|Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2009: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
GPI-anchor is a glycolipid acts as a membrane anchor of many eukaryotic cell surface proteins. In this study, we aimed to clarify (1) mechanisms and biological significance of fatty acid remodeling of GPI-anchored proteins (GPI-AP); (2) mechanism and biological significance of 1-alkyl, 2-acyl form of GPI anchors; and (3) roles of GPI structural remodeling in transport of GPI-AP. We found (1) that GPI fatty acid remodeling is important for homeostasis of humoral immunity; (2) that 1-alkyl, 2-acyl form of GPI anchors is defective in major peroxisome disorders; and (3) that proper remodeling of GPI-AP is critical for association with their cargo receptors and efficient transport.