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Decomposition between cornea stiffness and eye pressure based stiffness through non-invasive dynamic active sensing

Research Project

Project/Area Number 21246043
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionOsaka University

Principal Investigator

KANEKO MAKOTO  大阪大学, 工学(系)研究科(研究院), 教授 (70224607)

Co-Investigator(Kenkyū-buntansha) HIGASHIMORI Mitsuru  大阪大学, 大学院・工学研究科, 准教授 (30346522)
YAMADA Kenji  大阪大学, 大学院・医学研究科, 准教授 (70364114)
Co-Investigator(Renkei-kenkyūsha) KIUCHI Yoshiaki  広島大学, 大学院・医歯薬学研究科, 教授 (40214738)
Project Period (FY) 2009-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Keywords非接触センシング / 非侵襲 / ダイナミックセンシング / 眼計測 / 緑内障 / 眼剛性 / 硝子体 / バイオマーカー / 角膜変形 / 白内障 / 生体計測 / メカトロニクス / 眼圧計測 / 計測工学 / 機械力学 / 緑内障診断 / アクティブセンシング / 眼圧剛性と構造剛性 / 検査 / 診断システム / 非接触眼圧計 / 眼剛性計測 / 職内証診断
Research Abstract

By measuring the deformation of cornea surface during the impartment of air-puff to eye, the correlation of the eye stiffness and eye pressure was evaluated. Through five-years-research, the following points were made clear. (1) The deformation under the air-puff becomes larger for senior subjects rather than young ones. (2) The curvature under an air-puff becomes larger for senior subjects rather than young ones. (3) After vitreous surgery, the eye ball deforms ellipsoidal when an air-puff is given to eye. (4) The stiffness of retina of glaucoma patient becomes higher than that of normal subject. (5) The eye pressure under contact lens is predictable by considering the shape of the lens.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (12 results) Remarks (2 results)

  • [Journal Article] Ocular Surface Displacement with and without Contact Lenses during Non-Contact Tonometry2014

    • Author(s)
      Rimayanti U., Kuchi Y., Umemura S., Takenaka J., Mochizuki H., and Kaneko M
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 4 Pages: 1-7

    • DOI

      10.1371/journal.pone.0096066

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of Occular Stiffness on Intraocular Pressure Estimation Using Goldmann Applanation Tonometry2013

    • Author(s)
      Shirane M., Kiuchi Y., Otani K., Kaneko M., and Takenaka J
    • Journal Title

      Journal of Medical and Biological Engineering

      Volume: vol.33 Issue: 3 Pages: 293-300

    • DOI

      10.5405/jmbe.1381

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Evaluation of Cornea Displacement using High-Speed Photography at the Early and Late Phases of Noncontact Tonometry2013

    • Author(s)
      Nakakura S., Kiuchi Y., Kaneko M., Mochizuki H., Yamada K., Kimura Y., Tabuchi H
    • Journal Title

      Investigative Ophthalmology and Visual Science

      Volume: vol.54 Pages: 2474-2481

    • Related Report
      2013 Final Research Report
  • [Journal Article] 眼球内力学特性評価のための新しい力学的指標2013

    • Author(s)
      木村 洋介, 金子 真, 相澤 奈帆子, 田中 佑治, 國方 彦志, 中澤 徹
    • Journal Title

      日本機械学会論文集

      Volume: vol.79 Pages: 450-458

    • NAID

      130003374939

    • Related Report
      2013 Final Research Report
  • [Journal Article] コンタクトレンズ装着による眼圧計測ファントム現象の考察2013

    • Author(s)
      木村 洋介, 金子 真, 山 田 憲嗣, 木内 良明
    • Journal Title

      Imin KAO

      Volume: vol.79 Pages: 450-458

    • NAID

      130003374940

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of corneal displacement using high-speed photography at the early and late phases of noncontact tonometry2013

    • Author(s)
      Nakakura S., Kiuchi Y., Kaneko M., Mochizuki H., Takenaka J., Yamada K., Kimura Y., and Tabuchi H.
    • Journal Title

