーリッヒ,ドイツ
    • Related Report
      2011 Annual Research Report
  • [Presentation] X-ray Absorption Spectroscopic Analysis of DNA Damage Induced by Soft X-rays2011

    • Author(s)
      K.Fujii
    • Organizer
      7th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      ユーリッヒ,ドイツ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biological Assessment of Radiation Damage of ATP by Soft X-rays2011

    • Author(s)
      K.Fujii
    • Organizer
      7th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      ユーリッヒ,ドイツ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Study of Unpaired Electron Species in DNA Film Induced by Nitrogen and Oxygen K-sheell Photoabsorption2011

    • Author(s)
      T.Oka
    • Organizer
      7th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
    • Place of Presentation
      ユーリッヒ,ドイツ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Order effect of base excision processes to repair clustered DNA damage2011

    • Author(s)
      A.Yokoya
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      ワルシャワ,ポーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] Near Edge X-ray Absorption Spectroscopy of DNA Damage Induced by Soft X-rays2011

    • Author(s)
      K.Fujii
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      ワルシャワ,ポーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] EPR study of Unpaired Electron Species in DNA Film Induced by Nitrogen and Oxygen K-shell Photoabsorption2011

    • Author(s)
      T.Oka
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      ワルシャワ,ポーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] Significance of the repair synthesis in determining the biological consequences of clustered DNA damage2011

    • Author(s)
      N.Shikazono
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      ワルシャワ,ポーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] Introduction to Synchrotron Radiation and Radio-biological Studies2011

    • Author(s)
      A.Yokoya
    • Organizer
      Surface, Electro, Radiation, and Photo Chemistry International Master Course (SERP-Chem), EU Education & Training "ERASUMUS MUNDUS"
    • Place of Presentation
      Universite Paris-Sud(11),オルセー,フランス(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射線の直接作用による様々なDNA損傷生成モード2010

    • Author(s)
      横谷明徳
    • Organizer
      大阪大学産業科学研究所平成22年度-第2回量子ビーム科学研究施設研究会
    • Place of Presentation
      大阪大学,大阪
    • Year and Date
      2010-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線の直接作用による様々なDNA損傷生成モード2010

    • Author(s)
      横谷明徳
    • Organizer
      平成22年度量子ビーム科学研究施設研究会(第2回)
    • Place of Presentation
      大阪大学産業科学研究所 招待講演
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Near Edge X-ray absorption fine structure of DNA thin film irradiated with soft X-rays2010

    • Author(s)
      K. Fujii and A. Yokoya
    • Organizer
      37th International Conference on Vacuum Ultraviolet and X-ray Physics
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 難修復性のDNA損傷に関する物理学的及び生物学的アプローチによる研究2010

    • Author(s)
      横谷明徳
    • Organizer
      東北大学加齢研究所研究員会セミナー
    • Place of Presentation
      東北大学,仙台
    • Year and Date
      2010-08-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Various modes of DNA damage formation by the direct effect of radiation2010

    • Author(s)
      A.Yokoya
    • Organizer
      The 56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      ハワイ,アメリカ 招待講演
    • Year and Date
      2010-08-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 難修復性のDNA損傷に関する物理学的及び生物学的アプローチによる研究2010

    • Author(s)
      横谷明徳
    • Organizer
      東北大学加齢研究所研究員会セミナー
    • Place of Presentation
      東北大学加齢研究所 招待講演
    • Year and Date
      2010-08-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンクロトロン放射を用いたDNA損傷の分光研究2010

    • Author(s)
      横谷明徳
    • Organizer
      H22年度第1回東京RBC(放射線生物談話会)セミナー
    • Place of Presentation
      東京大学,東京
    • Year and Date
      2010-07-17
    • Related Report
      2011 Final Research Report
  • [Presentation] シンクロトロン放射を用いたDNA損傷の分光研究2010

    • Author(s)
      横谷明徳
    • Organizer
      H22年度第1回東京RBC(放射線生物談話会)セミナー
    • Place of Presentation
      東京大学 招待講演
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Soft X-ray absorption spectra of AMP and ATP in solutions2010

    • Author(s)
      H. Shimada, T. Fukao, H. Minami, M. Ukai, A. Yokoya, K. Fujii, Y. Fukuda, and Y. Saitoh
    • Organizer
      XII International Workshop on Radia-tion Damage to DNA
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2010-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Measurement of unpaired electron species in dry DNA thin films irradiated with synchrotron soft X-rays around oxygen and nitrogen K-edge studied by EPR2010

    • Author(s)
      T. Oka, A. Yokoya, K. Fujii, Y. Fukuda, and M. Ukai
    • Organizer
      2010 Inter-national Chemical Congress of Pacific Basin Societies(Pacifichem 2010)
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Various modes of DNA damage formation by the direct effect of radiation2010

    • Author(s)
      A. Yokoya
    • Organizer
      56th Annual Meeting of Radiation Research Society
    • Place of Presentation
      Hawaii, USA.
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel technique using DNA denaturation-annealing to detect multiply induced base lesions in plasmid DNA molecules by X-ray irradiation2010

    • Author(s)
      A. Yokoya, N. Shikazono, and K. Fujii
    • Organizer
      11th International Workshop on Radiation Damage to DNA
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel technique using DNA denaturation-annealing to detect multiply induced base lesions in plasmid DNA molecules by X-rav irradiation2010

    • Author(s)
      A.Yokoya
    • Organizer
      11^<th> International Workshop on Radiation Damage to DNA
    • Place of Presentation
      アトランタ,アメリカ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Near Edge X-ray Absorption Fine Structure of DNA Thin Film Irradiated with Soft X-rays2010

