Total Synthesis and Functional Analysis of Complex Natural Products
| Project/Area Number |
21241050
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
SASAKI Makoto 東北大学, 大学院・生命科学研究科, 教授 (80235267)
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| Co-Investigator(Kenkyū-buntansha) |
FUWA Haruhiko 東北大学, 大学院・生命科学研究科, 准教授 (90359638)
KONOKI Keiichi 東北大学, 大学院・農学研究科, 准教授 (40292825)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2011: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2010: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Keywords | 生物活性分子の設計・合成 / 天然物全合成 / ガンビエル酸 / ポリカバノシドA / ゴニオドミンA / 全合成 / 機能解析 / 海洋天然物 / 実践的全合成 |
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| Research Abstract |
Efficient synthetic routes to architecturally complex natural products with potent biological activities and molecular weights over 500 have been developed for exploring their biological functions. In particular, the first total synthesis and complete stereostructure determination of gambieric acid A have been accomplished. An efficient total synthesis of polycavernoside A has been also achieved in a convergent approach. In addition, efficient synthetic routes to the C1. C16 and C12. C36 fragments of goniodomin A have been developed by exploiting Stille-type coupling of thioesters.
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Report
(4 results)
Research Products
(127 results)
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[Journal Article] Comparative cytotoxicity of gambierol versus other marine neurotoxins2011
Author(s)
E.Cagide, M.C.Louzao, B.Espina, I.R.Ares, M.R.Vieytes, M.Sasaki, H.Fuwa, M.Yotsu-Yamashita, L.A.Paquette, T.Yasumoto, L.M.Botana
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Journal Title
Chemical Research in Toxicology
Volume: 24
Issue: 6
Pages: 835-842
DOI
Related Report
Peer Reviewed
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[Journal Article] Binding and selectivity of the marine toxins neodysiherbaine A, and its synthetic analogues, to GluK1 and GIuK2 kainate receptors2011
Author(s)
M.Unno, M.Shinohara, K.Takayama, H.Tanaka, K.Teruya, K.Doh-ura, R.Sakai, M.Sasaki, M.Ikeda-Saito
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Journal Title
Journal of Molecular Biology
Volume: 413
Issue: 3
Pages: 667-683
DOI
Related Report
Peer Reviewed
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