Mechanism of activation and inactivation of cell viability by generation and transport control of biological reactive plasma flow
| Project/Area Number |
21246032
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Takehiko 東北大学, 流体科学研究所, 教授 (10302225)
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| Co-Investigator(Kenkyū-buntansha) |
OHARA Taku 東北大学, 流体科学研究所, 教授 (40211833)
JOHKURA Kohei 信州大学, 医学部, 准教授 (30303473)
MIYAHARA Takashi 静岡大学, 工学部, 教授 (70239432)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2009: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
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| Keywords | バイオ流体力学 / 流体工学 / プラズマ工学 / 生体工学 / 化学的活性種 / 細胞反応 / 遺伝子発現 / 増殖 / ネクローシス |
|---|
| Research Abstract |
The chemical species of the biological reactive plasma flow was mainly transported by the generation of the expanding high temperature gas flow on the water surface and induced water flow due to the gas flow. Hydrogen peroxide among the stable chemical species generated by the plasma flow was identified as an important inactivation factor of the HeLa cell viability by the morphological variation process, the effect of catalase, the gene expression analysis, and so on. The energy transport in the cell membrane was affected by the transport directions and molecular types.
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Report
(4 results)
Research Products
(88 results)
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[Presentation] 大気放電による滅菌法の開発2011
Author(s)
石田将之, 佐藤岳彦
Organizer
第21回環境工学総合シンポジウム2011
Place of Presentation
産業技術総合研究所臨海副都心センター
Year and Date
2011-06-30
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