    • Author(s)
      K.Fujii
    • Organizer
      37^<th> International Conference on Vacuum Ultraviolet and X-ray physics
    • Place of Presentation
      バンクーバー,カナダ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Measurement of unpaired electron species in dry DNA thin films irradiated with synchrotron soft X-rays around oxygen and nitrogen K-edge studied by EPR2010

    • Author(s)
      T.Oka
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
    • Place of Presentation
      ハワイ,アメリカ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synchrotron radiation photoelectron studies for primary radiation effects in bio-solutions : Two dimensional electron spectra for liquid water in the soft X-ray region2009

    • Author(s)
      M.Ukai
    • Organizer
      11^<th> International Conference on Electronic Spectroscopy and Structure
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Near edge X-ray absorption fine structure of DNA thin film irradiated with soft x-ray2009

    • Author(s)
      K.Fujii
    • Organizer
      11^<th> International Conference on Electronic Spectroscopy and Structure
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体溶液試料に対する二次イオン質量分析法の開発2009

    • Author(s)
      住谷亮輔
    • Organizer
      原子衝突研究協会第34回年会
    • Place of Presentation
      首都大学 東京
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synchrotron radiation photoelectron studies for primary radiation effects in bio-solutions : two dimen-sional electron spectra for liquid water in the soft X-ray region2009

    • Author(s)
      M. Ukai, Y. Nonaka, R. Sumiya, S. Yasuhiro, A. Yokoya, K. Fujii, and Y. Saitoh
    • Organizer
      11th International Coference on Electronic Spectroscopy and Structur
    • Place of Presentation
      Nara, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Near Edge X-ray absorption fine structure of DNA thin film irradiated with soft X-rays2009

    • Author(s)
      K. Fujii and A. Yokoya
    • Organizer
      11th International Coference on Electronic Spectroscopy and Structure
    • Place of Presentation
      Nara, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Mutagenic potential of clustered DNA damage containing single strand break and 8-oxoGs2009

    • Author(s)
      M. Noguchi, A. Urushibara, A, Yokoya, P. O' Neill, and N. Shikazono
    • Organizer
      15th International Symposium on Microdosimetry : An Internation-al Meeting on Ionizing Radiation Quality
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis on the yield and the level of clustering of radiation-induced DNA strand breaks in hydrated plasmids2009

    • Author(s)
      N. Shikazono, A. Yokoya, A. Urushibara, M. Noguchi, and K. Fujii
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality
    • Place of Presentation
      Verona, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel technique using DNA denature-tion to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and He^<2+> ion irradia-tion2009

    • Author(s)
      A. Yokoya, N. Shikazono, A. Urushibara, M. Noguchi, and K. Fujii
    • Organizer
      15th International Symposium on Micro-dosimetry : An International Meeting on Ionizing Radiation Quality
    • Place of Presentation
      Verona, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体溶液試料に対する二次イオン質量分析法の開発2009

    • Author(s)
      住谷亮輔,安廣哲,野中裕介,鵜飼正敏,横谷明徳,藤井健太郎
    • Organizer
      原子衝突研究協会第34回年会
    • Place of Presentation
      首都大学東京,東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Mutagenic potential of clustered DNA damage containing single strand break and 8-oxoGs2009

    • Author(s)
      M.Noguchi
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on Ionizing Radiation Quality, Molecular Mechanisms Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Hotel San Marco, Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis on the Yield and the Level of Clustering of Radiation-induced DNA Strand Breaks in Hydrated Plasmids2009

    • Author(s)
      N.Shikazono
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on lonizing Radiation Quality, Molecular Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Hotel San Marco, Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Novel Technique Using DNA Denaturation to Detect Multiply Induced Single-strand Breaks in a Hydrated Plasmid DNA Molecule by X-ray and He^<2+> Ion Irradiation2009

    • Author(s)
      A.Yokoya
    • Organizer
      15th International Symposium on Microdosimetry : An International Meeting on lonizing Radiation Quality, Molecules Mechanisms, Cellular Effects, an Their Consequences for Low Level Risk Assessment and Radiation Therapy
    • Place of Presentation
      Hotel San Marco, Verona, Italy
    • Related Report
      2009 Annual Research Report
  • [Book] Spectroscopic study of radiation-induced DNA lesions and their susceptibility to enzymatic repair2011

    • Author(s)
      A. Yokoya, K. Fujii, N. Shikazono, and M. Ukai
    • Publisher
      CRC/Taylor & Francis Group
    • Related Report
      2011 Final Research Report
  • [Book] 放射線作用の基礎過程2011

    • Author(s)
      鵜飼正敏
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] ペニングイオン化2011

    • Author(s)
      鵜飼正敏
    • Publisher
      国際文献印刷社
    • Related Report
      2011 Final Research Report
  • [Book] Charged particle and photon interactions with matter-recent advances, applications and interfaces, Eds., Y.Hatano, Y.Katsumura, and A.Mozumder2011

    • Author(s)
      A.Yokoya
    • Publisher
      Chapter 20. Spectroscopic study of radiation-induced DNA lesions and their susce ptibility to enzymatic repair
    • Related Report
      2010 Annual Research Report
  • [Book] Charged Particle and Photon Interactions with Matter,-recent advances, applications and interfaces2010

    • Author(s)
      A.Yokoya(分担)
    • Publisher
      CRC Press/Taylor & Francis Group(印刷中)
    • Related Report
      2009 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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