      Innestigative Ophthalmology and Visual Science

      Volume: 54 Issue: 4 Pages: 2474-2481

    • DOI

      10.1167/iovs.12-11424

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 眼球内力学特性評価のための新しい力学的指標2013

    • Author(s)
      木村 洋介
    • Journal Title

      日本機械学会

      Volume: 79巻 Pages: 450-458

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コンタクトレンズ装着による眼圧計測ファントム現象の考察2013

    • Author(s)
      木村 洋介
    • Journal Title

      日本機械学会

      Volume: 79巻 Pages: 459-466

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corneal Displacement during Tonometry with a Noncontact Tonometer2012

    • Author(s)
      Yoshiaki Kiuchi, Makoto Kaneko, Hideki Mochizuki, Joji Takenaka, Kenji Yamada, Junko Tanaka
    • Journal Title

      Jpn J Ophthalmol

      Volume: (Published online)

    • NAID

      10030626992

    • Related Report
      2013 Final Research Report
  • [Journal Article] Modeling, Sensing and Interpretation of Viscoelastic Contact Interface2012

    • Author(s)
      C. Tsai, I. Kao, M. Higashimori, and M. Kaneko
    • Journal Title

      Journal of Advanced Robotics

      Volume: vol. 26, no. 11-12 Pages: 1393-1418

    • Related Report
      2013 Final Research Report
  • [Journal Article] Corneal Displacement during Tonometry with a Noncontact Tonometer2012

    • Author(s)
      Yoshiaki Kiuchi, Makoto Kaneko, Hideki Mochizuki, Joji Takenaka, Kenji Yamada, Junko Tanaka
    • Journal Title

      Japan Journal of J Ophthalmol

      Volume: 27(印刷中)(Online Publishment)

    • NAID

      10030626992

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 空気噴流印加時の曲率に着目した角膜剛性 のエイジング評価2011

    • Author(s)
      五所卓巳, 山田憲嗣, 東森充, 金子真, 竹中丈二, 木内良明, 戸田良太郎, 西田幸二
    • Journal Title

      生体医工学

      Volume: vol. 49, no. 3 Pages: 469-475

    • NAID

      130004947481

    • Related Report
      2013 Final Research Report
  • [Journal Article] Noncontact Active Sensing for Viscoelastic Parameters of Tissue with Coupling Effect2011

    • Author(s)
      Nobuyuki Tanaka, Mitsuru Higashimori, Makoto Kaneko, and Imin Kao
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: vol. 58, no. 4 Pages: 509-520

    • Related Report
      2013 Final Research Report
  • [Journal Article] 空気噴流印加時の曲率に着目した角膜剛性のエイジング評価2011

    • Author(s)
      五所卓巳, 山田憲嗣, 東森充, 金子真, 竹中丈二, 木内良明, 戸田良太郎, 西田幸二
    • Journal Title

      生体医工学

      Volume: 49 Pages: 469-475

    • NAID

      130004947481

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncontact Active Sensing for Viscoelastic Parameters of Tissue with Coupling Effect2011

    • Author(s)
      Nobuyuki Tanaka, Mitsuru Higashimori, Makoto Kaneko, Imin Kao
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 58 Pages: 509-520

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小型実験動物のためのバルーン式左心室組織弾性センシング2011

    • Author(s)
      東森充, 石井亮平, 多田隈建二郎, 金子真, 玉置俊介, 坂田泰史, 山本一博
    • Journal Title

      計測自動制御学会論文集

      Volume: 47 Pages: 649-655

    • NAID

      10030165740

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of Noncontact Tumor Imager for Video-Assisted Thoracic Surgery2010

    • Author(s)
      Tomohiro Kawahara, Yoshihiro Miyata, Koichi Akayama, Masazumi Okajima, and Makoto Kaneko
    • Journal Title

      IEEE Transactions on Mechatronics

      Volume: vol. 15, no. 6 Pages: 838-846

    • Related Report
      2013 Final Research Report
  • [Journal Article] 塑性変形分離に着目したレオロジー物体のアクティブシェイピング2010

    • Author(s)
      東森充, 吉本佳世, 金子真
    • Journal Title

      計測自動制御学会論文集

      Volume: 46 Pages: 31-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 空気噴流印加時における角膜の凹部変形を考慮したダイナミックセンシング2009

    • Author(s)
      山田憲嗣, 山崎直幸, 五所卓巳, 木内良明, 竹中丈二, 東森充, 金子真
    • Journal Title

      計測自動制御学会論文集 vol.45, no.10

      Pages: 495-501

    • NAID

      10026207087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Online Measurement of Cornea Deformation during Non-contact Tonometry2011

    • Author(s)
      Tim Krijger, Makoto Kaneko
    • Organizer
      IEEE SENSORS 2011
    • Place of Presentation
      Limerick (Ireland)
    • Year and Date
      2011-10-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトの能力を超えたハイパーヒューマン技術と医療診断2011

    • Author(s)
      金子真
    • Organizer
      医工学治療学会
    • Place of Presentation
      岡山県、岡山市、岡山コンベンションセンター(招待講演)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] High Risk of Underestimation of Internal Eye Pressure for Elderly People2010

    • Author(s)
      Makoto Kaneko
    • Organizer
      IEEE the 1^<st> Int.Conf.on EESS
    • Place of Presentation
      Monterey, California, USA
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bio/Medical Breakthrough by Hyper Human Vision2010

    • Author(s)
      Makoto Kaneko
    • Organizer
      IEEE Int.Conf.on Mechatronics and Automation
    • Place of Presentation
      Xian, China
    • Year and Date
      2010-08-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 3D Dynamic Active Sensing of Human Eye2009

    • Author(s)
      K.Yamada, T.Gosho, M.Higashimori, M.Kaneko, Y.Kiuchi
    • Organizer
      Proc. of the 6th Int. Conf. on Ubiquitous Robots and Ambient Intelligence, pp. 332-335
    • Place of Presentation
      Gwangju, Korea
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Is Cornea Compliant with respect to Age?2009

    • Author(s)
      T.Gosho, K.Yamada, N.Yamasaki, M.Higashimori, J.Takenaka, Y.Kiuchi, M.Kaneko
    • Organizer
      WC 2009, Medical Physics and Biomedical Engineering, Proceedings 25/XI, pp. 223-226
    • Place of Presentation
      Munichi, Germany
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 3D Dynamic Sensing of Human Eye Toward Evaluation of Cornea Stiffness2009

    • Author(s)
      K.Yamada, N.Yamasaki, T.Gosho, M.Higashimori, J.Takenaka, Y.Kiuchi, M.Kaneko
    • Organizer
      WC 2009, Medical Physics and Biomedical Engineering, Proceedings 25/XI, pp. 239-242
    • Place of Presentation
      Munichi, Germany
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] ダイナミックアクティブセンシングによる眼圧剛性と構造剛性の分離に向けて2009

    • Author(s)
      五所卓巳, 山田憲嗣, 山崎直幸, 東森充, 竹中丈二, 木内良明, 金子真
    • Organizer
      第48回日本生体医工学会大会,pp. 203
    • Place of Presentation
      東京
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 硝子体手術前後における空気噴流印加時の眼球変形特性

    • Author(s)
      上村祥平,金子真,相澤奈帆子,田中佑治,國方彦志,中澤徹
    • Organizer
      日本機械学会第26回バイオエンジニアリング講演会
    • Place of Presentation
      東北大学,仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] IOP Measurement Using Air-Puff Tonometry: Dynamic Modeling of Human Eyeball with Experimental Results

    • Author(s)
      Nishiyama J., Kao I. and Kaneko M.
    • Organizer
      The 10th International Conference on Ubiquitous Robots and Ambient Intelligence
    • Place of Presentation
      Ramada Plaza, Jeju, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Deformation of Yellow Spot Area by Compulsory Increase of Eye Pressure

    • Author(s)
      Y. Kimura
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC12)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Deformation of Macula Area under Compulsory Increase of Eye Pressure

    • Author(s)
      Y. Kimura
    • Organizer
      IEEE Int. Conf. on Mechatronics and Automation (ICMA12)
    • Place of Presentation
      Chengdu, China
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      https://sites.google.com/site/osakaubiomarker/

    • Related Report
      2013 Final Research Report
  • [Remarks] 革新的バイオマーカー創出とその臨床応用

    • URL

      https://sites.google.com/site/osakaubiomarker/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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